Biomaterial Related Infections

Author : Natália Martins,Célia F. Rodrigues
Publisher : MDPI
Page : 204 pages
File Size : 55,7 Mb
Release : 2020-12-23
Category : Medical
ISBN : 9783039434381

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Biomaterial-Related Infections by Natália Martins,Célia F. Rodrigues Pdf

The use of medical devices (e.g., catheters, implants, and probes) is a common and essential part of medical care for both diagnostic and therapeutic purposes. However, these devices quite frequently lead to the incidence of infections due to the colonization of their abiotic surfaces by biofilm-growing microorganisms, which are progressively resistant to antimicrobial therapies. Several methods based on anti-infective biomaterials that repel microbes have been developed to combat device-related infections. Among these strategies, surface coating with antibiotics (e.g., beta-lactams), natural compounds (e.g., polyphenols), or inorganic elements (e.g., silver and copper nanoparticles) has been widely recognized as exhibiting broad-spectrum bactericidal or bacteriostatic activity. So, in order to achieve a better therapeutic response, it is crucial to understand how these infections are different from others. This will allow us to find new biomaterials characterized by antifouling coatings with repellent properties or low adhesion towards microorganisms, or antimicrobial coatings that are capable of killing microbes approaching the surface, improving biomaterial functionalization strategies and supporting tissues’ bio-integration.

Author : Fintan Moriarty,Sebastian A.J. Zaat,Henk J. Busscher
Publisher : Springer Science & Business Media
Page : 564 pages
File Size : 47,6 Mb
Release : 2012-09-29
Category : Technology & Engineering
ISBN : 9781461410317

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Biomaterials Associated Infection by Fintan Moriarty,Sebastian A.J. Zaat,Henk J. Busscher Pdf

Biomaterials associated infection (BAI) is one of the most common complications associated with implantation of any biomaterial regardless of form or function. These infections usually involve bacterial colonization and biofilm formation on the biomaterial itself, rendering the infection impervious to antimicrobials and host defenses. In addition, it is becoming increasingly clear that infection of the surrounding tissues also plays an important role in BAI, and that the infection may be influenced by the composition and design of the implanted biomaterial. In this book, worldwide leaders in the field address this critical problem in the translation of biomaterials research into clinical practice. The book begins with an emphasis on the latest research in the pathogenesis of BAI from microbiological, immunological, and materials science perspectives. The current state of the art in antimicrobial activation of biomaterials through surface modification and the incorporation of antimicrobial agents is then discussed. In the concluding chapters, successful translation of a selection of antimicrobial technologies from preclinical research into clinical use is described alongside a discussion of the utility of these devices and perspectives for future development. This book is essential reading for researchers and clinicians who are interested in understanding the fundamentals of BAI, the latest in antimicrobial materials research, and the state of the art in clinically available antimicrobial containing medical devices.

Author : L Barnes,Ian Cooper
Publisher : Elsevier
Page : 278 pages
File Size : 54,5 Mb
Release : 2014-11-21
Category : Technology & Engineering
ISBN : 9780857097224

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Biomaterials and Medical Device - Associated Infections by L Barnes,Ian Cooper Pdf

Despite advances in materials and sterilisation, patients who receive biomaterials of medical device implants are still at risk of developing an infection around the implantation site. This book reviews the fundamentals of biomaterials and medical device related infections and methods and materials for the treatment and prevention of infection. The first part of the book provides readers with an introduction to the topic including analyses of biofilms, diagnosis and treatment of infection, pathology and topography. The second part of the book discusses a range of established and novel technologies and materials which have been designed to prevent infection. Provides analysis of biofilms and their relevance to implant associated infections. Assesses technologies for controlling biofilms. Considers advantages and disadvantages of in vivo infection studies.

Author : Sina Ebnesajjad
Publisher : Elsevier Inc. Chapters
Page : 368 pages
File Size : 42,9 Mb
Release : 2013-12-05
Category : Technology & Engineering
ISBN : 9780128076682

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Handbook of Polymer Applications in Medicine and Medical Devices by Sina Ebnesajjad Pdf

This chapter focuses on adhesives used in direct physiological contact in dental and medical procedures. Activity in both areas has been quite extensive outside the United States for decades. In contrast, adhesive use in medical devices, patches, and plasters has been ongoing in the United States for a long time. In the case of medical devices, adhesion is concerned with the joining of materials such as plastics, elastomers, textiles, metals, and ceramics, which are examined in other chapters of the present volume and are covered in various references [1–6], The coverage of this chapter is devoted to applications where to adhesives are in direct contact with tissues and other live organs.

