Cancer Biomarkers And Targets In Digestive Organs

Author : Nikki P. Lee,Nelson S. Yee
Publisher : MDPI
Page : 146 pages
File Size : 45,7 Mb
Release : 2019-09-03
Category : Medical
ISBN : 9783039214631

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Cancer Biomarkers and Targets in Digestive Organs by Nikki P. Lee,Nelson S. Yee Pdf

Identification and development of cancer biomarkers and targets have greatly accelerated progress towards precision medicine in oncology. Studies of tumor biology have not only provided insights into the mechanisms underlying carcinogenesis, but also led to discovery of molecules that have been developed into cancer biomarkers and targets. Multi-platforms for molecular characterization of tumors using next-generation genomic sequencing, immunohistochemistry, in situ hybridization, and blood-based biopsies have greatly expanded the portfolio of potential biomarkers and targets. These cancer biomarkers have been developed for diagnosis, early detection, prognosis, and prediction of treatment response. The molecular targets have been exploited for anti-cancer therapy and delivery of therapeutic agents. This Special Issue of Biomedicines focuses on recent advances in the discovery, characterization, translation, and clinical application of cancer biomarkers and targets in malignant diseases of the digestive system. The goal is to stimulate basic and translational research and clinical collaboration in this exciting field with the hope of developing strategies for prevention and early detection/diagnosis of cancer in digestive organs, and improving therapeutic and psychosocial outcomes in patients with these malignant diseases.

Author : Nelson Yee,Nikki Lee
Publisher : Unknown
Page : 1 pages
File Size : 43,7 Mb
Release : 2019
Category : Electronic books
ISBN : 3039214640

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Cancer Biomarkers and Targets in Digestive Organs by Nelson Yee,Nikki Lee Pdf

Identification and development of cancer biomarkers and targets have greatly accelerated progress towards precision medicine in oncology. Studies of tumor biology have not only provided insights into the mechanisms underlying carcinogenesis, but also led to discovery of molecules that have been developed into cancer biomarkers and targets. Multi-platforms for molecular characterization of tumors using next-generation genomic sequencing, immunohistochemistry, in situ hybridization, and blood-based biopsies have greatly expanded the portfolio of potential biomarkers and targets. These cancer biomarkers have been developed for diagnosis, early detection, prognosis, and prediction of treatment response. The molecular targets have been exploited for anti-cancer therapy and delivery of therapeutic agents. This Special Issue of Biomedicines focuses on recent advances in the discovery, characterization, translation, and clinical application of cancer biomarkers and targets in malignant diseases of the digestive system. The goal is to stimulate basic and translational research and clinical collaboration in this exciting field with the hope of developing strategies for prevention and early detection/diagnosis of cancer in digestive organs, and improving therapeutic and psychosocial outcomes in patients with these malignant diseases.

Author : Pallaval Veera Bramhachari,Nageswara Rao Reddy Neelapu
Publisher : Springer Nature
Page : 238 pages
File Size : 43,7 Mb
Release : 2020-07-21
Category : Medical
ISBN : 9789811544316

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Recent Advancements in Biomarkers and Early Detection of Gastrointestinal Cancers by Pallaval Veera Bramhachari,Nageswara Rao Reddy Neelapu Pdf

This book describes various novel biomarkers for the early diagnosis of gastrointestinal (GI) cancers. It also highlights recent advances in understanding the role of molecular markers and biomarkers, such as volatile biomarkers, serum biomarkers, predictive and prognostic molecular markers for the early detection of GI cancers. Further, it discusses novel biomarkers, including circulating microRNAs, serum microRNA and plasma microRNA in GI cancer. The book presents breakthrough technologies like ultra-sensitive nano-chips, nanosensors, nanodevices, biosensors, electrochemical biosensors, optical biosensors, DNA biosensors, synthetic biology devices, and 'omics' technologies for the early diagnosis of gastrointestinal cancer. In addition it examines the potential of genome-wide association studies, big data analytics, computation biology, systems biology, and nanotechnology for early diagnostics and therapeutics for gastrointestinal cancer, with a focus on personalized cancer treatment. The book is a valuable source for researchers and clinicians engaged in detection and diagnosis of gastrointestinal cancers.

Author : Mikhael Kular
Publisher : American Medical Publishers
Page : 0 pages
File Size : 48,6 Mb
Release : 2023-09-19
Category : Health & Fitness
ISBN : 9798887404196

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Recent Advancements in Biomarkers and Detection of Gastrointestinal Cancers by Mikhael Kular Pdf

A biomarker is a biological molecule present in the blood, other body fluids or tissues, that indicates normal or abnormal process, condition or a disease. It can act as an alternative tool and is helpful in selecting accurate treatment in various diseases. Gastrointestinal cancer is a malignant condition affecting gastrointestinal tract and organs of the digestive system including the stomach, pancreas, esophagus, small and large intestine, biliary system, rectum and anus. In the case of esophageal cancer, methylation of DNA can be used as a biomarker for early detection because methylation patterns appear in the initial stages. Protein biomarkers are utilized as markers for gastric tumor for effective diagnosis, prognosis and checking for recurrence of cancer after treatment. Various biomarkers that are utilized in case of stomach cancer include antigens like CA12-5 and CA72-4 as well as alpha-fetoprotein. This book provides comprehensive insights on biomarkers. The topics covered herein deal with the core aspects of the detection of gastrointestinal cancers through biomarkers. This book will serve as a reference to a broad spectrum of readers.

