Caspase 3

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Innovative Medicine

Kazuwa Nakao,Nagahiro Minato,Shinji Uemoto
Innovative Medicine Book PDF

Author : Kazuwa Nakao,Nagahiro Minato,Shinji Uemoto
Publisher : Springer
Page : 330 pages
File Size : 44,9 Mb
Release : 2015-10-13
Category : Science
ISBN : 9784431556510

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Innovative Medicine by Kazuwa Nakao,Nagahiro Minato,Shinji Uemoto Pdf

This book is devoted to innovative medicine, comprising the proceedings of the Uehara Memorial Foundation Symposium 2014. It remains extremely rare for the findings of basic research to be developed into clinical applications, and it takes a long time for the process to be achieved. The task of advancing the development of basic research into clinical reality lies with translational science, yet the field seems to struggle to find a way to move forward. To create innovative medical technology, many steps need to be taken: development and analysis of optimal animal models of human diseases, elucidation of genomic and epidemiological data, and establishment of “proof of concept”. There is also considerable demand for progress in drug research, new surgical procedures, and new clinical devices and equipment. While the original research target may be rare diseases, it is also important to apply those findings more broadly to common diseases. The book covers a wide range of topics and is organized into three complementary parts. The first part is basic research for innovative medicine, the second is translational research for innovative medicine, and the third is new technology for innovative medicine. This book helps to understand innovative medicine and to make progress in its realization.

Caspase-3

Lunawati L. Bennett
Caspase 3 Book PDF

Author : Lunawati L. Bennett
Publisher : Nova Science Publishers
Page : 169 pages
File Size : 53,8 Mb
Release : 2020
Category : Science
ISBN : 1536186864

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Caspase-3 by Lunawati L. Bennett Pdf

"Caspase 3: Structure, Functions and Interactions" is a book designed as an educational resource for researchers and health care providers who want to learn more about caspase 3. Physicians, pharmacists, other health care professionals can benefit from learning about the function of caspase 3 and its role in diseases and possible treatment options of using caspase 3-like compounds. New or seasoned scientists with research interests in caspases can learn novel ideas or interventions using caspase 3. Caspases are a family of enzymes that play an important role in developing normal organ formation and function, maintaining homeostasis, and regulating cell death and inflammation. There are 14 known caspase enzymes in mammals, and 12 present in humans. Each caspase varies in purpose and mechanism of action. Caspase-3 is a key cysteine-aspartic protease that is largely known for its role in executing cell death or apoptosis. There are a total of 8 chapters in the book. Chapter 1 introduces the caspase family, their classification, regulation, and role in apoptosis. Chapter 2 discusses caspase-3 role in causing or preventing diseases such as cardiac, diabetes, and cancer. Chapter 3 highlights the emerging roles of caspase-3 in biological processes beyond cell death. Complex regulatory mechanisms are required to coordinate timely and specific activation of caspase 3. As cancer continues to escalate as a major public health concern, caspase 3 role as the prominent executioner of apoptosis plays a central role as a key cellular protein as discussed in Chapter 4. Chapter 5 highlights our understanding on the activation of caspase 3/9 in starfish unfertilized eggs which elucidate the relationship of apoptosis in the vertebrates and nematodes. Chapter 6 discusses the interaction of caspase 3 with apoptotic peptide known as (KLAKLAK)2. Because of the cationic and amphipathic nature of (KLAKLAK)2, this peptide has the unique ability to cause the formation of apoptosome. Chapter 7 identifies caspase 3 role in central nervous system, aging, regeneration of neurons, and in Alzheimer's, Parkinson's, and other neurodegenerative diseases. Chapter 8 discusses biomarker and methods to detect caspase 3, and its interaction with different substrates and compounds. Recent reputable books, journals, monograms, clinical trial results, and hands-on research data are used. This book was written by doctor of philosophy (PhDs) that are doing research in the field of caspase 3. We hope this book become a valuable resource for researchers and others who want to know more about caspase 3 structure, functions and interactions"--

Programmed Cell Death in Cancer Progression and Therapy

Roya Khosravi-Far,Eileen White
Programmed Cell Death in Cancer Progression and Therapy Book PDF

Author : Roya Khosravi-Far,Eileen White
Publisher : Springer Science & Business Media
Page : 356 pages
File Size : 42,7 Mb
Release : 2007-12-29
Category : Medical
ISBN : 9781402065545

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Programmed Cell Death in Cancer Progression and Therapy by Roya Khosravi-Far,Eileen White Pdf

Programmed cell death (PCD) plays pivotal roles in tumor progression, cancer therapeutics and resistance of tumor cells to therapy. This book examines the mechanisms involved in mediating and regulating PCD in cancer. It also provides a detailed indication of the utility of PCD in cancer therapy. The book features chapters on the current and future of RNA interference in therapeutics and Pathways involved in Stem Cell Survival and Death.

