Cartilage Tissue Engineering And Regeneration Techniques

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Cartilage Tissue Engineering and Regeneration Techniques

Dimitrios D. Nikolopoulos,George K. Safos,Kalpaxis Dimitrios
Cartilage Tissue Engineering and Regeneration Techniques Book PDF

Author : Dimitrios D. Nikolopoulos,George K. Safos,Kalpaxis Dimitrios
Publisher : BoD – Books on Demand
Page : 160 pages
File Size : 48,9 Mb
Release : 2019-06-05
Category : Technology & Engineering
ISBN : 9781789238495

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Cartilage Tissue Engineering and Regeneration Techniques by Dimitrios D. Nikolopoulos,George K. Safos,Kalpaxis Dimitrios Pdf

Osteochondral defects can be challenging to treat, first, because the damaged articular cartilage has a poor intrinsic reparative capability, and second, because these defects cause chronic pain and serious disability. That is why cartilage repair remains one of the most challenging issues of musculoskeletal medicine. Arthroscopic and open techniques that have been developed over the last two decades intend to promote the success of complete repair of the articular cartilage defects; nevertheless, these therapies cannot always offer 100% success. Nowadays, cartilage tissue engineering is an emerging technique for the regeneration of cartilage tissue. Taking into consideration these perspectives, this book aims to present a summary of cartilage tissue engineering, including development, recent progress, and major steps taken toward the regeneration of functional cartilage tissue. Special emphasis is placed on the role of stimulating factors, including growth factors, gene therapies, as well as scaffolds, including natural, synthetic, and nanostructured.

Cartilage Tissue Engineering and Regeneration Techniques

Kalpaxis Dimitrios,George K. Safos,Dimitrios D. Nikolopoulos
Cartilage Tissue Engineering and Regeneration Techniques Book PDF

Author : Kalpaxis Dimitrios,George K. Safos,Dimitrios D. Nikolopoulos
Publisher : Unknown
Page : 158 pages
File Size : 41,5 Mb
Release : 2019
Category : Medicine (General)
ISBN : 1838807810

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Cartilage Tissue Engineering and Regeneration Techniques by Kalpaxis Dimitrios,George K. Safos,Dimitrios D. Nikolopoulos Pdf

Osteochondral defects can be challenging to treat, first, because the damaged articular cartilage has a poor intrinsic reparative capability, and second, because these defects cause chronic pain and serious disability. That is why cartilage repair remains one of the most challenging issues of musculoskeletal medicine. Arthroscopic and open techniques that have been developed over the last two decades intend to promote the success of complete repair of the articular cartilage defects; nevertheless, these therapies cannot always offer 100% success. Nowadays, cartilage tissue engineering is an emerging technique for the regeneration of cartilage tissue. Taking into consideration these perspectives, this book aims to present a summary of cartilage tissue engineering, including development, recent progress, and major steps taken toward the regeneration of functional cartilage tissue. Special emphasis is placed on the role of stimulating factors, including growth factors, gene therapies, as well as scaffolds, including natural, synthetic, and nanostructured.

Articular Cartilage Tissue Engineering

Kyriacos A. Athanasiou,Eric M. Darling,Jerry C. Hu
Articular Cartilage Tissue Engineering Book PDF

Author : Kyriacos A. Athanasiou,Eric M. Darling,Jerry C. Hu
Publisher : Morgan & Claypool Publishers
Page : 183 pages
File Size : 45,7 Mb
Release : 2010
Category : Medical
ISBN : 9781598298758

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Articular Cartilage Tissue Engineering by Kyriacos A. Athanasiou,Eric M. Darling,Jerry C. Hu Pdf

Cartilage injuries in children and adolescents are increasingly observed, with roughly 20% of knee injuries in adolescents requiring surgery. In the US alone, costs of osteoarthritis (OA) are in excess of $65 billion per year (both medical costs and lost wages). Comorbidities are common with OA and are also costly to manage. Articular cartilage's low friction and high capacity to bear load makes it critical in the movement of one bone against another, and its lack of a sustained natural healing response has necessitated a plethora of therapies. Tissue engineering is an emerging technology at the threshold of translation to clinical use. Replacement cartilage can be constructed in the laboratory to recapitulate the functional requirements of native tissues. This book outlines the biomechanical and biochemical characteristics of articular cartilage in both normal and pathological states, through development and aging. It also provides a historical perspective of past and current cartilage treatments and previous tissue engineering efforts. Methods and standards for evaluating the function of engineered tissues are discussed, and current cartilage products are presented with an analysis on the United States Food and Drug Administration regulatory pathways that products must follow to market. This book was written to serve as a reference for researchers seeking to learn about articular cartilage, for undergraduate and graduate level courses, and as a compendium of articular cartilage tissue engineering design criteria. Table of Contents: Hyaline Articular Cartilage / Cartilage Aging and Pathology / In Vitro / Bioreactors / Future Directions

