Brain Tumor Immunotherapy

Author : John H. Sampson
Publisher : Academic Press
Page : 406 pages
File Size : 51,8 Mb
Release : 2017-02-06
Category : Science
ISBN : 9780128026250

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Translational Immunotherapy of Brain Tumors by John H. Sampson Pdf

Translational Immunotherapy of Brain Tumors gives researchers and practitioners an up-to-date and comprehensive overview of the field. Chapters include adoptive immunotherapy, immunosuppression, CAR therapy of brain tumors, and dendritic cell therapy for brain tumors. Very few agents have been shown to be efficacious in the treatment of malignant gliomas. Recently, there have been a number of studies demonstrating the potential success of immunotherapy for brain tumors. Immunotherapeutics are becoming the most frequent drugs to be used in cancer therapy. These new breakthroughs, now approved by the FDA, are a part of multiple phase III international trials and ongoing research in malignant glioma, meaning that the information in this cutting-edge book will be of great importance to practitioners and researchers alike. Comprehensive overview, providing an update on immunology, translational immunotherapy, and clinical trials relating to malignant gliomas Edited by a prominent neurosurgeon with contributions by leading researchers in the field Ideal resource for researchers and practitioners interested in learning about mechanisms that use the immune system to treat brain tumors

Author : Linda M. Liau,Donald P. Becker,Timothy F. Cloughesy,Darell D. Bigner
Publisher : Springer Science & Business Media
Page : 369 pages
File Size : 52,6 Mb
Release : 2000-11-10
Category : Medical
ISBN : 9781592590353

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Brain Tumor Immunotherapy by Linda M. Liau,Donald P. Becker,Timothy F. Cloughesy,Darell D. Bigner Pdf

An authoritative panel of researchers and clinicians critically reviews the entire field to provide a comprehensive guide to modern brain tumor immunotherapy and thereby enhance future research in this area. The contributors detail many of the key laboratory experiments and clinical protocols that are currently being investigated, integrate the available information from previous and ongoing research, and help define the current status of the field. Topics range from adoptive cellular and antibody-mediated immunotherapy of brain tumors to tumor vaccines and related strategies, and include many vanguard experimental strategies and immunological techniques for studying brain tumor immunotherapy. Cutting-edge and comprehensive, Brain Tumor Immunotherapy brings together all the important recent advances in our understanding of central nervous system tumor immunology and illustrates in powerful detail the many new applications now harnessing the immune response for brain tumor therapeutics.

Author : Lois A. Lampson
Publisher : Frontiers Media SA
Page : 95 pages
File Size : 51,9 Mb
Release : 2018-07-09
Category : Electronic
ISBN : 9782889455355

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Immunotherapy for Tumor in the Brain: Insights From – and For – Other Tumor Sites by Lois A. Lampson Pdf

Tumor immunotherapy has now shown its promise for many, its disappointments and failings for others. Going forward, brain tumor patients can both benefit and contribute. Tumor immunotherapy is steadily progressing. As experience accumulates, it is important to consider its generality. The reviews herein emphasize the brain’s place among other tumor sites. Two major topics are addressed. THE SITE: WHAT CAN WE EXPECT FROM IMMUNOTHERAPY WHEN THE TARGET IS IN THE BRAIN? Experience with immunotherapy for different targets in the brain, including tumor and also pathogens, is reviewed. Long-standing assumptions are confronted. The potential for beneficial responses is stressed. BRAIN TUMOR IMMUNOTHERAPY: WHAT HAVE WE LEARNED SO FAR? Clinical experience with brain tumor immunotherapy, from a variety of centers, is reviewed. Primary tumors, emphasizing glioblastoma, and brain metastases are each considered.

Author : Herbert B. Newton
Publisher : Academic Press
Page : 848 pages
File Size : 55,9 Mb
Release : 2018-03-28
Category : Medical
ISBN : 9780128121016

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Handbook of Brain Tumor Chemotherapy, Molecular Therapeutics, and Immunotherapy by Herbert B. Newton Pdf

Handbook of Brain Tumor Chemotherapy, Molecular Therapeutics, and Immunotherapy, Second Edition, provides a comprehensive overview of the molecular methodologies in the neuro-oncology field. There have been profound changes in the landscape of approaches to brain tumor therapy since the first edition—mainly in the areas of molecular biology and molecular therapeutics, as well as in the maturation of immunotherapy approaches (e.g., vaccines). This updated edition has a new, primary focus on multidisciplinary molecular methods, and is broadened to include the latest cutting-edge molecular biology, therapeutics, immunobiology and immunotherapy approaches. As the first comprehensive book to address the molecular research into these concepts, users will find it to be an invaluable resource on the topics discussed. Provides the most up-to-date information regarding conventional forms of cytotoxic chemotherapy, as well as the basic science and clinical application of molecular therapeutics for the treatment of brain tumors Broadly appeals to anyone interested in neuro-oncology and the treatment of brain tumors Features updated chapters on molecular biology, molecular therapeutics, maturation of immunotherapy approaches, and a focus on multidisciplinary molecular methods Includes a new section on the basic science of immunology, as well as thorough updates on the use of vaccine technology and immunotherapy for the treatment of brain tumors