Author : Ying Deng,Wei Lv
Publisher : Woodhead Publishing
Page : 238 pages
File Size : 40,7 Mb
Release : 2016-10-24
Category : Technology & Engineering
ISBN : 9780081003985

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Biofilms and Implantable Medical Devices by Ying Deng,Wei Lv Pdf

Biofilms and Implantable Medical Devices: Infection and Control explores the increasing use of permanent and semi-permanent implants and indwelling medical devices. As an understanding of the growth and impact of biofilm formation on these medical devices and biomaterials is vital for protecting the health of the human host, this book provides readers with a comprehensive treatise on biofilms and their relationship with medical devices, also reporting on infections and associated strategies for prevention. Provides useful information on the fundamentals of biofilm problems in medical devices Discusses biofilm problems in a range of medical devices Focuses on strategies for prevention of biofilm formation

Author : Célia F. Rodrigues,Natália Martins
Publisher : Unknown
Page : 204 pages
File Size : 46,5 Mb
Release : 2020
Category : Electronic
ISBN : 303943439X

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Biomaterial-Related Infections by Célia F. Rodrigues,Natália Martins Pdf

The use of medical devices (e.g., catheters, implants, and probes) is a common and essential part of medical care for both diagnostic and therapeutic purposes. However, these devices quite frequently lead to the incidence of infections due to the colonization of their abiotic surfaces by biofilm-growing microorganisms, which are progressively resistant to antimicrobial therapies. Several methods based on anti-infective biomaterials that repel microbes have been developed to combat device-related infections. Among these strategies, surface coating with antibiotics (e.g., beta-lactams), natural compounds (e.g., polyphenols), or inorganic elements (e.g., silver and copper nanoparticles) has been widely recognized as exhibiting broad-spectrum bactericidal or bacteriostatic activity. So, in order to achieve a better therapeutic response, it is crucial to understand how these infections are different from others. This will allow us to find new biomaterials characterized by antifouling coatings with repellent properties or low adhesion towards microorganisms, or antimicrobial coatings that are capable of killing microbes approaching the surface, improving biomaterial functionalization strategies and supporting tissues' bio-integration.

Author : Torkel Wadström,Ingvar Eliasson,Ian Holder,Asa Ljungh
Publisher : Springer
Page : 570 pages
File Size : 45,8 Mb
Release : 2012-10-20
Category : Technology & Engineering
ISBN : 1447134559

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Pathogenesis of Wound and Biomaterial-Associated Infections by Torkel Wadström,Ingvar Eliasson,Ian Holder,Asa Ljungh Pdf

Despite the recent advances in medical treatment, patients suffering from wounds such as burns or receiving surgical implants are still in great danger of infection. This has called attention to the need for better understanding of infections at the molecular level. Scientists from various disciplines summarize our knowledge today and investigate how methods to avoid wound and biomaterial-associated infections can be developed. These methods include new antibiotics, surgical strategies to prevent infection, and ways to stimulate the immune system and the tissue healing process. Specific topics include: the definition of microbial cell surface determinants important for adhesion to graft; the definition of extracellular bacterial enzymes and toxins involved in tissue breakdown and the local spread of infection; the prevention of the systemic spreading of infection with immunoglobulins and antibiotics; and the problem of multiple antibiotic resistance in most versatile pathogens.

Author : Bingyun Li,Thomas Fintan Moriarty,Thomas Webster,Malcolm Xing
Publisher : Springer Nature
Page : 648 pages
File Size : 46,5 Mb
Release : 2020-03-02
Category : Medical
ISBN : 9783030344757

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Racing for the Surface by Bingyun Li,Thomas Fintan Moriarty,Thomas Webster,Malcolm Xing Pdf

This book covers the latest research in biofilm, infection, and antimicrobial strategies in reducing and treating musculoskeletal, skin, transfusion, implant-related infections, etc. Topics covered include biofilms, small colony variants, antimicrobial biomaterials (antibiotics, antimicrobial peptides, hydrogels, bioinspired interfaces, immunotherapeutic approaches, and more), antimicrobial coatings, engineering and 3D printing, antimicrobial delivery vehicles, and perspectives on clinical impacts. Antibiotic resistance, which shifts the race toward bacteria, and strategies to reduce antibiotic resistance, are also briefly touched on. Combined with its companion volume, Racing for the Surface: Pathogenesis of Implant Infection and Advanced Antimicrobial Strategies, this book bridges the gaps between infection and tissue engineering, and is an ideal book for academic researchers, clinicians, industrial engineers and scientists, governmental representatives in national laboratories, and advanced undergraduate students and post-doctoral fellows who are interested in infection, microbiology, and biomaterials and devices.

