Animal Models In Human Disease

Author : P. Michael Conn
Publisher : Academic Press
Page : 1108 pages
File Size : 49,6 Mb
Release : 2013-05-29
Category : Science
ISBN : 9780124159129

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Animal Models for the Study of Human Disease by P. Michael Conn Pdf

Animal Models for the Study of Human Disease identifies important animal models and assesses the advantages and disadvantages of each model for the study of human disease. The first section addresses how to locate resources, animal alternatives, animal ethics and related issues, much needed information for researchers across the biological sciences and biomedicine.The next sections of the work offers models for disease-oriented topics, including cardiac and pulmonary diseases, aging, infectious diseases, obesity, diabetes, neurological diseases, joint diseases, visual disorders, cancer, hypertension, genetic diseases, and diseases of abuse. Organized by disease orientation for ease of searchability Provides information on locating resources, animal alternatives and animal ethics Covers a broad range of animal models used in research for human disease

Author : P. Michael Conn
Publisher : Academic Press
Page : 1089 pages
File Size : 51,9 Mb
Release : 2013
Category : Medical
ISBN : 0124158943

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Animal Models for the Study of Human Disease by P. Michael Conn Pdf

Animal Models for the Study of Human Disease identifies important animal models and assesses the advantages and disadvantages of each model for the study of human disease. The first section addresses how to locate resources, animal alternatives, animal ethics and related issues, much needed information for researchers across the biological sciences and biomedicine.The next sections of the work offers models for disease-oriented topics, including cardiac and pulmonary diseases, aging, infectious diseases, obesity, diabetes, neurological diseases, joint diseases, visual disorders, cancer, hypertension, genetic diseases, and diseases of abuse. Organized by disease orientation for ease of searchability Provides information on locating resources, animal alternatives and animal ethics Covers a broad range of animal models used in research for human disease

Author : Bartholomew Ibeh
Publisher : BoD – Books on Demand
Page : 410 pages
File Size : 42,5 Mb
Release : 2018-05-23
Category : Science
ISBN : 9781789231649

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Experimental Animal Models of Human Diseases by Bartholomew Ibeh Pdf

The world has recorded losses in terms of human life as well as extensive time spent in experimentation with development of new drugs, elucidation of disease mechanism(s), and therapeutic agent discovery. Ethical and legal issues cojoin in slowing down scientific discoveries in medicine and biology. The past two (2) decades, therefore, have seen tremendous attempts that largely are successful in developing animal models with the characteristics of mimicking, approximating, or expressing transplanted human organs/tissues. These models or rather approaches seem to be fast, cost-effective, and easy to maintain compared to primates. This book is a collection of expert essays on animal models of human diseases of global interest. A visible objective of the book is to provide real-time experimental approach to scientists, clinicians, ethicists, medicolegal/medical jurisprudence workers, immunologists, postgraduate students, and vaccinologists and informative and multidisciplinary approach for the identification of new therapeutic targets and biomarkers using animal models as well as investigating the pathogenesis and therapeutic strategies of human diseases. An increased understanding of the genetic, molecular, and cellular mechanisms responsible for the development of human diseases has laid out the foundation for the development of rational therapies mainly with animal models.

Author : National Research Council,Institute of Medicine,Institute for Laboratory Animal Research,Commission on Life Sciences,Committee on the Use of Laboratory Animals in Biomedical and Behavioral Research
Publisher : National Academies Press
Page : 113 pages
File Size : 40,8 Mb
Release : 1988-02-01
Category : Science
ISBN : 9780309038393

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Use of Laboratory Animals in Biomedical and Behavioral Research by National Research Council,Institute of Medicine,Institute for Laboratory Animal Research,Commission on Life Sciences,Committee on the Use of Laboratory Animals in Biomedical and Behavioral Research Pdf

Scientific experiments using animals have contributed significantly to the improvement of human health. Animal experiments were crucial to the conquest of polio, for example, and they will undoubtedly be one of the keystones in AIDS research. However, some persons believe that the cost to the animals is often high. Authored by a committee of experts from various fields, this book discusses the benefits that have resulted from animal research, the scope of animal research today, the concerns of advocates of animal welfare, and the prospects for finding alternatives to animal use. The authors conclude with specific recommendations for more consistent government action.