Apoptosis and Cancer

Gil Mor,Ayesha Alvero
Apoptosis and Cancer Book PDF

Author : Gil Mor,Ayesha Alvero
Publisher : Humana Press
Page : 0 pages
File Size : 45,7 Mb
Release : 2014-10-13
Category : Medical
ISBN : 1493916602

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Apoptosis and Cancer by Gil Mor,Ayesha Alvero Pdf

In Apoptosis and Cancer: Methods and Protocols, Second Edition, expert researches in the field detail the performance of molecular and cellular biology techniques for studying and detecting the activation of the apoptotic pathway. Chapters focus on assays developed to detect its activation not only in vitro but also in vivo, optimized multiplex analysis, medium- to high-throughput screens, and the cellular process. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Apoptosis and Cancer: Methods and Protocols, Second Edition aids scientists as a stand-alone resource for the execution and analysis of the described protocols and as a reference for the study and detection of apoptosis within and outside the area of cancer research.

Protein Dimerization and Oligomerization in Biology

Jacqueline M. Matthews
Protein Dimerization and Oligomerization in Biology Book PDF

Author : Jacqueline M. Matthews
Publisher : Springer Science & Business Media
Page : 170 pages
File Size : 54,7 Mb
Release : 2012-09-04
Category : Medical
ISBN : 9781461432296

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Protein Dimerization and Oligomerization in Biology by Jacqueline M. Matthews Pdf

This volume has a strong focus on homo-oligomerization, which is surprisingly common. However, protein function is so often linked to both homo- and hetero-oligomerization and many heterologous interactions likely evolved from homologous interaction, so this volume also covers many aspects of hetero-oligomerization.

Design of Caspase Inhibitors as Potential Clinical Agents

Tom O'Brien,Steven D. Linton
Design of Caspase Inhibitors as Potential Clinical Agents Book PDF

Author : Tom O'Brien,Steven D. Linton
Publisher : CRC Press
Page : 312 pages
File Size : 48,5 Mb
Release : 2008-10-28
Category : Science
ISBN : 1420045415

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Design of Caspase Inhibitors as Potential Clinical Agents by Tom O'Brien,Steven D. Linton Pdf

Presents the Therapeutic Potential for Caspase Inhibitors: Present and Future Caspases represent one of the most specific protease families described to date. These extremely important enzymes are crucial to the destruction of aberrant cells – the body’s self-protection mechanism for warding off the growth of abnormal cells, many of which can promote cancer. Design of Caspase Inhibitors as Potential Clinical Agents introduces cutting-edge evidence regarding caspases’ role in pro-inflammatory responses. New research now shows that the inhibition of caspase function is a critical component for the treatment of many diseases, including: Arthritic and neurological disorders Lung disease Hereditary fever syndromes Inflammatory bowel and skin diseases Sepsis Liver fibrosis Outlines Efforts to Develop Molecule Inhibitors for Caspase Activity Transformation Under the editorial guidance of authoritative inflammatory disease, small molecule discovery, and apoptosis researchers, the book organizes the wide array of caspase literature into one convenient resource. It also summarizes the relative difficulty of transitioning a caspase small molecule inhibitor from the lab to the clinic and suggests approaches to circumvent this difficulty. Taking a novel, yet core approach to disease treatment, this seminal work sets the stage to combat a slew of debilitating diseases through groundbreaking drug development.

New Mechanisms for Anti-Cancer Drugs

Ayaz Shahid
New Mechanisms for Anti Cancer Drugs Book PDF

Author : Ayaz Shahid
Publisher : Frontiers Media SA
Page : 353 pages
File Size : 46,6 Mb
Release : 2024-04-15
Category : Science
ISBN : 9782832547847

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New Mechanisms for Anti-Cancer Drugs by Ayaz Shahid Pdf

Cancer is the second leading cause of death. Every year, many anticancer drug candidates are discovered and synthesized, but the major challenge lies in identifying, characterizing and evaluating their efficacy. The aim of this Research Topic, "New Mechanisms for Anti-Cancer Drugs" is to collect a group of publications focused on novel chemical compounds exhibiting new modes of actions and/or new target proteins to fulfill their cytotoxic activity on cancer cells. In this context, we will also be pleased to consider studies on drug repurposing, including approved, discontinued, and shelved drugs, when anti-cancer activity results from an unexpected mode of action.

