Blood Spinal Cord And Brain Barriers In Health And Disease

Author : Hari Shanker Sharma
Publisher : Elsevier
Page : 605 pages
File Size : 54,6 Mb
Release : 2003-12-21
Category : Science
ISBN : 9780080528229

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Blood-Spinal Cord and Brain Barriers in Health and Disease by Hari Shanker Sharma Pdf

Recent research into the anatomy and pathophysiology of the blood-brain and blood-spinal cord barriers suggests that a breakdown in these barriers can result in several diseases affecting the central nervous system (CNS). This book presents new findings in the area of blood-brain barrier research that suggest barriers play important roles in health and disease conditions. It also discusses the development of new drugs that can modulate the barrier function in the CNS and may provide new approaches to treating neurological diseases such as Alzheimer's disease and other motor neuron diseases, as well as spinal cord trauma. Key Features * Presents the recent progress made in the research on the blood-brain and spinal cord barrier * Contains numerous illustrations of light and electron micrographs * Includes Foreword written by two eminent researchers in the field, Milton Brightman and Jorge Cervos-Navarro

Author : Anthony J. Suckling,M. G. Rumsby,Michael William Blackburn Bradbury
Publisher : Ellis Horwood
Page : 216 pages
File Size : 50,8 Mb
Release : 1986
Category : Medical
ISBN : STANFORD:36105032335601

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The Blood-brain Barrier in Health and Disease by Anthony J. Suckling,M. G. Rumsby,Michael William Blackburn Bradbury Pdf

Author : Katerina Dorovini-Zis
Publisher : CRC Press
Page : 426 pages
File Size : 50,9 Mb
Release : 2015-06-23
Category : Medical
ISBN : 9781498727068

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The Blood-Brain Barrier in Health and Disease, Volume One by Katerina Dorovini-Zis Pdf

Located at the interface between blood and the brain, the blood-brain barrier is a dynamic permeability barrier formed by a continuous layer of specialized endothelial cells endowed with important permeability, transport, and regulatory functions that both protect the internal milieu of the brain and allow essential nutrients to be transported into the brain. Over the last 25 years, we have witnessed remarkable expansion of our knowledge of the structure, biology, and function of the cerebral endothelium. In The Blood-Brain Barrier in Health and Disease, Volume 1, international experts discuss basic and new concepts and most recent advances pertaining to the development of the cerebral microvascular system. Subjects include the structure, function, permeability properties, transport mechanisms, and the inherent heterogeneity of the cerebral endothelium; the anatomy and physiological properties of the neurovascular unit; functional aspects of the choroid plexus; and important concepts and advances made over the last two decades that have shaped our understanding of the immunological function of the blood-brain barrier. This book is intended to serve as a valuable source of basic and advanced information for researchers, students, and clinicians interested in this fast-expanding field and stimulate further research well into the future.

Author : Katerina Dorovini-Zis
Publisher : CRC Press
Page : 394 pages
File Size : 55,5 Mb
Release : 2015-10-21
Category : Medical
ISBN : 9781498727099

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The Blood-Brain Barrier in Health and Disease, Volume Two by Katerina Dorovini-Zis Pdf

Located at the interface between blood and the brain, the blood-brain barrier is a dynamic permeability barrier formed by a continuous layer of specialized endothelial cells endowed with important permeability, transport, and regulatory functions that both protect the internal milieu of the brain and allow essential nutrients to be transported into the brain. Abnormalities of the blood-brain barrier are increasingly recognized as a key component in the pathogenesis of a range of primary diseases of the brain and the secondary involvement of the brain from pathological processes in other organs. In The Blood-Brain Barrier in Health and Disease, Volume 2, international experts present comprehensive reviews and research accounts on blood-brain barrier dysfunction in infectious and inflammatory diseases, cerebrovascular diseases, stroke, trauma, vitamin deficiency, exposure to neurotoxicants, primary and metastatic brain tumors, and neurodegenerative diseases. This book is intended to serve as a guide and reference to basic and advanced information for researchers, students, and clinicians interested in this fast-expanding field and stimulate further research well into the future.

