Cartilage Regeneration

Author : Phuc Van Pham
Publisher : Springer
Page : 315 pages
File Size : 54,6 Mb
Release : 2017-01-24
Category : Science
ISBN : 9783319401447

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Bone and Cartilage Regeneration by Phuc Van Pham Pdf

This invaluable resource discusses clinical applications with effects and side-effects of applications of stem cells in bone and cartilage regeneration. Each chapter is contributed by a pre-eminent scientist in the field and covers such topics as skeletal regeneration by mesenchymal stem cells, clinical improvement of mesenchymal stem cell injection in injured cartilage and osteoarthritis, Good manufacturing practice (GMP), minimal critera of stem cells for clinical applications, future directions of the discussed therapies and much more. Bone & Cartilage Regeneration and the other books in the Stem Cells in Clinical Applications series will be invaluable to scientists, researchers, advanced students and clinicians working in stem cells, regenerative medicine or tissue engineering.

Author : Yunfeng Lin
Publisher : Humana Press
Page : 97 pages
File Size : 45,6 Mb
Release : 2017-02-21
Category : Science
ISBN : 9783319516172

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Cartilage Regeneration by Yunfeng Lin Pdf

This book focuses on cartilage defects and new mesenchymal stem cell-based treatments for their repair and regeneration. Early chapters provide a review of current etiological findings and repair methods of cartilage defects. The next chapters discuss fundamental concepts and features of MSCs, including their proliferation, differentiation, migration and immunomodulatory effects. The discussion also includes clinical applications of MSCs in cartilage tissues, especially with regards to various animal models, biomaterials and transferring techniques. Cartilage Regeneration focuses on the biology of MSCs and their possible applications in cartilage reconstruction, with the goal of bringing new insights into regenerative medicine. It will be essential reading for researchers and clinicians in stem cells, regenerative medicine, biomedical engineering and orthopedic surgery.

Author : Hala Zreiqat,Colin R. Dunstan,Vicki Rosen
Publisher : Springer
Page : 254 pages
File Size : 47,8 Mb
Release : 2014-12-05
Category : Technology & Engineering
ISBN : 9783319132662

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A Tissue Regeneration Approach to Bone and Cartilage Repair by Hala Zreiqat,Colin R. Dunstan,Vicki Rosen Pdf

Reviewing exhaustively the current state of the art of tissue engineering strategies for regenerating bones and joints through the use of biomaterials, growth factors and stem cells, along with an investigation of the interactions between biomaterials, bone cells, growth factors and added stem cells and how together skeletal tissues can be optimised, this book serves to highlight the importance of biomaterials composition, surface topography, architectural and mechanical properties in providing support for tissue regeneration. Maximizing reader insights into the importance of the interplay of these attributes with bone cells (osteoblasts, osteocytes and osteoclasts) and cartilage cells (chondrocytes), this book also provides a detailed reference as to how key signalling pathways are activated. The contribution of growth factors to drive tissue regeneration and stem cell recruitment is discussed along with a review the potential and challenges of adult or embryonic mesenchymal stem cells to further enhance the formation of new bone and cartilage tissues. This book serves to demonstrate the interconnectedness of biomaterials, bone/cartilage cells, growth factors and stem cells in determining the regenerative process and thus the clinical outcome.

Author : Dimitrios D. Nikolopoulos,George K. Safos,Kalpaxis Dimitrios
Publisher : BoD – Books on Demand
Page : 160 pages
File Size : 54,8 Mb
Release : 2019-06-05
Category : Technology & Engineering
ISBN : 9781789238495

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Cartilage Tissue Engineering and Regeneration Techniques by Dimitrios D. Nikolopoulos,George K. Safos,Kalpaxis Dimitrios Pdf

Osteochondral defects can be challenging to treat, first, because the damaged articular cartilage has a poor intrinsic reparative capability, and second, because these defects cause chronic pain and serious disability. That is why cartilage repair remains one of the most challenging issues of musculoskeletal medicine. Arthroscopic and open techniques that have been developed over the last two decades intend to promote the success of complete repair of the articular cartilage defects; nevertheless, these therapies cannot always offer 100% success. Nowadays, cartilage tissue engineering is an emerging technique for the regeneration of cartilage tissue. Taking into consideration these perspectives, this book aims to present a summary of cartilage tissue engineering, including development, recent progress, and major steps taken toward the regeneration of functional cartilage tissue. Special emphasis is placed on the role of stimulating factors, including growth factors, gene therapies, as well as scaffolds, including natural, synthetic, and nanostructured.

