A Tissue Regeneration Approach To Bone And Cartilage Repair

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A Tissue Regeneration Approach to Bone and Cartilage Repair

Hala Zreiqat,Colin R. Dunstan,Vicki Rosen
A Tissue Regeneration Approach to Bone and Cartilage Repair Book PDF

Author : Hala Zreiqat,Colin R. Dunstan,Vicki Rosen
Publisher : Springer
Page : 254 pages
File Size : 55,8 Mb
Release : 2014-12-05
Category : Technology & Engineering
ISBN : 9783319132662

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A Tissue Regeneration Approach to Bone and Cartilage Repair by Hala Zreiqat,Colin R. Dunstan,Vicki Rosen Pdf

Reviewing exhaustively the current state of the art of tissue engineering strategies for regenerating bones and joints through the use of biomaterials, growth factors and stem cells, along with an investigation of the interactions between biomaterials, bone cells, growth factors and added stem cells and how together skeletal tissues can be optimised, this book serves to highlight the importance of biomaterials composition, surface topography, architectural and mechanical properties in providing support for tissue regeneration. Maximizing reader insights into the importance of the interplay of these attributes with bone cells (osteoblasts, osteocytes and osteoclasts) and cartilage cells (chondrocytes), this book also provides a detailed reference as to how key signalling pathways are activated. The contribution of growth factors to drive tissue regeneration and stem cell recruitment is discussed along with a review the potential and challenges of adult or embryonic mesenchymal stem cells to further enhance the formation of new bone and cartilage tissues. This book serves to demonstrate the interconnectedness of biomaterials, bone/cartilage cells, growth factors and stem cells in determining the regenerative process and thus the clinical outcome.

Cartilage Tissue Engineering and Regeneration Techniques

Dimitrios D. Nikolopoulos,George K. Safos,Kalpaxis Dimitrios
Cartilage Tissue Engineering and Regeneration Techniques Book PDF

Author : Dimitrios D. Nikolopoulos,George K. Safos,Kalpaxis Dimitrios
Publisher : BoD – Books on Demand
Page : 160 pages
File Size : 52,5 Mb
Release : 2019-06-05
Category : Technology & Engineering
ISBN : 9781789238495

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Cartilage Tissue Engineering and Regeneration Techniques by Dimitrios D. Nikolopoulos,George K. Safos,Kalpaxis Dimitrios Pdf

Osteochondral defects can be challenging to treat, first, because the damaged articular cartilage has a poor intrinsic reparative capability, and second, because these defects cause chronic pain and serious disability. That is why cartilage repair remains one of the most challenging issues of musculoskeletal medicine. Arthroscopic and open techniques that have been developed over the last two decades intend to promote the success of complete repair of the articular cartilage defects; nevertheless, these therapies cannot always offer 100% success. Nowadays, cartilage tissue engineering is an emerging technique for the regeneration of cartilage tissue. Taking into consideration these perspectives, this book aims to present a summary of cartilage tissue engineering, including development, recent progress, and major steps taken toward the regeneration of functional cartilage tissue. Special emphasis is placed on the role of stimulating factors, including growth factors, gene therapies, as well as scaffolds, including natural, synthetic, and nanostructured.

Bone Tissue Engineering

Jeffrey O. Hollinger,Thomas A. Einhorn,Bruce Doll,Charles Sfeir
Bone Tissue Engineering Book PDF

Author : Jeffrey O. Hollinger,Thomas A. Einhorn,Bruce Doll,Charles Sfeir
Publisher : CRC Press
Page : 500 pages
File Size : 53,9 Mb
Release : 2004-10-14
Category : Medical
ISBN : 9781135501914

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Bone Tissue Engineering by Jeffrey O. Hollinger,Thomas A. Einhorn,Bruce Doll,Charles Sfeir Pdf

Focusing on bone biology, Bone Tissue Engineering integrates basic sciences with tissue engineering. It includes contributions from world-renowned researchers and clinicians who discuss key topics such as different models and approaches to bone tissue engineering, as well as exciting clinical applications for patients. Divided into four sections, t

Tissue Engineering of Cartilage and Bone

Gregory R. Bock,Jamie A. Goode
Tissue Engineering of Cartilage and Bone Book PDF

Author : Gregory R. Bock,Jamie A. Goode
Publisher : John Wiley & Sons
Page : 262 pages
File Size : 49,7 Mb
Release : 2003-07-22
Category : Medical
ISBN : 9780470864234

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Tissue Engineering of Cartilage and Bone by Gregory R. Bock,Jamie A. Goode Pdf