Zinc Signaling

Toshiyuki Fukada,Taiho Kambe
Zinc Signaling Book PDF

Author : Toshiyuki Fukada,Taiho Kambe
Publisher : Springer Nature
Page : 412 pages
File Size : 44,8 Mb
Release : 2019-12-13
Category : Medical
ISBN : 9789811505577

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Zinc Signaling by Toshiyuki Fukada,Taiho Kambe Pdf

This book, now in an extensively revised second edition, describes the crucial role of zinc signaling in biological processes on a molecular and physiological basis. Global leaders in the field review the latest knowledge, including the very significant advances in understanding that have been achieved since publication of the first edition. Detailed information is provided on all the essentials of zinc signaling, covering molecular aspects and the roles of zinc transporters, the zinc sensing receptor, and metallothioneins. Detection techniques for zinc signals, involving genetically encoded and chemical probes, are also described. The critical contributions of the zinc signal in maintaining health and the adverse consequences of any imbalance in the signal are then thoroughly addressed. Here, readers will find up-to-date information on the significance of the zinc signal in a wide range of conditions, including cardiovascular disorders, neurodegenerative diseases, diabetes, autoimmune diseases, inflammatory conditions, skin disease, osteoarthritis, and cancer. The book will be of value for researchers, clinicians, and advanced students.

Apoptotic Pathways as Targets for Novel Therapies in Cancer and Other Diseases

Marek Los,Spencer B. Gibson
Apoptotic Pathways as Targets for Novel Therapies in Cancer and Other Diseases Book PDF

Author : Marek Los,Spencer B. Gibson
Publisher : Springer Science & Business Media
Page : 411 pages
File Size : 42,8 Mb
Release : 2006-06-20
Category : Medical
ISBN : 9780387236957

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Apoptotic Pathways as Targets for Novel Therapies in Cancer and Other Diseases by Marek Los,Spencer B. Gibson Pdf

As our understanding of apoptotic pathway expands, we are coming to realize the great potential of utilizing this pathway to treat diseases such as cancer. The book attempts to review, summarize, and speculate on the apoptotic pathways, how are they regulated and how targeted therapies are being used to treat a wide variety of diseases. Special emphasis is placed on cancer since new treatments either being developed or currently in the clinical setting are showing great promise to increase survival rates for cancer patients. Chapters will address the biology behind regulating the apoptotic pathways and what goes wrong in disease states whereas other chapters will concentrate on new therapies targeting apoptotic pathways. The reader by the end of the book should have greater insight into the understanding and utilization of apoptotic pathways to fight diseases such as cancer.

Radicals for Life

Ernst van Faassen,Anatoly Vanin
Radicals for Life Book PDF

Author : Ernst van Faassen,Anatoly Vanin
Publisher : Elsevier
Page : 442 pages
File Size : 49,8 Mb
Release : 2011-10-13
Category : Science
ISBN : 0080489591

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Radicals for Life by Ernst van Faassen,Anatoly Vanin Pdf

Radicals for Life: the Various Forms of Nitric Oxide provides an up-to-date overview of the role of nitrosocompounds and nitrosyl-iron complexes in physiology. Nitrosocompounds can be considered as stabilised forms of nitric oxide, one of the most important regulatory molecules in physiology today. Many nitrosocompounds share some of the physiological functions of nitric oxide, and may be formed inside living organisms. This is the first book to be published that is dedicated to the role of such nitrosocompounds in physiology, with particular emphasis on the nitrosocompounds that are endogenously formed in higher organisms and humans. Points of discussion include: physical and chemical properties of the compounds, the main chemical pathways in vivo, as well as the physiological effects that have been recognised to date. Each of the nineteen chapters is written by distinguished specialists in the field, well known for their original and important contributions to the subject. Also included are results from a wide range of studies in vitro, in cell cultures, animal models and human volunteers. Examples of alternative forms of nitric oxide, with special emphasis on their protective role against widespread human diseases like atherosclerosis, Alzheimer's disease, diabetes, sexual dysfunction, and renal insufficiency to stroke and ischemia are also included. First monograph to consider and provide an overview of endogenous nitrosocompounds and nitrosyl-iron complexes Extensive bibliographic references, written by specialists of human physiology Providing high scientific quality with a focus on implications for human diseases

Human Cytomegalovirus

Thomas E. Shenk,Mark F. Stinski
Human Cytomegalovirus Book PDF

Author : Thomas E. Shenk,Mark F. Stinski
Publisher : Springer Science & Business Media
Page : 479 pages
File Size : 53,8 Mb
Release : 2008-05-09
Category : Medical
ISBN : 9783540773498

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Human Cytomegalovirus by Thomas E. Shenk,Mark F. Stinski Pdf

This volume has gathered some of the experts in the field to review aspects of our understanding of CMV and to offer perspectives of the current problems associated with CMV. The editors and authors hope that the chapters will lead to a better understanding of the virus that will assist in the development of new and unique antivirals, a protective vaccine, and a full understanding of CMV's involvement in human disease.

