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Author : Rosa Chiara Paolicelli,Amanda Sierra
Publisher : Frontiers Media SA
Page : 220 pages
File Size : 51,7 Mb
Release : 2022-02-04
Category : Science
ISBN : 9782889742912
Author : Alessandro Michelucci,Michel Mittelbronn,Diego Gomez-Nicola
Publisher : Frontiers Media SA
Page : 108 pages
File Size : 52,6 Mb
Release : 2018-10-05
Category : Electronic
ISBN : 9782889456017
Microglia are essential for the development and function of the adult brain. Their ontogeny, together with the absence of turnover from the periphery and the singular environment of the central nervous system (CNS), make microglia a unique cell population compared to other tissue-macrophages. The unique properties and functions of microglial cells, such as their role in synaptic pruning or the exceptional capacity to scan the brain parenchyma and rapidly react to its perturbations, have emerged in recent years. In the coming years, understanding how microglia acquire and maintain their unique profiles in order to fulfil distinct tasks in the healthy CNS and how these are altered in disease, will be essential to develop strategies to diagnose or treat CNS disorders with an immunological component. This Research Topic covers several aspects of microglial biology, ranging from their origin and the functional role of microglia during development and lifespan, their molecular properties compared with other brain and peripheral immune cells to microglial phenotypes and functional states in neurodegenerative diseases and brain tumours. In conclusion, the present Research Topic provides a comprehensive overview of our current understanding of several cellular and molecular mechanisms that make microglia a unique immune cell population within the healthy CNS as well as under inflammatory, neurodegenerative and tumorigenic processes.
Author : Marie-Ève Tremblay,Amanda Sierra
Publisher : Springer
Page : 486 pages
File Size : 51,8 Mb
Release : 2014-09-22
Category : Medical
ISBN : 9781493914296
These past few years have witnessed a revolution in our understanding of microglia, especially since their roles in the healthy central nervous system (CNS) have started to unravel. These cells were shown to actively maintain health, in concert with neurons and other types of CNS cells, providing further insight into their involvement with diseases. Edited by two pioneers in the field, Marie-Ève Tremblay and Amanda Sierra, Microglia in health and disease aims to share with the broader scientific community some of the recent discoveries in microglia research, from a broad perspective, with a collection of 19 chapters from 52 specialists working in 11 countries across 5 continents. To set microglia on the stage, the book begins by explaining briefly who they are, what they do in the healthy and diseased CNS, and how they can be studied. The first section describes in more details their physiological roles in the maturation, function, and plasticity of the CNS, across development, adolescence, adulthood, neuropathic pain, addiction, and aging. The second section focuses on their implication in pathological conditions impairing the quality of life: neurodevelopmental and neuropsychiatric disorders, AIDS, and multiple sclerosis; and in leading causes of death: ischemia and stroke, neurodegenerative diseases, as well as trauma and injury.
Author : Patrizia Giannoni,Silvia Fossati,Sylvie Claeysen,Elena Marcello
Publisher : Frontiers Media SA
Page : 288 pages
File Size : 52,6 Mb
Release : 2020-07-31
Category : Electronic
ISBN : 9782889639090
Author : Mario F. Wulliman,Barbara Rupp,Heinrich Reichert
Publisher : Birkhäuser
Page : 142 pages
File Size : 40,7 Mb
Release : 2012-12-06
Category : Science
ISBN : 9783034889797
Author : Subashika Govindan,Fiona Francis,Esther Klingler
Publisher : Frontiers Media SA
Page : 153 pages
File Size : 45,7 Mb
Release : 2024-02-07
Category : Science
ISBN : 9782832544402
Author : Chengjin Gao,Shuming Pan,Kun Xiong
Publisher : Frontiers Media SA
Page : 355 pages
File Size : 46,7 Mb
Release : 2024-03-19
Category : Medical
ISBN : 9782832546529
The systemic inflammatory response is evident in inflammatory diseases, and the immune system secretes many cytokines involved, resulting in a robust immune response. For example, the pathogenesis of sepsis includes abnormal immune cell activation in the early stages as well as sepsis-related immunosuppression. During the immunosuppressive phase, CD4+ T cells, CD8+ T cells, Th17 cells, and γδ T cells are reduced while regulatory T cells increase. At the same time, T lymphocytes and neutrophils, as immune effector cells, interact with each other and play a key role in regulating the immune response to immune-inflammatory diseases. The increased release of neutrophil extracellular trap networks (NETs) by neutrophils leads to a significant upregulation of NETs-DNA-MPO, which further aggravates the septic inflammatory response and organ functional impairment. Therefore, it is important to deeply investigate the characteristic clinical immune phenotypes and molecular mechanisms associated with inflammatory diseases, and targeting therapies against them may provide new ideas for the precise treatment of diseases.