Author : Anonim
Publisher : Unknown
Page : 0 pages
File Size : 54,8 Mb
Release : 2018
Category : Electronic
ISBN : OCLC:1368446742

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Immunotherapy for Tumor in the Brain: Insights From - and For - Other Tumor Sites by Anonim Pdf

Tumor immunotherapy has now shown its promise for many, its disappointments and failings for others. Going forward, brain tumor patients can both benefit and contribute. Tumor immunotherapy is steadily progressing. As experience accumulates, it is important to consider its generality. The reviews herein emphasize the brain's place among other tumor sites. Two major topics are addressed. THE SITE: WHAT CAN WE EXPECT FROM IMMUNOTHERAPY WHEN THE TARGET IS IN THE BRAIN? Experience with immunotherapy for different targets in the brain, including tumor and also pathogens, is reviewed. Long-standing assumptions are confronted. The potential for beneficial responses is stressed. BRAIN TUMOR IMMUNOTHERAPY: WHAT HAVE WE LEARNED SO FAR? Clinical experience with brain tumor immunotherapy, from a variety of centers, is reviewed. Primary tumors, emphasizing glioblastoma, and brain metastases are each considered.

Author : Christopher Jackson,Michael Lim
Publisher : Academic Press
Page : 190 pages
File Size : 55,7 Mb
Release : 2021-09-10
Category : Science
ISBN : 9780128197561

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Immunotherapeutic Strategies for the Treatment of Glioma by Christopher Jackson,Michael Lim Pdf

Immunotherapeutic Strategies for the Treatment of Glioma provides a review of the current state of immunotherapy for primary brain tumors. The topic is of interest to patients, clinicians, and researchers alike, particularly given the recent failure of large clinical trials. This book serves as an overview of the most promising approaches in the field and provides a foundation for considering novel and combination therapies moving forward. The book discusses several types of immunotherapies for glioma, such as peptide, dendritic cell and heat shock protein vaccines; immune checkpoint blockade; myeloid cells as target; oncolytic viruses; and CAR T cell therapy. Additionally, it discusses the mechanisms of immune suppression in patients and immunogenomics. This volume is a valuable source for cancer researchers, oncologists and several members of biomedical field who are interested in novel strategies to fight glioblastoma. Summarizes the work in immunotherapy for glioma to-date, including the available evidence from preclinical studies and clinical trials Reviews the challenges and successes of the most promising strategies for brain tumor immunotherapy Provides a foundation for considering novel and combination therapies moving forward

Author : American Brain Tumor Association
Publisher : Unknown
Page : 128 pages
File Size : 49,9 Mb
Release : 1991-01-01
Category : Electronic
ISBN : 0944093140

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Immunotherapy of Brain Tumors by American Brain Tumor Association Pdf

Author : Linda M. Liau
Publisher : Elsevier Health Sciences
Page : 208 pages
File Size : 40,6 Mb
Release : 2021-04-08
Category : Medical
ISBN : 9780323813068

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Glioblastoma, Part II: Molecular Targets and Clinical Trials, An Issue of Neurosurgery Clinics of North America by Linda M. Liau Pdf

This issue of Neurosurgery Clinics, guest edited by Dr. Linda M. Liau, is dedicated to Glioblastoma: Molecular and Clinical Trials. This issue is one of four selected each year by the series consulting editors, Drs. Russell R. Lonser and Daniel K. Resnick. Topics will include—but are not limited to—Pathology & Molecular Markers, Cellular States & Genetic Diversity in Glioblastoma, Mismatch Repair in Glioblastoma Resistance, Genetic Susceptibility in Brain Cancer, Pediatric Gliomas: Molecular Landscape & Emerging Targets, Molecularly Targeted Clinical Trials, Novel Radiation Sensitizers, Immunotherapy Checkpoint Inhibitors, Brain Tumor Vaccines, CAR T Cells, Oncolytic Virotherapy, Targeting Cancer Stem Cells, Therapeutic Delivery to CNS, Theranostics: Dual Modality PET Tracers, and Neuroimaging & Novel Response Assessments.

