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Medicinal and Biological Inorganic Chemistry by Ajay Kumar Goswami,Irena Kostova Pdf
The book provides a detailed state-of-the-art overview of inorganic chemistry applied to medicinal chemistry and biology. It covers the newly emerging field of metals in medicine and the future of medicinal inorganic chemistry. It is an essential reading for every researcher and student in medicinal and bioinorganic chemistry.
Bioinorganic Medicinal Chemistry by Enzo Alessio Pdf
This book gives a comprehensive overview about medicinal inorganic chemistry. Topics like targeting strategies, mechanism of action, Pt-based antitumor drugs, radiopharmaceuticals are covered in detail and offer the reader an in-depth overview about this important topic.
This book, with an organization based on the periodic table and the relevance of different chemical elements for life processes, offers a general reference and textbook on bioinorganic medicinal chemistry. Following an introductory chapter overview of bioinorganic chemistry comes a section on the essential bioinorganic systems of hydrogen, oxygen, and gases; and their role in disease and drug targeting. The next 13 chapters cover the classes of bioinorganic drugs and new developments in drug design for new therapeutic agents. Two following sections discuss the metalloprotein and nucleic acid targets with their potential medicinal chemistry applications. The final section addresses toxicity issues of bioinorganic drugs, which all medicinal chemists need to know in order to effectively design new drugs.
Medicinal Chemistry, Volume 75, the latest release in the Advances in Inorganic Chemistry series, presents timely and informative summaries on current progress in a variety of subject areas. This acclaimed serial features reviews written by experts in the field, serving as an indispensable reference to advanced researchers that empowers readers to pursue new developments in each field. Users will find this to be a comprehensive overview of recent findings and trends from the last decade that covers various kinds of inorganic topics, from theoretical oriented supramolecular chemistry, to the quest for accurate calculations of spin states in transition metals. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Advances in Inorganic Chemistry series Includes the latest information on medicinal chemistry
Author : Nicholas P Farrell Publisher : Royal Society of Chemistry Page : 174 pages File Size : 55,5 Mb Release : 2007-10-31 Category : Medical ISBN : 9781847552242
Uses of Inorganic Chemistry in Medicine by Nicholas P Farrell Pdf
Metal-based drugs are a commercially important sector of the pharmaceutical business, yet most bioinorganic textbooks lack the space to cover comprehensively the subject of metals in medicine. Uses of Inorganic Chemistry in Medicine approaches an understanding of the topic in a didactic and systematic manner. The field of inorganic chemistry in medicine may usefully be divided into two main categories - drugs which target metal ions in some form, whether free or protein-bound, and secondly, metal-based drugs where the central metal ion is usually the key feature of the mechanism of action. This latter category can further be subdivided into pharmacodynamic and chemotherapeutic applications, as well as those of imaging. The book summarises the chemical and biological studies on clinically used agents of lithium, gold and platinum, as well as highlighting the research on prospective new drugs, including those based on vanadium and manganese. The coverage allows a clear distinction between pharmacodynamic and therapeutic properties of metal-based drugs and focuses not only on those clinical agents in current use, but also on new drugs and uses. This book serves to fill an important niche, bridging bioinorganic and medicinal chemistry and will undoubtedly be of use to senior undergraduates and postgraduates, as well as being an invaluable asset for teachers and researchers in the discipline.
Essentials of Inorganic Chemistry by Katja A. Strohfeldt Pdf
A comprehensive introduction to inorganic chemistry and, specifically, the science of metal-based drugs, Essentials of Inorganic Chemistry describes the basics of inorganic chemistry, including organometallic chemistry and radiochemistry, from a pharmaceutical perspective. Written for students of pharmacy and pharmacology, pharmaceutical sciences, medicinal chemistry and other health-care related subjects, this accessible text introduces chemical principles with relevant pharmaceutical examples rather than as stand-alone concepts, allowing students to see the relevance of this subject for their future professions. It includes exercises and case studies.
Frontiers in Medicinal Chemistry by Atta-ur-Rahman,M. Iqbal Choudhary,Allen B. Reitz Pdf
"Frontiers in Medicinal Chemistry" is an Ebook series devoted to the review of areas of important topical interest to medicinal chemists and others in allied disciplines. "Frontiers in Medicinal Chemistry" covers all the areas of medicinal chemistry, including developments in rational drug design, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, chemoinformatics, and structure-activity relationships. Medicinal chemistry as.
Bioinorganic Chemistry of Copper by K.D. Karlin,Z. Tyeklar Pdf
Bioinorganic Chemistry of Copper focuses on the vital role of copper ions in biology, especially as an essential metalloenzyme cofactor. The book is highly interdisciplinary in its approach--the outstanding list of contributors includes coordination chemists, biochemists, biophysicists, and molecular biologists. Chapters are grouped into major areas of research interest in inorganic copper chemistry, spectroscopy, oxygen chemistry, biochemistry, and molecular biology. The book also discusses basic research of great potential importance to pharmaceutical scientists. This book is based on the first Johns Hopkins University Copper Symposium, held in August 1992. Researchers in chemistry, biochemistry, molecular biology, and medicinal chemistry will find it to be an essential reference on its subject.
