Postgenomics

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Postgenomics

Sarah S. Richardson,Hallam Stevens
Postgenomics Book PDF

Author : Sarah S. Richardson,Hallam Stevens
Publisher : Duke University Press
Page : 304 pages
File Size : 43,6 Mb
Release : 2015-04-15
Category : Science
ISBN : 9780822375449

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Postgenomics by Sarah S. Richardson,Hallam Stevens Pdf

Ten years after the Human Genome Project’s completion the life sciences stand in a moment of uncertainty, transition, and contestation. The postgenomic era has seen rapid shifts in research methodology, funding, scientific labor, and disciplinary structures. Postgenomics is transforming our understanding of disease and health, our environment, and the categories of race, class, and gender. At the same time, the gene retains its centrality and power in biological and popular discourse. The contributors to Postgenomics analyze these ruptures and continuities and place them in historical, social, and political context. Postgenomics, they argue, forces a rethinking of the genome itself, and opens new territory for conversations between the social sciences, humanities, and life sciences. Contributors. Russ Altman, Rachel A. Ankeny, Catherine Bliss, John Dupré, Michael Fortun, Evelyn Fox Keller, Sabina Leonelli, Adrian Mackenzie, Margot Moinester, Aaron Panofsky, Sarah S. Richardson, Sara Shostak, Hallam Stevens

The Postgenomic Condition

Jenny Reardon
The Postgenomic Condition Book PDF

Author : Jenny Reardon
Publisher : University of Chicago Press
Page : 320 pages
File Size : 50,6 Mb
Release : 2017-12-29
Category : Philosophy
ISBN : 9780226510453

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The Postgenomic Condition by Jenny Reardon Pdf

The postgenomic condition: an introduction -- The information of life or the life of information? -- Inclusion: can genomics be antiracist? -- Who represents the human genome? What is the human genome? -- Genomics for the people or the rise of the machines? -- Genomics for the 98 percent? -- The genomic open 2.0: the public v. the public -- Life on Third: knowledge and justice after the genome -- Epilogue

Biocapital

Kaushik Sunder Rajan
Biocapital Book PDF

Author : Kaushik Sunder Rajan
Publisher : Duke University Press
Page : 360 pages
File Size : 45,7 Mb
Release : 2006-04-24
Category : Business & Economics
ISBN : 0822337207

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Biocapital by Kaushik Sunder Rajan Pdf

DIVAn ethnography about the work of genome scientists, entrepreneurs, and policy makers in biotech drug development in the United States and India./div

The Gene

Hans-Jörg Rheinberger,Staffan Müller-Wille
The Gene Book PDF

Author : Hans-Jörg Rheinberger,Staffan Müller-Wille
Publisher : University of Chicago Press
Page : 156 pages
File Size : 45,7 Mb
Release : 2018-01-26
Category : Science
ISBN : 9780226474786

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The Gene by Hans-Jörg Rheinberger,Staffan Müller-Wille Pdf

Few concepts played a more important role in twentieth-century life sciences than that of the gene. Yet at this moment, the field of genetics is undergoing radical conceptual transformation, and some scientists are questioning the very usefulness of the concept of the gene, arguing instead for more systemic perspectives. The time could not be better, therefore, for Hans-Jörg Rheinberger and Staffan Müller-Wille's magisterial history of the concept of the gene. Though the gene has long been the central organizing theme of biology, both conceptually and as an object of study, Rheinberger and Müller-Wille conclude that we have never even had a universally accepted, stable definition of it. Rather, the concept has been in continual flux—a state that, they contend, is typical of historically important and productive scientific concepts. It is that very openness to change and manipulation, the authors argue, that made it so useful: its very mutability enabled it to be useful while the technologies and approaches used to study and theorize about it changed dramatically.

Gene Regulation and Metabolism

Julio Collado-Vides,Ralf Hofestädt
Gene Regulation and Metabolism Book PDF

Author : Julio Collado-Vides,Ralf Hofestädt
Publisher : MIT Press
Page : 326 pages
File Size : 42,7 Mb
Release : 2002
Category : Computers
ISBN : 0262532689

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Gene Regulation and Metabolism by Julio Collado-Vides,Ralf Hofestädt Pdf

An overview of current computational approaches to metabolism and gene regulation.

