Cell Adhesion Molecules

Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 46,7 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181

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Molecular Biology of The Cell by Bruce Alberts Pdf

Author : Vladimir Berezin
Publisher : Springer Science & Business Media
Page : 429 pages
File Size : 45,8 Mb
Release : 2009-12-17
Category : Medical
ISBN : 9781441911704

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Structure and Function of the Neural Cell Adhesion Molecule NCAM by Vladimir Berezin Pdf

This book describes recent developments concerning structural, functional and possible therapeutic aspects of one particular CAM, the neural cell adhesion molecule (NCAM).

Author : Victor R. Preedy
Publisher : CRC Press
Page : 534 pages
File Size : 47,8 Mb
Release : 2016-04-19
Category : Medical
ISBN : 9781439840603

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Adhesion Molecules by Victor R. Preedy Pdf

This book covers the structure and classification of adhesion molecules in relation to signaling pathways and gene expression. It discusses immunohistochemical localization, neutrophil migration, and junctional, functional, and inflammatory adhesion molecules in pathologies such as leukocyte decompression sickness and ischemia reperfusion injury. H

Author : Paul
Publisher : CRC Press
Page : 784 pages
File Size : 40,9 Mb
Release : 1997-05-16
Category : Science
ISBN : 0824798244

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Adhesion Molecules in Health and Disease by Paul Pdf

Provides an overview of the structure, transcription regulation and binding characteristics of cellular adhesion molecules and their ligands in the maintenance of function, immunological reactions and inflammatory processes with organ systems. The text examines the role of adhesion molecules in biological processes such as morphogenesis, blood coagulation, tumour metastasis, bone tissue remodelling and transplant rejection.

Author : Brian W. Metcalf,Barbara J. Dalton,George Poste
Publisher : Springer Science & Business Media
Page : 332 pages
File Size : 41,6 Mb
Release : 2013-11-11
Category : Medical
ISBN : 9781461524663

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Cellular Adhesion by Brian W. Metcalf,Barbara J. Dalton,George Poste Pdf

The books in this acclaimed series provide integrated, critical surveys of topics of current interest to the pharmaceutical industry. Cellular Adhesion: Molecular Definition to Therapeutic Potential covers the molecular definition of adhesion molecule structure and function, the biological consequences of cellular adhesion, and the therapeutic potential of targeting adhesion molecules.

Author : Jun-Lin Guan
Publisher : CRC Press
Page : 396 pages
File Size : 45,9 Mb
Release : 2019-04-30
Category : Medical
ISBN : 1420049437

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Signaling Through Cell Adhesion Molecules by Jun-Lin Guan Pdf

The field of signal transduction research is one of the fastest growing in all of biomedical research in recent years. Signaling through cell adhesion molecules have long been of interest because of their importance in embryonic development, homeostasis, immune responses, wound healing , and malignant transformation. However, it is only recently re

Author : Martin E. Hemler,Enrico Mihich
Publisher : Springer Science & Business Media
Page : 292 pages
File Size : 49,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461528302

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Cell Adhesion Molecules by Martin E. Hemler,Enrico Mihich Pdf

The Fourth Annual Pezcoller Symposium entitled Adhesion Molecules: Cellular Recognition Mechanisms was held in Rovereto, Italy, June 24-26, 1992 and was focussed on the detailed mechanisms whereby cells utilize certain integral membrane proteins to perceive their surrounding environment and interact with it. With timely presentations and stimulating discussions this Symposium addressed the genetics and biochemistry of adhesion molecules, the regulation of their functions and their role in cancer and the immune system. Emphasis was given to adhesion proteins in the integrin family because of the widespread distribution of this group of molecules and its important role in essentially all eukaryotic biological systems. The regulation of integrin genes and their expression are discussed in detail, as are specific aspects of the genetics of fibronectin. The molecular basis for the regulation of certain integrins, the function of these proteins in determining cell adhesion, and the consequences of this adhesion for the function of the cells involved are discussed. The role of certain integrins in stimulating signal transduction, the essential involvement of integrins in conditioning the function of T and NK cells function, the heterogeneity of integrins and its biological consequences, and the role of cell adhesion molecules in tumor cells invasion and metastases are all extensively analyzed. New information was presented on the role of CD44 and splice variants in normal differentiation and tumor progression.