Author : Paul Stoodley,Luanne Hall-Stoodley,Bill Costerton,Patrick DeMeo,Mark Shirtliff,Ellen Gawalt,Sandeep Kathju
Publisher : Elsevier Inc. Chapters
Page : 368 pages
File Size : 42,9 Mb
Release : 2013-12-05
Category : Technology & Engineering
ISBN : 9780128076675

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Handbook of Polymer Applications in Medicine and Medical Devices by Paul Stoodley,Luanne Hall-Stoodley,Bill Costerton,Patrick DeMeo,Mark Shirtliff,Ellen Gawalt,Sandeep Kathju Pdf

The initial design criteria in the choice of indwelling materials for medical and dental purposes may be pragmatic, and based on the necessary mechanical properties required to fashion a functional device. Orthopedic implants require strong materials for weight-bearing, and articulating surfaces such as joints require durability and resistance to wear. Stents and shunts require flexibility and patency, and sutures require a high tensile strength yet also must be flexible enough for intricate manipulation. As the devices became more sophisticated and developments in materials science provided more options for manufacture, implants are being used more frequently and with longer anticipated lifetimes. Concurrently, the design process increasingly incorporated biocompatibility and comfort into the design criteria. However, with longer lifetimes, the more frequent use of invasive surgical procedures involving indwelling devices and biologically-friendly materials, there has been a rise in the number of incidences of device-related infection. Urinary catheters have been estimated to account for 30% of all nosocomial infections [1]. Between 66 and 88% of these occur after urinary catheterization [2]. It is also reported that almost 100% of catheterized patients develop an infection in an openly draining indwelling catheter which has been in place for four days or more [2]. For some procedures, such as orthopedic joint arthroplasties, the diagnosed surgical site infection rates are relatively low (between 1% and 2%; [3]); however, the increasing number of patients undergoing joint-replacement surgery translates to large numbers of patients afflicted with the consequences of complicating infections per year. Furthermore, infection of artificial joints can be devastating, since oral or IV antibiotic therapy frequently fails to resolve the infection, with the only remaining course of action being surgical debridement or partial or total revision. These two examples, the first with very high numbers of patients but of lesser severity in terms of impact to the individual, and the second, low numbers but severe patient impact, reflect the incentive to pursue a third design criteria—that of infection resistance—into materials and devices [4]. In the following sections we will discuss the role of bacterial biofilms in infection, and the growing literature highlighting biofilms as an important cause of device-related infection.

Author : Florian Matl
Publisher : Cuvillier Verlag
Page : 204 pages
File Size : 54,5 Mb
Release : 2009-01-27
Category : Medical
ISBN : 9783736928718

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Infected Biomaterials New Strategies For Local Anti-Infective Treatment by Florian Matl Pdf

Author : J.J. Chris Arts,Jan Geurts
Publisher : Woodhead Publishing
Page : 304 pages
File Size : 44,9 Mb
Release : 2016-10-25
Category : Science
ISBN : 9780081002421

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Management of Periprosthetic Joint Infections (PJIs) by J.J. Chris Arts,Jan Geurts Pdf

Management of Periprosthetic Joint Infections (PJIs): Management of PJIs discusses periprosthetic joint infection (PJI), a fairly rare occurrence that is nonetheless one of the most serious complications in joint replacement surgery. Intricate interactions between the pathogen, the host, and the implant can result in PJIs which are not only physically devastating for the patient, but also financially crippling for health authorities and insurance companies. Actions taken to minimize the risk of PJIs can be extremely challenging for the orthopaedic community. Consequently, new research, which is detailed in this comprehensive book, is being undertaken to minimize and manage these challenging infections. Provides essential background knowledge on the mechanisms and identification of PJIs Dedicated chapters focus on the complex, but vital eccentricities between PJIs in different areas of the body Contains contributions from a mixture of clinical and academic experts in the field, thus ensuring balanced coverage