The Postgenomic Condition

Jenny Reardon
The Postgenomic Condition Book PDF

Author : Jenny Reardon
Publisher : University of Chicago Press
Page : 320 pages
File Size : 42,7 Mb
Release : 2017-12-29
Category : Science
ISBN : 9780226345192

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The Postgenomic Condition by Jenny Reardon Pdf

Now that we have sequenced the human genome, what does it mean? In The Postgenomic Condition, Jenny Reardon critically examines the decade after the Human Genome Project, and the fundamental questions about meaning, value and justice this landmark achievement left in its wake. Drawing on more than a decade of research—in molecular biology labs, commercial startups, governmental agencies, and civic spaces—Reardon demonstrates how the extensive efforts to transform genomics from high tech informatics practiced by a few to meaningful knowledge beneficial to all exposed the limits of long-cherished liberal modes of knowing and governing life. Those in the American South challenged the value of being included in genomics when no hospital served their community. Ethicists and lawyers charged with overseeing Scottish DNA and data questioned how to develop a system of ownership for these resources when their capacity to create things of value—new personalized treatments—remained largely unrealized. Molecular biologists who pioneered genomics asked whether their practices of thinking could survive the deluge of data produced by the growing power of sequencing machines. While the media is filled with grand visions of precision medicine, The Postgenomic Condition shares these actual challenges of the scientists, entrepreneurs, policy makers, bioethicists, lawyers, and patient advocates who sought to leverage liberal democratic practices to render genomic data a new source of meaning and value for interpreting and caring for life. It brings into rich empirical focus the resulting hard on-the-ground questions about how to know and live on a depleted but data-rich, interconnected yet fractured planet, where technoscience garners significant resources, but deeper questions of knowledge and justice urgently demand attention.

Rethinking Cancer

Bernhard Strauss,Marta Bertolaso,Ingemar Ernberg,Mina J. Bissell
Rethinking Cancer Book PDF

Author : Bernhard Strauss,Marta Bertolaso,Ingemar Ernberg,Mina J. Bissell
Publisher : MIT Press
Page : 433 pages
File Size : 45,5 Mb
Release : 2021-04-27
Category : Science
ISBN : 9780262045216

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Rethinking Cancer by Bernhard Strauss,Marta Bertolaso,Ingemar Ernberg,Mina J. Bissell Pdf

Leading scientists argue for a new paradigm for cancer research, proposing a complex systems view of cancer supported by empirical evidence. Current consensus in cancer research explains cancer as a disease caused by specific mutations in certain genes. After dramatic advances in genome sequencing, never before have we known so much about the individual cancer cell--and yet never before has it been so unclear what to do with this knowledge. In this volume, leading researchers argue for a new theory framework for understanding and treating cancer. The contributors propose a complex systems view of cancer, presenting conceptual building blocks for a new research paradigm supported by empirical evidence. The contributors first discuss the new research framework in terms of theoretical foundations and then take up the relevance of a systems approach, reviewing such topics as nonlinearity, recurrence after treatment, the cellular attractor concept, network theory, and non-coding DNA--the "dark matter" of our genome. They address the temporality of cancer progression, drawing on evolutionary theory and clinical experience. Finally, they cover the dominant role of the tissue microenvironment in cancer, analyzing topics including altered metabolic pathways, the disease-defining influence on metastasis, and the interconnectedness of different environmental niches across levels of organization.

Behavioral Genetics in the Postgenomic Era

Robert Plomin
Behavioral Genetics in the Postgenomic Era Book PDF

Author : Robert Plomin
Publisher : Amer Psychological Assn
Page : 608 pages
File Size : 42,5 Mb
Release : 2003
Category : Medical
ISBN : 1557989265

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Behavioral Genetics in the Postgenomic Era by Robert Plomin Pdf

The Human Genome Project-which has provided a working draft of the sequence of DNA in the human genome - is a remarkable scientific achievement. In this postgenomic world, it appears that all genes and all DNA variation will eventually be known. For behavioral researchers, this is especially exciting because behavioral dimensions and disorders are the most complex traits of all. To understand these traits, we need to understand the roles of many genes and many environmental influences.