Tissue engineering takes advantages of the combined use of cultured living cells and three-dimensional scaffolds to reconstruct adult tissues that are absent or malfunctioning. This book brings together scientists and clinicians working on a variety of approaches for regenerating of damaged or lost cartilage and bone to assess the progress of this dynamic field. In its early days, tissue engineering was driven by material scientists who designed novel bio-resorbable scaffolds on which to seed cells and grow tissues. This ground-breaking work generated high expectations, but there have been significant stumbling blocks holding back the widespread use of these techniques in the clinic. These challenges, and potential ways of overcoming them, are given thorough coverage in the discussions that follow each chapter. The key questions addressed in this book include the following. How good must cartilage repair be for it to be worthwhile? What is the best source of cells for tissue engineering of both bone and cartilage? Which are the most effective cell scaffolds? What are the best preclinical models for these technologies? And when it comes to clinical trials, what sort of outcome measures should be used? With contributions from some of the leading experts in this field, this timely publication will prove essential reading for anyone with an interest in the field of tissue engineering.

Musculoskeletal Tissue Regeneration

William S. Pietrzak
Musculoskeletal Tissue Regeneration Book PDF

Author : William S. Pietrzak
Publisher : Springer Science & Business Media
Page : 649 pages
File Size : 55,6 Mb
Release : 2008-04-11
Category : Medical
ISBN : 9781597452397

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Musculoskeletal Tissue Regeneration by William S. Pietrzak Pdf

The repair of musculoskeletal tissue is a vital concern of all surgical specialties, orthopedics and related disciplines. Written by recognized experts, this book aims to provide both basic and advanced knowledge of the newer methodologies being developed and introduced to the clinical arena. A valuable resource for researchers, developers, and clinicians, the book presents a foundation to propel the technology and integration of the current state of knowledge into the 21st century.

Bone and Cartilage Regeneration

Phuc Van Pham
Bone and Cartilage Regeneration Book PDF

Author : Phuc Van Pham
Publisher : Springer
Page : 315 pages
File Size : 51,6 Mb
Release : 2017-01-24
Category : Science
ISBN : 9783319401447

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Bone and Cartilage Regeneration by Phuc Van Pham Pdf

This invaluable resource discusses clinical applications with effects and side-effects of applications of stem cells in bone and cartilage regeneration. Each chapter is contributed by a pre-eminent scientist in the field and covers such topics as skeletal regeneration by mesenchymal stem cells, clinical improvement of mesenchymal stem cell injection in injured cartilage and osteoarthritis, Good manufacturing practice (GMP), minimal critera of stem cells for clinical applications, future directions of the discussed therapies and much more. Bone & Cartilage Regeneration and the other books in the Stem Cells in Clinical Applications series will be invaluable to scientists, researchers, advanced students and clinicians working in stem cells, regenerative medicine or tissue engineering.

Cartilage Regeneration

Yunfeng Lin
Cartilage Regeneration Book PDF

Author : Yunfeng Lin
Publisher : Humana Press
Page : 97 pages
File Size : 48,8 Mb
Release : 2017-02-21
Category : Science
ISBN : 9783319516172

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Cartilage Regeneration by Yunfeng Lin Pdf

This book focuses on cartilage defects and new mesenchymal stem cell-based treatments for their repair and regeneration. Early chapters provide a review of current etiological findings and repair methods of cartilage defects. The next chapters discuss fundamental concepts and features of MSCs, including their proliferation, differentiation, migration and immunomodulatory effects. The discussion also includes clinical applications of MSCs in cartilage tissues, especially with regards to various animal models, biomaterials and transferring techniques. Cartilage Regeneration focuses on the biology of MSCs and their possible applications in cartilage reconstruction, with the goal of bringing new insights into regenerative medicine. It will be essential reading for researchers and clinicians in stem cells, regenerative medicine, biomedical engineering and orthopedic surgery.

Developmental Biology and Musculoskeletal Tissue Engineering

Martin J. Stoddart,April M. Craft,Girish Pattappa,Oliver F.W. Gardner
Developmental Biology and Musculoskeletal Tissue Engineering Book PDF

Author : Martin J. Stoddart,April M. Craft,Girish Pattappa,Oliver F.W. Gardner
Publisher : Academic Press
Page : 270 pages
File Size : 42,8 Mb
Release : 2018-04-24
Category : Science
ISBN : 9780128115381

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Developmental Biology and Musculoskeletal Tissue Engineering by Martin J. Stoddart,April M. Craft,Girish Pattappa,Oliver F.W. Gardner Pdf

