Angiotensin And The Heart

Author : Edward D. Frohlich,Richard N. Re
Publisher : Springer Science & Business Media
Page : 187 pages
File Size : 42,8 Mb
Release : 2009-09-18
Category : Medical
ISBN : 9781441905284

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The Local Cardiac Renin-Angiotensin Aldosterone System by Edward D. Frohlich,Richard N. Re Pdf

Until recently, the renin-angiotensin-aldosterone system has been considered a systemic endocrine hormonal system exclusively. It is now known that each component of the renin-angiotensin system is produced, synthesized and indeed, present in many organisms including the heart and vessels. This volume presents the most recent clinical and laboratory experiences of the leading physicians and investigators in the field of the local cardiac renin-angiotensin aldosterone system. Cardiovascular, renal and hypertension oriented physicians, investigators and scientists would find this book of interest. Edward D. Frohlich, M.D., M.A.C.P, F.A.C.C., is the Alton Ochsner Distinguished Scientist at the Ochsner Clinic Foundation in New Orleans, Louisiana. He is also Professor of Medicine and of Physiology at Louisiana State University School of Medicine, New Orleans, and Clinical Professor of Medicine and Adjunct Professor of Pharmacology at Tulane University School of Medicine, New Orleans. He is past Editor-in-Chief of the American Heart Association journal HYPERTENSION. Richard N. Re, M.D., is the Section Head, Hypertension at the Ochsner Clinic Foundation in New Orleans, Louisiana. He is also Ochsner's Scientific Director of Research.

Author : Walmor C. De Mello
Publisher : John Wiley & Sons
Page : 256 pages
File Size : 47,5 Mb
Release : 2005-10-31
Category : Medical
ISBN : 9780470862940

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Renin Angiotensin System and the Heart by Walmor C. De Mello Pdf

Recent studies have shown that the heart possesses an intrinsic renin angiotensin system that is controlled by tissue-specific parameters that are activated by biomechanical stress. This book reviews the latest information on the way in which both the plasma and cardiac renin angiotensin systems affect heart function. It covers the cell and molecular biology of these systems, with contributions on renin synthesis, uptake and the intracellular signalling pathways. Particular insight comes from transgenic mouse models in which either mouse or human genes for various components of the renin angiotensin system are expressed. Other topics covered include wound healing as well as the trophic effects of aldosterone. Contains the most recent findings on the renin angiotensin system and the heart Written by an international team of distinguished scientists Covers both the cellular and molecular basis of the renin angiotensin system and the clinical relevance of this research

Author : Walmor C. DeMello,Edward D. Frohlich
Publisher : Springer Science & Business Media
Page : 249 pages
File Size : 44,5 Mb
Release : 2009-09-01
Category : Medical
ISBN : 9781607611868

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Renin Angiotensin System and Cardiovascular Disease by Walmor C. DeMello,Edward D. Frohlich Pdf

This book offers the latest research into the role of the renin angiotensin system on cardiac and vascular functions and in cardiovascular diseases. It covers vital aspects such as intracellular signaling and regulation of cell volume in the failing heart.

Author : Gerd Heusch,H. Grobecker,B.E. Strauer
Publisher : Springer Science & Business Media
Page : 358 pages
File Size : 47,7 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642724978

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Angiotensin and the Heart by Gerd Heusch,H. Grobecker,B.E. Strauer Pdf

In the last decade, ACE inhibitors have become a cornerstone of cardiovascular drug therapy. Beneficial effects in patients with hypertension, heart failure, and post myocardial infarction have been established in large clinical trials. In parallel, ex perimental research has shifted the interest from the immediate homeostatic function of the circulating renin-angiotensin-system to the multiple paracrine functions of local tissue renin-angiotensin-systems, including hypertrophy, hyperplasia, athe- oenesis, and vasomotion. . It was the aim or a symposium held in Hamburg, October 22-24, 1992, to bring together an international panel of experimental and clinical scientists and to discuss the most recent findings on the role of angiotensin and associated mediators in car diovascular adaptation and disease, with a particular emphasis on the treatment of such disease by ACE inhibitors. The meeting and this publication were generously supported by Astra Chemicals. H. Grobecker G. Heusch B.E. Strauer Contents Foreword. ... ... V Introduction Local expression and pathophysiological role of renin-angiotensin in the blood vessels and heart Dzau, V.J. ... ... 1 Myocardial Perfusion Angiotensin, ACE-inhibitors and endothelial control of vasomotor tone Luscher, T.F. ... ... 15 Local and neurohumoral control of coronary blood flow Krajcar, M., G. Heusch. ... 25 ACE-inhibitors in coronary artery disease? Vogt, M., W. Matz, B.E. Strauer ... 43 Myocardial Hypertrophy Molecular mechanisms of cardiac gene expression Nadal-Ginard, B., V. Mahdavi ... 65 Myocardial perfusion dependent and independent mechanisms of regional myocardial dysfunction in hypertrophy Vatner, S.F., L. Hittinger ...