Bioinformatics

Frédéric Dardel,François Képès
Bioinformatics Book PDF

Author : Frédéric Dardel,François Képès
Publisher : John Wiley & Sons
Page : 252 pages
File Size : 52,5 Mb
Release : 2007-01-11
Category : Science
ISBN : 0470020024

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Bioinformatics by Frédéric Dardel,François Képès Pdf

This book is an excellent introductory text describing the use of bioinformatics to analyze genomic and post-genomic data. It has been translated from the original popular French edition, which was based on a course taught at the well-respected École Polytechnique in Palaiseau. This edition has been fully revised and updated by the authors. After a brief introduction to gene structure and sequence determination, it describes the techniques used to identify genes, their protein-coding sequences and regulatory regions. The book discusses the methodology of comparative genomics, using information from different organisms to deduce information about unknown sequences. There is a comprehensive chapter on structure prediction, covering both RNA and protein. Finally, the book describes the complex networks of RNA and protein that exist within the cell and their interactions, ending with a discussion of the simulation approaches that can be used to model these networks. Praise from the reviews: “In context of the new developments the genomic era has brought, Bioinformatics: Genomics and Post-Genomics becomes a fundamental and indispensable resource for undergraduate and early graduate students...insightfully authored...will immensely help students...in establishing important foundations while shaping their careers.” NEWSLETTER, BRITISH SOCIETY OF CELL BIOLOGY

Sex Itself

Sarah S. Richardson
Sex Itself Book PDF

Author : Sarah S. Richardson
Publisher : University of Chicago Press
Page : 320 pages
File Size : 53,8 Mb
Release : 2013-12-13
Category : Science
ISBN : 9780226084718

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Sex Itself by Sarah S. Richardson Pdf

Human genomes are 99.9 percent identical—with one prominent exception. Instead of a matching pair of X chromosomes, men carry a single X, coupled with a tiny chromosome called the Y. Tracking the emergence of a new and distinctive way of thinking about sex represented by the unalterable, simple, and visually compelling binary of the X and Y chromosomes, Sex Itself examines the interaction between cultural gender norms and genetic theories of sex from the beginning of the twentieth century to the present, postgenomic age. Using methods from history, philosophy, and gender studies of science, Sarah S. Richardson uncovers how gender has helped to shape the research practices, questions asked, theories and models, and descriptive language used in sex chromosome research. From the earliest theories of chromosomal sex determination, to the mid-century hypothesis of the aggressive XYY supermale, to the debate about Y chromosome degeneration, to the recent claim that male and female genomes are more different than those of humans and chimpanzees, Richardson shows how cultural gender conceptions influence the genetic science of sex. Richardson shows how sexual science of the past continues to resonate, in ways both subtle and explicit, in contemporary research on the genetics of sex and gender. With the completion of the Human Genome Project, genes and chromosomes are moving to the center of the biology of sex. Sex Itself offers a compelling argument for the importance of ongoing critical dialogue on how cultural conceptions of gender operate within the science of sex.

Encyclopedia of Genetics, Genomics, Proteomics, and Informatics

George P. Rédei
Encyclopedia of Genetics Genomics Proteomics and Informatics Book PDF

Author : George P. Rédei
Publisher : Springer Science & Business Media
Page : 2139 pages
File Size : 40,8 Mb
Release : 2008-04-25
Category : Medical
ISBN : 9781402067532

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Encyclopedia of Genetics, Genomics, Proteomics, and Informatics by George P. Rédei Pdf

This new third edition updates a best-selling encyclopedia. It includes about 56% more words than the 1,392-page second edition of 2003. The number of illustrations increased to almost 2,000 and their quality has improved by design and four colors. It includes approximately 1,800 current databases and web servers. This encyclopedia covers the basics and the latest in genomics, proteomics, genetic engineering, small RNAs, transcription factories, chromosome territories, stem cells, genetic networks, epigenetics, prions, hereditary diseases, and patents. Similar integrated information is not available in textbooks or on the Internet.

