Cell Adhesion And Cytoskeletal Molecules In Metastasis
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Author : Anne E. Cress,Raymond B. Nagle Publisher : Springer Science & Business Media Page : 209 pages File Size : 47,6 Mb Release : 2007-01-20 Category : Medical ISBN : 9781402051296
Cell Adhesion and Cytoskeletal Molecules in Metastasis by Anne E. Cress,Raymond B. Nagle Pdf
This volume highlights the expression of specific adhesion molecules within human cancer tissues. It details the expression signatures from published DNA microarray and immunohistochemistry studies. Coverage discusses the concept that the alteration of specific adhesion molecules influence the cancer migration ability and cancer damage responses, both features are essential for the survival of an invading tumor cell.
Actin Cytoskeleton in Cancer Progression and Metastasis – Part C by Anonim Pdf
Actin Cytoskeleton in Cancer Progression and Metastasis - Part C, Volume 358 in the International Review of Cell and Molecular Biology series, provides an overview of the roles of the actin cytoskeleton and some of its key structural regulators, including WASp, Paxillin, Myosin, Testin, L-Plastin and profilin, in central processes underlying cancer progression and metastasis, such as changes in cell morphology and gene expression, acquisition of migratory and invasive capabilities, and evasion from the immune response. New chapters cover Actin isoforms in cancer, Actin cytoskeleton regulators at invadopodia, Cytoskeletal Mechanics Drives Heterogeneity in Epithelial Ovarian Cancer, and more. Provides comprehensive and timely reviews on actin cytoskeleton and its regulators in cancer biology Offers a wide range of perspectives for basic and translational research Discusses opportunities and challenges for translating knowledge of tumor cell actin cytoskeleton into clinical applications
The Actin Cytoskeleton in Cell Motility, Cancer, and Infection by Joel Pardee Pdf
The cell is no longer considered to be a bag full of enzymes dissolved in a liquid cytoplasm. It is now known that the cytoplasm is an exquisitely ordered structure of properly placed organelles and enzyme complexes that are suspended from an intricate network of structural protein polymers termed the cytoskeleton. All movement of organelles and vesicles within the cell is regulated by this cytoskeleton, and it is clear that the cytoskeleton is responsible for all of the cell's external movement as well. In this lecture, we will consider how the cytoskeleton elicits cell migration.The three main elements of the cytoskeleton are microtubules, intermediate filaments, and actin filaments. Microtubules are essential for (a) intracellular transport within the cytoplasm and transport between the nucleus and cytoplasm, (b) the structure and movement of all cilia and flagella, and (c) the structure of the mitotic spindle and movement of chromosomes on the spindle during cell division. Intermediate filaments give structural integrity to virtually all cells and tissues by providing an intracellular network of flexible cables that strengthen internal cell structure and stabilize cell-to-cell adhesion. It is this intercellular binding property that stably joins epithelial cells together to provide the protective functions of skin and the integrity of the intestinal mucosa.Actin is a highly conserved protein ubiquitous to all eukaryotic cells. Actin is absolutely required for (a) cell migration, (b) the contraction of muscle (both striated and smooth), (c) the structure and function of many cell protrusions (e.g., microvilli, filopodia, lamellopodia, blood platelet projections), (d) division of the cytoplasm (cytokinesis) during telophase of cell mitosis, and (e) movement and placement of organelles within the cell. Actin filaments are also called thin filaments because of their very slender (70 Ã…) diameter.