Developmental Biology and Musculoskeletal Tissue Engineering: Principles and Applications focuses on the regeneration of orthopedic tissue, drawing upon expertise from developmental biologists specializing in orthopedic tissues and tissue engineers who have used and applied developmental biology approaches. Musculoskeletal tissues have an inherently poor repair capacity, and thus biologically-based treatments that can recapitulate the native tissue properties are desirable. Cell- and tissue-based therapies are gaining ground, but basic principles still need to be addressed to ensure successful development of clinical treatments. Written as a source of information for practitioners and those with a nascent interest, it provides background information and state-of-the-art solutions and technologies. Recent developments in orthopedic tissue engineering have sought to recapitulate developmental processes for tissue repair and regeneration, and such developmental-biology based approaches are also likely to be extremely amenable for use with more primitive stem cells. Brings the fields of tissue engineering and developmental biology together to explore the potential for regenerative medicine-based research to contribute to enhanced clinical outcomes Initial chapters provide an outline of the development of the musculoskeletal system in general, and later chapters focus on specific tissues Addresses the effect of mechanical forces on the musculoskeletal system during development and the relevance of these processes to tissue engineering Discusses the role of genes in the development of musculoskeletal tissues and their potential use in tissue engineering Describes how developmental biology is being used to influence and guide tissue engineering approaches for cartilage, bone, disc, and tendon repair

Cartilage

Susanne Grässel,Attila Aszódi
Cartilage Book PDF

Author : Susanne Grässel,Attila Aszódi
Publisher : Springer
Page : 206 pages
File Size : 50,5 Mb
Release : 2017-05-09
Category : Medical
ISBN : 9783319533162

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Cartilage by Susanne Grässel,Attila Aszódi Pdf

In three Volumes this mini book series presents current knowledge and new perspectives on cartilage as a specialized yet versatile tissue. This third volume provides insight into current and future treatment strategies for repair of cartilage lesions. This book addresses Professors, researchers and PhD students who are interested in musculoskeletal and cartilage pathobiology and tissue-engineering.

Articular Cartilage Tissue Engineering

Kyriacos A. Athanasiou,Eric M. Darling,Jerry C. Hu
Articular Cartilage Tissue Engineering Book PDF

Author : Kyriacos A. Athanasiou,Eric M. Darling,Jerry C. Hu
Publisher : Morgan & Claypool Publishers
Page : 183 pages
File Size : 49,9 Mb
Release : 2010
Category : Medical
ISBN : 9781598298758

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Articular Cartilage Tissue Engineering by Kyriacos A. Athanasiou,Eric M. Darling,Jerry C. Hu Pdf

Cartilage injuries in children and adolescents are increasingly observed, with roughly 20% of knee injuries in adolescents requiring surgery. In the US alone, costs of osteoarthritis (OA) are in excess of $65 billion per year (both medical costs and lost wages). Comorbidities are common with OA and are also costly to manage. Articular cartilage's low friction and high capacity to bear load makes it critical in the movement of one bone against another, and its lack of a sustained natural healing response has necessitated a plethora of therapies. Tissue engineering is an emerging technology at the threshold of translation to clinical use. Replacement cartilage can be constructed in the laboratory to recapitulate the functional requirements of native tissues. This book outlines the biomechanical and biochemical characteristics of articular cartilage in both normal and pathological states, through development and aging. It also provides a historical perspective of past and current cartilage treatments and previous tissue engineering efforts. Methods and standards for evaluating the function of engineered tissues are discussed, and current cartilage products are presented with an analysis on the United States Food and Drug Administration regulatory pathways that products must follow to market. This book was written to serve as a reference for researchers seeking to learn about articular cartilage, for undergraduate and graduate level courses, and as a compendium of articular cartilage tissue engineering design criteria. Table of Contents: Hyaline Articular Cartilage / Cartilage Aging and Pathology / In Vitro / Bioreactors / Future Directions

Bone Regeneration and Repair

Jay R. Lieberman,Gary E. Friedlaender
Bone Regeneration and Repair Book PDF

Author : Jay R. Lieberman,Gary E. Friedlaender
Publisher : Springer Science & Business Media
Page : 398 pages
File Size : 40,9 Mb
Release : 2007-10-27
Category : Medical
ISBN : 9781592598632

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Bone Regeneration and Repair by Jay R. Lieberman,Gary E. Friedlaender Pdf

This collection of articles by leading orthopedic and craniofacial surgeons and researchers comprehensively reviews the biology of bone formation and repair, the basic science of autologous bone graft, allograft, bone substitutes, and growth factors, and explore their clinical application in patients with bone repair problems.

Bone and Cartilage Engineering

Ulrich Meyer,Hans Peter Wiesmann
Bone and Cartilage Engineering Book PDF

Author : Ulrich Meyer,Hans Peter Wiesmann
Publisher : Springer Science & Business Media
Page : 286 pages
File Size : 54,5 Mb
Release : 2006-03-14
Category : Medical
ISBN : 3540253475

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Bone and Cartilage Engineering by Ulrich Meyer,Hans Peter Wiesmann Pdf

Bone and Cartilage Engineering provides a complete overview of recent knowledge in bone and cartilage tissue engineering. It follows a logical approach to the various aspects of extracorporal bone and cartilage tissue engineering. The cooperation between a basic scientist and a clinician made it possible to structure the book's content and style according to the interdisciplinary character of the field. The comprehensive nature of the book, including detailed descriptions of laboratory procedures, preclinical approaches, clinical applications, and regulatory issues, will make it an invaluable basis for everyone working in this field. This book will serve as a fundamental tool for basic researchers to establish or refine tissue engineering techniques as well as for clinicians to understand and use this modern therapeutic option.