Author : Susanne Grässel,Attila Aszódi
Publisher : Springer
Page : 206 pages
File Size : 49,8 Mb
Release : 2017-05-09
Category : Medical
ISBN : 9783319533162

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Cartilage by Susanne Grässel,Attila Aszódi Pdf

In three Volumes this mini book series presents current knowledge and new perspectives on cartilage as a specialized yet versatile tissue. This third volume provides insight into current and future treatment strategies for repair of cartilage lesions. This book addresses Professors, researchers and PhD students who are interested in musculoskeletal and cartilage pathobiology and tissue-engineering.

Author : Alessandro Rozim Zorzi,João Batista de Miranda
Publisher : BoD – Books on Demand
Page : 230 pages
File Size : 50,9 Mb
Release : 2018-02-14
Category : Technology & Engineering
ISBN : 9789535137887

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Cartilage Repair and Regeneration by Alessandro Rozim Zorzi,João Batista de Miranda Pdf

This work is the result of a partnership that began in 2011, when I received for the first time the invitation to be the scientific editor of a book on bone grafting, by the still little publisher known as InTech. Now six years later, InTech has grown and thrived. My respect and warm approval for the quality of the publisher's work only increased. The hyaline cartilage is a tissue that challenges tissue engineering and regenerative medicine because of its avascular nature. In the 11 chapters of this book, the reader will find texts written by researchers working on advanced topics related to basic laboratory research, as well as excellent reviews on the clinical use of currently available therapies.

Author : Kalpaxis Dimitrios,George K. Safos,Dimitrios D. Nikolopoulos
Publisher : Unknown
Page : 158 pages
File Size : 54,7 Mb
Release : 2019
Category : Medicine (General)
ISBN : 1838807810

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Cartilage Tissue Engineering and Regeneration Techniques by Kalpaxis Dimitrios,George K. Safos,Dimitrios D. Nikolopoulos Pdf

Osteochondral defects can be challenging to treat, first, because the damaged articular cartilage has a poor intrinsic reparative capability, and second, because these defects cause chronic pain and serious disability. That is why cartilage repair remains one of the most challenging issues of musculoskeletal medicine. Arthroscopic and open techniques that have been developed over the last two decades intend to promote the success of complete repair of the articular cartilage defects; nevertheless, these therapies cannot always offer 100% success. Nowadays, cartilage tissue engineering is an emerging technique for the regeneration of cartilage tissue. Taking into consideration these perspectives, this book aims to present a summary of cartilage tissue engineering, including development, recent progress, and major steps taken toward the regeneration of functional cartilage tissue. Special emphasis is placed on the role of stimulating factors, including growth factors, gene therapies, as well as scaffolds, including natural, synthetic, and nanostructured.

Author : Pieter J. Emans,Lars Peterson
Publisher : Springer Science & Business Media
Page : 329 pages
File Size : 40,6 Mb
Release : 2013-10-16
Category : Medical
ISBN : 9781447153856

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Developing Insights in Cartilage Repair by Pieter J. Emans,Lars Peterson Pdf

This comprehensive book discusses cartilage repair and all its aspects. These aspects vary from basic insights in cartilage biology and regeneration via MRI, to results of existing cartilage repair techniques and upcoming novel approaches. Fundamental cartilage biology is the topic covered within the first chapters of the book. These chapters not only provide an insight in healthy, damaged and regenerative cartilage but also describe developments in gene therapy and methods to enhance chondrogenesis of stemcells and prevent hypertophic differentiation. There is a huge progress in the possibilities of MR imaging of both healthy, damaged and regenerative cartilage. These developments not only enable better monitoring of cartilage repair but may also unravel the pathophysiology of the development of cartilage defects. Different cartilage repair techniques (e.g. allografts, autologous chondrocytes transplantation [ACT], microfracture), there technical aspects (e.g. developments towards an total arthroscopic approach), pitfalls, and outcomes are reported in the following chapters. In these chapters factors important for the results of cartilage repair such as meniscal repair, patient factors are described. Finally, an overview of novel cartilage repair techniques such as minced cartilage, denovo cartilage and more areas are discussed in this comprehensive addition to the literature.

