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Author : Mario F. Wulliman,Barbara Rupp,Heinrich Reichert
Publisher : Birkhäuser
Page : 142 pages
File Size : 54,6 Mb
Release : 2012-12-06
Category : Science
ISBN : 9783034889797
Author : Dr. Thomas Mueller,Mario Wullimann
Publisher : Academic Press
Page : 258 pages
File Size : 47,9 Mb
Release : 2015-11-18
Category : Science
ISBN : 9780124172869
Atlas of Early Zebrafish Brain Development: A Tool for Molecular Neurogenetics, Second Edition, remains the only neuroanatomical expression atlas of important genetic and immunohistochemical markers of this vertebrate model system. It represents a key reference and interpretation matrix for analyzing expression domains of genes involved in Zebrafish brain development and neurogenesis, and serves as a continuing milestone in this research area. This updated volume provides in-situ hybridized and immunostained preparations of complete series of brain sections, revealing markers of the fundamental stages in the life history of neuronal cells in very high quality preparations and photographic plates. Specific additions to this edition include documentation on the distribution of neurons expressing GABA, dopamine and serotonin, material on the basal ganglia, hypothalamus, and the caudal, segmented part of the diencephalon, new theories on the early organization of the telencephalon and thalamus, and integration of a comparative perspective on the mid- and hindbrain. Documentation on the distribution of neurons expressing GABA, dopamine and serotonin Material on the basal ganglia, hypothalamus, and the caudal, segmented part of the diencephalon New theories about the early organization of the telencephalon and thalamus Integration of a comparative perspective on the mid- and hindbrain
Author : Thomas Mueller,Mario F. Wullimann
Publisher : Gulf Professional Publishing
Page : 204 pages
File Size : 52,5 Mb
Release : 2005-08-08
Category : Medical
ISBN : 0444517383
"The book introduces the reader to the field and shows principles of vertebrate brain development and neurogenesis. It will also be of great value to investigators of other model organisms such as frog, chick, and mouse."--BOOK JACKET.
Author : Gonzalo G. De Polavieja,German Sumbre
Publisher : Frontiers E-books
Page : 368 pages
File Size : 53,7 Mb
Release : 2014-11-07
Category : Electronic book
ISBN : 9782889193288
Understanding how the brain functions is one of the most ambitious current scientific goals. This challenge will only be accomplish by a multidisciplinary approach involving genetics, molecular biology, optics, ethology, neurobiology and mathematics and using tractable model systems. The zebrafish larva is a transparent genetically tractable small vertebrate, ideal for the combination state-of-the- art imaging techniques (e.g. two-photon scanning microscopy, single-plane illumination microscopy, spatial light modulator microscopy and lightfield microscopy), bioluminiscence and optogenetics to monitor and manipulate neuronal activity from single specific neurons up to the entire brain, in an intact behaving organism. Furthermore, the zebrafish model offers large and increasing collection of mutant and transgenic lines modelling human brain diseases. With these advantages in hand, the zebrafish larva became in the recent years, a novel animal model to study neuronal circuits and behaviour, taking us closer than ever before to understand how the brain controls behaviour.
