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Author : Stanley B. Kater,Paul C. Letourneau
Publisher : Unknown
Page : 380 pages
File Size : 52,8 Mb
Release : 1985
Category : Medical
ISBN : UOM:39015010066044
Author : Kater
Publisher : John Wiley & Sons
Page : 370 pages
File Size : 40,6 Mb
Release : 1985-09-18
Category : Electronic
ISBN : 0471844012
Author : Paul C. Letourneau,Stanley B. Kater,Eduardo R. Macagno
Publisher : Raven Press (ID)
Page : 570 pages
File Size : 51,9 Mb
Release : 1991
Category : Nerves
ISBN : UOM:39015022010584
Describes research on nerve growth cones, (the dynamic cell structure that plays a key role in establishing the specific neuronal interconnections that determine neural circuitry, and thus behaviour), from their individual molecular components to their behaviour within intact living animals.
Author : Phillip R. Gordon-Weeks
Publisher : Cambridge University Press
Page : 275 pages
File Size : 44,7 Mb
Release : 2000-07-03
Category : Medical
ISBN : 9780521444910
'I had the good fortune to behold for the first time that fantastic ending of the growing axon. In my sections of the spinal cord of the three day chick embryo, this ending appeared as a concentration of protoplasm of conical form, endowed with amoeboid movements. It could be compared with a living battering ram, soft and flexible, which advances, pushing aside mechanically the obstacles which it finds in its path, until it reaches the region of its peripheral termination. This curious terminal club, I christened the growth cone.' (Santiago Ramón y Cajal, Recollections of My Life, 1937). In Neuronal Growth Cones, Phillip Gordon-Weeks presents the molecular biology of the behavior of growth cones. The book covers the basic morphology and behavior of growth cones, motility and neurite extension via the growth cone cytoskeleton, pathfinding, intracellular signalling, and synaptogenesis. It is the first detailed, critical analysis of all aspects of growth cone biology.
Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 44,7 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181
Author : Dominique Bagnard
Publisher : Springer Science & Business Media
Page : 184 pages
File Size : 46,7 Mb
Release : 2008-12-10
Category : Medical
ISBN : 9780387767154
This book proposes an updated view of the current knowledge of the molecular and cellular mechanisms ensuring axon growth and guidance. The introductory chapter will remind the readers of all the features of a growth cone and the mechanisms controlling its growth. From there, one enters a fabulous journey with a growth cone, a Tom Thumb story filled with molecular encounters and complex interactions leading to one of the most fantastic developmental achievements: the nervous system wiring.
Author : Stephen G. Waxman,Jeffery D. Kocsis,Peter K. Stys
Publisher : Unknown
Page : 710 pages
File Size : 41,7 Mb
Release : 1995
Category : Axons
ISBN : 9780195082937
The axon, interposed between the cell body and the synaptic terminals in most neurons, plays a crucial role in connecting neurons and acting as a conduit for the transmission of information between them. This book provides a comprehensive and up-to-date compendium that brings together chapterson the structure, function, and pathophysiology of axons in both the PNS and CNS. Carefully written, well-illustrated with superb illustrations, and generously referenced, the 33 chapters and introduction have been authored by 49 world-renowned authorities. Recent advances in the molecularneurobiology of axons are carefully reviewed, and new areas, such as the molecular biology of ion channels and myelination, the role of calcium in pathophysiology and regeneration, cell adhesion molecules and their roles in axo-glial interactions and axonal guidance, and optical recording methods,are highlighted. This book will provide an essential reference for neuroscientists as well as clinicians such as neurologists, neurosurgeons, and clinical electrophysiologists interested in axons.
Author : Irwin B. Levitan,Leonard K. Kaczmarek
Publisher : Oxford University Press, USA
Page : 601 pages
File Size : 50,8 Mb
Release : 2015
Category : Medical
ISBN : 9780199773893
Intended for use by advanced undergraduate, graduate and medical students, this book presents a study of the unique biochemical and physiological properties of neurons, emphasising the molecular mechanisms that generate and regulate their activity.
