Studies Of Heparin And Its Binding With Biological Molecules

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Chemistry and Biology of Heparin and Heparan Sulfate

Author : Hari G. Garg,Robert J. Linhardt,Charles A. Hales
Publisher : Elsevier
Page : 792 pages
File Size : 50,6 Mb
Release : 2011-10-10
Category : Science
ISBN : 0080529054

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Chemistry and Biology of Heparin and Heparan Sulfate by Hari G. Garg,Robert J. Linhardt,Charles A. Hales Pdf

The chemistry, biochemistry and pharmacology of heparin and heparan sulfate have been and continue to be a major scientific undertaking - heparin and its derivative remain important drugs in clinical practice. Chemistry and Biology of Heparin and Heparan Sulfate provides readers with an insight into the chemistry, biology and clinical applications of heparin and heparan sulfate and examines their function in various physiological and pathological conditions. Providing a wealth of useful information, no other tome covers the diversity of topics in the field. Students, doctors, chemists, biochemists, and research scientists will find this book an invaluable source for updating their current knowledge of developments in this area. Comprehensively reviews all aspects of heparin and heparan sulfate research Uniquely describes the chemistry, biology and clinical application of heparins and heparan sulfates in one work Provides an invaluable source of knowledge of current developments for chemists, biochemists, medical doctors, researchers, students and practitioners

Heparin - A Century of Progress

Author : Rebecca Lever,Barbara Mulloy,Clive P. Page
Publisher : Springer Science & Business Media
Page : 457 pages
File Size : 52,9 Mb
Release : 2012-05-08
Category : Medical
ISBN : 9783642230561

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Heparin - A Century of Progress by Rebecca Lever,Barbara Mulloy,Clive P. Page Pdf

Heparins remain amongst the most commonly used drugs in clinical practice. Almost 100 years have passed since the initial discovery of this complex substance and, during this time, understanding of the nature and uses of heparin and related molecules has grown dramatically. The aim of this volume is to summarise the developments that have led to the current status of both heparins as drugs and the field of heparin research, with a focus on the particularly rapid progress that has been made over the past three decades. Individual sections are dedicated to the nature of heparin as a biological molecule, the current approaches and techniques that are used to ensure the safety and reliability of heparin as a medicine, the clinical pharmacology of heparin as an anticoagulant drug, effects and potential applications of heparin aside of those involving haemostasis and, finally, the nature and potential uses of heparin-like materials from both natural and synthetic sources.

Essentials of Glycobiology

Author : Ajit Varki,Maarten J. Chrispeels
Publisher : CSHL Press
Page : 694 pages
File Size : 41,6 Mb
Release : 1999
Category : Medical
ISBN : 0879696818

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Essentials of Glycobiology by Ajit Varki,Maarten J. Chrispeels Pdf

Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. "Essentials of Glycobiology" describes their biogenesis and function and offers a useful gateway to the understanding of glycans.

Transfusion Medicine for Pathologists

Author : Brian Castillo,Amitava Dasgupta,Kimberly Klein,Hlaing Tint,Amer Wahed
Publisher : Academic Press
Page : 222 pages
File Size : 51,5 Mb
Release : 2018-06-29
Category : Science
ISBN : 9780128143148

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Transfusion Medicine for Pathologists by Brian Castillo,Amitava Dasgupta,Kimberly Klein,Hlaing Tint,Amer Wahed Pdf

Transfusion Medicine for Pathologists: A Comprehensive Review for Board Preparation, Certification, and Clinical Practice is a concise study guide designed to complement standard textbooks in the field of clinical pathology. Pathology residents and fellows of transfusion medicine will find this book useful as a preparation tool for their exams. In addition, the book is a valuable timesaver for busy residents looking for a focused and compact study guide on transfusion medicine that will also be ideal for practicing pathologists who cross-cover transfusion medicine in their clinical practice. Incorporates key words at the end of each chapter for quick review before an exam Includes concise and easy-to-digest chapters ranging from Donor Selection and Testing, to Blood Bank Testing, Transfusion Reactions, Apheresis, Hemotherapy, Special Transfusion Situations, and more Focuses on key topics to study for board examinations, saving time during busy residency programs

Management of Hemostasis and Coagulopathies for Surgical and Critically Ill Patients

Author : Andy D. Nguyen,Amitava Dasgupta,Amer Wahed
Publisher : Elsevier
Page : 0 pages
File Size : 44,6 Mb
Release : 2016-04-19
Category : Medical
ISBN : 0128035315

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Management of Hemostasis and Coagulopathies for Surgical and Critically Ill Patients by Andy D. Nguyen,Amitava Dasgupta,Amer Wahed Pdf