Integrative Physiology in the Proteomics and Post-Genomics Age

Wolfgang Walz
Integrative Physiology in the Proteomics and Post Genomics Age Book PDF

Author : Wolfgang Walz
Publisher : Springer Science & Business Media
Page : 271 pages
File Size : 49,8 Mb
Release : 2007-11-10
Category : Medical
ISBN : 9781592599257

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Integrative Physiology in the Proteomics and Post-Genomics Age by Wolfgang Walz Pdf

There is a perception in the scientific community that the discipline of Physiology is in crisis, or at least, in a phase of profound transition and change. At the root of the problem is confusion between objectives (the biological questions to be solved) and the methods and technologies to be applied. Traditionally, ever since Claude Bernard’s concept of the “milieu interieur,” Physiology was an integrative science with the prime concern of studying regulatory mechanisms leading to adaptation and homeostasis in the presence of challenges from a dynamic internal and external environment. This study of control mechanisms can be applied on any level of fu- tion whether subcellular, cellular, and organ, but reaches its highest level of complexity with the functioning of the body as a whole and its interaction with the external environment. This involves the determination of the interaction of genetic with environmental factors and the resulting integrated body adaptation. It might seem obvious that in the pursuit of these questions any appropriate combination of techniques on any organizational level could be used. Yet the advent of molecular techniques has resulted in a preoccupation with the problems and challenges inherent in these techniques, sometimes at the expense of the original perspectives and concepts. The many new mechanisms that have been discovered at the molecular level, as well as their economical exploitation, have contributed to a climate of reductionism.

The Maternal Imprint

Sarah S. Richardson
The Maternal Imprint Book PDF

Author : Sarah S. Richardson
Publisher : University of Chicago Press
Page : 319 pages
File Size : 45,5 Mb
Release : 2021-11-05
Category : Medical
ISBN : 9780226544809

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The Maternal Imprint by Sarah S. Richardson Pdf

Introduction: The Maternal Imprint -- Sex Equality in Heredity -- Prenatal Culture -- Germ Plasm Hygiene -- Maternal Effects -- Race, Birth Weight, and the Biosocial Body -- Fetal Programming -- It's the Mother! -- Epilogue: Gender and Heredity in the Postgenomic Moment.

Weighing the Future

Natali Valdez
Weighing the Future Book PDF

Author : Natali Valdez
Publisher : Univ of California Press
Page : 289 pages
File Size : 48,6 Mb
Release : 2021-12-14
Category : Social Science
ISBN : 9780520380158

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Weighing the Future by Natali Valdez Pdf

Epigenetics, the study of heritable changes in gene expression, has been heralded as one of the most promising new fields of scientific inquiry. Current large-scale studies selectively draw on epigenetics to connect behavioral choices made by pregnant people, such as diet and exercise, to health risks for future generations. As the first ethnography of its kind, Weighing the Future examines the sociopolitical implications of ongoing pregnancy trials in the United States and the United Kingdom, illuminating how processes of scientific knowledge production are linked to capitalism, surveillance, and environmental reproduction. Natali Valdez argues that a focus on individual behavior rather than social environments ignores the vital impacts of systemic racism. The environments we imagine to shape our genes, bodies, and future health are intimately tied to race, gender, and structures of inequality. This groundbreaking book makes the case that science, and how we translate it, is a reproductive project that requires feminist vigilance. Instead of fixating on a future at risk, this book brings attention to the present at stake.

Intangible Intangibles

Brad Sherman
Intangible Intangibles Book PDF

Author : Brad Sherman
Publisher : Cambridge University Press
Page : 303 pages
File Size : 52,5 Mb
Release : 2024-04-30
Category : Law
ISBN : 9781009479653

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Intangible Intangibles by Brad Sherman Pdf

This book takes as its starting point recent debates over the dematerialisation of subject matter which have arisen because of changes in information technology, molecular biology, and related fields that produced a subject matter with no obvious material form or trace. Arguing against the idea that dematerialisation is a uniquely twenty-first century problem, this book looks at three situations where US patent law has already dealt with a dematerialised subject matter: nineteenth century chemical inventions, computer-related inventions in the 1970s, and biological subject matter across the twentieth century. In looking at what we can learn from these historical accounts about how the law responded to a dematerialised subject matter and the role that science and technology played in that process, this book provides a history of patentable subject matter in the United States. This title is available as Open Access on Cambridge Core.