Author : Yu Tang,Isidre Ferrer
Publisher : Frontiers Media SA
Page : 327 pages
File Size : 48,9 Mb
Release : 2018
Category : Electronic
ISBN : 9782889455256
Microglia-mediated neuroinflammation is one of the shared prominent hallmarks among various forms of neurodegeneration. Depending on the milieu in which microglia become activated, the polarization of microglia shows to be heterogeneous with diverse functional phenotypes that range from pro-inflammatory phenotypes to immunosuppressive phenotypes. Therefore, targeting microglial polarization holds great promise for the treatment of neurodegeneration. This eBook focuses on the potential mechanisms of microglial polarization that are critically associated with a broad spectrum of neurodegenerative diseases, including Parkinson’s disease (PD), Alzheimer’s disease (AD), Amyotrophic lateral sclerosis (ALS), Huntington’s disease (HD), Traumatic brain injury (TBI), glaucomatous neurodegeneration and prion diseases. This topic also involves the therapeutic targeting of microglial polarization by nutritional and pharmacological modulators. Moreover, this topic describes advanced technologies employed for studying microglia. Age-related changes in microglia functions are also discussed. Overall, this eBook provides comprehensive understandings of microglial polarization in the course of neurodegeneration, linking with aging-related microglial alterations and technologies developed for microglial studies. Hopefully, it will also give comprehensive insights into various aspects of therapeutic treatment for neurodegeneration, through targeting microglial polarization.
Author : Jane Williams,Lin Perry,Caroline Watkins
Publisher : John Wiley & Sons
Page : 367 pages
File Size : 53,8 Mb
Release : 2013-05-07
Category : Medical
ISBN : 9781118699621
Stroke is a medical emergency that requires immediate medical attention. With active and efficient nursing management in the initial hours after stroke onset and throughout subsequent care, effective recovery and rehabilitation is increased. Acute Stroke Nursing provides an evidence-based, practical text facilitating the provision of optimal stroke care during the primary prevention, acute and continuing care phases. This timely and comprehensive text is structured to follow the acute stroke pathway experienced by patients. It explores the causes, symptoms and effects of stroke, and provides guidance on issues such as nutrition, continence, positioning, mobility and carer support. The text also considers rehabilitation, discharge planning, palliative care and the role of the nurse within the multi-professional team. Acute Stroke Nursing is the definitive reference on acute stroke for all nurses and healthcare professionals wishing to extend their knowledge of stroke nursing. Evidence-based and practical in style, with case studies and practice examples throughout Edited and authored by recognised stroke nursing experts, clinicians and leaders in the field of nursing practice, research and education The first text to explore stroke management from UK and international perspectives, and with a nursing focus
Author : Maya Koronyo-Hamaoui,Sally Ann Frautschy,Jorge Ivan Alvarez
Publisher : Frontiers Media SA
Page : 461 pages
File Size : 46,5 Mb
Release : 2022-07-13
Category : Medical
ISBN : 9782889765621
Author : Jiahong Lu,Min Li,Juxian Song
Publisher : Frontiers Media SA
Page : 289 pages
File Size : 53,5 Mb
Release : 2022-05-24
Category : Science
ISBN : 9782889761913
Author : Raquel Ferreira,Liliana Bernardino,Maria Beatrice Passani,Cinzia Volonté
Publisher : Frontiers Media SA
Page : 176 pages
File Size : 48,7 Mb
Release : 2020-10-27
Category : Science
ISBN : 9782889661060
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Author : Tao Sun
Publisher : BoD – Books on Demand
Page : 456 pages
File Size : 41,7 Mb
Release : 2012-02-15
Category : Science
ISBN : 9789533079585
This book is a collective work of international experts in the neural stem cell field. The book incorporates the characterization of embryonic and adult neural stem cells in both invertebrates and vertebrates. It highlights the history and the most advanced discoveries in neural stem cells, and summarizes the mechanisms of neural stem cell development. In particular, this book provides strategies and discusses the challenges of utilizing neural stem cells for therapy of neurological disorders and brain and spinal cord injuries. It is suitable for general readers, students, doctors and researchers who are interested in understanding the principles of and new discoveries in neural stem cells and therapy.
Author : Ryan B. MacDonald,Stefanie Robel,Nathan Anthony Smith,Tim Czopka
Publisher : Frontiers Media SA
Page : 533 pages
File Size : 43,5 Mb
Release : 2023-04-11
Category : Science
ISBN : 9782832520406
Author : Gunawan Indrayanto,Kornkanok Ingkaninan,Abdul Rohman
Publisher : Frontiers Media SA
Page : 175 pages
File Size : 47,5 Mb
Release : 2022-12-08
Category : Science
ISBN : 9782832509081