Cartilage Regeneration

Yunfeng Lin
Cartilage Regeneration Book PDF

Author : Yunfeng Lin
Publisher : Humana Press
Page : 97 pages
File Size : 51,7 Mb
Release : 2017-02-21
Category : Science
ISBN : 9783319516172

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Cartilage Regeneration by Yunfeng Lin Pdf

This book focuses on cartilage defects and new mesenchymal stem cell-based treatments for their repair and regeneration. Early chapters provide a review of current etiological findings and repair methods of cartilage defects. The next chapters discuss fundamental concepts and features of MSCs, including their proliferation, differentiation, migration and immunomodulatory effects. The discussion also includes clinical applications of MSCs in cartilage tissues, especially with regards to various animal models, biomaterials and transferring techniques. Cartilage Regeneration focuses on the biology of MSCs and their possible applications in cartilage reconstruction, with the goal of bringing new insights into regenerative medicine. It will be essential reading for researchers and clinicians in stem cells, regenerative medicine, biomedical engineering and orthopedic surgery.

Cartilage Tissue Engineering

Martin J. Stoddart,Elena Della Bella,Angela R. Armiento
Cartilage Tissue Engineering Book PDF

Author : Martin J. Stoddart,Elena Della Bella,Angela R. Armiento
Publisher : Springer Nature
Page : 392 pages
File Size : 50,8 Mb
Release : 2022-11-10
Category : Science
ISBN : 9781071628393

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Cartilage Tissue Engineering by Martin J. Stoddart,Elena Della Bella,Angela R. Armiento Pdf

This detailed book brings together a collection of methodologies, from the most basic to the more complex, that provides researchers with a platform they can use to embark on a cartilage research career. To aid in the search for novel therapies for cartilage regeneration, this volume addresses 3D cartilage models, challenges associated with RNA and protein extraction, imaging, gene transfer, as well as stable differentiation and variations in cell phenotype from different tissue origins. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Cartilage Tissue Engineering serves as an ideal guide for researchers working to advance the vital study of cartilage biology and repair.

Cartilage: From Biology to Biofabrication

Mohamadreza Baghaban Eslaminejad,Samaneh Hosseini
Cartilage From Biology to Biofabrication Book PDF

Author : Mohamadreza Baghaban Eslaminejad,Samaneh Hosseini
Publisher : Springer Nature
Page : 531 pages
File Size : 46,9 Mb
Release : 2023-07-11
Category : Science
ISBN : 9789819924523

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Cartilage: From Biology to Biofabrication by Mohamadreza Baghaban Eslaminejad,Samaneh Hosseini Pdf

This book provides a comprehensive overview of cartilage structure, functions, and approaches for the regeneration of cartilage tissue. It reviews multiple signaling pathways that are involved in the growth and repair of cartilage tissue. The initial chapter of the book examines the etiology, diagnosis, and pathological features of various cartilage diseases. Subsequently, the book presents recent advances in biomaterial sciences, regenerative medicine, and fabrication technology for cartilage regeneration. It discusses hydrogels as a promising scaffold for cartilage tissue engineering, focusing on recapitulating microenvironments present during development or in adult tissue to induce the formation of cartilaginous constructs with biochemical and mechanical properties of native tissue. Lastly, it covers the applications of 3 D printing techniques for the fabrication of scaffolds for cartilage tissue regeneration for the production of biological implants capable of treating a range of conditions.

Tissue Engineering for Artificial Organs, 2 Volume Set

Anwarul Hasan
Tissue Engineering for Artificial Organs 2 Volume Set Book PDF

Author : Anwarul Hasan
Publisher : John Wiley & Sons
Page : 762 pages
File Size : 55,9 Mb
Release : 2017-06-19
Category : Science
ISBN : 9783527338634

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Tissue Engineering for Artificial Organs, 2 Volume Set by Anwarul Hasan Pdf

A comprehensive overview of the latest achievements, trends, and the current state of the art of this important and rapidly expanding field. Clearly and logically structured, the first part of the book explores the fundamentals of tissue engineering, providing a separate chapter on each of the basic topics, including biomaterials stem cells, biosensors and bioreactors. The second part then follows a more applied approach, discussing various applications of tissue engineering, such as the replacement or repairing of skins, cartilages, livers and blood vessels, to trachea, lungs and cardiac tissues, to musculoskeletal tissue engineering used for bones and ligaments as well as pancreas, kidney and neural tissue engineering for the brain. The book concludes with a look at future technological advances. An invaluable reading for entrants to the field in biomedical engineering as well as expert researchers and developers in industry.

