Cellular Adhesion

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Molecular Biology of The Cell

Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 53,8 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181

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Molecular Biology of The Cell by Bruce Alberts Pdf

Structure and Function of the Neural Cell Adhesion Molecule NCAM

Author : Vladimir Berezin
Publisher : Springer Science & Business Media
Page : 429 pages
File Size : 49,9 Mb
Release : 2009-12-17
Category : Medical
ISBN : 9781441911704

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Structure and Function of the Neural Cell Adhesion Molecule NCAM by Vladimir Berezin Pdf

This book describes recent developments concerning structural, functional and possible therapeutic aspects of one particular CAM, the neural cell adhesion molecule (NCAM).

Cellular Adhesion

Author : Brian W. Metcalf,Barbara J. Dalton,George Poste
Publisher : Springer Science & Business Media
Page : 332 pages
File Size : 51,9 Mb
Release : 2013-11-11
Category : Medical
ISBN : 9781461524663

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Cellular Adhesion by Brian W. Metcalf,Barbara J. Dalton,George Poste Pdf

The books in this acclaimed series provide integrated, critical surveys of topics of current interest to the pharmaceutical industry. Cellular Adhesion: Molecular Definition to Therapeutic Potential covers the molecular definition of adhesion molecule structure and function, the biological consequences of cellular adhesion, and the therapeutic potential of targeting adhesion molecules.

Surface and Interfacial Aspects of Cell Adhesion

Author : Alain Carré,Kash L. Mittal
Publisher : CRC Press
Page : 545 pages
File Size : 48,8 Mb
Release : 2011-01-19
Category : Science
ISBN : 9789004190788

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Surface and Interfacial Aspects of Cell Adhesion by Alain Carré,Kash L. Mittal Pdf

Cell adhesion comes into play in almost all domains of life. The range of situations in which it occurs, involving organisms, living tissues, microorganisms or single cells, is endless. Cell adhesion is involved in the binding of a cell to a surface, extracellular matrix, or another cell using cell adhesion molecules. It is crucial in the formation and maintenance of coherent multicellular structures. Cell surface adhesion molecules (integrins, for example) which transmit information from the extracellular matrix to the cell play vital roles in numerous cellular processes. Some of these include: cell growth, differentiation, embryogenesis, immune cell transmigration and response, and cancer metastasis. Also cell adhesion is involved in most of pathological situations. This book is divided into four parts as follows: Part 1: Fundamentals of Cell Adhesion; Part 2: Methods to Study Cell Adhesion; Part 3: Surface Treatments to Control Cell Adhesion and Behavior; and Part 4: Cell Adhesion in Medicine and Therapy. A bountiful information is covered in this book which represents the cumulative wisdom of many world-renowned researchers( physicists, materials scientists, chemists and biologists) engaged in unraveling the mechanisms of cell adhesion and how to mitigate or control it. It quite patent from the topics covered in this book that the subject of cell adhesion is truly interdisciplinary. This book should be of great interest and value to anyone interested in cell adhesion which is vitally important to human life.

Cellular Adhesion in Development and Disease

Author : Anonim
Publisher : Academic Press
Page : 536 pages
File Size : 46,8 Mb
Release : 2015-02-27
Category : Science
ISBN : 9780124078895

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Cellular Adhesion in Development and Disease by Anonim Pdf

Cell adhesion is a fundamental determinant of embryonic development and organogenesis. Cellular Adhesion in Development and Disease, volume 112 in Current Topics in Developmental Biology, comprehensively surveys current developments in understanding how adhesion systems affect organismal development. Topics covered include nectins, nectin-like molecules, and afadin in development; cadherin adhesion, signaling, and morphogenesis; endothelial cell junctions; epidermal development and barrier formation; and more. This book surveys current understanding of how adhesion systems affect organismal development

Adhesion Molecules

Author : Victor R. Preedy
Publisher : CRC Press
Page : 534 pages
File Size : 42,7 Mb
Release : 2016-04-19
Category : Medical
ISBN : 9781439840603

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Adhesion Molecules by Victor R. Preedy Pdf

This book covers the structure and classification of adhesion molecules in relation to signaling pathways and gene expression. It discusses immunohistochemical localization, neutrophil migration, and junctional, functional, and inflammatory adhesion molecules in pathologies such as leukocyte decompression sickness and ischemia reperfusion injury. H

Cell Adhesion

Author : Mary C. Beckerle
Publisher : Oxford University Press, USA
Page : 440 pages
File Size : 54,9 Mb
Release : 2001
Category : Cell adhesion
ISBN : 0199638713

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Cell Adhesion by Mary C. Beckerle Pdf

Cell adhesion plays a central role in development and disease. Cell adhesion to particular ligands can affect cytoskeletal organization and cell polarity, cell proliferation, and gene expression. This book is divided into two parts. The first section provides a discussion of the structure and function of the seven major classes of cell adhesion molecules: integrins, cadherins, selectins, heparan sulfate proteoglycans, the immunoglobulin superfamily, the ADAMs proteins, and transmembrane protein tyrosine phosphatases. The roles of these cell adhesion proteins in important processes such as cell mediated immunity, development and disease are discussed. In the second section, the molecular organization and function of junctional complexes, regions of the cell surface that are highly specialized for cell adhesion, are examined. Junctional complexes are now known to mediate adhesive interactions and contribute to transmembrane signaling events that dramatically influence cell behaviour. The biochemical organization of the adhesive membranes and the molecular mechanisms by which they transmit information to the cell are addressed. Written by contributors among the most prominent in the field, Cell Adhesion covers a wide range of topics in a single volume. It will be a great resource for students, teachers and researchers.

