Cellular And Biochemical Mechanisms Of Obesity

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Cellular and Biochemical Mechanisms of Obesity

Paramjit S. Tappia,Bram Ramjiawan,Naranjan S. Dhalla
Cellular and Biochemical Mechanisms of Obesity Book PDF

Author : Paramjit S. Tappia,Bram Ramjiawan,Naranjan S. Dhalla
Publisher : Springer Nature
Page : 420 pages
File Size : 42,7 Mb
Release : 2021-12-15
Category : Medical
ISBN : 9783030847630

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Cellular and Biochemical Mechanisms of Obesity by Paramjit S. Tappia,Bram Ramjiawan,Naranjan S. Dhalla Pdf

Global health has been challenged with the dawning of the era of the obesity epidemic, and thus as a consequence, strategies to reduce obesity have become public health priorities. According to the United Nations, obesity has been identified as a concern for achieving Sustainable Development Goals. Obesity is a serious health problem with an increased risk of several common diseases including diabetes, cardiovascular disease, and cancer. Although the fundamental cause of obesity and overweight is an imbalance between calorie intake and calorie expenditure, the underlying biochemical and metabolic processes that cause obesity are not fully understood. Two earlier volumes dedicated to the subject of obesity, published in the series “Advances in Biochemistry in Health and Disease” focused on the pathophysiology of obesity-induced health complications and the biochemistry of cardiovascular dysfunction in obesity. This book brings together contributions from international experts in the field to describe advancements on the mechanisms leading to development of obesity and related complications. There are 21 chapters in two different parts in this book, comprising of Part I: Pathophysiologic Mechanisms of Obesity (11 chapters) and Part II: Therapeutic Mechanisms of Obesity (10 chapters). This book will serve as a resource and be of interest to health professionals, medical students, fellows, residents and graduate students. It will also evoke innovative research and effective approaches for the prevention of obesity. This volume will accentuate that obesity is a major health hazard in its own right and that appropriate public health measures should be implemented to prevent or reduce or even reverse the impact of this global chronic disease.

Biochemistry of Cardiovascular Dysfunction in Obesity

Paramjit S. Tappia,Sukhwinder K. Bhullar,Naranjan S. Dhalla
Biochemistry of Cardiovascular Dysfunction in Obesity Book PDF

Author : Paramjit S. Tappia,Sukhwinder K. Bhullar,Naranjan S. Dhalla
Publisher : Springer Nature
Page : 402 pages
File Size : 51,8 Mb
Release : 2020-10-03
Category : Medical
ISBN : 9783030473365

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Biochemistry of Cardiovascular Dysfunction in Obesity by Paramjit S. Tappia,Sukhwinder K. Bhullar,Naranjan S. Dhalla Pdf

Obesity is an independent risk factor for cardiovascular disease (CVD) in adults as well as in obese children. This book will provide a description of the impact of obesity on the cardiovascular system and increased predisposition to CVD. It will identify the major biochemical mechanisms that lead to the occurrence of myocardial abnormalities and vascular alterations in obesity. We will also have some discussion on the biochemistry of the so-called obesity paradox in relation to CVD. The contributors to this book are international experts on obesity and associated cardiovascular complications. This book is also uniquely positioned as it focuses on the biochemistry of obesity-induced cardiovascular dysfunction. There are 20 chapters in 2 different parts in this book, comprising of Part A: Pathophysiology of Cardiovascular Complications in Obesity (11 chapters) and Part B: Modification of Cardiovascular Dysfunction in obesity (9 chapters). The intent of this volume is to provide current and basic understanding of the biochemical mechanisms of obesity induced cardiovascular dysfunction that will be of value not only to cardiologists and other allied health professionals, but will also stimulate and motivate biomedical researchers and scientists to find the way to prevent the epidemic of obesity associated cardiovascular abnormalities. Furthermore, this book will serve as a highly useful resource for medical students, fellows, residents and graduate students with an interest in the cardiovascular system. In summary, this book covers a broad range of biochemical mechanisms of obesity-induced cardiovascular complications. We hope that the reader will understand that obesity is linked to an increase in the risk and occurrence of fatal CVD. Furthermore, the underlying message presented in the book is that the cause of obesity related disorders is complex and that understanding the biochemistry of cardiovascular dysfunction may contribute to the development of novel interventions for the prevention and treatment of obesity associated comorbidities.

