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Evan Shepard is a young man with a chequered past when he first meets the Drakes, after his car breaks down outside their house. Behind him, he has a troubled adolescence, a failed marriage and a little daughter, but his meeting with the quiet and beautiful Rachel heralds a new start. However, after their swift marriage, things don't work out quite as planned and the stresses of living with Rachel's family, in their shared house in Cold Spring Harbor, begin to take their toll on the new couple.
The Road to Discovery by Jan Anthony Witkowski Pdf
The Road to Discovery: A Short History of Cold Spring Harbor Laboratory was published in 2015 to mark the 125th anniversary of Cold Spring Harbor Laboratory. At Cold Spring Harbor, in a bucolic setting on the north shore of New York's Long Island, two interdependent research centers in biology were founded as Charles Darwin's insights into heredity and evolution shook the world of science. Fifty years later, those centers would emerge as a single institution that would cradle another revolution, the new science of molecular biology, and advance to world renown in research and professional education. It is a remarkable story, with a path of progress that was neither simple nor assured. The Road to Discovery traces half a century of changes in name, leadership, governance, and financial fortune. And scientific missteps, most notoriously in eugenics, were triumphed by innovative work in genetics, human metabolism, and cancer. From the 1940s through the 1960s, the Laboratory was home to fundamental discoveries about the nature of genetic material and a cauldron of critical assessment of ideas about genes by sharp-tongued summer visitors. James D. Watson, a junior member of that group, would go on to deduce the structure of DNA with Francis Crick in 1953 and help create the new field of molecular genetics before returning to Cold Spring Harbor as Director 15 years later. As the book shows, his "Bold Plan" would inspire, cajole, and goad into existence an era of expansion, new research directions, and initiatives in conferences, courses, publishing, and education that redefined the scope of the Laboratory. Under Bruce Stillman's leadership, that scope has grown still more, making the Laboratory unique among research institutions worldwide--envied, imitated, but not reproduced. The book's author is the science historian Jan Witkowski. His knowledge of the subject is wide and his affection for it deep. He brings to his task insights that only a decades-long career as a staff member can provide. For over a century, the Laboratory has been influenced by exceptional personalities, outstanding achievements, and dramatic events. The Road to Discovery captures that history in a lively narrative illuminated by vignettes on the importance of individual scientists and their discoveries. Abundantly documented with material from the Laboratory's archives, it is an accessible book that will appeal to anyone interested in the development of biomedical science and biotechnology through the 20th century to the present day.
Essentials of Glycobiology by Ajit Varki,Maarten J. Chrispeels Pdf
Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. "Essentials of Glycobiology" describes their biogenesis and function and offers a useful gateway to the understanding of glycans.
Methods in Yeast Genetics by David C. Amberg,Dan Burke,Jeffrey N. Strathern Pdf
"Methods in Yeast Genetics" is a course that has been offered annually at Cold Spring Harbor for the last 30 years. This provides a set of teaching experiments along with the protocols and recipes for the standard techniques and reagents used in the study of yeast biology.
Enjoy Your Cells is a new series of children's books from the acclaimed creative partnership of scientist/author Fran Balkwill and illustrator Mic Rolph. The titles in the series include: Enjoy Your Cells Germ Zappers Have a Nice DNA! Gene Machines Once again, they use their unique brand of simple but scientifically accurate commentary and exuberantly colorful graphics to take young readers on an entertaining exploration of the amazing, hidden world of cells, proteins, and DNA. It's over ten years since Fran and Mic invented a new way of getting science across to children. Think what extraordinary advances have been made in biology in that time - and how often those discoveries made headlines. Stem cells, cloning, embryo transfer, emerging infections, vaccine development...here in these books are the basic facts behind the public debates. With these books, children will learn to enjoy their cells and current affairs at the same time. And they're getting information that has been written and reviewed by working scientists, so it's completely correct and up-to-date. Readers aged 7 and up will appreciate the stories' lively language and with help, even younger children will enjoy and learn from the jokes and illustrations - no expert required! This series is a must for all elementary school students and those who care about educating them to be well-informed in a world of increasingly complex health-related and environmental issues. Fran Balkwill is Professor of Cancer Biology at St. Bartholomew's Hospital and the London Queen Mary School of Medicine. Mic Rolph is a graphic designer with much television and publishing experience. Together, they have created many books for children, and have won several awards, including the prestigious COPUS Junior Science Book Prize.
Statistics at the Bench by Martina Bremer,Rebecca W. Doerge Pdf
This handbook is a convenient bench companion for biologists, designed as a handy reference guide for elementary and intermediate statistical analyses. Statistical methods most frequently used in publications and reports, as well as guidelines for the interpretation of results, are explained using simple examples with complete instructions for Excel.