Author : Edward Koenig
Publisher : Springer Science & Business Media
Page : 369 pages
File Size : 51,5 Mb
Release : 2009-09-01
Category : Science
ISBN : 9783642030192
Recent years have witnessed striking advances in research on axons at a cellular level that substantially impact our current understanding of axonal biology. Newer findings and their ramifications are critically reviewed in the 16 chapters of this volume by authors highly qualified by virtue of their scientific contributions to research areas they know and write about. Five basic areas (I to V) germane to axonal biology are highlighted, beginning with (I) signaling interactions mediating myelination, and differentiation of axonal membrane domains; (IIa) issues surrounding organization and transport dynamics of neurofilaments in axons, (IIb) mechanisms regulating microtubule organization and dynamics, misregulation of which causes axonal degeneration, and (IIc) the roles actin binding proteins play in regulating organization and functions of the actin filament system in mature and growing axons; (IIIa) myosin motor proteins and cargoes intrinsic to the axon compartment, (IIIb) mitochondrial transport motors, and imperatives governing transport dynamics and directional delivery, (IIIc) mechanisms mediating retrograde signaling associated with NGF’s role in trophic-dependent neuronal survival, and (IIId) potential for impaired subcellular targeting of a -synuclein as a mechanism for accumulation of Lewy body inclusions in synucleinopathies; (IVa) occurrence and organization of discrete ribosome-containing domains in axons, (IVb) endogenous mRNAs, classes of proteins translated locally, and RNP trafficking in axons, (IVc) importance of locally synthesized nuclear encoded mitochondrial proteins for maintenance, function and survival of axons, (IVd) occurrence of RNA trafficking from glial cells to axons, and significance glial RNA transcripts may play in expression in axons and axon terminals, (IVe) RNA trafficking and localization of RNA transcripts in axonal growth cones, and signaling pathways that modulate local protein synthesis for directional elongation, and (IVf) genetic and molecular defects underlying spinal muscular atrophy, and roles that SMN gene product plays as a molecular chaperone in mRNA transport and translation; (Va) injury-induced local synthesis of a protein forming a retrograde signaling complex in axons to stimulate regeneration, and (Vb) endogenous and exogenous factors that condition axonal regenerative capacity in PNS and CNS, including injury-induced activation of specific genes governing regeneration. Emergent complexities revealed in this volume compel a major revision in the traditional conceptual model of the axon’s intrinsic makeup and capacities.
Author : Ira Black
Publisher : Springer Science & Business Media
Page : 376 pages
File Size : 42,8 Mb
Release : 2013-11-11
Category : Medical
ISBN : 9781461327172
A central problem in neurobiology concerns mechanisms that generate the pro found diversity and specificity of the nervous system. What is the substance of diversification and specificity at the molecular, cellular, and systems levels? 4 How, for example, do 1011 neurons each form approximately 10 interconnec tions, allowing normal physiological function? How does disruption of these processes result in human disease? These proceedings represent the efforts of molecular biologists, embryologists, neurobiologists, and clinicians to approach these issues. in this volume are grouped by subject to present the varieties The chapters of methods used to approach each individual area. Section I deals with embry ogenesis and morphogenesis of the nervous system. In Chapter 3, Weston and co-workers describe the use of monoclonal antibodies that recognize specific neuronal epitopes (including specific gangliosides) for the purpose of defining heterogeneity in the neural crest, an important model system. Immunocyto chemical analysis reveals the existence of distinct sUbpopulations within the crest at extremely early stages; cells express neuronal or glial binding patterns at the time of migration. Consequently, interactions with the environment may select for predetermined populations. Le Douarin reaches similar conclusions in Chapter 1 by analyzing migratory pathways and developmental potentials in crest of quail-
Author : David Schubert
Publisher : Wiley-Interscience
Page : 344 pages
File Size : 47,6 Mb
Release : 1984
Category : Medical
ISBN : UOM:39015006031580
Author : H. Mei Liu
Publisher : Unknown
Page : 328 pages
File Size : 42,5 Mb
Release : 1981
Category : Medical
ISBN : UOM:39015000261092
Biology and Pathology of Nerve Growth ...