Adhesion Molecules in Health and Disease

Author : Paul
Publisher : CRC Press
Page : 784 pages
File Size : 50,9 Mb
Release : 1997-05-16
Category : Science
ISBN : 0824798244

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Adhesion Molecules in Health and Disease by Paul Pdf

Provides an overview of the structure, transcription regulation and binding characteristics of cellular adhesion molecules and their ligands in the maintenance of function, immunological reactions and inflammatory processes with organ systems. The text examines the role of adhesion molecules in biological processes such as morphogenesis, blood coagulation, tumour metastasis, bone tissue remodelling and transplant rejection.

Cell Adhesion Molecules

Author : Martin E. Hemler,Enrico Mihich
Publisher : Springer Science & Business Media
Page : 292 pages
File Size : 49,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461528302

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Cell Adhesion Molecules by Martin E. Hemler,Enrico Mihich Pdf

The Fourth Annual Pezcoller Symposium entitled Adhesion Molecules: Cellular Recognition Mechanisms was held in Rovereto, Italy, June 24-26, 1992 and was focussed on the detailed mechanisms whereby cells utilize certain integral membrane proteins to perceive their surrounding environment and interact with it. With timely presentations and stimulating discussions this Symposium addressed the genetics and biochemistry of adhesion molecules, the regulation of their functions and their role in cancer and the immune system. Emphasis was given to adhesion proteins in the integrin family because of the widespread distribution of this group of molecules and its important role in essentially all eukaryotic biological systems. The regulation of integrin genes and their expression are discussed in detail, as are specific aspects of the genetics of fibronectin. The molecular basis for the regulation of certain integrins, the function of these proteins in determining cell adhesion, and the consequences of this adhesion for the function of the cells involved are discussed. The role of certain integrins in stimulating signal transduction, the essential involvement of integrins in conditioning the function of T and NK cells function, the heterogeneity of integrins and its biological consequences, and the role of cell adhesion molecules in tumor cells invasion and metastases are all extensively analyzed. New information was presented on the role of CD44 and splice variants in normal differentiation and tumor progression.

The Adhesive Interaction of Cells

Author : David Garrod,A.J. North,M.A.J. Chidgey
Publisher : Elsevier
Page : 412 pages
File Size : 51,5 Mb
Release : 1999-03-31
Category : Science
ISBN : 0080877133

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The Adhesive Interaction of Cells by David Garrod,A.J. North,M.A.J. Chidgey Pdf

The aim of "The Adhesive Interaction of Cells" has been to assemble a series of reviews by leading international experts embracing many of the most important recent developments in this rapidly expanding field. The purpose of all biological research is to understand the form and function of living organisms and, by comprehending the normal, to find explanations and remedies for the abnormal and for disease conditions. The molecules involved in cell adhesion are of fundamental importance to the structure and function of all multicellular organisms. In this book, the contributors focus on the systems of vertebrates, especially mammals, since these are most relevant to human disease. It would have been equally possible to concentrate on developmental processes and adhesion in lower organisms. A major function of adhesion molecules is to bind cells to each other or to the extracellular matrix, but they are much more than "glue". Adhesions in animal tissues must be dynamic-forming, persisting, or declining in regulated fashion- to facilitate the mobility and turnover of tissue cells. Moreover, the majority of adhesion molecules are transmembrane molecules and thus provide links between the cells and their surroundings. This gives rise to another major function of adhesion molecules, the capacity to transduce signals across the hydrophobic barrier imposed by the plasma membrane. Such signal transduction is crucially important to many aspects of cellular function including the regulation of cell motility, gene expression, and differentiation. The work in this book progresses through four sections. Part I discusses the four major families of adhesion molecules themselves, the integrins (Green and Humphries), the cadherins (Stappert and Kemler), the selectins (Tedder et al.) and the immunoglobulin superfamily (Simmons); part 2 considers junctional complexes involved in cell interactions: focal adhesions and adherens junctions (Ben Ze'ev), desmosomes (Garrod et al.), and tight junctions (Citi and Cordenonsi). The signaling role of adhesion molecules is the focus of part 3, through integrins and the extracellular matrix (Edwards and Streuli), through platelet adhesion (Du and Ginsberg), and in the nervous system (Hemperley). In part 4, the aim is to show how adhesive phenomena contribute to important aspects of cell behavior and human health. Leukocyte trafficking (Haskard et al.), cancer metastasis (Marshall and Hart), cell migration (Paleck et al.), and implantation and placentation (Damsky et al.) are the topics considered in depth. The different sections are, of course, not mutually exclusive: it is both undesirable and impossible to separate structure from function when considering cell adhesion. Each chapter has its unique features, but some overlap is both invevitable and valuable since it provides different perspectives on closely related topics. We hope that the whole contributes a valuable and stimulating consideration of this important topic.