Author : Tiago Lazzaretti Fernandes,Daniela Franco Bueno,Kazunori Shimomura,Zhenxing Shao,Andreas H. Gomoll
Publisher : Frontiers Media SA
Page : 208 pages
File Size : 42,7 Mb
Release : 2022-10-05
Category : Science
ISBN : 9782832501450

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Tissue Engineering and Cell Therapy for Cartilage Restoration by Tiago Lazzaretti Fernandes,Daniela Franco Bueno,Kazunori Shimomura,Zhenxing Shao,Andreas H. Gomoll Pdf

Author : Charles Archer,Jim Ralphs
Publisher : Elsevier
Page : 504 pages
File Size : 42,9 Mb
Release : 2010-01-12
Category : Technology & Engineering
ISBN : 9781845697792

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Regenerative Medicine and Biomaterials for the Repair of Connective Tissues by Charles Archer,Jim Ralphs Pdf

Regenerative medicine for the repair of connective tissues is a fast moving field which generates a lot of interest. Unfortunately the biomaterials and biomechanics for soft tissue repair has been under-represented in the past. Particularly the natural association between cartilage, tendons and ligaments is often not made. Regenerative medicine and biomaterials for the repair of connective tissues addresses this gap in the market by bringing together the natural association of cartilage, tendons and ligaments to provide a review of the different structures, biomechanics and, more importantly, provide a clear discussion of practical techniques and biomaterials which may be used to repair the connective tissues. Part one discusses cartilage repair and regeneration with chapters on such topics as structure, biomechanics and repair of cartilage. Chapters in Part two focus on the repair of tendons on ligaments with particular techniques including cell-based therapies for the repair and regeneration of tendons and ligaments and scaffolds for tendon and ligament tissue engineering. Addresses the natural association between cartilage, tendons and ligaments which is often not made Provides a review of the different structures, biomechanics and practical techniques which are used in the repair of connective tissues Chapters focus on such areas as cartilage repair and regeneration, the repair of tendons and ligaments, investigating techniques including scaffolds and cell-based therapies

Author : Martin J. Stoddart,Elena Della Bella,Angela R. Armiento
Publisher : Springer Nature
Page : 392 pages
File Size : 41,6 Mb
Release : 2022-11-10
Category : Science
ISBN : 9781071628393

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Cartilage Tissue Engineering by Martin J. Stoddart,Elena Della Bella,Angela R. Armiento Pdf

This detailed book brings together a collection of methodologies, from the most basic to the more complex, that provides researchers with a platform they can use to embark on a cartilage research career. To aid in the search for novel therapies for cartilage regeneration, this volume addresses 3D cartilage models, challenges associated with RNA and protein extraction, imaging, gene transfer, as well as stable differentiation and variations in cell phenotype from different tissue origins. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Cartilage Tissue Engineering serves as an ideal guide for researchers working to advance the vital study of cartilage biology and repair.

Author : Roberto Narcisi,Eric Farrell
Publisher : Frontiers Media SA
Page : 185 pages
File Size : 54,9 Mb
Release : 2019-04-04
Category : Electronic
ISBN : 9782889457908

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Understanding and Modulating Bone and Cartilage Cell Fate for Regenerative Medicine by Roberto Narcisi,Eric Farrell Pdf

Author : Deepak Rajkumar Goyal
Publisher : Springer Nature
Page : 278 pages
File Size : 47,7 Mb
Release : 2020-10-26
Category : Medical
ISBN : 9783030471545