Tissue Engineering of Cartilage and Bone

Gregory R. Bock,Jamie A. Goode
Tissue Engineering of Cartilage and Bone Book PDF

Author : Gregory R. Bock,Jamie A. Goode
Publisher : John Wiley & Sons
Page : 262 pages
File Size : 53,9 Mb
Release : 2003-07-22
Category : Medical
ISBN : 9780470864234

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Tissue Engineering of Cartilage and Bone by Gregory R. Bock,Jamie A. Goode Pdf

Tissue engineering takes advantages of the combined use of cultured living cells and three-dimensional scaffolds to reconstruct adult tissues that are absent or malfunctioning. This book brings together scientists and clinicians working on a variety of approaches for regenerating of damaged or lost cartilage and bone to assess the progress of this dynamic field. In its early days, tissue engineering was driven by material scientists who designed novel bio-resorbable scaffolds on which to seed cells and grow tissues. This ground-breaking work generated high expectations, but there have been significant stumbling blocks holding back the widespread use of these techniques in the clinic. These challenges, and potential ways of overcoming them, are given thorough coverage in the discussions that follow each chapter. The key questions addressed in this book include the following. How good must cartilage repair be for it to be worthwhile? What is the best source of cells for tissue engineering of both bone and cartilage? Which are the most effective cell scaffolds? What are the best preclinical models for these technologies? And when it comes to clinical trials, what sort of outcome measures should be used? With contributions from some of the leading experts in this field, this timely publication will prove essential reading for anyone with an interest in the field of tissue engineering.

A Tissue Regeneration Approach to Bone and Cartilage Repair

Hala Zreiqat,Colin R. Dunstan,Vicki Rosen
A Tissue Regeneration Approach to Bone and Cartilage Repair Book PDF

Author : Hala Zreiqat,Colin R. Dunstan,Vicki Rosen
Publisher : Springer
Page : 254 pages
File Size : 40,8 Mb
Release : 2014-12-05
Category : Technology & Engineering
ISBN : 9783319132662

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A Tissue Regeneration Approach to Bone and Cartilage Repair by Hala Zreiqat,Colin R. Dunstan,Vicki Rosen Pdf

Reviewing exhaustively the current state of the art of tissue engineering strategies for regenerating bones and joints through the use of biomaterials, growth factors and stem cells, along with an investigation of the interactions between biomaterials, bone cells, growth factors and added stem cells and how together skeletal tissues can be optimised, this book serves to highlight the importance of biomaterials composition, surface topography, architectural and mechanical properties in providing support for tissue regeneration. Maximizing reader insights into the importance of the interplay of these attributes with bone cells (osteoblasts, osteocytes and osteoclasts) and cartilage cells (chondrocytes), this book also provides a detailed reference as to how key signalling pathways are activated. The contribution of growth factors to drive tissue regeneration and stem cell recruitment is discussed along with a review the potential and challenges of adult or embryonic mesenchymal stem cells to further enhance the formation of new bone and cartilage tissues. This book serves to demonstrate the interconnectedness of biomaterials, bone/cartilage cells, growth factors and stem cells in determining the regenerative process and thus the clinical outcome.

Cartilage Tissue Engineering

Pauline M. Doran
Cartilage Tissue Engineering Book PDF

Author : Pauline M. Doran
Publisher : Unknown
Page : 290 pages
File Size : 43,5 Mb
Release : 2015
Category : Biotechnology
ISBN : 1493929380

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Cartilage Tissue Engineering by Pauline M. Doran Pdf

This volume aims to describe clearly and in detail the key practical skills involved in cartilage tissue engineering. Methods are outlined for isolation and expansion of chondrocytes and stem cells; differentiation; synthesis and application of three-dimensional scaffolds; design and operation of bioreactors; in vivo testing of engineered constructs; and molecular and functional analysis of cartilage cells and tissues.

