Translational Immunotherapy Of Brain Tumors

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Translational Immunotherapy of Brain Tumors

John H. Sampson
Translational Immunotherapy of Brain Tumors Book PDF

Author : John H. Sampson
Publisher : Academic Press
Page : 406 pages
File Size : 49,5 Mb
Release : 2017-02-06
Category : Science
ISBN : 9780128026250

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Translational Immunotherapy of Brain Tumors by John H. Sampson Pdf

Translational Immunotherapy of Brain Tumors gives researchers and practitioners an up-to-date and comprehensive overview of the field. Chapters include adoptive immunotherapy, immunosuppression, CAR therapy of brain tumors, and dendritic cell therapy for brain tumors. Very few agents have been shown to be efficacious in the treatment of malignant gliomas. Recently, there have been a number of studies demonstrating the potential success of immunotherapy for brain tumors. Immunotherapeutics are becoming the most frequent drugs to be used in cancer therapy. These new breakthroughs, now approved by the FDA, are a part of multiple phase III international trials and ongoing research in malignant glioma, meaning that the information in this cutting-edge book will be of great importance to practitioners and researchers alike. Comprehensive overview, providing an update on immunology, translational immunotherapy, and clinical trials relating to malignant gliomas Edited by a prominent neurosurgeon with contributions by leading researchers in the field Ideal resource for researchers and practitioners interested in learning about mechanisms that use the immune system to treat brain tumors

The Immunology and Biology of Brain Tumors

Michael Graner
The Immunology and Biology of Brain Tumors Book PDF

Author : Michael Graner
Publisher : MDPI
Page : 88 pages
File Size : 53,7 Mb
Release : 2021-05-04
Category : Medical
ISBN : 9783036501024

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The Immunology and Biology of Brain Tumors by Michael Graner Pdf

Immunotherapy has become a viable treatment modality for a variety of cancers (and referred to as Science Magazine’s “Breakthrough of the Year” in 2013, as well as ASCO’s “Advance of the Year” in both 2016 and 2017). This Special Issue is focused on the relevance of immunobiology in brain tumors, touching on elements of immune suppression, immune stimulation, and the immune microenvironment, with culminations in translational immunotherapy.

Brain Tumor Immunotherapy

Linda M. Liau,Donald P. Becker,Timothy F. Cloughesy,Darell D. Bigner
Brain Tumor Immunotherapy Book PDF

Author : Linda M. Liau,Donald P. Becker,Timothy F. Cloughesy,Darell D. Bigner
Publisher : Springer Science & Business Media
Page : 369 pages
File Size : 48,7 Mb
Release : 2000-11-10
Category : Medical
ISBN : 9781592590353

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Brain Tumor Immunotherapy by Linda M. Liau,Donald P. Becker,Timothy F. Cloughesy,Darell D. Bigner Pdf

An authoritative panel of researchers and clinicians critically reviews the entire field to provide a comprehensive guide to modern brain tumor immunotherapy and thereby enhance future research in this area. The contributors detail many of the key laboratory experiments and clinical protocols that are currently being investigated, integrate the available information from previous and ongoing research, and help define the current status of the field. Topics range from adoptive cellular and antibody-mediated immunotherapy of brain tumors to tumor vaccines and related strategies, and include many vanguard experimental strategies and immunological techniques for studying brain tumor immunotherapy. Cutting-edge and comprehensive, Brain Tumor Immunotherapy brings together all the important recent advances in our understanding of central nervous system tumor immunology and illustrates in powerful detail the many new applications now harnessing the immune response for brain tumor therapeutics.

The Immunology and Biology of Brain Tumors

Michael Graner
The Immunology and Biology of Brain Tumors Book PDF

Author : Michael Graner
Publisher : Unknown
Page : 88 pages
File Size : 50,5 Mb
Release : 2021
Category : Electronic
ISBN : 3036501037

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The Immunology and Biology of Brain Tumors by Michael Graner Pdf

Immunotherapy has become a viable treatment modality for a variety of cancers (and referred to as Science Magazine's “Breakthrough of the Year” in 2013, as well as ASCO's “Advance of the Year” in both 2016 and 2017). This Special Issue is focused on the relevance of immunobiology in brain tumors, touching on elements of immune suppression, immune stimulation, and the immune microenvironment, with culminations in translational immunotherapy.

