Antiangiogenic Agents In Cancer Therapy

Author : Beverly A. Teicher,Lee M. Ellis
Publisher : Springer Science & Business Media
Page : 559 pages
File Size : 48,8 Mb
Release : 2008-01-08
Category : Medical
ISBN : 9781597451840

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Antiangiogenic Agents in Cancer Therapy by Beverly A. Teicher,Lee M. Ellis Pdf

This volume represents a compendium of scientific findings and approaches to the study of angiogenesis in cancer. The second edition of Antiangiogenic Agents in Cancer Therapy is intended to give a current perspective on the state-of-the-art of angiogenensis and therapy directed at this process. Antiangiogenesis is a dynamic and evolving field in oncology. New therapeutic targets continue to emerge followed by the rapid development of new therapeutic agents to be investigated in clinical trials. Optimizing the therapeutic potential of antiangiogenic agents in combination with the other therapies in the armamentarium to fight cancer will be an on-going challenge.

Author : Anonim
Publisher : Academic Press
Page : 296 pages
File Size : 44,7 Mb
Release : 2022-01-14
Category : Science
ISBN : 9780323905565

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Antiangiogenic Drugs as Chemosensitizers in Cancer Therapy by Anonim Pdf

Anti-angiogenic Drugs as Chemosensitizers in Cancer Therapy, Volume 19 focuses on the use of anti-angiogenic drugs as sensitizers of tumor cells to the inhibitory activity of antitumor agents. Conventional and novel anti-neoplastic agents (cytotoxic molecules, hormones/antihormones, immunotherapies) are taken into consideration, along with advances made in combination therapies. The book encompasses examples of studies on the use of antiangiogenic compounds—molecules that inhibit the growth of vessels inside a tumor—together with antineoplastic drugs in order to sensitize the resistant tumor to their cytotoxic effects, thus reducing adverse side reactions and resistance and improving the therapeutic response of cancer patients. In addition, the book discusses clinical applications in various types of cancer, such as colorectal, lung, breast, renal, genitourinary, skin and brain and circulating tumors. It is a valuable resource for cancer researchers, clinicians and members of the biomedical field who wants to be up-to-date on the most recent and promising developments in the field. Provides the most updated reviews on anti-angiogenic drugs as chemosensitizers by leaders in the field Encompasses summarized tables and schematic diagrams in each chapter to give a clear overview on recent findings in a didactic manner Brings not only relevant information of current research but also new ideas and suggestions for further investigations to help advance the field

Author : Darren W. Davis,Roy S. Herbst,James L. Abbruzzese
Publisher : CRC Press
Page : 864 pages
File Size : 52,8 Mb
Release : 2007-07-25
Category : Science
ISBN : 1420004298

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Antiangiogenic Cancer Therapy by Darren W. Davis,Roy S. Herbst,James L. Abbruzzese Pdf

Top Investigators Explore the Complexities of Angiogenesis Cancer Research The targeting of tumor angiogenesis has evolved into one of the most widely pursued therapeutic strategies. However, as of yet, no antiangiogenic agent used as a monotherapy has demonstrated a survival benefit in a randomized Phase III trial. The combination of bevacizumab, the first FDA approved angiogenesis inhibitor, with cytotoxic regimens has led to survival benefits in cancer patients. This has raised important questions about the complexities inherent in the clinical application of angiogenesis inhibitors. Compiles the results of four decades of progress Integrating fundamental concepts with therapeutic strategies, Anti-Angiogenic Cancer Therapy promotes the idea that an understanding of the molecular and cellular regulation of angiogenesis leads to optimal therapeutic strategies and positive clinical results. It brings together contributions from leading researchers to provide the most authoritative and encyclopedic volume available on this subject. Examines the role of angiogenesis in cancer, including strategies to prolong the nonangiogenic dormant state of human tumors, molecular mechanisms and cellular regulation of angiogenesis in solid tumors and hematologic malignancies, and the regulation of angiogenesis by the tumor microenvironment. Covers specific molecular targets for inhibiting angiogenesis in cancer therapy. Discusses clinical trial design and translational research approaches essential for identifying and developing effective angiogenesis inhibitors. Outlines current understanding of the molecular biology of each cancer type followed by discussions that examine strategies for targeting angiogenesis in specific cancers. This volume celebrates progress made in four decades, and more importantly, it provides a clear indication of the complex biology that needs further investigation to realize the possibilities envisioned for this beneficial therapeutic modality.