Author : William G. Mayhan,Denise M. Arrick
Publisher : Biota Publishing
Page : 77 pages
File Size : 51,5 Mb
Release : 2016-12-15
Category : Medical
ISBN : 9781615047406

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The Blood-Brain Barrier in Health and Disease by William G. Mayhan,Denise M. Arrick Pdf

The blood-brain barrier (BBB) is a complex and dynamic structure that protects the brain from cells within the vasculature, from the immune system and from pathogens. This barrier is present in arterioles, capillaries and venules and is formed at the level of adjacent endothelial cells, which are coupled to astrocytes, microglia, neurons and pericytes. The structure of this endothelial barrier is unique among endothelia of other organ systems and is composed of complexes made up of tight, gap and adherens junctions. In addition, it is the responsibility of the surrounding cellular elements to maintain the integrity of the junctional complexes and restrict the entry of substances from the blood into the brain. Changes in permeability of the BBB during physiologic and pathophysiologic conditions involve alterations in specific transporters at the level of the endothelium, activation of specific cellular second messenger pathways and/or the dissolution of the junctional complexes composing the BBB. This book focuses on various aspects that account for the formation and maintenance of the BBB, and on disease states that compromise this barrier.

Author : Marilyn J. Cipolla
Publisher : Biota Publishing
Page : 82 pages
File Size : 43,8 Mb
Release : 2016-07-28
Category : Medical
ISBN : 9781615047239

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The Cerebral Circulation by Marilyn J. Cipolla Pdf

This e-book will review special features of the cerebral circulation and how they contribute to the physiology of the brain. It describes structural and functional properties of the cerebral circulation that are unique to the brain, an organ with high metabolic demands and the need for tight water and ion homeostasis. Autoregulation is pronounced in the brain, with myogenic, metabolic and neurogenic mechanisms contributing to maintain relatively constant blood flow during both increases and decreases in pressure. In addition, unlike peripheral organs where the majority of vascular resistance resides in small arteries and arterioles, large extracranial and intracranial arteries contribute significantly to vascular resistance in the brain. The prominent role of large arteries in cerebrovascular resistance helps maintain blood flow and protect downstream vessels during changes in perfusion pressure. The cerebral endothelium is also unique in that its barrier properties are in some way more like epithelium than endothelium in the periphery. The cerebral endothelium, known as the blood-brain barrier, has specialized tight junctions that do not allow ions to pass freely and has very low hydraulic conductivity and transcellular transport. This special configuration modifies Starling's forces in the brain microcirculation such that ions retained in the vascular lumen oppose water movement due to hydrostatic pressure. Tight water regulation is necessary in the brain because it has limited capacity for expansion within the skull. Increased intracranial pressure due to vasogenic edema can cause severe neurologic complications and death.

Author : Katerina Dorovini-Zis
Publisher : CRC Press
Page : 0 pages
File Size : 51,9 Mb
Release : 2015-10-15
Category : Medical
ISBN : 1498727085

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The Blood-Brain Barrier in Health and Disease by Katerina Dorovini-Zis Pdf

Located at the interface between blood and the brain, the blood-brain barrier is a dynamic permeability barrier formed by a continuous layer of specialized endothelial cells endowed with important permeability, transport, and regulatory functions that both protect the internal milieu of the brain and allow essential nutrients to be transported into the brain. Abnormalities of the blood-brain barrier are increasingly recognized as a key component in the pathogenesis of a range of primary diseases of the brain and the secondary involvement of the brain from pathological processes in other organs. In The Blood-Brain Barrier in Health and Disease, Volume 2, international experts present comprehensive reviews and research accounts on blood-brain barrier dysfunction in infectious and inflammatory diseases, cerebrovascular diseases, stroke, trauma, vitamin deficiency, exposure to neurotoxicants, primary and metastatic brain tumors, and neurodegenerative diseases. This book is intended to serve as a guide and reference to basic and advanced information for researchers, students, and clinicians interested in this fast-expanding field and stimulate further research well into the future.

Author : Gert Fricker,Melanie Ott,Anne Mahringer
Publisher : Springer
Page : 169 pages
File Size : 49,6 Mb
Release : 2014-10-24
Category : Science
ISBN : 9783662437872

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The Blood Brain Barrier (BBB) by Gert Fricker,Melanie Ott,Anne Mahringer Pdf

Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.