Author : Klaus Ley
Publisher : Springer Science & Business Media
Page : 309 pages
File Size : 42,5 Mb
Release : 2007-10-27
Category : Medical
ISBN : 9783764379759

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Adhesion Molecules: Function and Inhibition by Klaus Ley Pdf

This volume gives a comprehensive overview on the most relevant leukocyte and endothelial adhesion molecules. The chapters are written by leaders in the field and focus on the biology, structure, function, and regulation of adhesion molecules. Currently approved adhesion molecule-based therapies are reviewed and an outlook for future approaches is also provided. The book is of interest to clinicians and scientists from immunology, physiology, cancer research, rheumatology, allergology, infectious diseases, gastroenterology, pulmonology and cardiology.

Author : Shaker A. Mousa
Publisher : Unknown
Page : 276 pages
File Size : 46,6 Mb
Release : 1998
Category : Medical
ISBN : STANFORD:36105022954817

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Cell Adhesion Molecules and Matrix Proteins by Shaker A. Mousa Pdf

Author : David Garrod,A.J. North,M.A.J. Chidgey
Publisher : Elsevier
Page : 412 pages
File Size : 54,9 Mb
Release : 1999-03-31
Category : Science
ISBN : 0080877133

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The Adhesive Interaction of Cells by David Garrod,A.J. North,M.A.J. Chidgey Pdf

The aim of "The Adhesive Interaction of Cells" has been to assemble a series of reviews by leading international experts embracing many of the most important recent developments in this rapidly expanding field. The purpose of all biological research is to understand the form and function of living organisms and, by comprehending the normal, to find explanations and remedies for the abnormal and for disease conditions. The molecules involved in cell adhesion are of fundamental importance to the structure and function of all multicellular organisms. In this book, the contributors focus on the systems of vertebrates, especially mammals, since these are most relevant to human disease. It would have been equally possible to concentrate on developmental processes and adhesion in lower organisms. A major function of adhesion molecules is to bind cells to each other or to the extracellular matrix, but they are much more than "glue". Adhesions in animal tissues must be dynamic-forming, persisting, or declining in regulated fashion- to facilitate the mobility and turnover of tissue cells. Moreover, the majority of adhesion molecules are transmembrane molecules and thus provide links between the cells and their surroundings. This gives rise to another major function of adhesion molecules, the capacity to transduce signals across the hydrophobic barrier imposed by the plasma membrane. Such signal transduction is crucially important to many aspects of cellular function including the regulation of cell motility, gene expression, and differentiation. The work in this book progresses through four sections. Part I discusses the four major families of adhesion molecules themselves, the integrins (Green and Humphries), the cadherins (Stappert and Kemler), the selectins (Tedder et al.) and the immunoglobulin superfamily (Simmons); part 2 considers junctional complexes involved in cell interactions: focal adhesions and adherens junctions (Ben Ze'ev), desmosomes (Garrod et al.), and tight junctions (Citi and Cordenonsi). The signaling role of adhesion molecules is the focus of part 3, through integrins and the extracellular matrix (Edwards and Streuli), through platelet adhesion (Du and Ginsberg), and in the nervous system (Hemperley). In part 4, the aim is to show how adhesive phenomena contribute to important aspects of cell behavior and human health. Leukocyte trafficking (Haskard et al.), cancer metastasis (Marshall and Hart), cell migration (Paleck et al.), and implantation and placentation (Damsky et al.) are the topics considered in depth. The different sections are, of course, not mutually exclusive: it is both undesirable and impossible to separate structure from function when considering cell adhesion. Each chapter has its unique features, but some overlap is both invevitable and valuable since it provides different perspectives on closely related topics. We hope that the whole contributes a valuable and stimulating consideration of this important topic.

Author : Mary C. Beckerle
Publisher : Oxford University Press, USA
Page : 440 pages
File Size : 50,5 Mb
Release : 2001
Category : Cell adhesion
ISBN : 0199638713

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Cell Adhesion by Mary C. Beckerle Pdf

Cell adhesion plays a central role in development and disease. Cell adhesion to particular ligands can affect cytoskeletal organization and cell polarity, cell proliferation, and gene expression. This book is divided into two parts. The first section provides a discussion of the structure and function of the seven major classes of cell adhesion molecules: integrins, cadherins, selectins, heparan sulfate proteoglycans, the immunoglobulin superfamily, the ADAMs proteins, and transmembrane protein tyrosine phosphatases. The roles of these cell adhesion proteins in important processes such as cell mediated immunity, development and disease are discussed. In the second section, the molecular organization and function of junctional complexes, regions of the cell surface that are highly specialized for cell adhesion, are examined. Junctional complexes are now known to mediate adhesive interactions and contribute to transmembrane signaling events that dramatically influence cell behaviour. The biochemical organization of the adhesive membranes and the molecular mechanisms by which they transmit information to the cell are addressed. Written by contributors among the most prominent in the field, Cell Adhesion covers a wide range of topics in a single volume. It will be a great resource for students, teachers and researchers.

