Neuronal Growth Cones

Author : Phillip R. Gordon-Weeks
Publisher : Cambridge University Press
Page : 275 pages
File Size : 55,7 Mb
Release : 2000-07-03
Category : Medical
ISBN : 9780521444910

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Neuronal Growth Cones by Phillip R. Gordon-Weeks Pdf

'I had the good fortune to behold for the first time that fantastic ending of the growing axon. In my sections of the spinal cord of the three day chick embryo, this ending appeared as a concentration of protoplasm of conical form, endowed with amoeboid movements. It could be compared with a living battering ram, soft and flexible, which advances, pushing aside mechanically the obstacles which it finds in its path, until it reaches the region of its peripheral termination. This curious terminal club, I christened the growth cone.' (Santiago Ramón y Cajal, Recollections of My Life, 1937). In Neuronal Growth Cones, Phillip Gordon-Weeks presents the molecular biology of the behavior of growth cones. The book covers the basic morphology and behavior of growth cones, motility and neurite extension via the growth cone cytoskeleton, pathfinding, intracellular signalling, and synaptogenesis. It is the first detailed, critical analysis of all aspects of growth cone biology.

Author : Paul C. Letourneau,Stanley B. Kater,Eduardo R. Macagno
Publisher : Raven Press (ID)
Page : 570 pages
File Size : 52,7 Mb
Release : 1991
Category : Nerves
ISBN : UOM:39015022010584

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The Nerve Growth Cone by Paul C. Letourneau,Stanley B. Kater,Eduardo R. Macagno Pdf

Describes research on nerve growth cones, (the dynamic cell structure that plays a key role in establishing the specific neuronal interconnections that determine neural circuitry, and thus behaviour), from their individual molecular components to their behaviour within intact living animals.

Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 47,9 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181

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Molecular Biology of The Cell by Bruce Alberts Pdf

Author : Stanley B. Kater,Paul C. Letourneau
Publisher : Unknown
Page : 380 pages
File Size : 50,6 Mb
Release : 1985
Category : Medical
ISBN : UOM:39015010066044

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Biology of the Nerve Growth Cone by Stanley B. Kater,Paul C. Letourneau Pdf

Author : Robert Henry Nichol
Publisher : Unknown
Page : 0 pages
File Size : 54,9 Mb
Release : 2017
Category : Electronic
ISBN : OCLC:981921439

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Intrinsic and Extrinsic Forces that Guide Growth Cone Motility by Robert Henry Nichol Pdf

Nerve growth cones are sensory-motile structures that guide developing neurites to form of trillions of synapses in the human brain. Growth cones interact with the extracellular matrix (ECM), such as laminin (LN), through integrin receptors at adhesion sites. Adhesions link ECM proteins to the actin cytoskeleton through numerous adaptor and signaling proteins. One presumed function of growth cone adhesions is to restrain or "clutch" myosin-II-based filamentous actin (F-actin) retrograde flow (RF) to promote leading edge membrane protrusion. In motile non-neuronal cells, myosin-II binds and exerts force upon actin filaments at the leading edge, where clutching forces occur. However, in growth cones, it is unclear whether similar F-actin-clutching forces affect axon outgrowth and guidance. I found in Xenopus spinal neurons RF is reduced in rapidly migrating growth cones on laminin (LN) compared with non-integrin-binding poly-D-lysine (PDL). I further illustrate this relationship between adhesion and RF locally via two-channel imaging of RF and paxillin, as well as on micropatterns of PDL and LN. Finally, I showed that RF is significantly attenuated in vivo, suggesting that it is restrained by molecular clutching forces within the spinal cord. In the second part of my thesis I investigated how extracellular mechanical forces influence neuritogenesis. I examined the role of mechanical forces on neurite development of human forebrain (hFBs) neurons and human motor neurons (hMNs) derived from induced pluripotent stem cells (iPSCs). These two populations of neurons extend axons into distinct environments. Using polyacrylamide (PAA) and collagen substrata of varying elasticity I found that the extension of hFB neurites exhibit little differential outgrowth, while hMN neuritogenesis was strongly promoted on more rigid substrata. I found that the observed differential growth rates are in part due to greater adhesion of the growth cone leading edge to more rigid environments, suggesting hMN growth cones form more stable adhesions leading to greater motility. Furthermore, I found RhoA, an important adhesion regulating GTPase, activity was higher on stiffer substrata in hMNs. Taken together, these data illustrate the mechanistic role of intrinsic and extrinsic forces during neurite outgrowth

Author : Jaap Pelt
Publisher : Elsevier
Page : 463 pages
File Size : 47,7 Mb
Release : 1994-10-11
Category : Medical
ISBN : 9780444818195

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The Self-Organizing Brain: From Growth Cones to Functional Networks by Jaap Pelt Pdf

This book concentrates on the organizational level of neurons and neuronal networks under the unifying theme "The Self-Organizing Brain - From Growth Cones to Functional Networks". Such a theme is attractive because it incorporates all phases in the emergence of complexity and (adaptive) organization, as well as involving processes that remain operative in the mature state. The order of the sections follows successive levels of organization from neuronal growth cones, neurite formation, neuronal morphology and signal processing to network development, network dynamics and, finally, to the formation of functional circuits.