Author : P. Michael Conn
Publisher : Springer Science & Business Media
Page : 756 pages
File Size : 55,7 Mb
Release : 2008-03-07
Category : Medical
ISBN : 9781597452854

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Sourcebook of Models for Biomedical Research by P. Michael Conn Pdf

The collection of systems represented in this volume is a unique effort to reflect the diversity and utility of models used in biomedicine. That utility is based on the consideration that observations made in particular organisms will provide insight into the workings of other, more complex systems. This volume is therefore a comprehensive and extensive collection of these important medical parallels.

Author : National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Board on Life Sciences,Committee on Animal Models for Testing Interventions Against Aerosolized Bioterrorism Agents
Publisher : National Academies Press
Page : 87 pages
File Size : 47,6 Mb
Release : 2006-08-07
Category : Political Science
ISBN : 9780309180900

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Overcoming Challenges to Develop Countermeasures Against Aerosolized Bioterrorism Agents by National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Board on Life Sciences,Committee on Animal Models for Testing Interventions Against Aerosolized Bioterrorism Agents Pdf

The National Institute of Allergy and Infectious Diseases (NIAID) gives the highest priority to developing countermeasures against bioterrorism agents that are highly infective when dispersed in aerosol form. Developing drugs to prevent or treat illnesses caused by bioterrorism agents requires testing their effectiveness in animals since human clinical trials would be unethical. At the request of NIAID, the National Academies conducted a study to examine how such testing could be improved. Overcoming Challenges to Develop Countermeasures Against Aerosolized Bioterrorism Agents provides recommendations to researchers on selecting the kinds of animal models, aerosol generators, and bioterrorism agent doses that would produce conditions that most closely mimic the disease process in humans. It also urges researchers to fully document experimental parameters in the literature so that studies can be reproduced and compared. The book recommends that all unclassified data on bioterrorism agent studies-including unclassified, unpublished data from U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID)-be published in the open literature. The book also calls on the U.S. Food and Drug Administration to improve the process by which bioterrorism countermeasures are approved based on the results of animal studies.

Author : Sara Green
Publisher : Cambridge University Press
Page : 161 pages
File Size : 52,6 Mb
Release : 2024-04-30
Category : Philosophy
ISBN : 9781009027427

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Animal Models of Human Disease by Sara Green Pdf

The crucial role of animal models in biomedical research calls for philosophical investigation of how and whether knowledge about human diseases can be gained by studying other species. This Element delves into the selection and construction of animal models to serve as preclinical substitutes for human patients. It explores the multifaceted roles animal models fulfil in translational research and how the boundaries between humans and animals are negotiated in this process. The book also covers persistent translational challenges that have sparked debates across scientific, philosophical, and public arenas regarding the limitations and future of animal models. Among the are persistent tensions between standardization and variation in medicine, as well as between strategies aiming to reduce and recapitulate biological complexity. Finally, the book examines the prospects of replacing animal models with animal-free methods. The Element demonstrates why animal modeling should be of interest to philosophers, social scientists, and scientists alike.

Author : Edwin J. Andrews,Billy C. Ward,Norman H. Altman
Publisher : Elsevier
Page : 345 pages
File Size : 48,7 Mb
Release : 2012-12-02
Category : Science
ISBN : 9780323138284

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Spontaneous Animal Models of Human Disease by Edwin J. Andrews,Billy C. Ward,Norman H. Altman Pdf

This two-volume work gathers together the diverse information presently available on spontaneous animal models of human disease. In addition to providing a comprehensive review of existing models, the book presents many previous unpublished new models.The scope of this work is limited to spontaneous models. Neoplasia, infectious diseases including parasitism, and nutritionally induced or other types of experimental models have not been included. The sixteen parts of the book are alphabetically arranged according to organ system with over 230 authors contributing to the overall effort. In addition to many illustrations, the book features an extensive bibliography.