Cartilage

Susanne Grässel,Attila Aszódi
Cartilage Book PDF

Author : Susanne Grässel,Attila Aszódi
Publisher : Springer
Page : 206 pages
File Size : 55,5 Mb
Release : 2017-05-09
Category : Medical
ISBN : 9783319533162

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Cartilage by Susanne Grässel,Attila Aszódi Pdf

In three Volumes this mini book series presents current knowledge and new perspectives on cartilage as a specialized yet versatile tissue. This third volume provides insight into current and future treatment strategies for repair of cartilage lesions. This book addresses Professors, researchers and PhD students who are interested in musculoskeletal and cartilage pathobiology and tissue-engineering.

Bone and Cartilage Regeneration

Phuc Van Pham
Bone and Cartilage Regeneration Book PDF

Author : Phuc Van Pham
Publisher : Springer
Page : 315 pages
File Size : 50,6 Mb
Release : 2017-01-24
Category : Science
ISBN : 9783319401447

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Bone and Cartilage Regeneration by Phuc Van Pham Pdf

This invaluable resource discusses clinical applications with effects and side-effects of applications of stem cells in bone and cartilage regeneration. Each chapter is contributed by a pre-eminent scientist in the field and covers such topics as skeletal regeneration by mesenchymal stem cells, clinical improvement of mesenchymal stem cell injection in injured cartilage and osteoarthritis, Good manufacturing practice (GMP), minimal critera of stem cells for clinical applications, future directions of the discussed therapies and much more. Bone & Cartilage Regeneration and the other books in the Stem Cells in Clinical Applications series will be invaluable to scientists, researchers, advanced students and clinicians working in stem cells, regenerative medicine or tissue engineering.

Bone and Cartilage Engineering

Ulrich Meyer,Hans Peter Wiesmann
Bone and Cartilage Engineering Book PDF

Author : Ulrich Meyer,Hans Peter Wiesmann
Publisher : Springer Science & Business Media
Page : 272 pages
File Size : 50,8 Mb
Release : 2006-08-02
Category : Medical
ISBN : 9783540336068

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Bone and Cartilage Engineering by Ulrich Meyer,Hans Peter Wiesmann Pdf

Bone and Cartilage Engineering provides a complete overview of recent knowledge in bone and cartilage tissue engineering. It follows a logical approach to the various aspects of extracorporal bone and cartilage tissue engineering. The cooperation between a basic scientist and a clinician made it possible to structure the book's content and style according to the interdisciplinary character of the field. The comprehensive nature of the book, including detailed descriptions of laboratory procedures, preclinical approaches, clinical applications, and regulatory issues, will make it an invaluable basis for everyone working in this field. This book will serve as a fundamental tool for basic researchers to establish or refine tissue engineering techniques as well as for clinicians to understand and use this modern therapeutic option.

Osteochondral Tissue Engineering

J. Miguel Oliveira,Sandra Pina,Rui L. Reis,Julio San Roman
Osteochondral Tissue Engineering Book PDF

Author : J. Miguel Oliveira,Sandra Pina,Rui L. Reis,Julio San Roman
Publisher : Springer
Page : 438 pages
File Size : 41,8 Mb
Release : 2018-04-24
Category : Science
ISBN : 9783319767116

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Osteochondral Tissue Engineering by J. Miguel Oliveira,Sandra Pina,Rui L. Reis,Julio San Roman Pdf

This book reviews the most recent developments in the field of osteochondral tissue engineering (OCTE) and presents challenges and strategies being developed that face not only bone and cartilage regeneration, but also establish osteochondral interface formation in order to translate it into a clinical setting. Topics include nanotechnology approaches and biomaterials advances in osteochondral engineering, advanced processing methodology, as well as scaffolding and surface engineering strategies in OCTE. Hydrogel systems for osteochondral applications are also detailed thoroughly. Osteochondral Tissue Engineering: Nanotechnology, Scaffolding-Related Developments and Translation is an ideal book for biomedical engineering students and a wide range of established researchers and professionals working in the orthopedic field.

Musculoskeletal Tissue Regeneration

William S. Pietrzak
Musculoskeletal Tissue Regeneration Book PDF

Author : William S. Pietrzak
Publisher : Springer Science & Business Media
Page : 649 pages
File Size : 41,6 Mb
Release : 2008-04-11
Category : Medical
ISBN : 9781597452397

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Musculoskeletal Tissue Regeneration by William S. Pietrzak Pdf

The repair of musculoskeletal tissue is a vital concern of all surgical specialties, orthopedics and related disciplines. Written by recognized experts, this book aims to provide both basic and advanced knowledge of the newer methodologies being developed and introduced to the clinical arena. A valuable resource for researchers, developers, and clinicians, the book presents a foundation to propel the technology and integration of the current state of knowledge into the 21st century.