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Author : Jasjit S. Bindra,Daniel Lednicer
Publisher : Wiley-Interscience
Page : 448 pages
File Size : 46,5 Mb
Release : 1993
Category : Medical
ISBN : UOM:39015036033846
Author : Jasjit Singh Bindra,Daniel Lednicer
Publisher : Unknown
Page : 283 pages
File Size : 40,5 Mb
Release : 1982
Category : Drugs
ISBN : LCCN:81011471
Author : Jasjit S. Bindra
Publisher : Unknown
Page : 128 pages
File Size : 40,7 Mb
Release : 1995-04-01
Category : Electronic
ISBN : 0471891045
Author : Walter Sneader
Publisher : John Wiley & Sons
Page : 484 pages
File Size : 55,7 Mb
Release : 2005-06-23
Category : Medical
ISBN : 0471899798
This edition provides expanded coverage of pre-20th century drugs, including emphasis on setting chapters in a wide historical and social context.
Author : Kishore R. Sakharkar,Meena K. Sakharkar,Ramesh Chandra
Publisher : CRC Press
Page : 451 pages
File Size : 51,8 Mb
Release : 2022-09-01
Category : Science
ISBN : 9781000795714
Over the past decade, genome sequencing projects and the associated efforts have facilitated the discovery of several novel disease targets and the approval of several innovative drugs. To further exploit this data for human health and disease, there is a need to understand the genome data itself in detail, discover novel targets, understand their role in physiological pathways and associated diseases, with the aim to translate these discoveries to clinical and preventive medicine. It is equally important to understand the labors and limitations in integrating clinical phenotypes with genomic, transcriptomic, proteomic and metabolomic approaches. T
Author : Anonim
Publisher : Unknown
Page : 28 pages
File Size : 50,7 Mb
Release : 2004
Category : Electronic
ISBN : OCLC:437143640
Author : Donald R. Kirsch,Ogi Ogas
Publisher : Simon and Schuster
Page : 328 pages
File Size : 50,9 Mb
Release : 2016-12-13
Category : Science
ISBN : 9781628727197
The surprising, behind-the-scenes story of how our medicines are discovered, told by a veteran drug hunter. The search to find medicines is as old as disease, which is to say as old as the human race. Through serendipity— by chewing, brewing, and snorting—some Neolithic souls discovered opium, alcohol, snakeroot, juniper, frankincense, and other helpful substances. Ötzi the Iceman, the five-thousand-year-old hunter frozen in the Italian Alps, was found to have whipworms in his intestines and Bronze-age medicine, a worm-killing birch fungus, knotted to his leggings. Nowadays, Big Pharma conglomerates spend billions of dollars on state-of the art laboratories staffed by PhDs to discover blockbuster drugs. Yet, despite our best efforts to engineer cures, luck, trial-and-error, risk, and ingenuity are still fundamental to medical discovery. The Drug Hunters is a colorful, fact-filled narrative history of the search for new medicines from our Neolithic forebears to the professionals of today, and from quinine and aspirin to Viagra, Prozac, and Lipitor. The chapters offer a lively tour of how new drugs are actually found, the discovery strategies, the mistakes, and the rare successes. Dr. Donald R. Kirsch infuses the book with his own expertise and experiences from thirty-five years of drug hunting, whether searching for life-saving molecules in mudflats by Chesapeake Bay or as a chief science officer and research group leader at major pharmaceutical companies.
Author : Walter Sneader
Publisher : Unknown
Page : 0 pages
File Size : 40,8 Mb
Release : 2008
Category : Electronic
ISBN : OCLC:1414905090
Author : Juan Alvarez,Brian Shoichet
Publisher : CRC Press
Page : 496 pages
File Size : 46,6 Mb
Release : 2005-03-24
Category : Medical
ISBN : 9781420028775
Virtual screening can reduce costs and increase hit rates for lead discovery by eliminating the need for robotics, reagent acquisition or production, and compound storage facilities. The increased robustness of computational algorithms and scoring functions, the availability of affordable computational power, and the potential for timely structural determination of target molecules, have provided new opportunities for virtual screening, and made it more practical. Why then, isn’t everyone using virtual screening? Examining the scope and limitations of this method, Virtual Screening in Drug Discovery explores the algorithms involved and how to actually use them. Part I offers perspectives on both ligand-based and docking-based virtual screens. The authors of these chapters frame many of the challenges currently facing the field. Part II considers the choice of compounds that are best suited as drug leads. Part III discusses ligand-based approaches, including descriptor-based similarity, traditional pharmacophore searching, and similarity based 3D-pharmacophore fingerprints. The final two sections are devoted to molecular docking. Part IV outlines some important and practical considerations relating to the energetics of protein-ligand binding and target-site topography, whereas specific docking algorithms and strategies are discussed in Part V. Notwithstanding this list of subjects, the book does not overwhelm you with more information than you need—many of the strategies outlined will transcend the specifics of any given method. Nor does the book purport to offer single best ways to use the programs. What it does is provide a snapshot of virtual screening that gives you easy access to strategies and techniques for lead discovery. Daniel E. Levy, editor of the Drug Discovery Series, is the founder of DEL BioPharma, a consulting service for drug discovery programs. He also maintains a blog that explores organic chemistry.