Author : William B. Coleman,Gregory J. Tsongalis
Publisher : Academic Press
Page : 634 pages
File Size : 51,7 Mb
Release : 2019-11-23
Category : Medical
ISBN : 9780128132586

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Essential Concepts in Molecular Pathology by William B. Coleman,Gregory J. Tsongalis Pdf

Essential Concepts in Molecular Pathology, Second Edition, offers an introduction to molecular genetics and the "molecular" aspects of human disease. The book illustrates how pathologists harness their understanding of these entities to develop new diagnostics and treatments for various human diseases. This new edition offers pathology, genetics residents, and molecular pathology fellows an advanced understanding of the molecular mechanisms of disease that goes beyond what they learned in medical and graduate school. By bridging molecular concepts of pathogenesis to the clinical expression of disease in cell, tissue and organ, this fully updated, introductory reference provides the background necessary for an understanding of today’s advances in pathology and medicine. Explains the practice of "molecular medicine" and the translational aspects of molecular pathology, including molecular diagnostics, molecular assessment and personalized medicine Orients non-pathologists on what pathologists look for and how they interpret their observational findings based on histopathology Provides the reader with what is missing from most targeted introductions to pathology—the cell biology behind pathophysiology

Author : Kenneth K. W. To
Publisher : Frontiers Media SA
Page : 188 pages
File Size : 40,8 Mb
Release : 2022-04-11
Category : Medical
ISBN : 9782889748594

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The Evolving Landscape, Clinical Implications and Future Perspective of Biomarkers in Gastrointestinal Cancers by Kenneth K. W. To Pdf

Author : Yoshimasa Saito
Publisher : Frontiers E-books
Page : 80 pages
File Size : 48,5 Mb
Release : 2014-11-10
Category : Biology (General)
ISBN : 9782889193455

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Alterations of Epigenetics and MicroRNAs in Cancer and Cancer Stem Cell by Yoshimasa Saito Pdf

Studies have shown that alterations of epigenetics and microRNAs (miRNAs) play critical roles in the initiation and progression of human cancer. Epigenetic silencing of tumor suppressor genes in cancer cells is generally mediated by DNA hypermethylation of CpG island promoter and histone modification such as methylation of histone H3 lysine 9 (H3K9) and tri-methylation of H3K27. MiRNAs are small non-coding RNAs that regulate expression of various target genes. Specific miRNAs are aberrantly expressed and play roles as tumor suppressors or oncogenes during carcinogenesis. Important tumor suppressor miRNAs are silenced by epigenetic alterations, resulting in activation of target oncogenes in human malignancies. Stem cells have the ability to perpetuate themselves through self-renewal and to generate mature cells of various tissues through differentiation. Accumulating evidence suggests that a subpopulation of cancer cells with distinct stem-like properties is responsible for tumor initiation, invasive growth, and metastasis formation, which is defined as cancer stem cells. Cancer stem cells are considered to be resistant to conventional chemotherapy and radiation therapy, suggesting that these cells are important targets of cancer therapy. DNA methylation, histone modification and miRNAs may be deeply involved in stem-like properties in cancer cells. Restoring the expression of tumor suppressor genes and miRNAs by chromatin modifying drugs may be a promising therapeutic approach for cancer stem cells. In this Research Topic, we discuss about alterations of epigenetics and miRNAs in cancer and cancer stem cell and understand the molecular mechanism underlying the formation of cancer stem cell, which may provide a novel insight for treatment of refractory cancer.

Author : Anonim
Publisher : Unknown
Page : 728 pages
File Size : 42,8 Mb
Release : 2010
Category : Government publications
ISBN : UCSD:31822037817723

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How Tobacco Smoke Causes Disease by Anonim Pdf

This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.

Author : Takahiro Ochiya,Ryou-u Takahashi
Publisher : MDPI
Page : 273 pages
File Size : 41,5 Mb
Release : 2018-10-16
Category : Electronic books
ISBN : 9783038972525

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MicroRNAs: Novel Biomarkers and Therapeutic Targets for Human Cancers by Takahiro Ochiya,Ryou-u Takahashi Pdf

This book is a printed edition of the Special Issue "MicroRNAs: Novel Biomarkers and Therapeutic Targets for Human Cancers" that was published in JCM

Author : Neal C. Dalrymple, MD,John R. Leyendecker, MD,Michael Oliphant, MD
Publisher : Elsevier Health Sciences
Page : 740 pages
File Size : 54,6 Mb
Release : 2009-06-29
Category : Medical
ISBN : 9780323043533

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Problem Solving in Abdominal Imaging with CD-ROM by Neal C. Dalrymple, MD,John R. Leyendecker, MD,Michael Oliphant, MD Pdf

