Chemistry And Biology Of Heparin And Heparan Sulfate

Author : Hari G. Garg,Robert J. Linhardt,Charles A. Hales
Publisher : Elsevier
Page : 792 pages
File Size : 44,8 Mb
Release : 2011-10-10
Category : Science
ISBN : 0080529054

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Chemistry and Biology of Heparin and Heparan Sulfate by Hari G. Garg,Robert J. Linhardt,Charles A. Hales Pdf

The chemistry, biochemistry and pharmacology of heparin and heparan sulfate have been and continue to be a major scientific undertaking - heparin and its derivative remain important drugs in clinical practice. Chemistry and Biology of Heparin and Heparan Sulfate provides readers with an insight into the chemistry, biology and clinical applications of heparin and heparan sulfate and examines their function in various physiological and pathological conditions. Providing a wealth of useful information, no other tome covers the diversity of topics in the field. Students, doctors, chemists, biochemists, and research scientists will find this book an invaluable source for updating their current knowledge of developments in this area. Comprehensively reviews all aspects of heparin and heparan sulfate research Uniquely describes the chemistry, biology and clinical application of heparins and heparan sulfates in one work Provides an invaluable source of knowledge of current developments for chemists, biochemists, medical doctors, researchers, students and practitioners

Author : Anonim
Publisher : Academic Press
Page : 408 pages
File Size : 50,6 Mb
Release : 2010-10-28
Category : Science
ISBN : 0123812836

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Glycosaminoglycans in Development, Health and Disease by Anonim Pdf

Glycosaminoglycans (GAGs) are a family of linear polysaccharides that are found in all animal tissues. Several are used as biomaterials, including heparin, heparin sulfate, keratan sulfate, dermatan sulfate, and chondroitin sulfate. This volume discusses the role of GAGs in development, health and disease. This series provides a forum for discussion of new discoveries, approaches, and ideas Contributions from leading scholars and industry experts Reference guide for researchers involved in molecular biology and related fields

Author : Ajit Varki,Maarten J. Chrispeels
Publisher : CSHL Press
Page : 694 pages
File Size : 44,8 Mb
Release : 1999
Category : Medical
ISBN : 0879696818

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Essentials of Glycobiology by Ajit Varki,Maarten J. Chrispeels Pdf

Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. "Essentials of Glycobiology" describes their biogenesis and function and offers a useful gateway to the understanding of glycans.

Author : Rebecca Lever,Barbara Mulloy,Clive P. Page
Publisher : Springer Science & Business Media
Page : 457 pages
File Size : 50,7 Mb
Release : 2012-05-08
Category : Medical
ISBN : 9783642230561

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Heparin - A Century of Progress by Rebecca Lever,Barbara Mulloy,Clive P. Page Pdf

Heparins remain amongst the most commonly used drugs in clinical practice. Almost 100 years have passed since the initial discovery of this complex substance and, during this time, understanding of the nature and uses of heparin and related molecules has grown dramatically. The aim of this volume is to summarise the developments that have led to the current status of both heparins as drugs and the field of heparin research, with a focus on the particularly rapid progress that has been made over the past three decades. Individual sections are dedicated to the nature of heparin as a biological molecule, the current approaches and techniques that are used to ensure the safety and reliability of heparin as a medicine, the clinical pharmacology of heparin as an anticoagulant drug, effects and potential applications of heparin aside of those involving haemostasis and, finally, the nature and potential uses of heparin-like materials from both natural and synthetic sources.

Author : Israel Vlodavsky,Ralph D. Sanderson,Neta Ilan
Publisher : Springer Nature
Page : 871 pages
File Size : 44,7 Mb
Release : 2020-04-09
Category : Medical
ISBN : 9783030345211

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Heparanase by Israel Vlodavsky,Ralph D. Sanderson,Neta Ilan Pdf

Written by internationally recognized leaders in Heparanase biology, the book’s eight chapters offer an opportunity for scientists, clinicians and advanced students in cell biology, tumor biology and oncology to obtain a comprehensive understanding of Heparanase’s multifaceted activities in cancer, inflammation, diabetes and other diseases, as well as its related clinical applications. Proteases and their involvement in cancer progression have been well addressed and documented; however, the emerging premise presented within this book is that Heparanase is a master regulator of aggressive cancer phenotypes and crosstalk with the tumor microenvironment. This endoglycosidase contributes to tumor-mediated remodeling of the extracellular matrix and cell surfaces, augmenting the bioavailability of pro-tumorigenic and pro-inflammatory growth factors and cytokines that are bound to Heparan sulfate. Compelling evidence ties Heparanase with all steps of tumor progression including tumor initiation, growth, angiogenesis, metastasis, and chemoresistance, supporting the notion that Heparanase is an important contributor to the poor outcome of cancer patients and a validated target for therapy. Unlike Heparanase, heparanase-2, a close homolog of Heparanase, lacks enzymatic activity, inhibits Heparanase, and regulates selected genes that promote normal differentiation and tumor suppression. Written by internationally recognized leaders in Heparanase biology, this volume presents a comprehensive understanding of Heparanase’s multifaceted activities in cancer, inflammation, diabetes and other diseases, as well as its related clinical applications to scientists, clinicians and advanced students in cell biology, tumor biology and oncology.