Author : Enrique Ravina
Publisher : John Wiley & Sons
Page : 531 pages
File Size : 46,5 Mb
Release : 2011-04-18
Category : Medical
ISBN : 9783527326693
Der Band zeichnet die oft spektakulären Erfolgs- oder Misserfolgsgeschichten neuartiger pharmazeutischer Wirkstoffe nach und nimmt den Leser dabei mit auf die Reise von den ersten Anfängen der Heilkunde bis zum Milliardengeschäft der modernen Pharmaindustrie. Sachkundig geschrieben, reich illustriert, anregend: Eine unterhaltsame Lektüre!
Author : Tudor I. Oprea
Publisher : John Wiley & Sons
Page : 515 pages
File Size : 55,6 Mb
Release : 2006-03-06
Category : Science
ISBN : 9783527604203
This handbook provides the first-ever inside view of today's integrated approach to rational drug design. Chemoinformatics experts from large pharmaceutical companies, as well as from chemoinformatics service providers and from academia demonstrate what can be achieved today by harnessing the power of computational methods for the drug discovery process. With the user rather than the developer of chemoinformatics software in mind, this book describes the successful application of computational tools to real-life problems and presents solution strategies to commonly encountered problems. It shows how almost every step of the drug discovery pipeline can be optimized and accelerated by using chemoinformatics tools -- from the management of compound databases to targeted combinatorial synthesis, virtual screening and efficient hit-to-lead transition. An invaluable resource for drug developers and medicinal chemists in academia and industry.
Author : Wolfgang Jahnke,Daniel A. Erlanson
Publisher : John Wiley & Sons
Page : 391 pages
File Size : 50,8 Mb
Release : 2006-12-13
Category : Science
ISBN : 9783527608607
This first systematic summary of the impact of fragment-based approaches on the drug development process provides essential information that was previously unavailable. Adopting a practice-oriented approach, this represents a book by professionals for professionals, tailor-made for drug developers in the pharma and biotech sector who need to keep up-to-date on the latest technologies and strategies in pharmaceutical ligand design. The book is clearly divided into three sections on ligand design, spectroscopic techniques, and screening and drug discovery, backed by numerous case studies.
Author : Keith Veronese
Publisher : Unknown
Page : 248 pages
File Size : 54,6 Mb
Release : 2022-06-15
Category : Electronic
ISBN : 1633887537
In Making Medicine: Surprising Stories from the History of Drug Discovery, author Keith Veronese examines eighteen different molecules and their unlikely discovery -or in many cases, their second discovery -en route to becoming invaluable medications.
Author : Miriam Boeri
Publisher : Univ of California Press
Page : 284 pages
File Size : 49,6 Mb
Release : 2017-11-21
Category : Social Science
ISBN : 9780520293472
The historical and social context -- The life course of baby boomers -- Relationships -- The war on drugs and mass incarceration -- The racial landscape of the drug war -- Women doing drugs -- Aging in drug use -- The culture of control expands -- Social reconstruction and social recovery -- Appendix : the older drug user study methodology
Author : Daniel Lednicer
Publisher : John Wiley & Sons
Page : 240 pages
File Size : 51,9 Mb
Release : 2006-10-20
Category : Science
ISBN : 9780470068267
A case history approach to drug synthesis and discovery Discover the origins of some of today’s most popular drug therapies. Explore case histories and gain insight into major classes of antibiotics, antiviral drugs, analgesics, steroids, compounds designed to lower cholesterol, and more. Review the steps required for FDA approval. This is a great reference for students in medicinal chemistry, researchers in pharmaceuticals, and medical practitioners.