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Author : Ignacio Arechaga,Eric Cascales
Publisher : Frontiers Media SA
Page : 235 pages
File Size : 51,8 Mb
Release : 2022-06-15
Category : Science
ISBN : 9782889763757
Author : Laure Journet,Eric Cascales
Publisher : Humana Press
Page : 528 pages
File Size : 45,8 Mb
Release : 2017-07-01
Category : Science
ISBN : 1493970313
This volume details protocols that cover the broad arsenal of techniques used to study a secretion system from A to Z. Chapters focus on identifying and localizing the different subunits, defining interactions within subunits, monitoring conformational changes, purifying and imaging of large complexes, defining the assembly pathway by fluorescence microscopy and the role of energy during assembly and/or secretion, identifying secreted effectors as well as reporters to follow effector transport. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Bacterial Protein Secretion Systems: Methods and Protocol aims to provide techniques that are not restricted to the study of secretion systems but are also of specific interest for any researcher interested on multi-protein complexes of the bacterial cell envelope.
Author : Maria Sandkvist,Eric Cascales,Peter J. Christie
Publisher : John Wiley & Sons
Page : 128 pages
File Size : 55,5 Mb
Release : 2020-07-02
Category : Science
ISBN : 9781683670285
Protein transport into and across membranes is a fundamental process in bacteria that touches upon and unites many areas of microbiology, including bacterial cell physiology, adhesion and motility, nutrient scavenging, intrabacterial signaling and social behavior, toxin deployment, interbacterial antagonism and collaboration, host invasion and disruption, and immune evasion. A broad repertoire of mechanisms and macromolecular machines are required to deliver protein substrates across bacterial cell membranes for intended effects. Some machines are common to most, if not all bacteria, whereas others are specific to Gram-negative or Gram-positive species or species with unique cell envelope properties such as members of Actinobacteria and Spirochetes. Protein Secretion in Bacteria, authored and edited by an international team of experts, draws together the many distinct functions and mechanisms involved in protein translocation in one concise tome. This comprehensive book presents updated information on all aspects of bacterial protein secretion encompassing: Individual secretory systems–Sec, Tat, and T1SS through the newly discovered T9SS Mechanisms, structures, and functions of bacterial secretion systems Lipoprotein sorting pathways, outer membrane vesicles, and the sortase system Structures and roles of surface organelles, including flagella, pili, and curli Emerging technologies and translational implications Protein Secretion in Bacteria serves as both an introductory guide for students and postdocs and a ready reference for seasoned researchers whose work touches on protein export and secretion. This volume synthesizes the diversity of mechanisms of bacterial secretion across the microbial world into a digestible resource to stimulate new research, inspire continued identification and characterization of novel systems, and bring about new ways to manipulate these systems for biotechnological, preventative, and therapeutic applications.
Author : Laure Journet,Eric Cascales
Publisher : Humana
Page : 528 pages
File Size : 53,9 Mb
Release : 2018-08-08
Category : Science
ISBN : 1493983741
This volume details protocols that cover the broad arsenal of techniques used to study a secretion system from A to Z. Chapters focus on identifying and localizing the different subunits, defining interactions within subunits, monitoring conformational changes, purifying and imaging of large complexes, defining the assembly pathway by fluorescence microscopy and the role of energy during assembly and/or secretion, identifying secreted effectors as well as reporters to follow effector transport. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Bacterial Protein Secretion Systems: Methods and Protocol aims to provide techniques that are not restricted to the study of secretion systems but are also of specific interest for any researcher interested on multi-protein complexes of the bacterial cell envelope.
Author : Abrielle Benton
Publisher : American Medical Publishers
Page : 0 pages
File Size : 45,9 Mb
Release : 2023-09-19
Category : Medical
ISBN : 163927913X
Secretion refers to the movement of materials from one point to another. In bacterial species, secretion is the transport of effector molecules like toxins, enzymes or proteins from the cytoplasm to exterior of the bacterial cell. It is a crucial mechanism in bacterial functioning and operation for their survival and adaptability in their natural surroundings. Bacterial secretion systems are the protein complexes on the cell membranes of bacteria for secretion of substances. These protein secretion systems play the role of cellular devices utilized by pathogenic bacteria to secrete their virulence factors to attack the host cells. They may be categorized on the basis of their composition, activity and distinct structure. Usually, proteins may be secreted via two distinct processes. In one process, cytoplasm of the bacteria is translocated and delivered directly in the host from cell membrane. Whereas, in the second process, proteins are transported to the inner membrane, deposited on periplasm, and then transmitted to the host by the outer cell membrane. The topics included in this book on bacterial protein secretion systems are of utmost significance and bound to provide incredible insights to readers. With state-of-the-art inputs by acclaimed experts of this field, it targets medical students and professionals.