Actin Cytoskeleton in Cancer Progression and Metastasis - Part B by Anonim Pdf
Actin Cytoskeleton in Cancer Progression and Metastasis (Part B), Volume 356 in the International Review of Cell and Molecular Biology series, provides an overview on the roles of the actin cytoskeleton and its key structural regulators, including WASp, Paxillin, Myosin, Testin, L-Plastin and profilin, and in central processes underlying cancer progression and metastasis, such as changes in cell morphology and gene expression, acquisition of migratory and invasive capabilities, and evasion from the immune response. Specific chapters in this release cover Actin dynamics during tumor cell dissemination, Actin cytoskeleton remodeling during cancer cell migration, Cytoskeletal Mechanics Drives Heterogeneity in Epithelial Ovarian Cancer, and much more. Provides comprehensive and timely reviews on actin cytoskeleton and its regulators in cancer biology Offers a wide range of perspectives for basic and translational research Discusses opportunities and challenges for translating knowledge of tumor cell actin cytoskeleton into clinical applications
Actin Cytoskeleton in Cancer Progression and Metastasis - Part A by Anonim Pdf
Actin Cytoskeleton in Cancer Progression and Metastasis - Part A, Volume 355 in the International Review of Cell and Molecular Biology series, provides an overview of the roles of the actin cytoskeleton and some of its key structural regulators, including WASp, Paxillin, Myosin, Testin, L-Plastin and profilin, in central processes underlying cancer progression and metastasis, such as changes in cell morphology and gene expression, acquisition of migratory and invasive capabilities, and evasion from the immune response. Provides comprehensive and timely reviews on actin cytoskeleton and its regulators in cancer biology Offers a wide range of perspectives for basic and translational research Discusses opportunities and challenges for translating knowledge of tumor cell actin cytoskeleton into clinical applications
Cell Adhesion Molecules by Martin E. Hemler,Enrico Mihich Pdf
The Fourth Annual Pezcoller Symposium entitled Adhesion Molecules: Cellular Recognition Mechanisms was held in Rovereto, Italy, June 24-26, 1992 and was focussed on the detailed mechanisms whereby cells utilize certain integral membrane proteins to perceive their surrounding environment and interact with it. With timely presentations and stimulating discussions this Symposium addressed the genetics and biochemistry of adhesion molecules, the regulation of their functions and their role in cancer and the immune system. Emphasis was given to adhesion proteins in the integrin family because of the widespread distribution of this group of molecules and its important role in essentially all eukaryotic biological systems. The regulation of integrin genes and their expression are discussed in detail, as are specific aspects of the genetics of fibronectin. The molecular basis for the regulation of certain integrins, the function of these proteins in determining cell adhesion, and the consequences of this adhesion for the function of the cells involved are discussed. The role of certain integrins in stimulating signal transduction, the essential involvement of integrins in conditioning the function of T and NK cells function, the heterogeneity of integrins and its biological consequences, and the role of cell adhesion molecules in tumor cells invasion and metastases are all extensively analyzed. New information was presented on the role of CD44 and splice variants in normal differentiation and tumor progression.
Metastasis: From Cell Adhesion and Beyond by Vasiliki Gkretsi,Triantafyllos Stylianopoulos Pdf
This eBook consists of a collection of articles focused on fundamental processes of cancer cell metastasis, such as cell-Extracellular matrix adhesions, epithelial-to-mesenchymal transition (EMT) and lymph node metastasis as well as on upcoming research fields including the effects of biomechanical factors, the use of analytical and statistical tools and experimental techniques to further understand and characterize the invasive and metastatic potential of tumors.
Cell Migration by Frank Entschladen,Kurt S. Zänker Pdf
Cell migration is a highly complex process which involves several compartments of the cell, including surface receptors, signalling elements and the cytoskeleton. It plays an essential role in embryogenesis, wound healing and inflammatory responses, and a dysregulation of cell movement can cause pathological states such as developmental defects, chronic inflammation, cancer invasion and metastasis. Covering extracellular regulatory signals and intracellular signal transduction pathways as well as the molecular mechanisms of migration in stem cells, leukocytes and tumor cells in the adult human organism, this book summarizes the current state of knowledge about cell migration. In the first part, the major aspects of different migratory cells in health and disease are covered, with special emphasis on T lymphocytes. The second part provides a comprehensive overview of the principal molecular mechanisms of migration such as adhesion receptors, cytoskeletal rearrangements and locomotor force generation, which, together, can be referred to as a cell's 'migrosome'.With contributions by eminent international scientists from different disciplines this book will serve as a valuable resource not only for researchers in cell biology, immunology and oncology, but also for clinicians who wish to learn more about the role of migratory processes in health and disease.