Obesity and Lipotoxicity

Ayse Basak Engin,Atilla Engin
Obesity and Lipotoxicity Book PDF

Author : Ayse Basak Engin,Atilla Engin
Publisher : Springer
Page : 624 pages
File Size : 50,6 Mb
Release : 2017-06-05
Category : Science
ISBN : 9783319483825

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Obesity and Lipotoxicity by Ayse Basak Engin,Atilla Engin Pdf

Due to the resultant health consequences and considerable increase in prevalence, obesity has become a major worldwide health problem. “Obesity and Lipotoxicity” is a comprehensive review of the recent researches to provide a better understanding of the lipotoxicity-related mechanisms of obesity and the potential for the development of new treatment strategies. This book overviews the biochemical pathways leading to obesity-related metabolic disorders that occur subsequent to lipotoxicity. Chapters examine the deleterious effects of nutrient excess at molecular level including the cellular and molecular aspects of breast cancer, resistance to leptin, insulin, adiponectin, and interconnection between the circadian clock and metabolic pathways during high-fat feeding. “Lipotoxicity and Obesity” will be a useful resource for clinicians and basic science researchers, such as biochemists, toxicologists, immunologists, nutritionists, adult and pediatric endocrinologists, cardiologists, as well as students who are thought in this field.

Pathophysiology of Obesity-Induced Health Complications

Paramjit S. Tappia,Bram Ramjiawan,Naranjan S. Dhalla
Pathophysiology of Obesity Induced Health Complications Book PDF

Author : Paramjit S. Tappia,Bram Ramjiawan,Naranjan S. Dhalla
Publisher : Springer Nature
Page : 348 pages
File Size : 42,7 Mb
Release : 2020-01-17
Category : Medical
ISBN : 9783030353582

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Pathophysiology of Obesity-Induced Health Complications by Paramjit S. Tappia,Bram Ramjiawan,Naranjan S. Dhalla Pdf

​According to the World Health Organization, the epidemic of global obesity has nearly tripled since 1975. In 2016, more than 1.9 billion adults were overweight, over 650 million of which were obese. Being overweight and obese has been linked to a number of non-communicable, chronic diseases. Pathophysiology of Obesity-Induced Health Complications is a compilation of review articles dedicated to describe co-morbidities associated with obesity. The wide range that is covered is of significant interest to basic research scientists, clinicians and graduate students who are engaged in studying obesity-induced health complications. Furthermore, this book highlights the potential of novel approaches for the prevention and treatment of obesity and its related illnesses. Nineteen articles in this book are organized in four sections that are designed to provide an overview of obesity-induced health complications. The first section serves as an introductory section on the prevalence, causes, consequences, treatments and preventive approaches for obesity. Section two covers the metabolic disturbances and inflammation due to obesity. The third section is focused on neurological and visceral complications as a consequence of obesity. The final section covers strategies for the prevention of obesity-induced complications. The book illustrates that obesity can result in a diverse range of pathophysiological conditions that adversely affect health.

TNF Pathophysiology

George Kollias,Petros P. Sfikakis
TNF Pathophysiology Book PDF

Author : George Kollias,Petros P. Sfikakis
Publisher : Karger Medical and Scientific Publishers
Page : 223 pages
File Size : 40,9 Mb
Release : 2010-01-01
Category : Medical
ISBN : 9783805593830

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TNF Pathophysiology by George Kollias,Petros P. Sfikakis Pdf

TNF is a multifunctional proinflammatory cytokine central to the development and homeostasis of the immune system and a regulator of cell activation, differentiation and death. Recent decades have seen an enormous scientific and clinical interest in the function of TNF in physiology and disease. A vast amount of data has been accumulated at the biochemical, molecular and cellular level, establishing TNF as a prototype for in-depth understanding of the physiological and pathogenic functions of cytokines. This volume covers several current aspects of TNF regulation and function, including transcriptional and posttranscriptional control mechanisms, cellular modes of action, signaling networks that mediate its effect, involvement in pathogenesis and clinical outcomes of TNF antagonists. It combines basic science at the molecular and cellular level with research in animal models of disease and clinical findings to provide a comprehensive review of recent developments in TNF biology. A thorough understanding of the mechanisms by which this key molecular player is produced and functions to regulate cell biology, immunity and disease postulates novel paradigms on how genes contribute to the development and physiology of biological systems.