Management of Hemostasis and Coagulopathies for Surgical and Critically Ill Patients: An Evidence-Based Approach offers a concise guide to a sub-specialty of transfusion medicine from the clinical laboratory perspective. It focuses on the clinical tests that may be done during preoperative assessment, intraoperative, and postoperative assessment and management of surgical or critically ill patients. Management of hemostasis and coagulopathies is approached from an evidence-based perspective-the coagulation status of a patient according to the laboratory test results. Algorithms and decision-support software, designed by the authors, guide clinicians with an additional tool to base transfusion dosage on specific laboratory results, including the use of an artificial neural network for predicting more accurate blood use. Chapters reflect the experience of all three authors who have successfully applied the algorithm for better patient management as well as decreased wastage of expensive blood products, from both the clinical laboratory/pathology and clinical medicine perspective. This book will appeal to a broad section of clinical laboratory and medical practitioners from hematopathology, to internal medicine, surgery, and anesthesiology. For hematopathologists and pathologists who are involved in laboratory medicine and transfusion medicine, this book will help them understand the proper utilization of blood products and how to avoid unnecessary waste and costs for the hospital. For general surgery practitioners, this book will provide practical guidelines on how to use blood products rationally for best medical practice. Internists will also gain insight from this book, learning which patients are at higher risk of bleeding during surgery so that they can alert their clinical colleagues.

Cancer-Associated Thrombosis

Author : Alok A. Khorana,Charles W. Francis
Publisher : CRC Press
Page : 296 pages
File Size : 42,7 Mb
Release : 2007-09-26
Category : Medical
ISBN : 9781420048001

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Cancer-Associated Thrombosis by Alok A. Khorana,Charles W. Francis Pdf

Showcasing the expertise of top-tier specialists who contributed to the newly released guidelines for the care of thrombosis in cancer patients, this exciting guide was written and edited by members of the American Society of Clinical Oncology panel, (ASCO), on the prevention and treatment of cancer-associated thrombosis, among others, and provides

Glycosaminoglycans in Development, Health and Disease

Author : Anonim
Publisher : Academic Press
Page : 408 pages
File Size : 47,6 Mb
Release : 2010-10-28
Category : Science
ISBN : 0123812836

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Glycosaminoglycans in Development, Health and Disease by Anonim Pdf

Glycosaminoglycans (GAGs) are a family of linear polysaccharides that are found in all animal tissues. Several are used as biomaterials, including heparin, heparin sulfate, keratan sulfate, dermatan sulfate, and chondroitin sulfate. This volume discusses the role of GAGs in development, health and disease. This series provides a forum for discussion of new discoveries, approaches, and ideas Contributions from leading scholars and industry experts Reference guide for researchers involved in molecular biology and related fields

Synthesis of Essential Drugs

Author : Ruben Vardanyan,Victor Hruby
Publisher : Elsevier
Page : 634 pages
File Size : 41,9 Mb
Release : 2006-03-10
Category : Medical
ISBN : 008046212X

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Synthesis of Essential Drugs by Ruben Vardanyan,Victor Hruby Pdf

Synthesis of Essential Drugs describes methods of synthesis, activity and implementation of diversity of all drug types and classes. With over 2300 references, mainly patent, for the methods of synthesis for over 700 drugs, along with the most widespread synonyms for these drugs, this book fills the gap that exists in the literature of drug synthesis. It provides the kind of information that will be of interest to those who work, or plan to begin work, in the areas of biologically active compounds and the synthesis of medicinal drugs. This book presents the synthesis of various groups of drugs in an order similar to that traditionally presented in a pharmacology curriculum. This was done with a very specific goal in mind – to harmonize the chemical aspects with the pharmacology curriculum in a manner useful to chemists. Practically every chapter begins with an accepted brief definition and description of a particular group of drugs, proposes their classification, and briefly explains the present model of their action. This is followed by a detailed discussion of methods for their synthesis. Of the thousands of drugs existing on the pharmaceutical market, the book mainly covers generic drugs that are included in the WHO’s Essential List of Drugs. For practically all of the 700+ drugs described in the book, references (around 2350) to the methods of their synthesis are given along with the most widespread synonyms. Synthesis of Essential Drugs is an excellent handbook for chemists, biochemists, medicinal chemists, pharmacists, pharmacologists, scientists, professionals, students, university libraries, researchers, medical doctors and students, and professionals working in medicinal chemistry. * Provides a brief description of methods of synthesis, activity and implementation of all drug types * Includes synonyms * Includes over 2300 references

Anticoagulation Therapy

Author : Ozcan Basaran,Murat Biteker
Publisher : BoD – Books on Demand
Page : 152 pages
File Size : 43,8 Mb
Release : 2016-09-08
Category : Medical
ISBN : 9789535126669