Author : Anthony William Maresso
Publisher : Springer Nature
Page : 212 pages
File Size : 49,6 Mb
Release : 2019-09-05
Category : Medical
ISBN : 9783030204648
This textbook introduces in an engaging way the fundamentals of how pathogenic bacteria interact with, and are virulent within, the human host. To inspire and educate the next generation of microbe hunters, the author, Microbiologist and Scientist Anthony William Maresso, integrates the major findings of the field into a single, easy-to-understand volume emphasizing a molecular appreciation of the concepts underlying bacterial infectious diseases. The work explores such themes as the history of Microbiology, bacterial structure and physiology, bacterial toxins, secretion systems, and adhesins, the host immune system and its battle with bacteria, biofilms, sepsis, and technologies/techniques to the present day. Fully illustrated in concept and packed with idea-provoking challenges highlighting “out-of-the-box” thinking, the work moves beyond being just a review of the scientific literature intent on equipping the next generation of Microbiologists and their teachers with the knowledge to confront, and hopefully one day defeat, the insidious microbes which undermine human health. This textbook is a resource for undergraduate, graduate, and medical students, as well as other health-oriented learners, postdoctoral scholars, basic scientists, and professors intent on expanding their knowledge of bacterial infection and virulence mechanisms.
Author : Joseph E. Alouf,Daniel Ladant,Michel R. Popoff
Publisher : Elsevier
Page : 1072 pages
File Size : 43,5 Mb
Release : 2005-12-20
Category : Science
ISBN : 9780080456980
This book describes the major achievements and discoveries relevant to bacterial protein toxins since the turn of the new century illustrated by the discovery of more than fifty novel toxins (many of them identified through genome screening). The establishment of the three-dimensional crystal structure of more than 20 toxins during the same period offers deeper knowledge of structure-activity relationships and provides a framework to understand how toxins recognize receptors, penetrate membranes and interact with and modify intracellular substrates. Edited by two of the most highly regarded experts in the field from the Institut Pasteur, France 14 brand new chapters dedicated to coverage of historical and general aspects of toxinology Includes the major toxins of both basic and clinical interest are described in depth Details applied aspects of toxins such as therapy, vaccinology, and toolkits in cell biology Evolutionary and functional aspects of bacterial toxins evaluated and summarized Toxin applications in cell biology presented Therapy (cancer therapy, dystonias) discussed Vaccines (native and genetically engineered vaccines) featured Toxins discussed as biological weapons, comprising chapters on anthrax, diphtheria, ricin etc.
Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 47,6 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181
Author : Frans J. de Bruijn
Publisher : John Wiley & Sons
Page : 1472 pages
File Size : 52,7 Mb
Release : 2016-07-13
Category : Science
ISBN : 9781119004899
Bacteria in various habitats are subject to continuously changing environmental conditions, such as nutrient deprivation, heat and cold stress, UV radiation, oxidative stress, dessication, acid stress, nitrosative stress, cell envelope stress, heavy metal exposure, osmotic stress, and others. In order to survive, they have to respond to these conditions by adapting their physiology through sometimes drastic changes in gene expression. In addition they may adapt by changing their morphology, forming biofilms, fruiting bodies or spores, filaments, Viable But Not Culturable (VBNC) cells or moving away from stress compounds via chemotaxis. Changes in gene expression constitute the main component of the bacterial response to stress and environmental changes, and involve a myriad of different mechanisms, including (alternative) sigma factors, bi- or tri-component regulatory systems, small non-coding RNA’s, chaperones, CHRIS-Cas systems, DNA repair, toxin-antitoxin systems, the stringent response, efflux pumps, alarmones, and modulation of the cell envelope or membranes, to name a few. Many regulatory elements are conserved in different bacteria; however there are endless variations on the theme and novel elements of gene regulation in bacteria inhabiting particular environments are constantly being discovered. Especially in (pathogenic) bacteria colonizing the human body a plethora of bacterial responses to innate stresses such as pH, reactive nitrogen and oxygen species and antibiotic stress are being described. An attempt is made to not only cover model systems but give a broad overview of the stress-responsive regulatory systems in a variety of bacteria, including medically important bacteria, where elucidation of certain aspects of these systems could lead to treatment strategies of the pathogens. Many of the regulatory systems being uncovered are specific, but there is also considerable “cross-talk” between different circuits. Stress and Environmental Regulation of Gene Expression and Adaptation in Bacteria is a comprehensive two-volume work bringing together both review and original research articles on key topics in stress and environmental control of gene expression in bacteria. Volume One contains key overview chapters, as well as content on one/two/three component regulatory systems and stress responses, sigma factors and stress responses, small non-coding RNAs and stress responses, toxin-antitoxin systems and stress responses, stringent response to stress, responses to UV irradiation, SOS and double stranded systems repair systems and stress, adaptation to both oxidative and osmotic stress, and desiccation tolerance and drought stress. Volume Two covers heat shock responses, chaperonins and stress, cold shock responses, adaptation to acid stress, nitrosative stress, and envelope stress, as well as iron homeostasis, metal resistance, quorum sensing, chemotaxis and biofilm formation, and viable but not culturable (VBNC) cells. Covering the full breadth of current stress and environmental control of gene expression studies and expanding it towards future advances in the field, these two volumes are a one-stop reference for (non) medical molecular geneticists interested in gene regulation under stress.