Initiator Caspases—Advances in Research and Application: 2013 Edition

Anonim
Initiator Caspases Advances in Research and Application 2013 Edition Book PDF

Author : Anonim
Publisher : ScholarlyEditions
Page : 66 pages
File Size : 51,7 Mb
Release : 2013-06-21
Category : Science
ISBN : 9781481688949

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Initiator Caspases—Advances in Research and Application: 2013 Edition by Anonim Pdf

Initiator Caspases—Advances in Research and Application: 2013 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Caspase 8 in a concise format. The editors have built Initiator Caspases—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Caspase 8 in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Initiator Caspases—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Effector Caspases—Advances in Research and Application: 2012 Edition

Anonim
Effector Caspases Advances in Research and Application 2012 Edition Book PDF

Author : Anonim
Publisher : ScholarlyEditions
Page : 661 pages
File Size : 53,9 Mb
Release : 2012-12-26
Category : Science
ISBN : 9781464994128

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Effector Caspases—Advances in Research and Application: 2012 Edition by Anonim Pdf

Effector Caspases—Advances in Research and Application: 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Effector Caspases. The editors have built Effector Caspases—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Effector Caspases in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Effector Caspases—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

New Developments in Metastasis Suppressor Research

Paul Jackson
New Developments in Metastasis Suppressor Research Book PDF

Author : Paul Jackson
Publisher : Nova Publishers
Page : 340 pages
File Size : 48,5 Mb
Release : 2007
Category : Antioncogenes
ISBN : 160021603X

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New Developments in Metastasis Suppressor Research by Paul Jackson Pdf

The spread of cancer cells from their organ of origin to distant tissues is called metastasis. Cancer metastasis is the main cause of death from cancer, and in many cases is difficult to detect or treat. The process by which tumour cells become metastatic is complex and involves many stages, including detachment of cells from the main tumour mass, degradation of the surrounding extra-cellular matrix, invasion into nearby blood vessels, travel and survival through the circulatory system, attachment to a vessel wall, extra-vasation, degradation of the extra-cellular matrix into a distant tissue/organ, and the development of a novel blood supply. In order to accomplish this process, the cells acquire characteristics which are important for each stage. Recently, a class of genes known as metastasis suppressors' has been the subject of intense investigation. For some metastasis suppressor genes, there is strong evidence from both in vitro and in vivo studies to demonstrate key roles in the metastatic process, for others data is much more limited, and their importance uncertain. In this book, chapters are devoted to providing up-to-date summaries of our understanding of individual metastasis suppressor genes. Each is written by a leading authority in the study of that gene. Topics covered include discussions on how each metastasis suppressor was discovered, the mechanisms underlying their loss of expression in tumours and tumour cell lines, their proposed molecular functions, and the consequences to a tumour cell of the loss of this function. This compilation aims to provide, in a single volume, comprehensive information that will be valuable to all scientists working in cancer research, to students needing to understand molecular events that regulate tumour progression and the acquisition of metastasis, and to clinicians who might wish to know more of the roles of potentially new markers for cancer diagnosis and prognosis.

Neurotoxic Factors in Parkinson’s Disease and Related Disorders

Michael Storch,Alexander Storch,Michael A. Collins
Neurotoxic Factors in Parkinson s Disease and Related Disorders Book PDF

Author : Michael Storch,Alexander Storch,Michael A. Collins
Publisher : Springer Science & Business Media
Page : 362 pages
File Size : 45,8 Mb
Release : 2000
Category : Medical
ISBN : 0306465299

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Neurotoxic Factors in Parkinson’s Disease and Related Disorders by Michael Storch,Alexander Storch,Michael A. Collins Pdf

nd This book stems from the 2 Parkinson's Disease Symposium on "Neurotoxic Factors in Parkinsons disease and related disorders", held on August 6-7,1999 at the University ofUlm Medical School in Ulm at the Danube, Germany. The symposium wasalso asatellite ofthejointmeetingofthe InternationalSocietyfor Neurochemistry (ISN) and the European Society for Neurochemistry (ESN) that followed immediately afterwards in Berlin. The specific topic, neurotoxic factors in Parkinson's disease (PD), was chosen in light of accumulating neurobiological and epidemiological evidence indicating that the causes of this second most common neurodegenerative disorder, and possibly of related conditions such as multiple systems atrophy, in some manner involve environ­ mental (xenobiotic) and even endogenous toxic agents. This volume brings together much of that neurobiological evidence; and in epidemiology, several recent major studies ofPD - for example, a study of20,000 twins published in the Journal of the American Medical Association in 1999 - conclude that environmental and life style than genetics, appear to be critical in the idiopathic disease. However, factors, rather the precise roles of neurotoxic factors in the pathogenesis of PD and related basal ganglia disorders remain uncertain, despite the cascade of research resulting from the discovery of the prototype MPTP in the early 1980's, and frankly, we have been surprised by the paucity of concentrated attention on specific environmental agents other than MPTP.