Author : Dan H. Sanes,Thomas A. Reh,William A. Harris
Publisher : Academic Press
Page : 500 pages
File Size : 40,6 Mb
Release : 2000-06-07
Category : Medical
ISBN : 0080951473
Development of the Nervous System presents a broad outline of neural development principles as exemplified by key experiments and observations from past and recent times. The text is organized along a development pathway from the induction of the neural primordium to the emergence of behavior. It covers all the major topics including the patterning and growth of the nervous system, neuronal determination, axonal navigation and targeting, synapse formation and plasticity, and neuronal survival and death. This new text reflects the complete modernization of the field achieved through the use of model organisms and the intensive application of molecular and genetic approaches. Original, artist-rendered drawings combined with clear, concise writing make Development of the Nervous System well suited to anyone approaching this complex field for the first time. Key Features * Provides a synopsis of concepts and experimental strategies * Includes designs of critical experiments that are easy to understand * Outlines the molecular and genetic bases for many developmental events * Presents new information on the function of the developing central nervous system * Richly illustrated with original drawings * Treats the field as an experimental rather than a descriptive science * Written at a level that is appropriate for undergraduates and beyond
Author : Anonim
Publisher : Academic Press
Page : 253 pages
File Size : 47,9 Mb
Release : 2009-05-07
Category : Medical
ISBN : 9780080922614
The nervous system is highly complex both in its structural order and in its ability to perform the many functions required for survival and interaction with the environment; understanding how it develops has proven to be one of the greatest challenges in biology. Such precision demands that key events at every developmental stage are executed properly and are coordinated to produce the circuitry underlying each of the adult nervous system's functions. This volume describes the latest research on the cellular and molecular mechanisms of neural circuitry development, while providing researchers with a one-stop overview and synthesis of contemporary thought in the area. Reviews current research findings on the development of neural circuitry, providing researchers with an overview and synthesis of the latest contemporary thought in the cellular and molecular mechanisms that underlie the development of neural circuitry Includes chapters discussing topics such as the guidance of nerve growth and the formation of plasticity of synapses, helping researchers better understand underlying mechanisms of neural circuit development and maintenance that may play a role in such human diseases/conditions as depression, anxiety, and pain Chapters make use of a variety of human and animal models, allowing researchers to compare and contrast neural circuitry development across a wide spectrum of models
Author : Robert Henry Nichol
Publisher : Unknown
Page : 0 pages
File Size : 46,9 Mb
Release : 2017
Category : Electronic
ISBN : OCLC:981921439
Nerve growth cones are sensory-motile structures that guide developing neurites to form of trillions of synapses in the human brain. Growth cones interact with the extracellular matrix (ECM), such as laminin (LN), through integrin receptors at adhesion sites. Adhesions link ECM proteins to the actin cytoskeleton through numerous adaptor and signaling proteins. One presumed function of growth cone adhesions is to restrain or "clutch" myosin-II-based filamentous actin (F-actin) retrograde flow (RF) to promote leading edge membrane protrusion. In motile non-neuronal cells, myosin-II binds and exerts force upon actin filaments at the leading edge, where clutching forces occur. However, in growth cones, it is unclear whether similar F-actin-clutching forces affect axon outgrowth and guidance. I found in Xenopus spinal neurons RF is reduced in rapidly migrating growth cones on laminin (LN) compared with non-integrin-binding poly-D-lysine (PDL). I further illustrate this relationship between adhesion and RF locally via two-channel imaging of RF and paxillin, as well as on micropatterns of PDL and LN. Finally, I showed that RF is significantly attenuated in vivo, suggesting that it is restrained by molecular clutching forces within the spinal cord. In the second part of my thesis I investigated how extracellular mechanical forces influence neuritogenesis. I examined the role of mechanical forces on neurite development of human forebrain (hFBs) neurons and human motor neurons (hMNs) derived from induced pluripotent stem cells (iPSCs). These two populations of neurons extend axons into distinct environments. Using polyacrylamide (PAA) and collagen substrata of varying elasticity I found that the extension of hFB neurites exhibit little differential outgrowth, while hMN neuritogenesis was strongly promoted on more rigid substrata. I found that the observed differential growth rates are in part due to greater adhesion of the growth cone leading edge to more rigid environments, suggesting hMN growth cones form more stable adhesions leading to greater motility. Furthermore, I found RhoA, an important adhesion regulating GTPase, activity was higher on stiffer substrata in hMNs. Taken together, these data illustrate the mechanistic role of intrinsic and extrinsic forces during neurite outgrowth