Author : David A. Lane,I. Björk,Ulf Lindahl
Publisher : Springer Science & Business Media
Page : 372 pages
File Size : 55,8 Mb
Release : 2013-11-11
Category : Medical
ISBN : 9781489924445

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Heparin and Related Polysaccharides by David A. Lane,I. Björk,Ulf Lindahl Pdf

This volume is a record of a meeting entitled "Heparin and Related Polysaccharides" that was held at the Biomedical Center, Uppsala, Sweden between 1-6 September 1991. The meeting was hosted by U. Lindahl, L. Kjellen and I. Bjork, who were helped in their preparations by a scientific advisory panel that included U. Abildgaard, B. Casu, E. Holmer and D. Lane. Altogether, 230 participants from 18 countries attended the meeting, and most were present to be included in a photograph, which is to be found at the end of this volume. The selection of presentations for inclusion in the Symposia of the meeting was made on the basis of the known high quality of the work of the individuals or groups involved. This, we believe, is reflected in the contents of the enclosed articles, which collectively give a comprehensive overview of the present state of knowledge of heparin and related compounds. Some of the areas covered are evolving or controversial and the views expressed in each article should be regarded as those of the author(s). The authors have taken various amounts of care to define all their abbreviations and some familiarity with the different forms of nomenclature used in the fields of polysaccharide chemistry and of the coagulation proteinases and their inhibitors will assist the reader.

Author : Hari G. Garg,Mary K. Cowman,Charles A. Hales
Publisher : Elsevier
Page : 432 pages
File Size : 45,5 Mb
Release : 2011-09-06
Category : Science
ISBN : 0080558143

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Carbohydrate Chemistry, Biology and Medical Applications by Hari G. Garg,Mary K. Cowman,Charles A. Hales Pdf

The finding by Emil Fischer that glucose and fructose on treatment with phenylhydrazine gave the identical osazone led him to the elucidation of stereochemistry of carbohydrates. Since then, progress in the field of carbohydrates has been amazing with the unraveling their basic structure, biosynthesis, immunology, functions, and clinical uses, for pure carbohydrates and for protein-linked carbohydrates (glycoproteins and proteoglycans). The chapters in Carbohydrate Chemistry, Biology and Medical Applications present a logical sequence leading from the chemistry and biochemistry of carbohydrates, followed by their role in various pathological conditions, to carbohydrates as potential therapeutic and diagnostic agents. This book offers a detailed panoramic review of the chemistry and biology of carbohydrates for chemists, biologists and health professionals. Each chapter is authored by contributors expert in the particular area of research. Explains how carbohydrates are important to life Details the chemistry, biology and medical aspects of carbohydrates Interdisciplinary and international team of authors

Author : Kuberan Balagurunathan,Hiroshi Nakato,Umesh R. Desai
Publisher : Unknown
Page : 625 pages
File Size : 54,5 Mb
Release : 2015
Category : Biochemistry
ISBN : 1493917145

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Glycosaminoglycans by Kuberan Balagurunathan,Hiroshi Nakato,Umesh R. Desai Pdf

Author : Jin Xie
Publisher : ProQuest
Page : 220 pages
File Size : 48,6 Mb
Release : 2007
Category : Chemistry
ISBN : 0549455191

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Applications of Chromatography and Spectroscopy to Heparin and Heparan Sulfate Glycomics by Jin Xie Pdf

Author : Naoyuki Taniguchi,Koichi Honke,Minoru Fukuda
Publisher : Springer Science & Business Media
Page : 668 pages
File Size : 50,6 Mb
Release : 2011-06-28
Category : Science
ISBN : 9784431678779

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Handbook of Glycosyltransferases and Related Genes by Naoyuki Taniguchi,Koichi Honke,Minoru Fukuda Pdf

The so-called postgenomic research era has now been launched, and the field of gly cobiology and glycotechnology has become one of the most important areas in life science because glycosylation is the most common post-translational modification reaction of proteins in vivo. On the basis of Swiss-Prot data, over 50% proteins are known to undergo glycosylation, but in fact the actual functions of most of the sugar chains in the glycoconjugates remain unknown. The complex carbohydrate chains of glycoproteins, glycolipids, and proteoglycans represent the secondary gene products formed through the reactions of glycosyl transferases. The regulation of the biosynthesis of sugar chains is under the control of the expression of glycosyltransferases, their substrate specificity, and their local ization in specific tissue sites. There is a growing body of evidence to suggest that these enzymes play pivotal roles in a variety of important cellular differentiation and developmental events, as well as in disease processes. Over 300 glycosyltransferases appear to exist in mammalian tissues. If the genes that have been purified and cloned from various species such as humans, cattle, pigs, rats and mice are counted as one, approximately 110 glycogenes that encode glycosyltransferases and related genes have been cloned at present, and this number continues to grow each day. However, most of the functions of the glycosyltransferase genes and related genes are unknown. This fact has stimulated numerous new and interesting approaches in molecular biologi cal investigations.