Author : Michael E. Selzer,Stephanie Clarke,Leonardo G. Cohen,Gert Kwakkel (Professor),Robert H. Miller (Professor)
Publisher : Cambridge University Press
Page : 693 pages
File Size : 49,7 Mb
Release : 2014
Category : Nervous system
ISBN : 9781107011670

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Textbook of Neural Repair and Rehabilitation by Michael E. Selzer,Stephanie Clarke,Leonardo G. Cohen,Gert Kwakkel (Professor),Robert H. Miller (Professor) Pdf

In two freestanding volumes, the Textbook of Neural Repair and Rehabilitation provides comprehensive coverage of the science and practice of neurological rehabilitation. Revised throughout, bringing the book fully up to date, this volume, Neural Repair and Plasticity, covers the basic sciences relevant to recovery of function following injury to the nervous system, reviewing anatomical and physiological plasticity in the normal central nervous system, mechanisms of neuronal death, axonal regeneration, stem cell biology, and research strategies targeted at axon regeneration and neuron replacement. New chapters have been added covering pathophysiology and plasticity in cerebral palsy, stem cell therapies for brain disorders and neurotrophin repair of spinal cord damage, along with numerous others. Edited and written by leading international authorities, it is an essential resource for neuroscientists and provides a foundation for the work of clinical rehabilitation professionals.

Author : John Elam
Publisher : Springer Science & Business Media
Page : 292 pages
File Size : 40,6 Mb
Release : 2013-11-11
Category : Medical
ISBN : 9781468411973

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Axonal Transport in Neuronal Growth and Regeneration by John Elam Pdf

Over the past several years, the pace of research on the control of axonal growth has increased at a remarkable rate, and this activity is reflected in a growing literature dealing with various aspects of axonal growth and regener ation. It appears timely to review the role played by axonal transport in the intrinsic responses of neurons in the growth and regrowth processes. Through the cooperation of the senior editors of this series, we have been given the opportunity to bring such a focus to the current volume. We wish to acknowledge that the contributing authors attended a confer ence on "The Role of Axonal Transport in Neuronal Growth and Regenera tion" held in Tallahassee, Florida in March, 1983, sponsored by the Psycho biology Research Center of the Florida State University. It is our hope that many of the perceptions and insights expressed in these chapters resulted from our interactions.

Author : Pere M. Pares-Casanova
Publisher : BoD – Books on Demand
Page : 98 pages
File Size : 48,9 Mb
Release : 2017-07-12
Category : Technology & Engineering
ISBN : 9789535133650

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New Insights into Morphometry Studies by Pere M. Pares-Casanova Pdf

There have been brilliant studies in the field of morphometry in recent years. This book increases the literature on this domain by presenting some recent advances and emerging applications upon biological structures, ranging in a variety of purposes and objectives: from animal visual system to growth models, from amphibians to humans, all in a comprehensive and accessible way of information. All chapters are written by leading internationally recognized experts from academia, who explain their own topics in plain English and in a totally rigorous manner. Suitable for a wide range of expert readers, this book represents a high valuable work for scientists and advanced students working in biological and medical morphometric topics.

Author : Eduardo E. Benarroch,Jeremy K. Cutsforth-Gregory,Kelly D. Flemming
Publisher : Oxford University Press
Page : 850 pages
File Size : 42,5 Mb
Release : 2017-11-06
Category : Medical
ISBN : 9780190209421

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Mayo Clinic Medical Neurosciences by Eduardo E. Benarroch,Jeremy K. Cutsforth-Gregory,Kelly D. Flemming Pdf

Fully updated and revised according to student feedback, the sixth edition of Mayo Clinic Medical Neurosciences: Organized by Neurologic System and Level provides a systematic approach to anatomy, physiology, and pathology of the nervous system inspired by the neurologist's approach to solving clinical problems. This volume has 4 sections: 1) an overview of the neurosciences necessary for understanding anatomical localization and pathophysiologic characterization of neurologic disorders; 2) an approach to localizing lesions in the 7 longitudinal systems of the nervous system; 3) an approach to localizing lesions in the 4 horizontal levels of the nervous system; and 4) a collection of clinical problems. This book provides the neuroscience framework to support the neurologist in a clinical setting and is also a great resource for neurology and psychiatry board certifications. This is the perfect guide for all medical students and neurology, psychiatry, and physical medicine residents at early stages of training. New to This Edition - A chapter devoted to multiple-choice questions for self-assessment - Discussion of emerging concepts in molecular, cellular, and system neurosciences - New chapters on emotion and consciousness systems - Incorporation of new discoveries in neuroimaging and an appendix for tables of medications commonly used to treat neurologic disorders

Author : Dominique Bagnard
Publisher : Springer Science & Business Media
Page : 184 pages
File Size : 50,8 Mb
Release : 2008-12-10
Category : Medical
ISBN : 9780387767154

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Axon Growth and Guidance by Dominique Bagnard Pdf

This book proposes an updated view of the current knowledge of the molecular and cellular mechanisms ensuring axon growth and guidance. The introductory chapter will remind the readers of all the features of a growth cone and the mechanisms controlling its growth. From there, one enters a fabulous journey with a growth cone, a Tom Thumb story filled with molecular encounters and complex interactions leading to one of the most fantastic developmental achievements: the nervous system wiring.