ABC of Obesity

Naveed Sattar,Mike Lean
ABC of Obesity Book PDF

Author : Naveed Sattar,Mike Lean
Publisher : John Wiley & Sons
Page : 64 pages
File Size : 53,5 Mb
Release : 2009-04-08
Category : Medical
ISBN : 9781444312706

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ABC of Obesity by Naveed Sattar,Mike Lean Pdf

Obesity is a hugely expensive and increasing problem worldwide,leading to disability, reproductive problems, depression andaccelerated metabolic and vascular diseases in a large proportionof men, women and children. The ABC of Obesity is a newguide which will aid its effective management, addressing issuessuch as dieting, exercise, self esteem, drug treatment and surgery.Recent evidence is used to highlight frequent problems, successfultreatment options, and the most common causes. Written by leading experts, this is a widely accessible text andan indispensable guide for all general practitioners, juniordoctors, nurses, and other healthcare professionals who areinvolved in the treatment and research of this commoncondition.

Fat Detection

Jean-Pierre Montmayeur,Johannes le Coutre
Fat Detection Book PDF

Author : Jean-Pierre Montmayeur,Johannes le Coutre
Publisher : CRC Press
Page : 643 pages
File Size : 43,7 Mb
Release : 2009-09-14
Category : Science
ISBN : 1420067761

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Fat Detection by Jean-Pierre Montmayeur,Johannes le Coutre Pdf

Presents the State-of-the-Art in Fat Taste Transduction A bite of cheese, a few potato chips, a delectable piece of bacon – a small taste of high-fat foods often draws you back for more. But why are fatty foods so appealing? Why do we crave them? Fat Detection: Taste, Texture, and Post Ingestive Effects covers the many factors responsible for the sensory appeal of foods rich in fat. This well-researched text uses a multidisciplinary approach to shed new light on critical concerns related to dietary fat and obesity. Outlines Compelling Evidence for an Oral Fat Detection System Reflecting 15 years of psychophysical, behavioral, electrophysiological, and molecular studies, this book makes a well-supported case for an oral fat detection system. It explains how gustatory, textural, and olfactory information contribute to fat detection using carefully designed behavioral paradigms. The book also provides a detailed account of the brain regions that process the signals elicited by a fat stimulus, including flavor, aroma, and texture. This readily accessible work also discusses: The importance of dietary fats for living organisms Factors contributing to fat preference, including palatability Brain mechanisms associated with appetitive and hedonic experiences connected with food consumption Potential therapeutic targets for fat intake control Genetic components of human fat preference Neurological disorders and essential fatty acids Providing a comprehensive review of the literature from the leading scientists in the field, this volume delivers a holistic view of how the palatability and orosensory properties of dietary fat impact food intake and ultimately health. Fat Detection represents a new frontier in the study of food perception, food intake, and related health consequences.

New Perspectives in Adipose Tissue

A. Cryer,R. L. R. Van
New Perspectives in Adipose Tissue Book PDF

Author : A. Cryer,R. L. R. Van
Publisher : Butterworth-Heinemann
Page : 490 pages
File Size : 49,8 Mb
Release : 2014-04-24
Category : Medical
ISBN : 9781483163970

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New Perspectives in Adipose Tissue by A. Cryer,R. L. R. Van Pdf

New Perspectives in Adipose Tissue: Structure, Function and Development reviews the state of knowledge on adipose tissue. The book begins with discussions of the anatomy and morphology of adipose tissue. This is followed by separate chapters on the nervous control of circulation and metabolism in white adipose tissue; hormonal regulation of biosynthetic activities in white adipose tissue; hormonal control of lipid degradation; and plasma membrane properties and receptors in white adipose tissue. Subsequent chapters cover topics such as lipoproteins and adipose tissue; brown adipose tissue thermogenesis and energy balance in animals and man; methodological approaches to the study of the adipose tissues; adipose tissue growth following lipectomy; the adipocyte precursor cell; and adipose tissue dysfunction and its consequences. In addition to being authoritative source material, the chapters presented in this book are wide in their coverage and appeal.