Elsevier's new Problem Solving in Abdominal Imaging offers you a concise, practical, and instructional approach to your most common imaging questions. It presents basic principles of problem solving to apply to imaging the abdominal and pelvic organs, gastrointestinal tract, and genitourinary tract. Inside, you'll find expert guidance on how to accurately read what you see, and how to perform critical techniques including biopsy and percutaneous drainage. User-friendly features, such as tables and boxes, tips, pitfalls, and rules of thumb, place today's best practices at your fingertips. A full-color design, including more than 700 high-quality images, highlights critical elements and compliments the text, to enhance your understanding. Best of all, a bonus CD provides you with an atlas of basic surgical procedures and survival guides for managing musculoskeletal and chest findings encountered on abdominal imaging examinations. Provides problem-solving advice to help you find abnormalities and accurately identify what you see. Presents a section devoted to clinical scenarios-organized by presenting signs or disease processes-covering those you're most likely to encounter in daily practice. Includes tips for optimization of the most common advanced imaging techniques used for the abdominal and pelvic regions-with general indications for use and special situations-to help you make the most of each modality. Offers step-by-step guidance that will help you safely approach challenging abdominal interventions, reduce complications, and improve outcomes. Features tables and boxes, tips, pitfalls, and other teaching points for easy reference. Incorporates high-quality images and a full-color design that illuminate important elements. Includes a CD containing an atlas of basic surgical procedures and survival guides for managing incidental musculoskeletal and chest findings encountered on abdominal imaging examinations.

Author : Michael J. Murphy
Publisher : Springer Science & Business Media
Page : 328 pages
File Size : 50,6 Mb
Release : 2011-12-02
Category : Medical
ISBN : 9781607614333

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Diagnostic and Prognostic Biomarkers and Therapeutic Targets in Melanoma by Michael J. Murphy Pdf

This book describes both the technologies used in the discovery of melanoma biomarkers and the clinical application of these biomarkers for diagnosis and staging of disease, determination of prognosis, treatment planning, monitoring of response to therapy, identification of novel therapeutic targets and drug development. A broad range of biomarkers (DNA/chromosomal, mRNA, microRNA, mitochondrial DNA, epigenetic and protein) is outlined. As therapies for melanoma become increasingly more target specific, the identification, validation and use of biomarkers will invariably play a greater role in the management of patients with this disease. Diagnostic and Prognostic Biomarkers and Therapeutic Targets in Melanoma is an essential resource for oncologists, dermatologists, dermatopathologists, general pathologists with an interest in melanoma, and melanoma researchers.

Author : Daming Zuo,Zhi-Bin Zhao,Chunqing Guo,Jingbo Wang
Publisher : Frontiers Media SA
Page : 140 pages
File Size : 44,7 Mb
Release : 2023-01-17
Category : Medical
ISBN : 9782832511633

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DAMP-sensing pattern recognition receptors in digestive tract inflammatory responses by Daming Zuo,Zhi-Bin Zhao,Chunqing Guo,Jingbo Wang Pdf

Author : Jitian Li,Apeng Chen,Ruowen Zhang,Changwei Li,Jian-Guo Zhou
Publisher : Frontiers Media SA
Page : 862 pages
File Size : 40,9 Mb
Release : 2023-06-07
Category : Science
ISBN : 9782832525456

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Genetic and proteomic biomarkers in solid tumor detection and treatment by Jitian Li,Apeng Chen,Ruowen Zhang,Changwei Li,Jian-Guo Zhou Pdf

Author : Leming Sun,Zhen Fan,Zhe-Sheng Chen
Publisher : Frontiers Media SA
Page : 120 pages
File Size : 43,8 Mb
Release : 2023-01-09
Category : Science
ISBN : 9782832511213

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Volume II: Novel molecular mechanisms and innovative therapeutic approaches for age-associated diseases by Leming Sun,Zhen Fan,Zhe-Sheng Chen Pdf

Author : Andrew W. Bruce,John Trachtenberg
Publisher : Springer Science & Business Media
Page : 363 pages
File Size : 50,7 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781447113980

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Adenocarcinoma of the Prostate by Andrew W. Bruce,John Trachtenberg Pdf

Carcinoma of the prostate increasingly dominates the attention of urologists for both scientific and clinical reasons. The search for an explanation and the prediction of the variable behaviour of the malignant prostatic cell continues unabated. The search for more precise tumour staging and more effective treatment is equally vigorous. Editors Andrew Bruce and John Trachtenberg have assembled acknowledged leaders in prostate cancer to present those areas of direct interest to the clinician. There are a number of other topics that might have been considered but most of these, such as experimental tumour models or biochemical factors affecting cell growth, still lack immediate application for the clinician. Carcinoma of the prostate continues to have its highest incidence in the western world, and the difference in comparison with the incidence in the Far East appears to be real and not masked by diagnostic or other factors. A number of other epidemiological aspects need careful analysis: Is the incidence increasing? Is the survival improving? Is the prognosis worse in the younger patient? Epidemiological data are easily misused and misinterpreted so that a precise analysis of the known facts makes an important opening chapter to this book.