Signaling Through Cell Adhesion Molecules

Author : Jun-Lin Guan
Publisher : CRC Press
Page : 396 pages
File Size : 46,7 Mb
Release : 2019-04-30
Category : Medical
ISBN : 1420049437

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Signaling Through Cell Adhesion Molecules by Jun-Lin Guan Pdf

The field of signal transduction research is one of the fastest growing in all of biomedical research in recent years. Signaling through cell adhesion molecules have long been of interest because of their importance in embryonic development, homeostasis, immune responses, wound healing , and malignant transformation. However, it is only recently re

Inflammation and the Microcirculation

Author : D. Neil Granger,Elena Senchenkova
Publisher : Morgan & Claypool Publishers
Page : 99 pages
File Size : 52,8 Mb
Release : 2010
Category : Medical
ISBN : 9781615041657

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Inflammation and the Microcirculation by D. Neil Granger,Elena Senchenkova Pdf

The microcirculation is highly responsive to, and a vital participant in, the inflammatory response. All segments of the microvasculature (arterioles, capillaries, and venules) exhibit characteristic phenotypic changes during inflammation that appear to be directed toward enhancing the delivery of inflammatory cells to the injured/infected tissue, isolating the region from healthy tissue and the systemic circulation, and setting the stage for tissue repair and regeneration. The best characterized responses of the microcirculation to inflammation include impaired vasomotor function, reduced capillary perfusion, adhesion of leukocytes and platelets, activation of the coagulation cascade, and enhanced thrombosis, increased vascular permeability, and an increase in the rate of proliferation of blood and lymphatic vessels. A variety of cells that normally circulate in blood (leukocytes, platelets) or reside within the vessel wall (endothelial cells, pericytes) or in the perivascular space (mast cells, macrophages) are activated in response to inflammation. The activation products and chemical mediators released from these cells act through different well-characterized signaling pathways to induce the phenotypic changes in microvessel function that accompany inflammation. Drugs that target a specific microvascular response to inflammation, such as leukocyte-endothelial cell adhesion or angiogenesis, have shown promise in both the preclinical and clinical studies of inflammatory disease. Future research efforts in this area will likely identify new avenues for therapeutic intervention in inflammation. Table of Contents: Introduction / Historical Perspectives / Anatomical Considerations / Impaired Vasomotor Responses / Capillary Perfusion / Angiogenesis / Leukocyte-Endothelial Cell Adhesion / Platelet-Vessel Wall Interactions / Coagulation and Thrombosis / Endothelial Barrier Dysfunction / Epilogue / References

Cell Adhesion and Human Disease

Author : Joan Marsh,Jamie A. Goode
Publisher : John Wiley & Sons
Page : 254 pages
File Size : 40,7 Mb
Release : 2008-04-30
Category : Science
ISBN : 9780470514726

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Cell Adhesion and Human Disease by Joan Marsh,Jamie A. Goode Pdf

Experts in their respective fields present papers concerned with the range of human diseases caused by defective or abnormal functioning of cell adhesion molecules. Discusses new therapeutic approaches to these maladies.

Adhesion Protein Protocols

Author : Amanda S. Coutts
Publisher : Springer Science & Business Media
Page : 237 pages
File Size : 42,7 Mb
Release : 2008-02-03
Category : Science
ISBN : 9781597453530

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Adhesion Protein Protocols by Amanda S. Coutts Pdf

The second edition of Adhesion Protein Protocols combines traditional techniques with cutting-edge and novel techniques that can be adapted easily to different molecules and cell types. The topics discussed include novel techniques for studying cell-cell adhesion, neutrophil chemotaxis, in vitro assays used to study leukocyte migration through monolayers of cultured endothelial cells, and novel techniques to purify pseudopodia from migratory cells. The protocols discussed in this volume are suitable for both novice and expert scientists, who will gain further insight into the complex and incompletely understood processes involved in cellular adhesion.

Principles of Cell Adhesion (1995)

Author : Peter D. Richardson,Manfred Steiner
Publisher : CRC Press
Page : 849 pages
File Size : 54,5 Mb
Release : 2017-11-22
Category : Science
ISBN : 9781351358972

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Principles of Cell Adhesion (1995) by Peter D. Richardson,Manfred Steiner Pdf

Intended for cell biologists, biophysicists, biochemists, molecular biologists, physiologists, researchers in hemostatsis and thrombosis and pathologists, this book provides an insight into cell adhesion from three interdisciplinary perspectives: fundamental facts of adhesion; molecular biochemistry of adhesion and physiological aspects. It summarizes the basic aspects of surfaces in general and describes the theoretical and experimental tools necessary to investigate cell adhesion, including the basic biochemistry and molecular biology of adhesion. The book offers concise treatment of individual topics, features current material, and provides key references as a guide to further study.