Glia by Ben Barres,Marc R. Freeman,Beth Stevens Pdf
The majority of cells in the nervous system are glia. Long thought of as passive bystanders, glial cells are increasingly being appreciated for their active roles in nourishing, supporting, and protecting the neuronal cells that relay electrical signals through the nervous system. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology examines the development of the major classes of glial cells-astrocytes, oligodendrocytes, Schwann cells, and microglia-and their roles in normal physiology and disease. The contributors describe how glia help establish and refine synaptic connections, maintain the metabolic and ionic milieu of nerve cells, myelinate axons, modulate nerve signal propagation, and contribute to the blood-brain barrier. The biological characteristics of glial cells in vertebrate and invertebrate model systems, including those of Drosophila, Caenorhabditis elegans, and zebrafish, are also covered. The authors also discuss the roles of glia in repair and regeneration, as well as in cancer and neurodegenerative diseases (e.g., Alzheimer's). This volume is therefore a valuable reference for all neurobiologists and biomedical scientists wishing to understand these diverse and dynamic cells.
Telomeres by Titia De Lange,Vicki Lundblad,Elizabeth Helen Blackburn Pdf
An up-to-date survey of the current exciting state of telomere biology. Telomeres – specialized structures found at the ends of chromosomes – are essential for maintaining the integrity of chromosomes and their faithful duplication during cell division. Chapters in this volume cover telomere structure and function in a range of organisms, focusing on how they are maintained, their roles in cell division and gene expression, and how deficiencies in these structures contribute to cancers and other diseases and even aging.
Houses for Science traces the unique architectural and scientific evolution of Cold Spring Harbor Laboratory from whaling village, to "summer camp" for biologists, to world-renowned research and educational institution. Situated on Long Island's fabled North Shore, Cold Spring Harbor Laboratory has a one-hundred-year heritage of superlative basic research in genetics and an architectural patrimony that spans nearly two centuries. In Houses for Science architectural historian Elizabeth Watson skillfully integrates the fascinating story of the construction and preservation of this village of science with a chronological account of the history of the Laboratory and the fundamental discoveries made here. Augmenting this account are essays by Nobel laureate James D. Watson on the key advances made in genetics research during the Laboratory's first one hundred years.
Stem Cells by Kristy Red-Horse,Cristina Lo Celso,Fiona M Watt Pdf
Stem cells are multipotent cells that sustain and repair tissues by dividing and differentiating to form the various different cell types normally present. Embryonic stem cells are capable of differentiating into any cell type, whereas adult stem cells are typically restricted to a particular lineage. This book examines recent progress in our understanding of the biology of these cells, how they are regulated, and opportunities for using them in disease therapies.
Defines the current status of research in the genetics, anatomy, and development of the nematode C. elegans, providing a detailed molecular explanation of how development is regulated and how the nervous system specifies varied aspects of behavior. Contains sections on the genome, development, neural networks and behavior, and life history and evolution. Appendices offer genetic nomenclature, a list of laboratory strain and allele designations, skeleton genetic maps, a list of characterized genes, a table of neurotransmitter assignments for specific neurons, and information on codon usage. Includes bandw photos. For researchers in worm studies, as well as the wider community of researchers in cell and molecular biology. Annotation copyrighted by Book News, Inc., Portland, OR
Based on a popular course at Cold Spring Harbor Laboratory, this new manual assembles cutting-edge protocols, helpful hints, and lecture notes to teach researchers from a wide variety of disciplines the essential methods of proteomics using state-of-the-art instrumentation. Detailed protocols involving protein microarrays, liquid chromatography, high-throughput cloning of expression constructs, IMAC, mass spectrometry, MALDI–TOF, and MudPIT are provided, along with well-illustrated descriptions of experimental procedures and lists of recommended Web sites and reading material. Proteomics: A Cold Spring Harbor Laboratory Course Manualcan be used both as the basis for a course and as a detailed bench manual for those performing indispensable proteomic experiments. It is authored by Andrew J. Link and Joshua LaBaer, both leaders in their fields, who bring complementary expertise to the manual.
Ras and Cancer in the 21st Century by Linda VanAelst,Frank McCormick Pdf
Ras proteins are key molecular switches in cell signaling pathways that, when activated, trigger cell growth and division. Mutations that produce abnormally active Ras proteins are common in human cancers, particularly those of the pancreas, lung, and colon. These cancers can be difficult to treat because Ras oncoproteins have long been considered 'undruggable.' Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine covers the recent progress that has been made in understanding Ras biology, how Ras activation leads to tumorigenesis, and ways in which oncogenic Ras signaling may be targeted therapeutically. The contributors review the biochemical characteristics of the different Ras isoforms (HRAS, KRAS, and NRAS), their main effectors and signaling pathways, and the mutations that lead to their constitutive activation. Recent work showing that some Ras oncoproteins may be effectively inhibited by small molecules is covered, as is work on alternative targets (e.g., enzymes that catalyze posttranslational modifications of Ras) and inhibitors (e.g., nucleic acids). The authors also discuss how organoids and mouse models are being used to study tumor progression and therapeutic efficacy. This volume is therefore essential reading for all cancer biologists, cell and molecular biologists, and pharmacologists concerned with understanding and treating Ras-driven cancers.