Author : Jerry J. Buccafusco
Publisher : CRC Press
Page : 341 pages
File Size : 54,7 Mb
Release : 2000-08-29
Category : Medical
ISBN : 9781420041811
Using the most well-studied behavioral analyses of animal subjects to promote a better understanding of the effects of disease and the effects of new therapeutic treatments on human cognition, Methods of Behavior Analysis in Neuroscience provides a reference manual for molecular and cellular research scientists in both academia and the pharmaceutic
Author : Jeroen Pasterkamp,Marten P. Smidt,J. Peter H. Burbach
Publisher : Springer Science & Business Media
Page : 143 pages
File Size : 54,5 Mb
Release : 2009-12-16
Category : Medical
ISBN : 9781441903228
Theneurotransmitter dopamine has just celebrated its 50thbirthday. The discovery of dopamine as a neuronal entity in the late 1950s and the notion that it serves in neurotransmission has been a milestone in the field of neuroscience research. This milestone marked the beginning of an era that explored the brain as an integrated collection of neuronal systems that one could distinguish on basis of neurotransm- ter identities, and importantly, in which one started to be able to pinpoint the seat of brain disease. The mesodiencephalic dopaminergic (mdDA) system, previously designated as midbraindopaminergic system, has received much attention since its discovery. The initial identification of dopamine as a neurotransmitter in the central nervous system (CNS) and its relevance to psychiatric and neurological disorders have stimulated a plethora of neurochemical, pharmacological and genetic studies into the function of dopamine neurons and theirprojections. In the last decade, studies on gene expression and development have further increased the knowledge of this neuronal population and have unmasked a new level of complexity. The start of the molecular dissection of the mdDA system has been marked by the cloning and characterization ofNurrl and Pitx3. These transcription factors were shown to have a critical function during mdDA development. These initial studies have been followed by the identification of many other proteins, which have a crucial function in the creation of a dopamine neuron permissive region, induction of precursors, induction of terminaldifferent- tion and finally maintenance of the mdDA neuronal pool.
Author : Jeffery A. Winer,Christoph E. Schreiner
Publisher : Springer Science & Business Media
Page : 705 pages
File Size : 46,6 Mb
Release : 2005-12-05
Category : Science
ISBN : 9780387270838
Connecting the auditory brain stem to sensory, motor, and limbic systems, the inferior colliculus is a critical midbrain station for auditory processing. Winer and Schreiner's The Inferior Colliculus, a critical, comprehensive reference, presents the current knowledge of the inferior colliculus from a variety of perspectives, including anatomical, physiological, developmental, neurochemical, biophysical, neuroethological and clinical vantage points. Written by leading researchers in the field, the book is an ideal introduction to the inferior colliculus and central auditory processing for clinicians, otolaryngologists, graduate and postgraduate research workers in the auditory and other sensory-motor systems.
Author : Robert T. Gerlai
Publisher : Academic Press
Page : 800 pages
File Size : 44,7 Mb
Release : 2020-04
Category : Medical
ISBN : 0128175281
The past decade has seen a rapid accumulation of knowledge on the behavioral characteristics of zebrafish, and increased investigation into the neurobiological basis of behavior using zebrafish. This simple vertebrate represents an ideal compromise between system complexity and practical simplicity, with its mammalian sequence homology, fecundity, and conveniently small size and transparent embryology. Behavioral and Neural Genetics of Zebrafish assembles state of the art methodologies and the most current concepts pertinent to the neurobehavioral genetics of zebrafish. Discussing its natural behavior, motor function, and learning and memory, it focuses on the fry and adult zebrafish and features a comprehensive account of modern genetic and neural methods adapted to or specifically developed for Danio rerio. Numerous examples of how these behavioral methods may be utilized for disease models using the zebrafish will be presented, as well as a section on bioinformatics and "big-data" related questions. Focusing on this excellent translational tool, this book examines a species with which investigators may model and analyze even such complex human diseases as those associated with brain dysfunction. Provides the most comprehensive snapshot of the fast-evolving zebrafish neurobehavior genetics field Describes description of behavioral, genetic, and neural methods and concepts and adult and larval zebrafish Features examples of zebrafish models of human central nervous system disorders Discusses bioinformatics questions pertinent to zebrafish neurobehavioral genetics
Author : Raya Eilam-Altstadter,Liora Las,Menno Witter,Nachum Ulanovsky