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Anticoagulation Therapy by Ozcan Basaran,Murat Biteker Pdf

The available parenteral and oral anticoagulants have a large clinical use. Understanding biochemistry of anticoagulants may help to improve therapeutic strategies. Resistance to vitamin K antagonist drugs might be a problem for rodent populations. Patients who have thrombogenic risk factors should be anticoagulated. The need for cardiac implantable electronic devices is increasing, and there is a substantial number of patients who are on oral anticoagulant therapy. Prothrombin complex concentrate and other plasma concentrates are useful to deal with over-coagulated situations. The efficacy and safety of non-vitamin K antagonist oral anticoagulants have been proven in large phase III trials. The real-world data suggest even better outcomes with these agents compared to vitamin K antagonists.

Molecular Biology of Alzheimer's Disease

Author : Christian Haass
Publisher : CRC Press
Page : 350 pages
File Size : 47,9 Mb
Release : 2003-09-02
Category : Science
ISBN : 9780203303610

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Molecular Biology of Alzheimer's Disease by Christian Haass Pdf

Highlighting the latest and the most timely aspects of Alzheimer's disease research, this text will enable scientists in related research fields, as well as physicians working with Alzheimer's disease patients, to obtain a quick and complete overview of the current state of the art in one of the most exciting fields in neuroscience research. Leading scientists have contributed articles focusing on key developments in this field. This includes an overview about the pathology, the genetics of familial Alzheimer's disease, proteolytic generation and aggregation of amyloid -peptide, presenilins, risk factors such as ApoE, and transgenic animal models. Some of the latest developments in Alzheimer's disease research, including the effect of presenilin knock outs on amyloid -peptide generation, are also included.

Heparin-Binding Proteins

Author : H. Edward Conrad
Publisher : Elsevier
Page : 553 pages
File Size : 44,6 Mb
Release : 1997-10-02
Category : Medical
ISBN : 9780080533902

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Heparin-Binding Proteins by H. Edward Conrad Pdf

This book describes the complex structures of heparins and heparan sulfates (heparinoids) and how they are generated by their biosynthetic pathways. The book also details the methodologies for studying these structures and their cellular metabolism. Heparin-Binding Proteins introduces the general nature of interactions between heparinoids and proteins, and presents the role for these structures in their interactions with the proteins of the hemostatic mechanisms, fibroblasts growth factors, superoxide dismutase, and lipoproteins. Covers cellular metabolism of heparinoid proteoglycans Written by a distinguished expert in the field of carbohydrate biochemistry Describes the roles of heparan sulfate proteoglycans in Blood coagulation and fibrinolysis Lipoprotein metabolism Superoxide dismutase activity Fibroblast growth factor responses of cells

The Molecular and Cellular Biology of Wound Repair

Author : R.A.F. Clark
Publisher : Springer Science & Business Media
Page : 624 pages
File Size : 49,9 Mb
Release : 2013-11-11
Category : Science
ISBN : 9781489901859

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The Molecular and Cellular Biology of Wound Repair by R.A.F. Clark Pdf

'Provides comprehensive detail on the various aspects of particular molecules involved in the phases of injury and repair and the cellular movements and processes....This is an excellent reference book for libraries serving biology and health science clientele and for workers in this field of research.' -American Scientist, from a review of the First Edition All chapters of this second edition have been completely revised and expanded-especially the chapters on growth factors and extracellular matrix molecules. New chapters discuss provisional matrix proteins, extracellular matrix receptors, and scarring versus nonscarring wound healing.

Progress in Molecular Biology and Translational Science

Author : Anonim
Publisher : Academic Press
Page : 551 pages
File Size : 47,6 Mb
Release : 2019-04-26
Category : Science
ISBN : 9780128177419

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Progress in Molecular Biology and Translational Science by Anonim Pdf

Glycans and Glycosaminoglycans as Clinical Biomarkers and Therapeutics - Part B, Volume 163 in the Progress in Molecular Biology and Translational Science series, provides informative monographs on a variety of research topics related to Glycans and glycosaminoglycans as clinical biomarkers and therapeutics. Topics in this update include an Overview of Fugal Glycan-based Therapeutics, Heparin: An Essential Drug for Modern Medicine, Low Molecular Weight Heparins and Their Clinical Applications, The Clinical Use of Fondaparinux: A Synthetic Heparin Pentasaccharid, Heparinoids as Clinically Used Drugs, Marine Glycan-Derived Therapeutics in China, Efficacy of Heparinoid PSS in Treating Cardiovascular and other Diseases—30 Years Clinical Applications in China, and more. Includes comprehensive coverage of molecular biology Presents ample use of tables, diagrams, schemata and color figures to enhance the reader's ability to rapidly grasp the information provided Contains contributions from renowned experts in the field