Adhesive Interactions in Normal and Transformed Cells by Yury A. Rovensky Pdf
Adhesive Interactions in Normal and Transformed Cells describes the basic mechanisms of the ability of tissue cells to attach to each other and to the extracellular matrix. These adhesive interactions are pivotal regulators of main cellular functions, such as proliferation, survival and migration. The adhesive interactions are involved in embryonic development, regeneration, and also in inflammation and degeneration processes, which are at the basis of many diseases. Serious alterations in cell adhesion caused by the oncogenic transformation play a key role in cancer invasion and metastasis. This volume provides comprehensive information about structural, mechanistic and signaling aspects of adhesive interactions in both normal and cancer cells in comparison. Integration of such aspects of the adhesive process as structure, relation to cell systems of receptors and cytoskeleton, function, signaling pathways, and the alterations in tumor cells constitutes the strongest point of this work. The results of the long-time author’s research are included in the book. The author was one of pioneers, who used scanning electron microscopy (SEM) to study the cell surface morphology of normal cultured cells and the cells underwent the oncogenic transformation, processes of their attachment to and spreading on the surfaces of a solid substratum, and also surprising ability of the cells to respond to various geometric configurations of the substrata surfaces. Adhesive Interactions in Normal and Transformed Cells has both biological and medical aspects and, therefore, it can be interesting not only for cell biologists, developmental biologists and cancer researchers, but also for physicians. It is intended for researchers, postdocs, undergraduate and graduate students.
Cancer Metastasis, Molecular and Cellular Mechanisms and Clinical Intervention by Wen G. Jiang,R.E. Mansel Pdf
This book covers the molecular and cellular aspects of cancer metastasis, and discusses the clinical aspect of micro- and macro-metastases, which result in the death of the majority of patients with cancer. The current edition attempts to examine the current status of the basic scientific and clinical research in the area, and is a very useful reference for clinicians, oncologists, and biologists. It is intended for undergraduates as well as postgraduates in the area of medicine, oncology, and cancer biology.
Adhesion Molecules in Health and Disease by Paul Pdf
Provides an overview of the structure, transcription regulation and binding characteristics of cellular adhesion molecules and their ligands in the maintenance of function, immunological reactions and inflammatory processes with organ systems. The text examines the role of adhesion molecules in biological processes such as morphogenesis, blood coagulation, tumour metastasis, bone tissue remodelling and transplant rejection.
Adherens Junctions: from Molecular Mechanisms to Tissue Development and Disease by Tony Harris Pdf
Cell–cell adhesion is fundamental for the development and homeostasis of animal tissues and organs. Adherens junctions (AJs) are the best understood cell-cell adhesion complexes. In this volume, a group of internationally recognized experts reviews AJ biology over a wide range of organization; from atoms to molecules, to protein complexes, molecular networks, cells, tissues, and overall animal development. AJs have also been an integral part of animal evolution, and play central roles in cancer development, pathogen infection and other diseases. This book addresses major questions encompassing AJ biology. • How did AJs evolve? • How do cadherins and catenins interact to assemble AJs and mediate adhesion? • How do AJs interface with other cellular machinery to couple adhesion with the whole cell? • How do AJs affect cell behaviour and multicellular development? • How can abnormal AJ activity lead to disease?
Intermolecular Cross-talk in Tumor Metastasis by George G. Skouteris,Garth L. Nicolson Pdf
Metastasis of tumours is a sequence of events taking place after the appearance of a primary tumour. The potency of a tumour to metastasise greatly depends on the molecular interactions between tumour components (cellular differentiation and heterogeneity, surface antigenic determinants etc.) and the micro-environment. The complexity and diversity in the composition of tissue micro-environment is in great extent determining the metastatic behaviour or a primary tumour. Extracellular matrix composition, rearrangement of cytoskeleton, cell antigenicity , expression of metastasis-related novel genes, cell adhesion and novel therapeutical approaches such as blockage of angiogenesis, are the major topics discussed in detail in this volume.
Cell-Extracellular Matrix Interactions in Cancer by Roy Zent,Ambra Pozzi Pdf
Cancer was thought to originate from alterations in intercellular signaling that resulted in the transformation of cells, their uncontrolled proliferation and metastasis. There is now an increasing body of evidence demonstrating that the surrounding matrix and cell-matrix interactions are also major players in this process. Cells adhere and receive signals from various extracellular matrices via transmembrane receptors, the best known of which are the heterodimeric glycoproteins, integrins.