Immunotherapy in Translational Cancer Research

Laurence J. N. Cooper,Elizabeth A. Mittendorf,Judy Moyes,Sabitha Prabhakaran
Immunotherapy in Translational Cancer Research Book PDF

Author : Laurence J. N. Cooper,Elizabeth A. Mittendorf,Judy Moyes,Sabitha Prabhakaran
Publisher : Unknown
Page : 128 pages
File Size : 49,8 Mb
Release : 2018
Category : HEALTH & FITNESS
ISBN : 1118684532

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Immunotherapy in Translational Cancer Research by Laurence J. N. Cooper,Elizabeth A. Mittendorf,Judy Moyes,Sabitha Prabhakaran Pdf

"Immunotherapy in Translational Cancer Research is a volume in Translational Oncology, an exciting book series that focuses on translational cancer research. Immunotherapy has become a key aspect in the treatment of a wide variety of cancers, and this book is specifically designed for physicians, clinical fellows, medical students, graduate students, scientists, pharmaceutical executives, public health and public policy government leaders and community oncologists. Each chapter is consistently organized and features three essential themes: Development of the immunotherapy; Hurdles that were overcome to scale up and undertake clinical trials; and Clinical experience and application of research. Concepts, examples and alternative strategies to achieve individualized targeted therapy are presented, with thorough consideration of the relevant history, current state and future directions of emerging cancer-fighting therapies, drug development, clinical trials, and governmental resources and regulatory issues."--Provided by publisher.

Oncology of CNS Tumors

Jörg-Christian Tonn,Manfred Westphal,J. T. Rutka
Oncology of CNS Tumors Book PDF

Author : Jörg-Christian Tonn,Manfred Westphal,J. T. Rutka
Publisher : Springer Science & Business Media
Page : 793 pages
File Size : 49,6 Mb
Release : 2010-02-03
Category : Medical
ISBN : 9783642028748

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Oncology of CNS Tumors by Jörg-Christian Tonn,Manfred Westphal,J. T. Rutka Pdf

Knowledge about the etiology and diagnosis as well as treatment concepts of neu- oncologic diseases is rapidly growing. This turnover of knowledge makes it dif? cult for the physician engaged in the treatment to keep up to date with current therapies. This book sets out to close the gap and pursues several innovative concepts. As a comprehensive text on neuro-oncology, its chapters are interconnected, but at the same time some chapters or subdivisions are so thoroughly assembled that the whole volume gives the impression of several books combined into one. Neuropathology is treated in an extensive and clearly structured section. The int- ested reader ? nds for each tumor entity the latest well-referenced consensus rega- ing histologic and molecular pathology. Through this “book-in-the-book” concept, information on neuropathology is readily at hand in a concise form and without ov- loading the single chapters. Pediatric neuro-oncology differs in many entities from tumors in adult patients; also, certain tumors of the CNS are typically or mainly found only in the child. Therefore, pediatric neuro-oncology was granted its own, book-like section. Tumor entities that are treated differently in children and adults are included both in the pediatric neuro-oncology section and in the general section. Entities that typically occur only in the child and adolescent are found in the pediatric section in order to avoid redundancies.

Immunotherapy of Hepatocellular Carcinoma

Tim F. Greten
Immunotherapy of Hepatocellular Carcinoma Book PDF

Author : Tim F. Greten
Publisher : Springer
Page : 167 pages
File Size : 43,7 Mb
Release : 2017-10-04
Category : Medical
ISBN : 9783319649580

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Immunotherapy of Hepatocellular Carcinoma by Tim F. Greten Pdf