Author : Naranjan S. Dhalla,Sukhwinder K. Bhullar,Anureet K. Shah
Publisher : Springer Nature
Page : 453 pages
File Size : 40,9 Mb
Release : 2023-01-01
Category : Medical
ISBN : 9783031149528

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The Renin Angiotensin System in Cardiovascular Disease by Naranjan S. Dhalla,Sukhwinder K. Bhullar,Anureet K. Shah Pdf

This book on “Renin-Angiotensin System in Cardiovascular Disease” includes 25 chapters, which are organized in three sections, namely (i) modulatory aspects, (ii) pathophysiological aspects, and (iii) pharmacotherapeutic aspects. It includes an updated as well as comprehensive knowledge about molecular and cellular aspects for the role of the renin-angiotensin system (RAS) in the pathophysiology and therapy of cardiovascular diseases such as hypertension, atherosclerosis, ischemic heart disease, and heart failure. This book emphasizes the molecular and cellular mechanisms, signaling transduction pathways involved in the development of different cardiovascular diseases due to the prolonged activation of RAS. Furthermore, biochemical mechanisms are outlined for the inhibition of this system by the blockade of angiotensin converting enzyme as well as angiotensin II type 1 receptors in patients suffering from cardiovascular abnormalities. Since cardiovascular disease is the number one cause of death worldwide, leading to approximately 17.9 million deaths each year, there is a keen interest in understanding the pathogenesis and improving its therapy. In this regard, we can attest that this book provides ample information about essential components of RAS and their role in the development of cardiovascular disease. From the selection of recognized global experts in their area of investigation, this book can be seen to cover diverse cardiovascular aspects and molecular and cellular mechanisms of angiotensin II action for the development of different cardiovascular abnormalities. It is our contention that this book will be most suitable for promoting knowledge in the field of RAS biology and will be of great interest to health professionals involved in both experimental and clinical cardiology as well as academic investigators and cardiovascular scientists, graduate students, and fellows worldwide.

Author : Naranjan S. Dhalla,Peter Zahradka,Ian M.C. Dixon,Robert E. Beamish
Publisher : Springer Science & Business Media
Page : 607 pages
File Size : 44,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461557432

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Angiotensin II Receptor Blockade Physiological and Clinical Implications by Naranjan S. Dhalla,Peter Zahradka,Ian M.C. Dixon,Robert E. Beamish Pdf

The relationship between angiotensin II and hypertension was established in 1898 when angiotensin II was shown to modulate systemic blood pressure. Over the intervening decades, a complete characterization of the renin-angiotensin system (RAS) has been achieved, and our understanding of its biochemistry and physiology has led to the directed development of agents such ·as ACE inhibitors and receptor antagonists capable of controlling hypertension. More recently, it was shown that angiotensin II is secreted within certain tissues and that these tissue-specific systems operate independently of the systemic RAS. The novel concept that angiotensin II regulates a number of cardiovascular processes that are unrelated to blood pressure has renewed the interest of both basic and clinical scientists in angiotensin II. The association between angiotensin II and cardiac growth, in particular, has indicated that therapies currently in use for hypertension may have direct application to the treatment of heart failure. The Manitoba Cardiovascular Forum on Angiotensin Receptor Blockade in Winnipeg was convened October 18-20, 1996 to examine the clinical and basic aspects of angiotensin receptor biology as they apply to hypertension and heart failure. In addition, the potential treatment of these conditions using specific angio tensin receptor antagonists was addressed within the context of their immediate therapeutic application and future potential.