Author : Vladimir Berezin,Peter S. Walmod
Publisher : Springer Science & Business Media
Page : 424 pages
File Size : 47,5 Mb
Release : 2013-11-18
Category : Medical
ISBN : 9781461480907

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Cell Adhesion Molecules by Vladimir Berezin,Peter S. Walmod Pdf

Cell Adhesion Molecules: Implications in Neurological Diseases contains review articles on recent developments in the field of neural cell adhesion molecules (CAMs). The main focus is on the role of cell adhesion molecules in various neurological and neurodegenerative diseases. This perspective has been essentially overlooked in recently published books on neural CAMs. In addition, the contributors cover many newly identified cell adhesion molecules and some that have not received much attention in recent years. This books fills an important gap in the currently available literature. ​

Author : D. Neil Granger,Elena Senchenkova
Publisher : Morgan & Claypool Publishers
Page : 99 pages
File Size : 44,7 Mb
Release : 2010
Category : Medical
ISBN : 9781615041657

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Inflammation and the Microcirculation by D. Neil Granger,Elena Senchenkova Pdf

The microcirculation is highly responsive to, and a vital participant in, the inflammatory response. All segments of the microvasculature (arterioles, capillaries, and venules) exhibit characteristic phenotypic changes during inflammation that appear to be directed toward enhancing the delivery of inflammatory cells to the injured/infected tissue, isolating the region from healthy tissue and the systemic circulation, and setting the stage for tissue repair and regeneration. The best characterized responses of the microcirculation to inflammation include impaired vasomotor function, reduced capillary perfusion, adhesion of leukocytes and platelets, activation of the coagulation cascade, and enhanced thrombosis, increased vascular permeability, and an increase in the rate of proliferation of blood and lymphatic vessels. A variety of cells that normally circulate in blood (leukocytes, platelets) or reside within the vessel wall (endothelial cells, pericytes) or in the perivascular space (mast cells, macrophages) are activated in response to inflammation. The activation products and chemical mediators released from these cells act through different well-characterized signaling pathways to induce the phenotypic changes in microvessel function that accompany inflammation. Drugs that target a specific microvascular response to inflammation, such as leukocyte-endothelial cell adhesion or angiogenesis, have shown promise in both the preclinical and clinical studies of inflammatory disease. Future research efforts in this area will likely identify new avenues for therapeutic intervention in inflammation. Table of Contents: Introduction / Historical Perspectives / Anatomical Considerations / Impaired Vasomotor Responses / Capillary Perfusion / Angiogenesis / Leukocyte-Endothelial Cell Adhesion / Platelet-Vessel Wall Interactions / Coagulation and Thrombosis / Endothelial Barrier Dysfunction / Epilogue / References

Author : Agamemnon A. Epenetos,Massimo Pignatelii
Publisher : CRC Press
Page : 264 pages
File Size : 53,8 Mb
Release : 1995-06-01
Category : Science
ISBN : 3718655160

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Cell Adhesion Molecules in Cancer and Inflammation by Agamemnon A. Epenetos,Massimo Pignatelii Pdf

Begins a series for clinicians, graduate students, and researchers in academia, regulatory agencies, or industry, offering monographs both on classes of adhesion molecules and on the function of such molecules in particular systems. Here the emphasis is on the clinical evaluation of these molecules, particularly as novel biochemical and genetic markers to define tumor differentiation based on functional and morphological assessment, and also their potential use as targets for biological therapy. Includes ten pages of color plates. Annotation copyright by Book News, Inc., Portland, OR

Author : Joan Marsh,Jamie A. Goode
Publisher : John Wiley & Sons
Page : 254 pages
File Size : 55,6 Mb
Release : 2008-04-30
Category : Science
ISBN : 9780470514726

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Cell Adhesion and Human Disease by Joan Marsh,Jamie A. Goode Pdf

Experts in their respective fields present papers concerned with the range of human diseases caused by defective or abnormal functioning of cell adhesion molecules. Discusses new therapeutic approaches to these maladies.