Author : Beverly A. Teicher
Publisher : Unknown
Page : 470 pages
File Size : 50,9 Mb
Release : 2014-01-15
Category : Electronic
ISBN : 1475745176

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Antiangiogenic Agents in Cancer Therapy by Beverly A. Teicher Pdf

Author : Shaker Mousa,Paul Davis
Publisher : Academic Press
Page : 210 pages
File Size : 55,7 Mb
Release : 2016-11-28
Category : Medical
ISBN : 9780128026731

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Anti-Angiogenesis Strategies in Cancer Therapies by Shaker Mousa,Paul Davis Pdf

Anti-angiogenesis Strategies in Cancer Therapeutics provides a detailed look at the current status and future directions in the discovery and development of novel anti-angiogenesis strategies in oncology. This book highlights the different mechanisms involved in the modulation of angiogenesis, including inflammation, thrombosis, and microRNA, and shows how nanotechnology can further enhance the potential of existing and new anti-angiogenesis approaches. Written for industry scientists, researchers, oncologists, hematologists, and professors and students in the field, this comprehensive book covers all aspects of anti-angiogenesis strategies and their differences. Covers important preclinical models and clinical trials in the discovery and development of novel anti-angiogenesis agents Reviews FDA-approved anti-angiogenesis agents Illustrates the value of nanotechnology in improving the utility of anti-angiogenesis agents Offers insight into the development of novel anti-angiogenesis agents and future direction in this area

Author : Dieter Marmé,Norbert Fusenig
Publisher : Springer Science & Business Media
Page : 845 pages
File Size : 41,9 Mb
Release : 2007-12-05
Category : Medical
ISBN : 9783540331773

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Tumor Angiogenesis by Dieter Marmé,Norbert Fusenig Pdf

Tumor angiogenesis is one of the most prominent mechanisms driving tumor development and progression. This book is written by internationally renowned experts. Part 1 describes the basic mechanisms. Tumor-angiogenic signaling pathways are presented as new potential targets for anti-angiogenic therapy. Part 2 reviews the efforts made to validate new targets and to show efficacy in animals. Part 3 is devoted to the clinical development of the novel anti-angiogenic drugs and their use in clinical practice.

Author : Sudip Mukherjee,Vijay Sagar Madamsetty
Publisher : Springer Nature
Page : 85 pages
File Size : 40,9 Mb
Release : 2022-09-27
Category : Technology & Engineering
ISBN : 9783031112843

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Nanoparticles in Angiogenesis and Cancer by Sudip Mukherjee,Vijay Sagar Madamsetty Pdf

This book highlights recent developments of organic and inorganic nanomedicine that play a major role in anti-angiogenic cancer therapy. In addition, the authors present examples of nanomedicine based anti-angiogenic agents and their applications in cancer therapy. Angiogenesis is a pathophysiological phenomenon that modulates cell proliferation and cell migration and plays important roles in cancer. Anti-angiogenic nanotherapies have gained immense attention in recent times as alternative cost-effective therapies that opened a new dimension in cancer theranostics. Further the challenges of the anti-angiogenic nanotherapies and possible future perspective are detailed.

Author : Dieter Marmé
Publisher : Springer
Page : 0 pages
File Size : 46,9 Mb
Release : 2019-10-18
Category : Medical
ISBN : 3319336711

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Tumor Angiogenesis by Dieter Marmé Pdf

This exhaustive work shows that new therapies using anti-angiogenic drugs are of particular importance because they can be used against many different types of cancer, as tumor angiogenesis seems to be involved in most if not all solid metastasizing malignancies. The first part of this book summarizes the knowledge acquired on the molecular entities that play a role in tumor angiogenesis and their mechanisms of action. Furthermore, the identification of molecular markers and their validation as predictive and/or prognostic tools is reviewed. In the second and most important part, the clinical applications of anti-angiogenic treatments are documented for a wide variety of tumors. In particular, the modes of combination with other targeted and/or cytotoxic cancer therapies are presented.​

Author : Elmer T. Skinard
Publisher : Nova Publishers
Page : 180 pages
File Size : 46,8 Mb
Release : 2007
Category : Blood-vessels
ISBN : 1600214738

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New Research on Angiogenesis Inhibitors by Elmer T. Skinard Pdf