In this book we provide insights into liver – cancer and immunology. Experts in the field provide an overview over fundamental immunological questions in liver cancer and tumorimmunology, which form the base for immune based approaches in HCC, which gain increasing interest in the community due to first promising results obtained in early clinical trials. Hepatocellular carcinoma (HCC) is the third most common cause of cancer related death in the United States. Treatment options are limited. Viral hepatitis is one of the major risk factors for HCC, which represents a typical “inflammation-induced” cancer. Immune-based treatment approaches have revolutionized oncology in recent years. Various treatment strategies have received FDA approval including dendritic cell vaccination, for prostate cancer as well as immune checkpoint inhibition targeting the CTLA4 or the PD1/PDL1 axis in melanoma, lung, and kidney cancer. Additionally, cell based therapies (adoptive T cell therapy, CAR T cells and TCR transduced T cells) have demonstrated significant efficacy in patients with B cell malignancies and melanoma. Immune checkpoint inhibitors in particular have generated enormous excitement across the entire field of oncology, providing a significant benefit to a minority of patients.

Epidemiology of Brain and Spinal Tumors

Jahangir Moini,Nicholas Avgeropoulos,Mohtashem Samsam
Epidemiology of Brain and Spinal Tumors Book PDF

Author : Jahangir Moini,Nicholas Avgeropoulos,Mohtashem Samsam
Publisher : Academic Press
Page : 554 pages
File Size : 43,5 Mb
Release : 2021-04-09
Category : Medical
ISBN : 9780128217559

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Epidemiology of Brain and Spinal Tumors by Jahangir Moini,Nicholas Avgeropoulos,Mohtashem Samsam Pdf

Epidemiology of Brain and Spinal Tumors provides a single volume resource on imaging methods and neuroepidemiology of both brain and spinal tumors. The book covers a variety of imaging techniques, including computed tomography (CT), MRI, positron emission tomography (PET), and other laboratory tests used in diagnosis and treatment. Detailed epidemiology, various imaging methods, and clinical considerations of tumors of the CNS make this an ideal reference for users who will also find diverse information about structures and functions, cytology, epidemiology (including molecular epidemiology), diagnosis and treatment. This book is appropriate for neuroscience researchers, medical professionals and anyone interested in a complete guide to visualizing and understanding CNS tumors. Provides the most up-to-date information surrounding the epidemiology, biology and imaging techniques for brain and spinal tumors, including CT, MRI, PET, and others Includes full color figures, photos, tables, graphs and radioimaging Contains information that will be valuable to anyone interested in the field of neurooncology and the treatment of patients with brain and spinal tumors Serves as a source of background information for basic scientists and pharmaceutical researchers who have an interest in imaging and treatment

The Duke Glioma Handbook

Allan H. Friedman
The Duke Glioma Handbook Book PDF

Author : Allan H. Friedman
Publisher : Cambridge University Press
Page : 237 pages
File Size : 48,6 Mb
Release : 2016-03-31
Category : Medical
ISBN : 9781107065970

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The Duke Glioma Handbook by Allan H. Friedman Pdf

Provides a summary of glioma biology, genetics and management, based on the world-leading Duke University Preston Robert Tisch Brain Tumor Center program.

Conn's Translational Neuroscience

P. Michael Conn
Conn s Translational Neuroscience Book PDF

Author : P. Michael Conn
Publisher : Academic Press
Page : 776 pages
File Size : 49,8 Mb
Release : 2016-09-28
Category : Medical
ISBN : 9780128025963

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Conn's Translational Neuroscience by P. Michael Conn Pdf