Author : Michael Graner
Publisher : MDPI
Page : 88 pages
File Size : 49,5 Mb
Release : 2021-05-04
Category : Medical
ISBN : 9783036501024

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The Immunology and Biology of Brain Tumors by Michael Graner Pdf

Immunotherapy has become a viable treatment modality for a variety of cancers (and referred to as Science Magazine’s “Breakthrough of the Year” in 2013, as well as ASCO’s “Advance of the Year” in both 2016 and 2017). This Special Issue is focused on the relevance of immunobiology in brain tumors, touching on elements of immune suppression, immune stimulation, and the immune microenvironment, with culminations in translational immunotherapy.

Author : Liangxue Zhou,Jianguo Xu,Laura Donovan
Publisher : Frontiers Media SA
Page : 357 pages
File Size : 40,6 Mb
Release : 2023-12-19
Category : Medical
ISBN : 9782832541487

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Immune Microenvironment and Immunotherapy in Malignant Brain Tumors by Liangxue Zhou,Jianguo Xu,Laura Donovan Pdf

Author : Shiv K. Gupta,Sani H. Kizilbash,Thierry M. Muanza
Publisher : Frontiers Media SA
Page : 180 pages
File Size : 50,9 Mb
Release : 2020-01-22
Category : Electronic
ISBN : 9782889633531

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Targeted Therapies for Glioblastoma: A Critical Appraisal by Shiv K. Gupta,Sani H. Kizilbash,Thierry M. Muanza Pdf

Author : Manmeet Ahluwalia,Philippe Metellus,Riccardo Soffietti
Publisher : Springer Nature
Page : 421 pages
File Size : 54,8 Mb
Release : 2019-11-05
Category : Medical
ISBN : 9783030234171

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Central Nervous System Metastases by Manmeet Ahluwalia,Philippe Metellus,Riccardo Soffietti Pdf

This book provides a comprehensive overview of brain metastases, from the molecular biology aspects to therapeutic management and perspectives. Due to the increasing incidence of these tumors and the urgent need to effectively control brain metastatic diseases in these patients, new therapeutic strategies have emerged in recent years. The volume discusses all these innovative approaches combined with new surgical techniques (fluorescence, functional mapping, integrated navigation), novel radiation therapy techniques (stereotactic radiosurgery) and new systemic treatment approaches such as targeted- and immunotherapy. These combination strategies represent a new therapeutic model in brain metastatic patients in which each medical practitioner (neurosurgeon, neurologist, medical oncologist, radiation oncologist) plays a pivotal role in defining the optimal treatment in a multidisciplinary approach. Written by recognized experts in the field, this book is a valuable tool for neurosurgeons, neuro-oncologists, neuroradiologists, medical oncologists, radiation oncologists, cognitive therapists, basic scientists and students working in the area of brain tumors.

Author : Quan Cheng,Wen Cheng,Junxia Zhang,Longbo Zhang
Publisher : Frontiers Media SA
Page : 418 pages
File Size : 41,9 Mb
Release : 2023-06-08
Category : Medical
ISBN : 9782832525654

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The Interconnection Between the Tumor Microenvironment and Immunotherapy in Brain Tumors by Quan Cheng,Wen Cheng,Junxia Zhang,Longbo Zhang Pdf

Author : Peter Siesjö
Publisher : Unknown
Page : 142 pages
File Size : 51,8 Mb
Release : 1997
Category : Cancer
ISBN : UOM:39015042131709

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Immunotherapy of Rat Brain Tumors with Mutagen Induced, Cross-reactive Tumor Cell Variants by Peter Siesjö Pdf

Author : Herbert B. Newton
Publisher : Elsevier
Page : 586 pages
File Size : 43,8 Mb
Release : 2005-12-19
Category : Medical
ISBN : 008045593X

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Handbook of Brain Tumor Chemotherapy by Herbert B. Newton Pdf

Treatment of patients with a brain tumor remains one of the most challenging and difficult areas of modern oncology. Recent advances in the molecular biology of these neoplasms have improved our understanding of the malignant phenotype and have lead to the development of novel forms of chemotherapy, including “targeted agents. The Handbook of Brain Tumor Chemotherapy reviews the state-of-the-art of chemotherapy development and clinical treatment of patients with this devastating disease. Handbook of Brain Tumor Chemotherapy offers a unique cutting-edge compendium of basic science and clinical information on the subject of brain tumor chemotherapy, reviewing what has been accomplished thus far and how the field will continue to evolve with the development of more specific and efficacious chemotherapeutic agents. This book represents the most complete single-volume resource available for information on the subject of brain tumor chemotherapy. Provides the most up to date information regarding conventional forms of cytotoxic chemotherapy, as well as the basic science and clinical application of molecular therapeutics, for the treatment of brain tumors Broadly appeals to anyone interested in the field of Neuro-Oncology and in the treatment of patients with brain tumors Useful to clinicians interested in a thorough overview of the use of chemotherapy in patients with a broad range of brain tumors as well as serving as a source of background information to basic scientists and pharmaceutical researchers with an interest in the molecular therapeutics of brain tumors