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The Illustrative Book of Cartilage Repair by Deepak Rajkumar Goyal Pdf

This book employs a wealth of high-quality illustrations to provide the reader with a detailed understanding of the anatomy and the histology of the cartilage, the etiology and the classification of the cartilage lesions, and the numerous techniques employed for cartilage repair. Detailed attention is devoted to healthy cartilage, to each stage in the degenerative process, and to the response of the cartilage to the treatment. Imaging of the damaged and the repaired cartilage, as well as the information on the biomechanics are provided in great detail. The chapters on the techniques cover a wide range of approaches: marrow stimulation techniques, osteochondral cylinder transfer techniques, first, second and third generation autologous chondrocyte implantation techniques, allografts, cell-based therapies, orthobiologic approaches, and the role of 3D printing. The chapters closes with a consideration of the success of rehabilitation devices and the long-term results of cartilage repair.The book will be invaluable for all general orthopaedic and arthroscopic surgeons seeking a deeper knowledge of cartilage science and will help to dispel the confusion that still surrounds the reparative treatment. The authors are recognized experts in the fields of cartilage histology, assessment, classification, and repair.

Author : Peter Giannoudis,Elena Jones,Xuebin Yang,Dennis McGonagle
Publisher : Academic Press
Page : 0 pages
File Size : 40,8 Mb
Release : 2013-03-18
Category : Science
ISBN : 0124079156

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Mesenchymal Stem Cells and Skeletal Regeneration by Peter Giannoudis,Elena Jones,Xuebin Yang,Dennis McGonagle Pdf

This book covers our current understanding of the role of mesenchymal stem cells (MSCs) and other mesenchymal progenitors in skeletal regeneration, encompassing bone, cartilage and whole joint regeneration. The expansion reflects developments in the field to include data on the use of MSCs in drug development, growth factors, scaffolds and biomechanical manipulations for skeletal trauma and diseases, including osteoporosis and arthritis. Written for an audience of clinicians and young researchers who are exposed to MSCs in their work, this work summarizes recent findings pertaining to the definition and characterization of MSCs in skeletal tissues and discusses the mechanisms of their actions in regeneration of bone in vivo. The authors describe recent findings pertaining to the efficacy of MSC therapies in animal models and in human clinical trials and bring together literature showing that the ways MSCs are extracted, expanded and implanted can considerably affect bone formation outcomes. Finally, it presents the latest knowledge on the nature of native MSCs in skeletal tissues, which provide a platform for novel in situ tissue regeneration approaches for systemic bone disease such as osteoporosis. Focuses specifically on the use of stem cells in skeletal tissue generation for a broad audience of stem cell, cancer, and bone biologists, orthopedists, oncologists, and regenerative medicine specialists Provides a short historical 'detour' and foundational information on founding concepts, discoveries and personalities in MSC research Assists a new generation of scientists and clinicians in digesting the multitude of journal articles on the topic by providing easily-absorbed and condensed foundational context

Author : Mohamadreza Baghaban Eslaminejad,Samaneh Hosseini
Publisher : Springer Nature
Page : 531 pages
File Size : 43,5 Mb
Release : 2023-07-11
Category : Science
ISBN : 9789819924523

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Cartilage: From Biology to Biofabrication by Mohamadreza Baghaban Eslaminejad,Samaneh Hosseini Pdf

This book provides a comprehensive overview of cartilage structure, functions, and approaches for the regeneration of cartilage tissue. It reviews multiple signaling pathways that are involved in the growth and repair of cartilage tissue. The initial chapter of the book examines the etiology, diagnosis, and pathological features of various cartilage diseases. Subsequently, the book presents recent advances in biomaterial sciences, regenerative medicine, and fabrication technology for cartilage regeneration. It discusses hydrogels as a promising scaffold for cartilage tissue engineering, focusing on recapitulating microenvironments present during development or in adult tissue to induce the formation of cartilaginous constructs with biochemical and mechanical properties of native tissue. Lastly, it covers the applications of 3 D printing techniques for the fabrication of scaffolds for cartilage tissue regeneration for the production of biological implants capable of treating a range of conditions.