Angiogenesis -- the growth of new blood vessels -- is an important natural process occurring in the body, both for health and as related to disease. Angiogenesis occurs in the healthy body to help heal wounds and to help to restore blood flow to tissues after injury or insult. In females, Angiogenesis also occurs during the monthly reproductive cycle (to rebuild the uterus lining, to mature the egg during ovulation) and during pregnancy (to build the placenta, the circulation between mother and foetus). The healthy body controls angiogenesis through a series of "on" and "off" switches. The main "on" switches are known as angiogenesis-stimulating growth factors. The main "off switches" are known as angiogenesis inhibitors. When angiogenic growth factors are produced in excess of angiogenesis inhibitors the balance is tipped in favour of blood vessel growth. When inhibitors are present in excess of stimulators, angiogenesis is stopped. The normal, healthy body maintains a perfect balance of angiogenesis modulators. In general, angiogenesis is "turned off" by the production of more inhibitors than stimulators. Tumour angiogenesis is the proliferation of a network of blood vessels that penetrates into cancerous growths, supplying nutrients and oxygen and removing waste products. Tumour angiogenesis actually starts with cancerous tumour cells releasing molecules that send signals to surrounding normal host tissue. This signalling activates certain genes in the host tissue that, in turn, cause proteins to encourage growth of new blood vessels. This book examines its angiogenesis within the context of theory and its applications to cancer treatment.

Author : Atta-ur-Rahman,M. Iqbal Choudhary
Publisher : Bentham Science Publishers
Page : 252 pages
File Size : 43,5 Mb
Release : 2016-10-06
Category : Medical
ISBN : 9781681081557

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Anti-Angiogenesis Drug Discovery and Development by Atta-ur-Rahman,M. Iqbal Choudhary Pdf

The inhibition of angiogenesis is an effective mechanism of slowing down tumor growth and malignancies. The process of induction or pro-angiogenesis is highly desirable for the treatment of cardiovascular diseases, wound healing disorders, etc. Efforts to understand the molecular basis, both for inhibition and induction, have yielded fascinating results. Anti-angiogenesis Drug Discovery and Development provides an excellent compilation of well-written reviews on various aspects of the anti-angiogenesis process. These reviews have been contributed by leading practitioners in drug discovery science and highlight the major developments in this exciting field in the last two decades. The feast of these reader-friendly reviews on topics of great scientific importance – many of which are considered significant medical breakthroughs, makes this book excellent reading both for the novice as well as for expert medicinal chemists and clinicians. This volume brings together 5 reviews on these topics: -Beta-blockers for treating premature retinopathy -Anti-angiogenic activity of disintegrin-based, synthetic cyclic KTS peptides -Anti-angiogenic therapy of lung cancer -Oral anti-angiogenic therapy for NSCLC -Angiogenesis in hepatocellular carcinoma

Author : Malay Chatterjee,Ajay Rana,Basabi Rana
Publisher : Bentham Science Publishers
Page : 238 pages
File Size : 54,9 Mb
Release : 2010
Category : Medical
ISBN : 9781608050079

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Angiogenesis & Therapeutic Targets in Cancer by Malay Chatterjee,Ajay Rana,Basabi Rana Pdf

Angiogenesis plays rate limiting roles in tumor growth and invasion. Angiogenesis inhibition has been proposed as a general strategy to fight against cancers. This book covers different therapeutic targets for angiogenesis interventions with emphasis on c

Author : Tim Meyer
Publisher : Springer Science & Business Media
Page : 256 pages
File Size : 55,7 Mb
Release : 2010-09-02
Category : Medical
ISBN : 9781441966094

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Vascular Disruptive Agents for the Treatment of Cancer by Tim Meyer Pdf

Angiogenesis (formation of new vessels from pre-existing ones) is a crucial early event in the process of tumor development. New vessels supply the tumor with nutrients that are needed for further local growth and enable distant metastases (Folkman 1995). Judah Folkman (1971) highlighted the potential therapeutic imp- cations of tumor angiogenesis. He hypothesized that if tumor angiogenesis is inhibited, then tumor growth and metastasis will be impaired greatly or even impossible. The subsequent quest for endogenous and exogenous inhibitors of angiogenesis has yielded a variety of promising therapeutic agents that block one or more angiogenic pathways, a few of which have been approved by the FDA (e. g. , bevacizumab, sorafenib, sunitinib) for use as single agents or in combination with chemotherapy in specific populations of cancer patients (Sessa et al. 2008). There has also been a dramatic expansion in the exploration of novel anti-angiogenic agents pre-clinically and in clinical trials (Ferrara 2002). Some of the most promising data comes from the development of agents that inhibit one of the key growth factors involved in tumor angiogenesis – vascular endothelial growth factor (VEGF) (Ferrara et al. 2003). Bevacizumab is a monoclonal antibody against VEGF that was the first an- angiogenic agent that improved significantly the overall survival of patients with colorectal and non-squamous non-small cell lung cancer (Ferrara et al. 2005). Various agents that target tumor angiogenesis are currently under investigation in different cancer types in many clinical trials (Ferrara and Kerbel 2005).