Conn’s Translational Neuroscience provides a comprehensive overview reflecting the depth and breadth of the field of translational neuroscience, with input from a distinguished panel of basic and clinical investigators. Progress has continued in understanding the brain at the molecular, anatomic, and physiological levels in the years following the 'Decade of the Brain,' with the results providing insight into the underlying basis of many neurological disease processes. This book alternates scientific and clinical chapters that explain the basic science underlying neurological processes and then relates that science to the understanding of neurological disorders and their treatment. Chapters cover disorders of the spinal cord, neuronal migration, the autonomic nervous system, the limbic system, ocular motility, and the basal ganglia, as well as demyelinating disorders, stroke, dementia and abnormalities of cognition, congenital chromosomal and genetic abnormalities, Parkinson's disease, nerve trauma, peripheral neuropathy, aphasias, sleep disorders, and myasthenia gravis. In addition to concise summaries of the most recent biochemical, physiological, anatomical, and behavioral advances, the chapters summarize current findings on neuronal gene expression and protein synthesis at the molecular level. Authoritative and comprehensive, Conn’s Translational Neuroscience provides a fully up-to-date and readily accessible guide to brain functions at the cellular and molecular level, as well as a clear demonstration of their emerging diagnostic and therapeutic importance. Provides a fully up-to-date and readily accessible guide to brain functions at the cellular and molecular level, while also clearly demonstrating their emerging diagnostic and therapeutic importance Features contributions from leading global basic and clinical investigators in the field Provides a great resource for researchers and practitioners interested in the basic science underlying neurological processes Relates and translates the current science to the understanding of neurological disorders and their treatment

Cancer Immunology and Immunotherapy

Mansoor M. Amiji,Lara Scheherazade Milane
Cancer Immunology and Immunotherapy Book PDF

Author : Mansoor M. Amiji,Lara Scheherazade Milane
Publisher : Academic Press
Page : 550 pages
File Size : 52,7 Mb
Release : 2021-08-18
Category : Business & Economics
ISBN : 9780128236376

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Cancer Immunology and Immunotherapy by Mansoor M. Amiji,Lara Scheherazade Milane Pdf

Delivery Technologies for Immuno-Oncology: Volume 1: Delivery Strategies and Engineering Technologies in Cancer Immunotherapy examines the challenges of delivering immuno-oncology therapies. Immuno-oncology (IO) is a growing field of medicine at the interface of immunology and cancer biology leading to development of novel therapeutic approaches, such as chimeric antigen receptor T-cell (CAR-T) and immune checkpoint blockade antibodies, that are clinically approved approaches for cancer therapy. Although currently approved IO approaches have shown tremendous promise for select types of cancers, broad application of IO strategies could even further improve the clinical success, especially for diseases such as pancreatic cancer, brain tumors where the success of IO so far has been limited. Nanotechnology-based targeted delivery strategies could improve the delivery efficiency of IO agents as well as provide additional avenues for novel therapeutic and vaccination strategies. Additionally, a number of locally-administered immunogenic scaffolds and therapeutic strategies, such as the use of STING agonist, could benefit from rationally designed biomaterials and delivery approaches. Delivery Technologies for Immuno-Oncology: Volume 1: Delivery Strategies and Engineering Technologies in Cancer Immunotherapy creates a comprehensive treaty that engages the scientific and medical community who are involved in the challenges of immunology, cancer biology, and therapeutics with possible solutions from the nanotechnology and drug delivery side. Comprehensive treaty covering all aspects of immuno-oncology (IO) Novel strategies for delivery of IO therapeutics and vaccines Forecasting on the future of nanotechnology and drug delivery for IO

Brain Tumors

Amit Agrawal
Brain Tumors Book PDF

Author : Amit Agrawal
Publisher : BoD – Books on Demand
Page : 214 pages
File Size : 48,9 Mb
Release : 2022-04-20
Category : Medical
ISBN : 9781839698033

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Brain Tumors by Amit Agrawal Pdf

Brain tumors comprise a spectrum of histological patterns. Their presentation and management depend on their location, size, and grade of lesions. This book is a collection of high-quality research work from global experts on brain tumors, including meningiomas, and their treatment.

