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Author : Anonim
Publisher : DIANE Publishing
Page : 166 pages
File Size : 43,5 Mb
Release : 2005
Category : Cancer
ISBN : 9781428904569
Author : Ching-Hung Hsu,Todd Stedeford
Publisher : John Wiley & Sons
Page : 727 pages
File Size : 41,6 Mb
Release : 2010-12-08
Category : Science
ISBN : 9781118035122
With a weight-of-the-evidence approach, cancer risk assessment indentifies hazards, determines dose-response relationships, and assesses exposure to characterize the true risk. This book focuses on the quantitative methods for conducting chemical cancer risk assessments for solvents, metals, mixtures, and nanoparticles. It links these to the basic toxicology and biology of cancer, along with the impacts on regulatory guidelines and standards. By providing insightful perspective, Cancer Risk Assessment helps researchers develop a discriminate eye when it comes to interpreting data accurately and separating relevant information from erroneous.
Author : United States. Environmental Protection Agency. Office of Research and Development
Publisher : Unknown
Page : 178 pages
File Size : 54,5 Mb
Release : 1995
Category : Carcinogens
ISBN : IND:30000112325224
Author : Peter G. Shields
Publisher : CRC Press
Page : 800 pages
File Size : 44,7 Mb
Release : 2005-05-24
Category : Medical
ISBN : 9781000611342
The assessment of cancer risk is a complex process that requires the examination of etiological agents, real-world environments, and individual rates of exposure. This reference offers practical approaches to determine cancer risk in individuals, groups of exposed persons, and the general public in relation to individual genetic and acquired suscep
Author : C. C. Travis
Publisher : Unknown
Page : 210 pages
File Size : 43,6 Mb
Release : 1988
Category : Cancer
ISBN : 0879692316
Author : Wai Nang Choy
Publisher : CRC Press
Page : 405 pages
File Size : 41,8 Mb
Release : 2001-08-31
Category : Medical
ISBN : 9780824745226
Presents state-of-the-art regulatory cancer risk assessment models including a biologically based model for two-hit carcinogenesis and cell proliferation! This book comprehensively reviews the various roles of genetic toxicology in human cancer risk assessment conducted by United States and worldwide regulatory agencies-discussing hazard identification, dose-response relationships, exposure assessment, and current practices of risk characterization. Examines predictive values of mutagenicity tests, mechanisms of carcinogenesis, and conventional genotoxicity tests required by the International Conference on Harmonization and the Organization for Economic Cooperation and Development/Environmental Protection Agency guidelines! Comprised of contributions from prominent experts and risk assessors and including nearly 1200 references to facilitate further study, Genetic Toxicology and Cancer Risk Assessment reviews contemporary human cancer genetics as related to the mutagenic nature of carcinogenesis calculates acceptable exposure levels based on a carcinogenic threshold dose for nongenotoxic carcinogens reveals the rationale and methodology of quantitative estimation of human cancer risks using mathematical models discusses the threshold concept of carcinogenesis demonstrates how bacterial mutagenicity assays are the most reliable for predicting rodent carcinogens considers structural activity relationship (SAR) analysis of chemical carcinogenicity describes the emergence of the mouse lymphoma microwell and in vitro micronucleus assays illustrates the use of genetic biomarkers for dosimetry analysis and more! Linking human cancer genetics, mutagenicity assays, mechanisms of carcinogenesis, carcinogenic thresholds, molecular epidemiology, mathematical modeling, and quantitative cancer risk analysis, Genetic Toxicology and Cancer Risk Assessment is a must-have reference for toxicologists; oncologists; geneticists; biostatisticians; reproductive, developmental, cell, and molecular biologists; endocrinologists; biochemists; and upper-level undergraduate, graduate, and medical school students in these disciplines.