Author : Wei Zheng,Adam Chodobski
Publisher : CRC Press
Page : 668 pages
File Size : 47,9 Mb
Release : 2005-03-30
Category : Medical
ISBN : 1420023403

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The Blood-Cerebrospinal Fluid Barrier by Wei Zheng,Adam Chodobski Pdf

Despite the existence of two barrier systems in the brain, research over the last century has mostly focused on the blood-brain barrier rather than on the blood-CSF barrier. Today, there is a greater understanding of the function of the blood-CSF barrier and of the choroid plexus, a tissue that is the primary site of this barrier. With the growing number of studies that focus on the role of the blood-CSF barrier in CNS homeostasis and neurological disorders, a modern overview of the blood-CSF barrier is long overdue. The Blood-Cerebrospinal Fluid Barrier is exclusively devoted to the blood-CSF barrier. Internationally renowned experts discuss the most recent progress in the field of choroid plexus physiology and update our knowledge of the function of the blood-CSF barrier. The book begins with an overview of the development and morphology of the choroid plexus, and then covers various aspects of its function, such as the regulation of choroidal blood flow, ion transport, and the production and transport of polypeptides. Following an extensive section on the role of the choroid plexus in CNS disorders, the final section discusses in vitro, in vivo, and in situ models of the blood-CSF barrier. This unique book analyzes a wealth of new research on the proven and potential roles of the choroid plexus/blood-CSF barrier in the brain. It is a valuable resource that will foster future studies in neuroscience, pharmacology, and toxicology.

Author : Elga de Vries,Alexandre Prat
Publisher : CRC Press
Page : 544 pages
File Size : 47,7 Mb
Release : 2005-08-24
Category : Medical
ISBN : 0849398924

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The Blood-Brain Barrier and Its Microenvironment by Elga de Vries,Alexandre Prat Pdf

This reference analyzes the cellular and molecular biology and mechanisms of the blood-brain barrier (BBB) and presents the most recent studies on the role of the BBB in the development and initiation of a wide range of physiological and pathological conditions affecting the central nervous system.

Author : Naren L. Banik,Swapan K. Ray,Abel Lajtha
Publisher : Springer Science & Business Media
Page : 685 pages
File Size : 42,5 Mb
Release : 2009
Category : Medical
ISBN : 9780387303437

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Handbook of Neurochemistry and Molecular Neurobiology by Naren L. Banik,Swapan K. Ray,Abel Lajtha Pdf

Therapeutic approaches in spinal cord injury.- Cell death and tissue degeneration in traumatic brain injury.- neurotransmitters and electrophysiology in brain injury.- neurotransmitters and electrophysiology in brain injury.- Parkinsonism in the MPTP model.- EAE Demyelination.- EAE Neurodegeneration.- Cataract.- Uveitis.- Optic neuritis.- GBS/peripherial neuropathy, paraproteinemia.- Brain Tumor(Tumor Mechanisma).- Brain Tumor and angiogenesis.- SCIDS.- Phenylketone urea and mental retardation.- Neurofibromatosis.- BBB.- Muscular dystrophy.- Stracher.- Diabetic neuropathy/retinopathy/cataract.- Peroxisomes and adrenoleukodystrophy ALD.- Neuroprotection.- NFkB (Inflammation and spinal cord injury).- spinal cord injury and traumatic brain injury.- free radicals and neuroprotection.- Traumatic brain injury.- white matter degeneration.- Mitochondrial membrane defects.- Encephalomyopathies.- metal induced neurodegenaration.- neurometals in protein misfolding neurodegenerative diseases.- hyperammonemia.- kyneurenines in the brain preclinical and clinical studies, therapeutic condiserations.

Author : Anonim
Publisher : Academic Press
Page : 374 pages
File Size : 55,5 Mb
Release : 2020-05-22
Category : Medical
ISBN : 9780128211151

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Novel Therapeutic Advances in Glioblastoma by Anonim Pdf

Novel Therapeutic Advances in Glioblastoma, Volume 151 in the International Review of Neurobiology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of topics, including Blood-brain barrier and pathophysiology of brain tumors, Promising strategies of glioblastoma treatment: personalized genotoxic therapy and stem cell transplantation, Extracellular matrix and biocompatible materials in glioblastoma treatment, Expression of Twist associated to microcirculation patterns of human glioma correlated with progression and survival of the patient, Advanced Multimodal Imaging in Differentiating Glioma Recurrence from Post-radiotherapy Changes, Advanced Multimodal Imaging in Differentiating Glioma Recurrence from Post-radiotherapy Changes, and much more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the International Review of Neurobiology series Updated release includes the latest information on glioblastomas

Author : Suptendra Nath Sarbadhikari
Publisher : Nova Publishers
Page : 376 pages
File Size : 44,9 Mb
Release : 2005
Category : Brain
ISBN : 1594541140