Central Nervous System Metastases

Manmeet Ahluwalia,Philippe Metellus,Riccardo Soffietti
Central Nervous System Metastases Book PDF

Author : Manmeet Ahluwalia,Philippe Metellus,Riccardo Soffietti
Publisher : Springer Nature
Page : 421 pages
File Size : 43,6 Mb
Release : 2019-11-05
Category : Medical
ISBN : 9783030234171

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Central Nervous System Metastases by Manmeet Ahluwalia,Philippe Metellus,Riccardo Soffietti Pdf

This book provides a comprehensive overview of brain metastases, from the molecular biology aspects to therapeutic management and perspectives. Due to the increasing incidence of these tumors and the urgent need to effectively control brain metastatic diseases in these patients, new therapeutic strategies have emerged in recent years. The volume discusses all these innovative approaches combined with new surgical techniques (fluorescence, functional mapping, integrated navigation), novel radiation therapy techniques (stereotactic radiosurgery) and new systemic treatment approaches such as targeted- and immunotherapy. These combination strategies represent a new therapeutic model in brain metastatic patients in which each medical practitioner (neurosurgeon, neurologist, medical oncologist, radiation oncologist) plays a pivotal role in defining the optimal treatment in a multidisciplinary approach. Written by recognized experts in the field, this book is a valuable tool for neurosurgeons, neuro-oncologists, neuroradiologists, medical oncologists, radiation oncologists, cognitive therapists, basic scientists and students working in the area of brain tumors.

Pediatric Neuro-oncology

Katrin Scheinemann,Eric Bouffet
Pediatric Neuro oncology Book PDF

Author : Katrin Scheinemann,Eric Bouffet
Publisher : Springer
Page : 0 pages
File Size : 43,5 Mb
Release : 2024-08-27
Category : Medical
ISBN : 303162016X

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Pediatric Neuro-oncology by Katrin Scheinemann,Eric Bouffet Pdf

While the first edition of this book provided a succinct introduction to pediatric neuro-oncology, biological knowledge of childhood CNS tumors has “exploded” over the past few years and a new edition of this textbook is needed to keep it up-to-date. This updated edition will include chapters on cancer predisposition in children with brain tumors, gliomas, embryonal brain tumors, ependymoma, CNS-GCT, targeted therapies in pediatric brain tumors, and long-term sequelae. New developments covered include the following: - Techniques like DNA methylation have improved the diagnostic process, and have led to an integrated diagnosis of histology, ICH and methylation. - Tumor pathways have been detected, which defines more subgroups within a tumor entity, and results in more individualized treatment for the patient. - Therapeutic options outside the standard combination of surgery, chemotherapy, and radiation have either been implemented within the last years, or are currently under consideration. This book will be aimed at pediatric oncologists and neurooncologists, neurosurgeons, radiation oncologists. Chapters detailing quality of life and supportive care will make this 2nd edition a useful resource for nurses, social workers, physiotherapists, and occupational therapists alike.

Gliomas

Anonim
Gliomas Book PDF

Author : Anonim
Publisher : Academic Press
Page : 464 pages
File Size : 54,8 Mb
Release : 2016-03-02
Category : Medical
ISBN : 9780128030073

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Gliomas by Anonim Pdf

Researchers’ knowledge of gliomas continues to advance rapidly at both the basic and translational levels, and Gliomas provides a thorough overview of the evolving fields of tumor biology and clinical medicine as they relate to our understanding of brain tumors. Gliomas reviews the current paradigms that underlie these fields, beginning with the molecular epidemiology of glioma susceptibility and prognosis through population-based science and genome-wide association studies. The book’s discussion of imaging modalities extends beyond advances in anatomical imaging to include metabolic and physiological studies. This work provides thorough discussion of the clinical view of tumors, ranging from the presentation of the patient to surgical management, and covers all therapeutic options for patient care, including chemotherapy, targeted molecular therapies, immunotherapies, and even personalized approaches to impact the set of lesions. Additionally, the book discusses radiotherapy with regard to the many options available to treat patients using myriad fractionated techniques with various sources. Finally, Gliomas reviews issues specific to the quality of life for patients, and techniques for maximizing the effect of caregivers. Edited and authored by premier researchers from around the world, Gliomas is a comprehensive reference for clinicians and researchers seeking the most up-to-date information on gliomas, and a guide to the best ways to effectively manage glioma patients and their care. Synthesizes widely dispersed information on the management of gliomas into one comprehensive resource Chapters written by international authors who are preeminent researchers in the field Fully explores the therapeutic options for patient care, from chemotherapy to radiotherapy to personalized approaches