Publisher : Academic Press
Page : 164 pages
File Size : 44,8 Mb
Release : 2022-02-15
Category : Medical
ISBN : 9780323996150
The Stereotaxic Brain Atlas of the Egyptian Fruit Bat provides the first stereotaxic atlas of the brain of the Egyptian fruit bat (Rousettus aegyptiacus), an emerging model in neuroscience. This atlas contains coronal brain sections stained with cresyl violet (Nissl), AChE, and Parvalbumin – all stereotaxically calibrated. It will serve the needs of any neuroscientist who wishes to work with these bats – allowing to precisely target specific brain areas for electrophysiology, optogenetics, pharmacology, and lesioning. More broadly, this atlas will be useful to all neuroscientists working with bats, as it delineates many brain regions that were not delineated so far in any bat species. Finally, this atlas will provide a useful resource for researchers interested in comparative neuroanatomy of the mammalian brain. Provides detailed and accurate stereotaxic coverage of the Egyptian fruit bat forebrain Contains 87 plates of coronal sections of adult Egyptian fruit bats, each with one Nissl-stained hemisphere and the other stained either for AChE or Parvalbumin Delineates brain structures in the bat brain Serves as an essential tool for directing electrophysiology, imaging, optogenetics, pharmacology and lesioning in Egyptian fruit bats, and bats more generally Provides a rich resource for comparative neuroanatomy of the mammalian brain
Author : Tomas Hökfelt
Publisher : Springer Science & Business Media
Page : 286 pages
File Size : 40,7 Mb
Release : 2010-08-18
Category : Science
ISBN : 3034602286
Galanin is a neuropeptide found both in the central and peripheral nervous system. The 29-amino acid peptide (named after its N-terminal glycine and C-terminal alanine) was identified in 1983 by its C-terminal amidation. This 'reverse' approach, that is to discover a substance through a distinct chemical feature, and only subsequently to characterize its biological activity, was novel and has been successful in the identification of several other peptides. After the structure of galanin was determined in 1983, functional studies were performed with material purified from natural sources until the synthetic form of the peptide became available. Galanin can act as transmitter, modulator and trophic factor, and is involved in a number of physiological processes such as hormone secretion, cardiovascular mechanisms, feeding and cognition. This peptide may also be of significance for a number of pathological processes/disorders including pain, depression, Alzheimer's disease, epilepsy, addiction and cancer. This wide diversity of actions is mediated by three galanin receptor subtypes. The studies reviewed in this volume give a fairly complete overview of the spectrum of the biological actions and functions of galanin and its receptors and on possible therapeutic applications in a number of pathological conditions.
Author : Anonim
Publisher : Unknown
Page : 0 pages
File Size : 53,6 Mb
Release : 2014
Category : Electronic
ISBN : OCLC:1368418721
Understanding how the brain functions is one of the most ambitious current scientific goals. This challenge will only be accomplish by a multidisciplinary approach involving genetics, molecular biology, optics, ethology, neurobiology and mathematics and using tractable model systems. The zebrafish larva is a transparent genetically tractable small vertebrate, ideal for the combination state-of-the- art imaging techniques (e.g. two-photon scanning microscopy, single-plane illumination microscopy, spatial light modulator microscopy and lightfield microscopy), bioluminiscence and optogenetics to monitor and manipulate neuronal activity from single specific neurons up to the entire brain, in an intact behaving organism. Furthermore, the zebrafish model offers large and increasing collection of mutant and transgenic lines modelling human brain diseases. With these advantages in hand, the zebrafish larva became in the recent years, a novel animal model to study neuronal circuits and behaviour, taking us closer than ever before to understand how the brain controls behaviour.
Author : Fred W. Leeuwen
Publisher : Elsevier Publishing Company
Page : 456 pages
File Size : 53,9 Mb
Release : 1988
Category : Medical
ISBN : UOM:39015013585156
For a thorough study of the dynamics of particular brain compounds it is now possible to use and combine various molecular neuroanatomical methods (e.g. in situ hybridization, receptor localisation and immunocytochemistry) in a quantitative way on whole brain sections maintaining morphological details. Molecular Neuroanatomy deals with the many practical aspects and recent developments in these areas. The theoretical background of many techniques is presented, as well as clear, step-by-step instructions on the preparation and application of all the methods and techniques described in this book. It will be invaluable to all those working in the field of neuroscience. Available in both hardback and paperback, with colour illustrations.