Author : William Slikker, Jr.,Merle G. Paule,Cheng Wang
Publisher : Academic Press
Page : 616 pages
File Size : 45,9 Mb
Release : 2018-01-04
Category : Science
ISBN : 9780128093948

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Handbook of Developmental Neurotoxicology by William Slikker, Jr.,Merle G. Paule,Cheng Wang Pdf

Handbook of Developmental Neurotoxicology, Second Edition, provides a comprehensive view of the fundamental aspects of neurodevelopment, the pathways and agents that affect them, relevant clinical syndromes, and risk assessment procedures for developmental neurotoxicants. The editors and chapter authors are internationally recognized experts whose collaboration heralds a remarkable advance in the field, bridging developmental neuroscience with the principles of neurotoxicology. The book features eight new chapters with newly recruited authors, making it an essential text for students and professionals in toxicology, neurotoxicology, developmental biology, pharmacology, and neuroscience. Presents a comprehensive, up-to-date resource on developmental neurotoxicology with updated chapters from the first edition Contains new chapters that focus on subjects recent to the field Includes well-illustrated material, with diagrams, charts, and tables Contains compelling case studies and chapters written by world experts

Author : Ivan Curtis
Publisher : Springer Science & Business Media
Page : 347 pages
File Size : 48,6 Mb
Release : 2007-04-03
Category : Medical
ISBN : 9780387685618

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Intracellular Mechanisms for Neuritogenesis by Ivan Curtis Pdf

This book present in novel, distinct, but highly related aspects of the intracellular mechanisms required for the formation of a functional neurite, which include cytoskeletal organization, membrane traffic, and signal transduction. Its aim is to present this topic to the general readership of neurobiologists and molecular and cellular biologists to further stimulate the interest into this exciting section of neurobiology.

Author : David L. Stocum
Publisher : Academic Press
Page : 474 pages
File Size : 41,6 Mb
Release : 2012-06-07
Category : Technology & Engineering
ISBN : 9780123848611

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Regenerative Biology and Medicine by David L. Stocum Pdf

Regenerative Biology and Medicine, Second Edition — Winner of a 2013 Highly Commended BMA Medical Book Award for Medicine — discusses the fundamentals of regenerative biology and medicine. It provides a comprehensive overview, which integrates old and new data into an ever-clearer global picture. The book is organized into three parts. Part I discusses the mechanisms and the basic biology of regeneration, while Part II deals with the strategies of regenerative medicine developed for restoring tissue, organ, and appendage structures. Part III reflects on the achievements of regenerative biology and medicine; future challenges; bioethical issues that need to be addressed; and the most promising developments in regenerative medicine. The book is designed for multiple audiences: undergraduate students, graduate students, medical students and postdoctoral fellows, and research investigators interested in an overall synthesis of this field. It will also appeal to investigators from fields not directly related to regenerative biology and medicine, such as chemistry, informatics, computer science, mathematics, physics, and engineering. Highly Commended 2013 BMA Medical Book Award for Medicine Includes coverage of skin, hair, teeth, cornea, and central neural tissues Provides description of regenetive medicine in digestive, respiratory, urogenital, musculoskeletal, and cardiovascular systems Includes amphibians as powerful research models with discussion of appendage regeneration in amphibians and mammals

Author : Andrew J. Murray
Publisher : Humana
Page : 0 pages
File Size : 45,7 Mb
Release : 2014-05-17
Category : Medical
ISBN : 149390776X

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Axon Growth and Regeneration by Andrew J. Murray Pdf

Axon Growth and Regeneration: Methods and Protocols brings together a diverse set of techniques for the study of the mechanisms underlying central nervous system axon growth, consequently providing a resource that will aid in the development of repair strategies. After an introductory section, this detailed volume continues with sections focusing on axon growth in vitro, providing a range of protocols that can be used to examine intracellular signalling pathways, axonal responses to extracellular factors and methods for quantifying outgrowth. The next section provides protocols for inducing experimental injury in vivo as well as some highly promising protocols for promoting regeneration, which segues into the final section highlighting a series of protocols that can be used to monitor the extent of axon regeneration in vivo, ranging from tract tracing to in vivo imaging and functional recovery. As a book in the Methods in Molecular Biology series, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and tips on troubleshooting and avoiding known pitfalls. Practical and reliable, Axon Growth and Regeneration: Methods and Protocols aims to serve researchers studying axon regeneration with a significant set of diverse tools, vital for moving on to the next generation of exciting new discoveries in the field.