Author : 978-3-03842-836-7
Publisher : MDPI
Page : 247 pages
File Size : 54,9 Mb
Release : 2018-07-04
Category : Electronic books
ISBN : 9783038428350

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Glycosaminoglycans and Proteoglycans by 978-3-03842-836-7 Pdf

This book is a printed edition of the Special Issue "Glycosaminoglycans and Proteoglycans" that was published in Pharmaceuticals

Author : Renato V. Iozzo
Publisher : Springer Science & Business Media
Page : 547 pages
File Size : 49,5 Mb
Release : 2008-02-02
Category : Science
ISBN : 9781592592098

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Proteoglycan Protocols by Renato V. Iozzo Pdf

Proteoglycans are some of the most elaborate macromolecules of mammalian and lower organisms. The covalent attachment of at least five types of glycosami- glycan side chains to more than forty individual protein cores makes these molecules quite complex and endows them with a multitude of biological functions. Proteoglycan Protocols offers a comprehensive and up-to-date collection of prepa- tive and analytical methods for the in-depth analysis of proteoglycans. Featuring st- by-step detailed protocols, this book will enable both novice and experienced researchers to isolate intact proteoglycans from tissues and cultured cells, to establish the composition of their carbohydrate moieties, to generate strategies for prokaryotic and eukaryotic expression, to utilize methods for the suppression of specific proteoglycan gene expression and for the detection of mutant cells and degradation products, and to study specific interactions between proteoglycans and extracellular matrix proteins as well as growth factors and their receptors. The readers will find concise, yet comprehensive techniques carefully drafted by leading experts in the field. Each chapter commences with a general Introduction, followed by a detailed Materials section, and an easy-to-follow Methods section. An asset of each chapter is the extensive notation that includes troubleshooting tips and practical considerations that are often lacking in formal methodology papers. The reader will find this section most valuable because it is clearly provided by experienced scientists who have first-hand knowledge of the techniques they outline. In addition, most of the chapters are well illustrated with examples of typical data generated with each method.

Author : Wei-Lien Chuang
Publisher : Unknown
Page : 794 pages
File Size : 51,8 Mb
Release : 2000
Category : Heparin
ISBN : UCR:31210014021875

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Studies of Heparin and Its Binding with Biological Molecules by Wei-Lien Chuang Pdf

Author : Ryan J. Huxtable
Publisher : Springer Science & Business Media
Page : 454 pages
File Size : 51,7 Mb
Release : 2013-11-11
Category : Science
ISBN : 9781475794380

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Biochemistry of Sulfur by Ryan J. Huxtable Pdf

There can be few elements with a biochemistry as coherent as that of sulfur. This important element is crucial to myriad aspects of metabo lism, catalysis, and structure. The plurality of functions in which sulfur is involved derives squarely from the numerous oxidation states in which it may exist, some having great stability, some being capable of ready redox interconversions, and yet others having great instability. As a result, the flux of sulfur from the geosphere through the various kingdoms of life leaves few biochemical processes unaffected. Although there are large gaps in the fabric of our basic knowledge of sulfur biochemistry, it is sufficiently framed to allow a unified and organized story, a story which many of the best-known names in bio chemistry have helped to write. It has been both a task and a privilege to try and summarize this story, one that is enormous, complex, fast moving, still developing and, above all, exciting. I suppose that no mo nographer of such a vast subject could be satisfied with his efforts. It is unfortunately probable that in attempting this task I have made as many errors as a Stilton cheese has blue streaks, and as many omissions as a Swiss cheese has holes. Perfection is not to be achieved in a monograph. Inasmuch as I have succeeded, the credit belongs to those whose efforts gave us the knowledge we have. Where I have failed, the fault is only mine.

Author : Shang-Cheng Hung,Medel Manuel L. Zulueta
Publisher : John Wiley & Sons
Page : 574 pages
File Size : 52,7 Mb
Release : 2016-10-10
Category : Science
ISBN : 9781118299845

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Glycochemical Synthesis by Shang-Cheng Hung,Medel Manuel L. Zulueta Pdf

This book is a comprehensive and concise review on principles, strategies, and crucial advances in glycochemistry. It focuses on synthesis and practical applications and emphasizes state-of-the-art approaches to the assembly and design of sugars. • Provides detailed discussion on specific topics like oligosaccharide assembly and design of sugars, techniques in glycoconjugate preparation, multivalency, and carbohydrate-based drug design • Uses notable examples, like solution-based one-pot methods and automated methods for sugar assembly, to illustrate important concepts and advances in a rapidly emerging field • Discusses practical applications of carbohydrates, like medicine, therapeutics, drug and vaccine development