Ligand Design in Medicinal Inorganic Chemistry by Tim Storr Pdf
Increasing the potency of therapeutic compounds, while limiting side-effects, is a common goal in medicinal chemistry. Ligands that effectively bind metal ions and also include specific features to enhance targeting, reporting, and overall efficacy are driving innovation in areas of disease diagnosis and therapy. Ligand Design in Medicinal Inorganic Chemistry presents the state-of-the-art in ligand design for medicinal inorganic chemistry applications. Each individual chapter describes and explores the application of compounds that either target a disease site, or are activated by a disease-specific biological process. Ligand design is discussed in the following areas: Platinum, Ruthenium, and Gold-containing anticancer agents Emissive metal-based optical probes Metal-based antimalarial agents Metal overload disorders Modulation of metal-protein interactions in neurodegenerative diseases Photoactivatable metal complexes and their use in biology and medicine Radiodiagnostic agents and Magnetic Resonance Imaging (MRI) agents Carbohydrate-containing ligands and Schiff-base ligands in Medicinal Inorganic Chemistry Metalloprotein inhibitors Ligand Design in Medicinal Inorganic Chemistry provides graduate students, industrial chemists and academic researchers with a launching pad for new research in medicinal chemistry.
Bioinorganic Chemistry by Rosette M. Roat-Malone Pdf
An updated, practical guide to bioinorganic chemistry Bioinorganic Chemistry: A Short Course, Second Edition provides the fundamentals of inorganic chemistry and biochemistry relevant to understanding bioinorganic topics. Rather than striving to provide a broad overview of the whole, rapidly expanding field, this resource provides essential background material, followed by detailed information on selected topics. The goal is to give readers the background, tools, and skills to research and study bioinorganic topics of special interest to them. This extensively updated premier reference and text: Presents review chapters on the essentials of inorganic chemistry and biochemistry Includes up-to-date information on instrumental and analytical techniques and computer-aided modeling and visualization programs Familiarizes readers with the primary literature sources and online resources Includes detailed coverage of Group 1 and 2 metal ions, concentrating on biological molecules that feature sodium, potassium, magnesium, and calcium ions Describes proteins and enzymes with iron-containing porphyrin ligand systems-myoglobin, hemoglobin, and the ubiquitous cytochrome metalloenzymes-and the non-heme, iron-containing proteins aconitase and methane monooxygenase Appropriate for one-semester bioinorganic chemistry courses for chemistry, biochemistry, and biology majors, this text is ideal for upper-level undergraduate and beginning graduate students. It is also a valuable reference for practitioners and researchers who need a general introduction to bioinorganic chemistry, as well as chemists who want an accessible desk reference.
Frontiers in Medicinal Chemistry by Bentham Science Publishers Pdf
"Frontiers in Medicinal Chemistry is an Ebook series devoted to reviews on research topics relevant to medicinal chemistry and allied disciplines. Frontiers in Medicinal Chemistry covers developments in rational drug design, bioorganic chemistry, high-thro"
Bioinorganic Chemistry provides a broad overview of this dynamic field, reviewing the key chemical elements that have important biological function, and exploring how the chemistry of these elements is central to the function of biological systems.
Insights from Imaging in Bioinorganic Chemistry by Anonim Pdf
Insights from Imaging in Bioinorganic Chemistry continues a long-running series that describes recent advances in scientific research, in particular, in the field of inorganic chemistry. Several highly regarded experts, mostly from academe, contribute on specific topics. The series editor chooses a sub-field within inorganic chemistry as the theme and focus of the volume, extending invitations to experts for their contributions; the current theme is insights from metal ion imaging in bioinorganic and medicinal chemistry. Contains concise, informative accounts that are not too highly specialized, therefore appealing to a wide range of scientists and health professionals Presents contributions from highly qualified international experts Provides intrinsic scientific interest and applications, including important issues relating to the diagnosis and therapeutics that are relevant to public health
The study of the chemistry of living processes – biochemistry – has traditionally centered on the behavior of organic chemical compounds in water, the principle solvent in all cells. Organic compounds and water account for 99 % of the matter in living systems. Some 20 inorganic elements are also essential for life, and they are found in similar amounts in most living systems. Bioinorganic Chemistry is essentially the border between inorganic chemistry and biology. The overall purpose of bioinorganic research is to study the relationship between inorganic metal ions such as copper and iron, and biologically specific macromolecules, experimentally as well as theoretically. The importance of inorganic chemistry in biology, especially metal ion coordination, has gained considerable attention during the last decade. The discoveries of the roles of metal ions and metalloproteins in health and disease through genetic and biochemical studies have drawn the attention of both inorganic chemists and molecular and cell biologists. Bioinorganic courses deal with the specific properties of metal ions as expressed in the functioning of biochemical systems, with the objective to deepen student insight into the chemical behaviour of metal ions in biological systems. Ochiai is generally considered the father of the discipline. When first published in 1977, the very successful first edition provided a clear and concise introduction to the brand new field of bioinorganic chemistry. • Provides the streamlined coverage appropriate for one-semester courses or independent study, with all of the necessary but none of the excessive information • Prepares readers to move to the next level of study (whether they continue on in the field or transition to medicine/industry) • Presents concepts through extensive four-color visuals, appealing to a range of learning styles • Promotes critical thinking through open-ended questions throughout the narrative and at the end of each chapter
Studies in Natural Products Chemistry by Atta-ur- Rahman Pdf
Natural products present in the plant and animal kingdom offer a huge diversity of chemical structures which are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate, and then determine the structures and biological activity of natural products rapidly, thus opening up exciting new opportunities in the field of new drug development to the pharmaceutical industry. The series also covers the synthesis or testing and recording of the medicinal properties of natural products. Describes the chemistry of bioactive natural products Contains contributions by leading authorities in the field A valuable resource for natural product and medicinal chemistry