Author : Klaus Lindpaintner,Detlev Ganten
Publisher : Wiley-Blackwell
Page : 366 pages
File Size : 53,6 Mb
Release : 1994-01-01
Category : Medical
ISBN : 0879935715

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The Cardiac Renin-angiotensin System by Klaus Lindpaintner,Detlev Ganten Pdf

The potential significance of the cardiac renin–angiotensin system is indicated by the beneficial effects of angiotensin–converting enzyme inhibitors in the treatment of congestive heart failure and regional myocardial ischemia. It has become clear that the cardiac renin–angiotensin system may contribute to post–myocardial infarction ventricular remodeling. This book details the cardiac renin–angiotensin system and its importance as the key to new therapeutic strategies. It will be an important addition to the library of any physician who is involved with the treatment of hypertension or congestive heart failure

Author : H. Grobecker,Horst Grobecker,G. Heusch,B. E. Strauer
Publisher : Springer
Page : 0 pages
File Size : 47,5 Mb
Release : 1993
Category : Angiotensin converting enzyme
ISBN : 0387914323

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Angiotensin and the Heart by H. Grobecker,Horst Grobecker,G. Heusch,B. E. Strauer Pdf

Author : Brian Harvey,Frederic Jaisser
Publisher : BoD – Books on Demand
Page : 302 pages
File Size : 43,6 Mb
Release : 2019-09-25
Category : Medical
ISBN : 9781839621987

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Aldosterone-Mineralocorticoid Receptor by Brian Harvey,Frederic Jaisser Pdf

This book is an open access dissemination of the EU COST Action ADMIRE in Aldosterone/Mineralocorticoid Receptor (MR) physiology and pathophysiology. Aldosterone is the major hormone regulating blood pressure. Alterations in blood levels of aldosterone and genetic mutations in the MR receptor are major causes of hypertension and comorbidities. Many of the drugs in clinical use, and in development for treating hypertension, target aldosterone and MR actions in the kidney and cardiovascular system. The ADMIRE book assembles review chapters from 16 European ADMIRE laboratories providing the latest insights into mechanisms of aldosterone synthesis/secretion, aldosterone/MR physiology and signaling, and the pathophysiological roles of aldosterone/MR activation.

Author : May Sherman,National Heart and Lung Institute
Publisher : Unknown
Page : 158 pages
File Size : 48,9 Mb
Release : 1970
Category : Angiotensins
ISBN : UCAL:B4111843

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Renin-angiotensin Mechanisms by May Sherman,National Heart and Lung Institute Pdf

Author : Dulce Elena Casarini,Danielle Yuri Arita,Tatiana Sousa Cunha,Juliana Almada Colucci
Publisher : Bentham Science Publishers
Page : 387 pages
File Size : 48,7 Mb
Release : 2016-11-03
Category : Medical
ISBN : 9781681083131

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New Aspects of the Renin Angiotensin System in Cardiovascular and Renal Diseases by Dulce Elena Casarini,Danielle Yuri Arita,Tatiana Sousa Cunha,Juliana Almada Colucci Pdf

The renin-angiotensin system (RAS) is a hormonal system that is responsible for regulating plasma sodium ion concentration and arterial blood pressure in the body. The system involves several peptides such as angiotensin I and II as well as angiotensin converting enzyme (ACE) to enable the constriction of arterial blood vessels in the lung. Angiotensin II also stimulates the production of the hormone aldosterone in the kidneys which brings sodium ions into the bloodstream in exchange for potassium ions. Malfunctions of the RAS can lead to hypertension, heart failure, diabetes and renal complications. Thus the biochemical components of this system serve as important targets for therapeutic drugs. This monograph is a compilation of updated reviews on the RAS. The monograph covers describes the components of the system to explaining its physiological and clinical features in the cardiovascular system and the kidneys. This is followed by sections explaining the biochemistry of the RAS system in cardiovascular and renal disease and the pharmacology of relevant therapeutic drugs. Additional information on the effect of exercise states and methods to quantify angiotensins for molecular diagnosis is also presented in the concluding sections. Information in the monograph will be of interest to physiologists and endocrinologists involved in medical studies or clinical practice. Readers will be able to understand the RAS with a holistic frame of reference.