Author : I Barry Holland,Susan P. C. Cole,Karl Kuchler,Christopher F. Higgins
Publisher : Elsevier
Page : 530 pages
File Size : 44,8 Mb
Release : 2003-01-07
Category : Science
ISBN : 9780080481876
ABC Proteins is an in-depth, up-to-date analysis of all that is known about the subject to date. It discusses and compares evolution, biology and mechanism of action of all known ABC proteins, including the first structural studies as well as clinical implications. It will be useful to anyone trying to stay abreast of the latest findings. This book is sure to become a classic and will regularly be updated. Phylogeny and Evoloution of ABC Transporters Fundamental Aspects of the Mechanism of Action of ABC Transporters Prokaryote ABC Transporters Non-Mammalian Transporters Multidrug Transporters ABC Transporters, Physiological Roles and Human Disease Full color throughout
Author : Juan-Luis Ramos,Johanna B. Goldberg,Alain Filloux
Publisher : Springer
Page : 319 pages
File Size : 54,7 Mb
Release : 2014-12-13
Category : Medical
ISBN : 9789401795555
Pseudomonas volume 7 collects some of the most relevant and emerging issues in the biology of these microorganisms, and a number of other important issues that were not collected in the previous volumes. The first six volumes of the Pseudomonas series covered the biology of pseudomonads in a wide range of contexts, including the niches they inhabit, the taxonomic relations among its members of this group, the molecular biology of gene expression in different niches and under different environmental conditions, the analysis of virulence in plants, animal and human pathogens, as well as the determinants that make some of these strains of interesting for biotechnological applications. This seventh volume covers the following topics: The history of the biology of Pseudomonas The use of Pseudomonas as biological agents New trends in the molecular biology of these microorganisms Pseudomonas and the immune system of insects and animals This book will be of use to researchers working on these bacteria, particularly those studying medical aspects of Pseudomonas, and their use as a means to control pathogens or to stimulate plant growth. This volume is also interesting for those studying the physiology, genetics, molecular biology of Pseudomonas and those using novel-omics approaches to understand bacteria of the genus Pseudomonas.
Author : Günther Winkelmann
Publisher : John Wiley & Sons
Page : 501 pages
File Size : 46,8 Mb
Release : 2008-01-08
Category : Science
ISBN : 9783527612727
Transport of molecules across the cell membrane is a fundamental process of all living organisms. It is essential for understanding growth, development, nutrition as well as uptake and excretion of exogenous or synthesized molecules. Microbes respresent general and basic functional systems where many transport processes have been studied on a molecular basis. Knowledge of the microbial transport processes will provide new perspectives to treatments by inhibitors, drugs, antibiotics, vitamins, growth promotion compounds, activators and toxic compunds of various kinds.
Author : Eduardo A. Groisman
Publisher : Academic Press
Page : 863 pages
File Size : 47,5 Mb
Release : 2001-01-09
Category : Medical
ISBN : 9780080539584
Principles of Bacterial Pathogenesis presents a molecular perspective on a select group of bacterial pathogens by having the leaders of the field present their perspective in a clear and authoritative manner. Each chapter contains a comprehensive review devoted to a single pathogen. Several chapters include work from authors outside the pathogenesis field, providing general perspectives on the evolution, regulation, and secretion of virulence and determinants. Explains the basic principles of bacterial pathogenesis Covers diverse aspects integrating regulation, cellular microbiology and evolution of microbial disease of humans Discusses current strategies for the identification of virulence determinants and the methods used by microbes to deliver virulence factors Presents authoritative treatises of the major disease microorganisms
Author : Don J. Brenner,Noel R. Krieg,James R. Staley
Publisher : Springer Science & Business Media
Page : 1128 pages
File Size : 47,6 Mb
Release : 2007-12-14
Category : Science
ISBN : 9780387280226
Includes a description of the Gammaproteobacteria (1203 pages, 222 figures, and 300 tables). This large taxon includes many well known medically and environmentally important groups. Especially notable are the Enterobacteriaceae, Aeromonas, Beggiatoa, Chromatium, Legionella, Nitrococcus, Oceanospirillum, Pseudomonas, Rickettsiella, Vibrio, Xanthomonas and 155 additional genera.
Author : Kenneth Murphy,Paul Travers,Mark Walport,Peter Walter
Publisher : Garland Science
Page : 128 pages
File Size : 40,7 Mb
Release : 2010-06-22
Category : Medical
ISBN : 0815344570
The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.