Author : G. Rakhorst,Rutger Jan Ploeg
Publisher : World Scientific
Page : 279 pages
File Size : 46,5 Mb
Release : 2008
Category : Medical
ISBN : 9789812709561

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Biomaterials in Modern Medicine by G. Rakhorst,Rutger Jan Ploeg Pdf

Design of biomedical products / G.J. Verkerke & E.B. van der Houwen -- Animal models in biomaterials research / G. Rakhorst ... [et al.] -- Technology assessment / J.M. Hummel -- Hemocompatibility of medical devices / W. van Oeveren -- Tissue and cell interactions with (bio)materials / T.G. van Kooten & R. Kuijer -- Biomaterials-associated surgery and infection / P.G.M. Maathuis ... [et al.] -- Cardiopulmonary bypass and postoperative organ dysfunction / Y.J. Gu -- Mechanical circulatory support systems / G. Rakhorst & M.E. Erasmus -- Biomaterials-related infections in orthopedic implants / D. Neut & R.L. Diercks -- Biomaterials for voice reconstruction / G.J. Verkerke ... [et al.] -- Biomaterials in ophthalmology / V.W. Renardel de Lavalette & S.A. Koopmans -- Biomaterials in plastic surgery / M.F. Meek -- Surgical meshes : morphology-dependent bacterial colonization / A.F. Engelsman

Author : Jessica Amber Jennings,Lauren B. Priddy,Mark Smeltzer
Publisher : Frontiers Media SA
Page : 152 pages
File Size : 53,8 Mb
Release : 2022-12-28
Category : Science
ISBN : 9782832509746

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Biofilm-biomaterial interactions: understanding, preventing, and eradicating attachment in infection by Jessica Amber Jennings,Lauren B. Priddy,Mark Smeltzer Pdf

Author : Nehal I. Abu-Lail,Haluk Beyenal
Publisher : Elsevier Inc. Chapters
Page : 450 pages
File Size : 40,6 Mb
Release : 2013-03-12
Category : Science
ISBN : 9780128071007

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Characterization of Biomaterials by Nehal I. Abu-Lail,Haluk Beyenal Pdf

Bacterial adhesion to biomaterials is generally accepted to be the first step in the development of biomaterial-centred bacterial infections (BCBIs). A better understanding of how bacteria interact with biomaterials is essential to the development of surgical intervention strategies that can be used to reduce BCBIs and coatings capable of preventing bacterial adhesion to their surfaces. Bacterial adhesion to a surface is a multi-step process during which single bacterial cells first initiate attachment to the biomaterial, followed by biofilm formation. The first part of this chapter is devoted to an exploration of how the initial bacterial adhesion to biomaterials can be quantified while the second part focuses on how biofilms can be imaged and how such images can be processed to quantify biofilm structure. We have paid special attention to guiding future biomaterials scientists on the best practices currently used in quantifying bacterial interactions with biomaterials at the nano- and macroscales.

Author : Abraham J Domb,Konda Reddy Kunduru,Shady Farah
Publisher : Royal Society of Chemistry
Page : 546 pages
File Size : 55,9 Mb
Release : 2019-08-02
Category : Technology & Engineering
ISBN : 9781788011884

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Antimicrobial Materials for Biomedical Applications by Abraham J Domb,Konda Reddy Kunduru,Shady Farah Pdf

With the need to combat emerging infectious diseases, research around antimicrobial biomaterials and their applications is booming. This book provides the field with a much-needed fundamental overview of the science, addressing the chemistry of a broad range of biomaterial types, and their applications in the biomedical industry. Materials covered include polymers, from those with inherent antimicrobial activity to those that release antimicrobial agents, antimicrobial ceramics and inorganic compounds, such as metal based antimicrobial additives, and the developing field of biomimetic materials, are discussed. Surfaces, coatings and adhesives are covered, whilst the applications of these antimicrobial materials in biomedical applications, from catheters to orthopaedics, dentistry to ophthalmology, are explored. Edited by international leaders and with contributions from the best in the field, this book is the go-to resource for graduates and researchers in biomaterials science, biomedical engineering, chemical engineering, and materials and polymer chemistry.