Author : Atta-ur-Rahman, Muhammad Iqbal Choudhary
Publisher : Bentham Science Publishers
Page : 212 pages
File Size : 49,6 Mb
Release : 2020-10-05
Category : Medical
ISBN : 9789811432866

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Anti-Angiogenesis Drug Discovery and Development: Volume 5 by Atta-ur-Rahman, Muhammad Iqbal Choudhary Pdf

The inhibition of angiogenesis is an effective mechanism of slowing down tumor growth and malignancies. The process of induction or pro-angiogenesis is highly desirable for the treatment of cardiovascular diseases, and wound healing disorders. Efforts to understand the molecular basis, both for inhibition and induction, have yielded fascinating results. Anti-angiogenesis Drug Discovery and Development provides an excellent compilation of well-written reviews on various aspects of the anti-angiogenesis process. These reviews have been contributed by leading practitioners in drug discovery science and highlight the major developments in this exciting field in the last two decades. The feast of these reader-friendly reviews on topics of great scientific importance – many of which are considered significant medical breakthroughs, makes this series excellent reading both for the novice as well as for expert medicinal chemists and clinicians. The fifth volume brings together reviews on the following topics: - Targeted therapy for tumor vasculature - Anti-angiogenic therapy for breast and prostate cancers (including information updates on clinical trials) - Microbe-based and other novel antiangiogenesis therapies such as chromene-based agents

Author : Hans-Jörg Senn,Richard D. Gelber,Aron Goldhirsch,Beat Thürlimann
Publisher : Springer Science & Business Media
Page : 505 pages
File Size : 48,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642457692

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Adjuvant Therapy of Primary Breast Cancer VI by Hans-Jörg Senn,Richard D. Gelber,Aron Goldhirsch,Beat Thürlimann Pdf

This RRCR-conference-volume marks "number six" in a 20-year evolution of international conferences on the adjuvant therapy of primary breast cancer. Starting in 1978, a handful of some 80 en thusiastic breast cancer surgeons and oncologists, met in a se cluded mountain resort near st. Gallen in Eastern Switzerland, to exchange their early data of some pioneer trials on adjuvant sys temic therapy of early breast cancer, and to correlate their future research efforts to overcome the frustrating prognostic stagna tion of this dominant neoplastic disease in Western females dur ing the past decades. Repeated every 3-4 years, these St. Gallen International Conferences on Adjuvant Therapy of Primary Breast Cancer have continuously grown in numbers of partici pants and in normative, therapeutic influence by being published in major oncology journals [1-3], the last (6th) conference hav ing taken place from February 25-28, 1998 with more than 1800 attendees from over 50 countries worldwide. What is the fascination of adjuvant therapy in primary (early) breast cancer, and what has changed,during the last 3 years since March 1995, to justify another international gathering of this size, and of the world's leading experts in the field? There is no question, that providing even more effective care and designing appropriate recommendations for the multitudes of patients with so-called early breast cancer or at high risk of developing the disease, remain highly important public health goals.

Author : Guido Bocci,Giulio Francia
Publisher : Springer
Page : 295 pages
File Size : 48,6 Mb
Release : 2014-09-04
Category : Medical
ISBN : 9783662436042

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Metronomic Chemotherapy by Guido Bocci,Giulio Francia Pdf

This book analyzes all aspects of metronomic chemotherapy, a new approach involving low-dose, long-term, and frequently administered therapy that has preclinical and clinical activity in various tumors. After an opening section on the pharmacological bases of metronomic chemotherapy, including its antiangiogenic effects and impact on immunity, preclinical studies on various classes of drug are discussed. Clinical applications of metronomic chemotherapy in a wide variety of tumors are then addressed in detail, with description of the results of all published studies. The clinical pharmacology of metronomic chemotherapy is also considered in depth, encompassing pharmacokinetics, pharmacogenetics, pharmacoeconomics, and adverse drug reactions. The book closes by describing the role of this therapy in the veterinarian clinic.