Author : Masamitsu Yamaguchi
Publisher : Springer
Page : 308 pages
File Size : 50,7 Mb
Release : 2018-06-27
Category : Medical
ISBN : 9789811305290

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Drosophila Models for Human Diseases by Masamitsu Yamaguchi Pdf

Most biological pathways, physical and neurological properties are highly conserved between humans and Drosophila and nearly 75% of human disease-causing genes have a functional homologue in Drosophila. This volume provides recent advances in Drosophila models for various human diseases, with each chapter providing a review of studies involving Drosophila models, as well as detailed protocols commonly used in laboratories. Starting with a review of Drosophila’s value as a highly tractable model organism for studying human diseases, subsequent chapters present Drosophila models for specific human diseases. The book provides a useful resource for all scientists who are starting to use the Drosophila model in their studies, and for researchers working in the pharmaceutical industry and using new screening models to develop new medicines for various diseases.

Author : Anonim
Publisher : Academic Press
Page : 550 pages
File Size : 46,9 Mb
Release : 2011-03-04
Category : Science
ISBN : 9780123848796

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Animal Models of Human Disease by Anonim Pdf

Animal experiments have contributed much to our understanding of mechanisms of disease and are important for determining new therapies. This volume reviews the latest research and developments in this field. * Discusses new discoveries, approaches, and ideas * Contributions from leading scholars and industry experts * Reference guide for researchers involved in molecular biology and related fields

Author : Anonim
Publisher : Unknown
Page : 128 pages
File Size : 42,6 Mb
Release : 1970
Category : Electronic
ISBN : OCLC:221739772

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Animal models in human disease by Anonim Pdf

Author : Armed Forces Institute of Pathology. the Registry of Comparative Pathology,United States. Armed Forces Institute of Pathology. Registry of Comparative Pathology
Publisher : Unknown
Page : 0 pages
File Size : 41,5 Mb
Release : 1972
Category : Diseases
ISBN : OCLC:53626629

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Animal Models of Human Disease by Armed Forces Institute of Pathology. the Registry of Comparative Pathology,United States. Armed Forces Institute of Pathology. Registry of Comparative Pathology Pdf

Author : Anonim
Publisher : Unknown
Page : 128 pages
File Size : 55,6 Mb
Release : 1973
Category : Electronic
ISBN : WISC:89034682898

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Animal Models of Human Disease by Anonim Pdf

Author : Kathrin Herrmann,Kimberley Jayne
Publisher : BRILL
Page : 749 pages
File Size : 55,5 Mb
Release : 2019-04-30
Category : Philosophy
ISBN : 9789004391192

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Animal Experimentation: Working Towards a Paradigm Change by Kathrin Herrmann,Kimberley Jayne Pdf

Animal experimentation has been one of the most controversial areas of animal use, mainly due to the intentional harms inflicted upon animals for the sake of hoped-for benefits in humans. Despite this rationale for continued animal experimentation, shortcomings of this practice have become increasingly more apparent and well-documented. However, these limitations are not yet widely known or appreciated, and there is a danger that they may simply be ignored. The 51 experts who have contributed to Animal Experimentation: Working Towards a Paradigm Change critically review current animal use in science, present new and innovative non-animal approaches to address urgent scientific questions, and offer a roadmap towards an animal-free world of science.

Author : Aimin Liu
Publisher : Unknown
Page : 248 pages
File Size : 51,5 Mb
Release : 2020
Category : Abnormalities, Human
ISBN : 9811523916

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Animal Models of Human Birth Defects by Aimin Liu Pdf

This book focuses on the use of animal models to study various human defects. It summarizes our current understanding of a variety of common human birth defects and the essential role of animal models in shedding light on the underlying mechanisms of these disorders. Birth defects are the leading cause of infant deaths, and cost billions of dollars in care for those affected. Unfortunately, the lack of a clear understanding of the mechanisms leading to many of these developmental disorders has hindered effective prevention and early intervention strategies. Studies using animal models have provided essential insights into several human birth defects. This book serves as a valuable reference resource for researchers and graduate students who are interested in learning the basic principles as well as the latest advances in the study of the mechanisms of human birth defects.