Biochemistry and Cell Biology of Ageing: Part II Clinical Science

J. Robin Harris,Viktor I. Korolchuk
Biochemistry and Cell Biology of Ageing Part II Clinical Science Book PDF

Author : J. Robin Harris,Viktor I. Korolchuk
Publisher : Springer
Page : 499 pages
File Size : 40,8 Mb
Release : 2019-03-19
Category : Medical
ISBN : 9789811336812

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Biochemistry and Cell Biology of Ageing: Part II Clinical Science by J. Robin Harris,Viktor I. Korolchuk Pdf

This volume of the subcellular Biochemistry series will attempt to bridge the gap between the subcellular events that are related to aging as they were described in the first volume of this set of two books and the reality of aging as this is seen in clinical practice. All chapters will start from the biochemistry or cell biology, where the data is available and work up towards the understanding that we have of aging in the various areas that are related to the subject. Key focus points for this volume are nutrition, external factors and genetics on aging. There will also be chapters that will focus on various organs or tissues in which aging has been well studied, like the eyes, the muscles, the immune system and the bones. The aim of the book project and the book project that is published in concert with this volume is to bring the subcellular and clinical areas into closer contact.

Weight Control and Physical Activity

Harri Vainio,Franca Bianchini
Weight Control and Physical Activity Book PDF

Author : Harri Vainio,Franca Bianchini
Publisher : IARC
Page : 346 pages
File Size : 55,7 Mb
Release : 2002
Category : Health & Fitness
ISBN : 928323006X

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Weight Control and Physical Activity by Harri Vainio,Franca Bianchini Pdf

Avoiding overweight and obesity is the best-established diet-related risk factor for cancer. The proportion of people who are overweight/obese is increasing, and the amount of physical activity is decreasing in most populations, including urban populations in many developing countries. The increasing prevalence of overweight/obesity is presumably due to the increasing availability of highly palatable, high-energy foods, and an increasing sedentary lifestyle due to mechanisation of both workplace and leisure activities. Overweight/obesity and reduced physical activity increases the risk of cancers in various organs. Maintaining a healthy body weight and regular physical activity is the second most important way to prevent cancer, after tobacco control. The suggestions of possible public health actions to tackle these risk factors include the promotion of balanced diets, which are not excessive in energy, and broad education and planning to enable and encourage physical activity during work and leisure. Recommendations and a full discussion of these topics are included in the sixth volume in this series of Handbooks.

Molecular Basis of Health and Disease

Undurti N. Das
Molecular Basis of Health and Disease Book PDF

Author : Undurti N. Das
Publisher : Springer Science & Business Media
Page : 591 pages
File Size : 55,5 Mb
Release : 2011-04-02
Category : Medical
ISBN : 9789400704954

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Molecular Basis of Health and Disease by Undurti N. Das Pdf

The book describes how the balance between pro- and anti-inflammatory molecules is related to health and disease. It is suggested that many diseases are initiated and their progress is influenced by inflammatory molecules and a decrease in the production and/or action of anti-inflammatory molecules and this imbalance between pro- and anti-inflammatory molecules seems to have been initiated in the perinatal period. This implies that strategies to prevent and manage various adult diseases should start in the perinatal period. An alteration in the metaolism of essential fatty acids and their anti-inflammatory molecules such as lipoxins, resolvins, protecitns, maresins and nitrolipids seems to play a major role in the pathobiology of several adult diseases. Based on these concepts, novel therapeutic approaches in the management of insulin resistance, obesity, type 2 diabetes mellitus, metabolic syndrome, cancer, lupus, rheumatoid arthritis and other auto-immune diseases are presented. Based on all these evidences, a unified concept that several adult diseases are due to an alteration in the balance between pro- and anti-inflammatory molecules is discussed and novel methods of their management are presented.

The Mediterranean Diet

Victor R. Preedy,Ronald Ross Watson
The Mediterranean Diet Book PDF

Author : Victor R. Preedy,Ronald Ross Watson
Publisher : Academic Press
Page : 698 pages
File Size : 47,8 Mb
Release : 2014-11-19
Category : Technology & Engineering
ISBN : 9780124079427

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The Mediterranean Diet by Victor R. Preedy,Ronald Ross Watson Pdf

The Mediterranean Diet offers researchers and clinicians a single authoritative source which outlines many of the complex features of the Mediterranean diet: ranging from supportive evidence and epidemiological studies, to the antioxidant properties of individual components. This book embraces a holistic approach and effectively investigates the Mediterranean diet from the cell to the nutritional well-being of geographical populations. This book represents essential reading for researchers and practicing clinicians in nutrition, dietetics, endocrinology, and public health, as well as researchers, such as molecular or cellular biochemists, interested in lipids, metabolism, and obesity. Presents one comprehensive, translational source for all aspects of how the Mediterranean diet plays a role in disease prevention and health Experts in nutrition, diet, and endocrinology (from all areas of academic and medical research) take readers from the bench research (cellular and biochemical mechanisms of vitamins and nutrients) to new preventive and therapeutic approaches Features a unique section on novel nutraceuticals and edible plants used in the Mediterranean region