Author : Anonim
Publisher : Unknown
Page : 30 pages
File Size : 40,6 Mb
Release : 1986
Category : Risk assessment
ISBN : OCLC:48539251
Author : Anonim
Publisher : DIANE Publishing
Page : 182 pages
File Size : 42,6 Mb
Release : 1996
Category : Carcinogens
ISBN : UCBK:C049970462
Author : National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Improving Risk Analysis Approaches Used by the U.S. EPA
Publisher : National Academies Press
Page : 422 pages
File Size : 48,7 Mb
Release : 2009-03-24
Category : Political Science
ISBN : 9780309120463
Risk assessment has become a dominant public policy tool for making choices, based on limited resources, to protect public health and the environment. It has been instrumental to the mission of the U.S. Environmental Protection Agency (EPA) as well as other federal agencies in evaluating public health concerns, informing regulatory and technological decisions, prioritizing research needs and funding, and in developing approaches for cost-benefit analysis. However, risk assessment is at a crossroads. Despite advances in the field, risk assessment faces a number of significant challenges including lengthy delays in making complex decisions; lack of data leading to significant uncertainty in risk assessments; and many chemicals in the marketplace that have not been evaluated and emerging agents requiring assessment. Science and Decisions makes practical scientific and technical recommendations to address these challenges. This book is a complement to the widely used 1983 National Academies book, Risk Assessment in the Federal Government (also known as the Red Book). The earlier book established a framework for the concepts and conduct of risk assessment that has been adopted by numerous expert committees, regulatory agencies, and public health institutions. The new book embeds these concepts within a broader framework for risk-based decision-making. Together, these are essential references for those working in the regulatory and public health fields.
Author : National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Committee on Risk Assessment Methodology
Publisher : National Academies Press
Page : 375 pages
File Size : 41,9 Mb
Release : 1993-02-01
Category : Science
ISBN : 9780309047869
The scientific basis, inference assumptions, regulatory uses, and research needs in risk assessment are considered in this two-part volume. The first part, Use of Maximum Tolerated Dose in Animal Bioassays for Carcinogenicity, focuses on whether the maximum tolerated dose should continue to be used in carcinogenesis bioassays. The committee considers several options for modifying current bioassay procedures. The second part, Two-Stage Models of Carcinogenesis, stems from efforts to identify improved means of cancer risk assessment that have resulted in the development of a mathematical dose-response model based on a paradigm for the biologic phenomena thought to be associated with carcinogenesis.
Author : National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Committee on Emerging Issues and Data on Environmental Contaminants,Committee on How Toxicogenomics Could Inform Critical Issues in Carcinogenic Risk Assessment of Environmental Chemicals
Publisher : National Academies Press
Page : 68 pages
File Size : 54,8 Mb
Release : 2005-10-17
Category : Science
ISBN : 9780309181785
Toxicogenomics is a discipline that combines expertise in toxicology, genetics, molecular biology, and environmental health to help understand the response of living organisms to stressful environments. The National Research Council convened a workshop to discuss how toxicogenomic data could be applied to improve risk assessments, particularly cancer risk from environmental exposure to chemicals. Risk assessments serve as the basis of many public-health decisions in environmental, occupational, and consumer protection from chemicals. The workshop provided a forum for communities of experts, including those working in "-omics" and those in the policy arena, to discuss where their fields intersect, and how toxicogenomics could address critical knowledge gaps in risk assessments.
Author : United States. Environmental Protection Agency
Publisher : Unknown
Page : 12 pages
File Size : 54,9 Mb
Release : 1986
Category : Carcinogenicity testing
ISBN : OCLC:40827215
Author : Anonim
Publisher : Unknown
Page : 118 pages
File Size : 55,9 Mb
Release : 1989
Category : Carcinogens
ISBN : UOM:39015019674772
Author : Ronald W. Hart,Fred D. Hoerger
Publisher : Cold Spring Harbor Laboratory Press
Page : 384 pages
File Size : 45,6 Mb
Release : 1988
Category : Medical
ISBN : UCAL:B4513976
Papers and discussions from a conference, date and place unspecified. This volume is in a series on carcinogen and health-related topics. Discussion is centered on structure-activity relationship data, pharmacokinetic and metabolic activity data, molecular biological data, approaches toward integrat
Author : Samuel C. Morris
Publisher : CRC Press
Page : 417 pages
File Size : 40,5 Mb
Release : 2020-07-24
Category : Medical
ISBN : 9781000104301
Based on the National Academy of Sciences approach to quantitative risk assessment. Emphasizes how an accurate assessment of cancer risk must draw on a wide range of disciplines, such as biology, chemistry, physics, engineering, and the social sciences. Provides tables of Poisson confidence limit fa