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Depression and Dementia by Suptendra Nath Sarbadhikari Pdf

Many of the mechanisms of brain action, in health, as well as diseases like depression and dementia, are non-linear. The psychomotor theory can shed some light on the brain-mind-body interaction in health and disease. Specific neurotransmitters through their different receptor subtypes ultimately act along some final common pathway, in a lateralised fashion to produce depression and dementia. The currently available neurochemical and genetic evidences and their correlation with life events from population based studies, may be useful in screening susceptibility to dementia and depression. Further, criteria may be set up for susceptibility to these diseases and they might help designing early interventions in prevention of depression and dementia. The breakdown of the BBB (Blood brain barrier) through Heat Shock Protein (HSP) is also responsible for many neurodegenerative diseases. Aggressive and individualised management of patients suffering from depression and dementia may be the most promising gift of medical science and technology to humanity. Nonlinear dynamic analysis (NDA) of EEG (electroencephalography) may aid in the differential diagnosis of dementias. However, the methodologies have to be standardised further to make it clinically acceptable universally. ERPs (event related potentials in EEG) can be of great help in diagnosis and also assessing prognosis of dementias. Finally, fusion or hybrid techniques, especially those incorporating fMRI or functional magnetic resonance imaging (along with qEEG or quantitative EEG) can be of immense help in diagnosing, managing and predicting the prognosis of depression and dementia. This book discusses the above issues and offers an important update in the area of depression and dementia.

Author : Anonim
Publisher : Elsevier
Page : 356 pages
File Size : 44,9 Mb
Release : 2023-11-01
Category : Medical
ISBN : 9780443294693

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Nanowired Delivery of Drugs and Antibodies for Neuroprotection in Brain Diseases with Co-Morbidity Factors Part B by Anonim Pdf

Nanowired Delivery of Drugs and Antibodies for Neuroprotection in Brain Diseases with Co-morbidity Factors Part B, Volume 172 in the International Review of Neurobiology series, highlights new advances in the field with this new volume presenting interesting chapters on Spinal cord injury induced exacerbation of Alzheimer's disease pathophysiology in the cord is reduced by topical application of nanowired cerebrolysin and antibodies to tumor necrosis factor alpha, Nanodelivery of histamine H3 receptor inverse agonist BF-2549 with clobenpropit a H3 receptor antagonist and H4 receptor agonist induced neuroprotection in spinal cord injury is potentiated by antioxidant compound H-290/51, and Neuromodulation and quality of life for patient with spasticity after spinal cord injury, and much more. Other sections cover Efficacy of invasive and non-invasive methods for the treatment of Parkinson ́s disease: nanodelivery and enriched environment, Co-administration of DL-3-n-butylphthalide and neprilysin is neuroprotective in Alzheimer disease associated with brain injury, Nicotine Neurotoxicity Exacerbation following Engineered Ag and Cu (50-60 nm) nanoparticles intoxication. Neuroprotection with nanowired delivery of antioxidant compound H-290/51 together with serotonin 5-HT3 receptor antagonist ondansetron, and more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in International Review on Neurobiology series Updated release includes the latest information on Nanowired Delivery of Drugs and Antibodies for Neuroprotection in Brain Diseases with Co-Morbidity Factors

Author : Juerg Hodler,Rahel A. Kubik-Huch,Gustav K. von Schulthess
Publisher : Springer Nature
Page : 252 pages
File Size : 49,7 Mb
Release : 2020-02-14
Category : Medical
ISBN : 9783030384906

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Diseases of the Brain, Head and Neck, Spine 2020–2023 by Juerg Hodler,Rahel A. Kubik-Huch,Gustav K. von Schulthess Pdf

This open access book offers an essential overview of brain, head and neck, and spine imaging. Over the last few years, there have been considerable advances in this area, driven by both clinical and technological developments. Written by leading international experts and teachers, the chapters are disease-oriented and cover all relevant imaging modalities, with a focus on magnetic resonance imaging and computed tomography. The book also includes a synopsis of pediatric imaging. IDKD books are rewritten (not merely updated) every four years, which means they offer a comprehensive review of the state-of-the-art in imaging. The book is clearly structured and features learning objectives, abstracts, subheadings, tables and take-home points, supported by design elements to help readers navigate the text. It will particularly appeal to general radiologists, radiology residents, and interventional radiologists who want to update their diagnostic expertise, as well as clinicians from other specialties who are interested in imaging for their patient care.