Lipid Signaling and Metabolism

James M. Ntambi
Lipid Signaling and Metabolism Book PDF

Author : James M. Ntambi
Publisher : Academic Press
Page : 566 pages
File Size : 40,5 Mb
Release : 2020-08-09
Category : Science
ISBN : 9780128194058

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Lipid Signaling and Metabolism by James M. Ntambi Pdf

Lipid Signaling and Metabolism provides foundational knowledge and methods to examine lipid metabolism and bioactive lipid signaling mediators that regulate a broad spectrum of biological processes and disease states. Here, world-renowned investigators offer a basic examination of general lipid, metabolism, intracellular lipid storage and utilization that is followed by an in-depth discussion of lipid signaling and metabolism across disease areas, including obesity, diabetes, fatty liver disease, inflammation, cancer, cardiovascular disease and mood-related disorders. Throughout, authors demonstrate how expanding our understanding of lipid mediators in metabolism and signaling enables opportunities for novel therapeutics. Emphasis is placed on bioactive lipid metabolism and research that has been impacted by new technologies and their new potential to transform precision medicine. Provides a clear, up-to-date understanding of lipid signaling and metabolism and the impact of recent technologies critical to advancing new studies Empowers researchers to examine bioactive lipid signaling and metabolism, supporting translation to clinical care and precision medicine Discusses the role of lipid signaling and metabolism in obesity, diabetes, fatty liver disease, inflammation, cancer, cardiovascular disease and mood-related disorders, among others

Bioactive Ceramides in Health and Disease

Johnny Stiban
Bioactive Ceramides in Health and Disease Book PDF

Author : Johnny Stiban
Publisher : Springer Nature
Page : 153 pages
File Size : 40,5 Mb
Release : 2019-09-09
Category : Science
ISBN : 9783030211622

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Bioactive Ceramides in Health and Disease by Johnny Stiban Pdf

This book is about the various roles of bioactive ceramides and other sphingolipids in cellular biology. The enigmatic biophysical and biochemical properties of ceramides and their propensity to influence membranes whether as rafts or protein-permeable channels are heavily discussed. Metabolism of ceramides and their metabolites is also focused with ceramide synthase family of proteins being a target of extensive review. Ceramide 1-phosphate and other sphingolipids are also presented in cellular physiology and pathophysiology. Prokaryotic origins of mitochondria at the level of membranes and the occurrence of apoptosis in bacteria are presented. Many aspects of ceramide and sphingolipid biology are addressed in this book. Its focus is the metabolism of ceramide in normal and diseased states and the biophysical and biochemical mechanisms governing the bioactivity of these molecules. Sphingolipid research has surged over the past thirty years and this book gathers the recent findings of various aspects of sphingolipid biochemistry. World-renowned scientists from the field of lipid biology, specifically sphingolipid biochemistry, were gathered to write this book. Scholars from most continents of the globe committed to write diligently about their expertise and the newest findings in the relevant fields. This book came to fruition after almost a year and a half of laborious preparation and diligent writings. This book is targeted to the experienced reader who is looking to read about the various aspects of bioactive ceramide signaling, as well as to the newcomer into the field, as the topics are explained in concise yet very informative manner. The authors and editor wish all readers a pleasant time reading this volume, and are adamant that this book will meet all expectations.

Adipose Tissue in Health and Disease

Todd Leff,James G. Granneman
Adipose Tissue in Health and Disease Book PDF

Author : Todd Leff,James G. Granneman
Publisher : John Wiley & Sons
Page : 530 pages
File Size : 47,7 Mb
Release : 2010-03-19
Category : Science
ISBN : 352762953X

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Adipose Tissue in Health and Disease by Todd Leff,James G. Granneman Pdf

This timely and most comprehensive reference available on the topic covers all the different aspects vital in the fight against the global obesity epidemic. Following a look at adipose tissue development and morphology, the authors go on to examine its metabolic and endocrine functions and its role in disease. The final section deals with comparative and evolutionary aspects of the tissue. The result is an essential resource for cell and molecular biologists, physiologists, biochemists, pharmacologists, and those working in the pharmaceutical industry.