Author : Pawan K. Singal,Ian M.C. Dixon,Naranjan S. Dhalla,Lorrie A. Kirshenbaum
Publisher : Springer Science & Business Media
Page : 570 pages
File Size : 53,8 Mb
Release : 2003-02-28
Category : Medical
ISBN : 1402071779

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Cardiac Remodeling and Failure by Pawan K. Singal,Ian M.C. Dixon,Naranjan S. Dhalla,Lorrie A. Kirshenbaum Pdf

The importance of the developmental approach for experimental and clinical cardiology is indisputable. Clinical-epidemiological studies have clearly shown that the risk factors of serious cardiovascular diseases, such as atherosclerosis and ischemic heart disease, are already present during the early phases of ontogenetic development. Furthermore, congenital cardiovascular malformations remain the single largest cause of infant mortality from congenital defects in industrial countries. It is therefore not surprising that the interest of theoretical and clinical cardiologists in the developmental approach keeps increasing. Advances in molecular biology accelerated this trend substantially. This book is based on contributions presented at the international symposium The Developing Heart in Prague in May 2000. It is our contention that the biological, electrophysiological, morphological, functional, biochemical and functional approaches employed by distinguished scientists worldwide will provide the reader with a global picture for changes characterizing the developing heart. It should stimulate the curiosity of cardiovascular scientists in gaining insight into the mechanisms of normal and pathological development.

Author : Eugene Braunwald,Norman Hollenberg
Publisher : Springer Science & Business Media
Page : 337 pages
File Size : 52,7 Mb
Release : 2013-03-14
Category : Medical
ISBN : 9781468469097

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Atlas of Heart Diseases by Eugene Braunwald,Norman Hollenberg Pdf

In this edition of the Atlas of Hypertension, Dr. Norman Hollenberg and more than 20 leading authorities have worked together to capture the most updated and pertinent information in the field of hypertension. This new edition is a modern and complete visual library of up-to-date information on the most current pharmacologic and treatment advances in the field. With over 600 vivid illustrations, clinical photographs, instructive diagrams and charts, this updated reference provides a detailed and accurate insight into treatment and management of hypertension, covering a full range of topics. Together with detailed legends and extensive reference listings, the illustrations deliver comprehensive guidance to effective diagnosis and treatment of a wide breadth of these clinical challenges.

Author : Sukhwinder K. Bhullar,Paramjit S. Tappia,Naranjan S. Dhalla
Publisher : Springer Nature
Page : 499 pages
File Size : 42,8 Mb
Release : 2023-03-14
Category : Medical
ISBN : 9783031236211

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The Renin Angiotensin System in Cancer, Lung, Liver and Infectious Diseases by Sukhwinder K. Bhullar,Paramjit S. Tappia,Naranjan S. Dhalla Pdf

This book of the series on “Advances in Biochemistry in Health and Disease” includes state-of-the-art information on the status of renin-angiotensin system (RAS) in the form of 24 chapters. This book has been organized into three sections: (i) General Implications of RAS in human health and Infectious Diseases, (ii) Lung, Liver and Kidney Diseases, and (iii) Development of Cancer. Each chapter has discussed comprehensive knowledge regarding the molecular and cellular aspects of the role of RAS in the pathophysiology and pharmacotherapy of different disease processes. Biochemical mechanisms associated with angiotensin II type 1 and type II receptors, and angiotensin (1-7) MAS receptors for the occurrence of both harmful and beneficial effects of prolonged activation of RAS in different diseases have been outlined. It is noteworthy to point out that different chapter in this book were prepared by recognized global expertise in the area of inflammation, oxidative stress and signal transduction pathways to highlight the role of RAS in different diseases. It is our sincere hope that this book will be of great interest to both biomedical investigators and health professionals as well as graduate students and postdoctoral fellows all over the world.

Author : Thomas Unger,Bernward A. Schölkens
Publisher : Springer Science & Business Media
Page : 634 pages
File Size : 49,7 Mb
Release : 2004
Category : Biochemistry
ISBN : 3540406417

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Angiotensin Vol. II by Thomas Unger,Bernward A. Schölkens Pdf

Nearly thirty years ago, in 1974, the volume on Angiotensin edited by Irvine H.Page and F. Merlin Bumpus expanded the Handbook of Experimental Pharmacology. Even after two decades the multiplicity of its actions appears not to have been fully discovered. To call attention to its many functions is one of the purposes of this book. This new edition of the volume on Angiotensin attempts to provide an updated account of the knowledge and findings accumulated since the complexity of angiotensin was so accurately recognized.