Cartilage Tissue Engineering

Martin J. Stoddart,Elena Della Bella,Angela R. Armiento
Cartilage Tissue Engineering Book PDF

Author : Martin J. Stoddart,Elena Della Bella,Angela R. Armiento
Publisher : Springer Nature
Page : 392 pages
File Size : 53,6 Mb
Release : 2022-11-10
Category : Science
ISBN : 9781071628393

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Cartilage Tissue Engineering by Martin J. Stoddart,Elena Della Bella,Angela R. Armiento Pdf

This detailed book brings together a collection of methodologies, from the most basic to the more complex, that provides researchers with a platform they can use to embark on a cartilage research career. To aid in the search for novel therapies for cartilage regeneration, this volume addresses 3D cartilage models, challenges associated with RNA and protein extraction, imaging, gene transfer, as well as stable differentiation and variations in cell phenotype from different tissue origins. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Cartilage Tissue Engineering serves as an ideal guide for researchers working to advance the vital study of cartilage biology and repair.

Stem Cell and Tissue Engineering

Krishna Pramanik
Stem Cell and Tissue Engineering Book PDF

Author : Krishna Pramanik
Publisher : CRC Press
Page : 355 pages
File Size : 50,5 Mb
Release : 2024-03-29
Category : Technology & Engineering
ISBN : 9781000999471

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Stem Cell and Tissue Engineering by Krishna Pramanik Pdf

This book covers conventional clinical treatment methods for handling bone, cartilage, and related disorders along with their limitations and highlights the current state of the art of tissue engineering as an alternative for regenerating such defective tissue. Potential biomimetic scaffolding materials and their development, desired properties, modifications, and optimizations are described. The design and advancement in fabrication, characterization, properties, and biological functions of scaffolds, their integration with stem cells, and various bioreactor systems for tissue regeneration are presented. It further reviews in vitro and in vivo (pre-clinical) assessments of tissue constructs, involved translational challenges, and strategies in various stages of neo-tissue production. Features: Discusses the key aspects of generating engineered bone, cartilage, and associated tissues through tissue engineering approach Describes multiple engineering principles, and processes involved in the various stages of developing biomaterials and scaffolds Covers integration of stem cells with scaffolds, including assessment of tissue grafts, and translational strategy Explores key factors influencing tissue graft generation in bioreactors and challenges involved in various stages Includes several exercises including review questions and numerical problems for better understanding of the subject This book is aimed at researchers, students, and professionals in biomedical engineering, tissue engineering, stem cells, biomaterials, and orthopaedics.

Nanomaterials in Tissue Engineering

A K Gaharwar,S Sant,M J Hancock,S A Hacking
Nanomaterials in Tissue Engineering Book PDF

Author : A K Gaharwar,S Sant,M J Hancock,S A Hacking
Publisher : Elsevier
Page : 468 pages
File Size : 52,8 Mb
Release : 2013-07-31
Category : Technology & Engineering
ISBN : 9780857097231

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Nanomaterials in Tissue Engineering by A K Gaharwar,S Sant,M J Hancock,S A Hacking Pdf

Nanomaterial technologies can be used to fabricate high-performance biomaterials with tailored physical, chemical, and biological properties. They are therefore an area of interest for emerging biomedical technologies such as scaffolding, tissue regeneration, and controlled drug delivery. Nanomaterials in tissue engineering explores the fabrication of a variety of nanomaterials and the use of these materials across a range of tissue engineering applications. Part one focuses on the fabrication of nanomaterials for tissue engineering applications and includes chapters on engineering nanoporous biomaterials, layer-by-layer self-assembly techniques for nanostructured devices, and the synthesis of carbon based nanomaterials. Part two goes on to highlight the application of nanomaterials in soft tissue engineering and includes chapters on cardiac, neural, and cartilage tissue engineering. Finally, the use of nanomaterials in hard tissue engineering applications, including bone, dental and craniofacial tissue engineering is discussed in part three. Nanomaterials in tissue engineering is a standard reference for researchers and tissue engineers with an interest in nanomaterials, laboratories investigating biomaterials, and academics interested in materials science, chemical engineering, biomedical engineering and biological sciences. Explores the fabrication of a variety of nanomaterials and their use across a range of tissue engineering applications Examines engineering nanoporous biomaterials, layer-by-layer self-assembly techniques for nanostructured devices, and the synthesis of carbon based nanomaterials Highlights the application of nanomaterials in soft tissue engineering and includes chapters on cardiac, neural, and cartilage tissue engineering