Author : Laszlo Zaborszky,Floris G. Wouterlood,José Luis Lanciego
Publisher : Springer Science & Business Media
Page : 703 pages
File Size : 41,6 Mb
Release : 2006-11-22
Category : Medical
ISBN : 9780387289427
The first two editions of this title had a tremendous impact in neuroscience. Between the Second edition in 1989 and today, there has been an explosion of information in the field, including advances in molecular techniques, such as genomics and proteomics, which have become increasing important in neuroscience. A renaissance in fluorescence has occurred, driven by the development of new probes, new microscopes, live imagers, and computer processing. The introduction of new markers has enormously stimulated the field, moving it from tissue culture to neurophysiology to functional MRI techniques.
Author : Ann B. Butler,William Hodos
Publisher : John Wiley & Sons
Page : 739 pages
File Size : 48,6 Mb
Release : 2005-09-02
Category : Medical
ISBN : 9780471733836
Comparative Vertebrate Neuroanatomy Evolution and Adaptation Second Edition Ann B. Butler and William Hodos The Second Edition of this landmark text presents a broad survey of comparative vertebrate neuroanatomy at the introductory level, representing a unique contribution to the field of evolutionary neurobiology. It has been extensively revised and updated, with substantially improved figures and diagrams that are used generously throughout the text. Through analysis of the variation in brain structure and function between major groups of vertebrates, readers can gain insight into the evolutionary history of the nervous system. The text is divided into three sections: * Introduction to evolution and variation, including a survey of cell structure, embryological development, and anatomical organization of the central nervous system; phylogeny and diversity of brain structures; and an overview of various theories of brain evolution * Systematic, comprehensive survey of comparative neuroanatomy across all major groups of vertebrates * Overview of vertebrate brain evolution, which integrates the complete text, highlights diversity and common themes, broadens perspective by a comparison with brain structure and evolution of invertebrate brains, and considers recent data and theories of the evolutionary origin of the brain in the earliest vertebrates, including a recently proposed model of the origin of the brain in the earliest vertebrates that has received strong support from newly discovered fossil evidence Ample material drawn from the latest research has been integrated into the text and highlighted in special feature boxes, including recent views on homology, cranial nerve organization and evolution, the relatively large and elaborate brains of birds in correlation with their complex cognitive abilities, and the current debate on forebrain evolution across reptiles, birds, and mammals. Comparative Vertebrate Neuroanatomy is geared to upper-level undergraduate and graduate students in neuroanatomy, but anyone interested in the anatomy of the nervous system and how it corresponds to the way that animals function in the world will find this text fascinating.
Author : Moo K Chung
Publisher : World Scientific
Page : 420 pages
File Size : 52,8 Mb
Release : 2012-09-05
Category : Computers
ISBN : 9789814472814
Computational neuroanatomy is an emerging field that utilizes various non-invasive brain imaging modalities, such as MRI and DTI, in quantifying the spatiotemporal dynamics of the human brain structures in both normal and clinical populations. This discipline emerged about twenty years ago and has made substantial progress in the past decade. The main goals of this book are to provide an overview of various mathematical, statistical and computational methodologies used in the field to a wide range of researchers and students, and to address important yet technically challenging topics in further detail. Contents:Statistical PreliminaryDeformation-Based MorphometryTensor-Based MorphometryVoxel-Based MorphometryGeometry of Cortical ManifoldsSmoothing on Cortical ManifoldsSurface-Based MorphometryWeighted Fourier RepresentationStructural Brain ConnectivityTopological Data Analysis Readership: Researchers and graduate students in the fields of computational neuroscience and brain imaging, medical image analysis and pattern recognition. Keywords:Computational Neuroanatomy;Brain Image Analysis;NeuroimageKey Features:Includes necessary and very practical mathematical and statistical methodologiesAccessible to a wide range of readers and provides methodological understanding in a manner immediately usable to researchersCovers various topics in great detail without sacrificing readability; it can be used as both a textbook for graduate students and a reference for researchers Reviews: "The book is a comprehensive treatise on computational neuroanatomy — an area that has emerged with the enormous advancements of magnetic resonance imaging (MRI). The book is a solid and evidently needed testimony to the recent developments in the area of computational neuroanatomy. It is a welcome publication, which may appeal to senior graduate students, researchers and practitioners." Zentralblatt MATH