Telomeres

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The Telomere Effect

Dr. Elizabeth Blackburn,Dr. Elissa Epel
The Telomere Effect Book PDF

Author : Dr. Elizabeth Blackburn,Dr. Elissa Epel
Publisher : Grand Central Publishing
Page : 328 pages
File Size : 47,6 Mb
Release : 2017-01-03
Category : Health & Fitness
ISBN : 9781455587964

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The Telomere Effect by Dr. Elizabeth Blackburn,Dr. Elissa Epel Pdf

The New York Times bestselling book coauthored by the Nobel Prize winner who discovered telomerase and telomeres' role in the aging process and the health psychologist who has done original research into how specific lifestyle and psychological habits can protect telomeres, slowing disease and improving life. Have you wondered why some sixty-year-olds look and feel like forty-year-olds and why some forty-year-olds look and feel like sixty-year-olds? While many factors contribute to aging and illness, Dr. Elizabeth Blackburn discovered a biological indicator called telomerase, the enzyme that replenishes telomeres, which protect our genetic heritage. Dr. Blackburn and Dr. Elissa Epel's research shows that the length and health of one's telomeres are a biological underpinning of the long-hypothesized mind-body connection. They and other scientists have found that changes we can make to our daily habits can protect our telomeres and increase our health spans (the number of years we remain healthy, active, and disease-free). The Telemere Effect reveals how Blackburn and Epel's findings, together with research from colleagues around the world, cumulatively show that sleep quality, exercise, aspects of diet, and even certain chemicals profoundly affect our telomeres, and that chronic stress, negative thoughts, strained relationships, and even the wrong neighborhoods can eat away at them. Drawing from this scientific body of knowledge, they share lists of foods and suggest amounts and types of exercise that are healthy for our telomeres, mind tricks you can use to protect yourself from stress, and information about how to protect your children against developing shorter telomeres, from pregnancy through adolescence. And they describe how we can improve our health spans at the community level, with neighborhoods characterized by trust, green spaces, and safe streets. The Telemere Effect will make you reassess how you live your life on a day-to-day basis. It is the first book to explain how we age at a cellular level and how we can make simple changes to keep our chromosomes and cells healthy, allowing us to stay disease-free longer and live more vital and meaningful lives.

Telomeres and Telomerase

Predrag Slijepcevic
Telomeres and Telomerase Book PDF

Author : Predrag Slijepcevic
Publisher : S. Karger AG (Switzerland)
Page : 0 pages
File Size : 44,7 Mb
Release : 2008
Category : Telomerase
ISBN : 3805590636

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Telomeres and Telomerase by Predrag Slijepcevic Pdf

Telomeres are essential functional elements of eukaryotic chromosomes. Their fundamental biological role as protectors of chromosome stability was identified for the first time in the 1930s by Hermann Muller and Barbara McClintock based on pioneering cytological experiments. Modern molecular research carried out more recently revealed that telomeres and telomerase play important roles in processes such as carcinogenesis and cellular senescence. This special issue presents the most recent developments in this highly active field of research. It is becoming increasingly clear that molecular pathways involved in regulation of telomere length and structure are functionally linked with pathways involved in DNA damage response, cellular stress response, chromatin organization and perhaps even pathways that regulate evolutionary chromosome rearrangements. The above functional link is explored by the leading experts in the field of telomere biology. Cell biologists, molecular biologists, oncologists, gerontologists, and radiobiologists with an interest in the role of telomeres/telomerase will appreciate the up-to-date information in this publication.

Telomeres and Telomerase in Aging, Disease, and Cancer

K. Lenhard Rudolph
Telomeres and Telomerase in Aging Disease and Cancer Book PDF

Author : K. Lenhard Rudolph
Publisher : Springer Science & Business Media
Page : 332 pages
File Size : 42,6 Mb
Release : 2007-11-07
Category : Medical
ISBN : 9783540737094

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Telomeres and Telomerase in Aging, Disease, and Cancer by K. Lenhard Rudolph Pdf

Telomere shortening represents one of the basic aspects of ageing and telomere dysfunction could contribute to the accumulation of DNA damage during ageing. This book summarizes evidence and data indicating that telomere dysfunction influences human ageing, diseases and cancer. The book describes our current knowledge on checkpoints that limit cellular lifespan and survival in response to telomere dysfunction. There is special focus on adult stem cells.

Telomeres

Titia De Lange,Vicki Lundblad,Elizabeth Helen Blackburn
Telomeres Book PDF

Author : Titia De Lange,Vicki Lundblad,Elizabeth Helen Blackburn
Publisher : Unknown
Page : 598 pages
File Size : 50,7 Mb
Release : 2006
Category : Medical
ISBN : UOM:39015064106506

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Telomeres by Titia De Lange,Vicki Lundblad,Elizabeth Helen Blackburn Pdf

An up-to-date survey of the current exciting state of telomere biology. Telomeres – specialized structures found at the ends of chromosomes – are essential for maintaining the integrity of chromosomes and their faithful duplication during cell division. Chapters in this volume cover telomere structure and function in a range of organisms, focusing on how they are maintained, their roles in cell division and gene expression, and how deficiencies in these structures contribute to cancers and other diseases and even aging.

Telomeres and Telomerase in Cancer

Keiko Hiyama
Telomeres and Telomerase in Cancer Book PDF

Author : Keiko Hiyama
Publisher : Springer Science & Business Media
Page : 380 pages
File Size : 47,6 Mb
Release : 2009-03-18
Category : Medical
ISBN : 9781603278799

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Telomeres and Telomerase in Cancer by Keiko Hiyama Pdf

Telomerase, an enzyme that maintains telomeres and endows eukaryotic cells with immortality, was first discovered in tetrahymena in 1985. In 1990s, it was proven that this enzyme also plays a key role in the infinite proliferation of human cancer cells. Now telomere and telomerase are widely accepted as important factors involved in cancer biology, and as promising diagnostic tools and therapeutic targets. Recently, role of telomerase in “cancer stem cells” has become another attractive story. Until now, there are several good books on telomere and telomerase focusing on biology in ciliates, yeasts, and mouse or basic sciences in human, providing basic scientists or students with updated knowledge.

Telomeres, Diet and Human Disease

Amelia Marti,Guillermo Zalba
Telomeres Diet and Human Disease Book PDF

Author : Amelia Marti,Guillermo Zalba
Publisher : CRC Press
Page : 178 pages
File Size : 52,9 Mb
Release : 2017-08-30
Category : Medical
ISBN : 9781351648479

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Telomeres, Diet and Human Disease by Amelia Marti,Guillermo Zalba Pdf

The maintenance of telomeres—repetitive sequences at the end of chromosome—is essential to health. Dysfunction in telomere maintenance pathways plays a role in aging, cancer, atherosclerosis and other diseases. This has led to telomere maintenance as a prime target for patient therapies. This book describes the advances in telomere research as it applies to human health and especially how lifestyle and dietary factors could modify the telomerase maintenance process. The book examines the mechanisms involved, the primary of which are oxidative stress and the role of sirtuins, and how they can be modified by dietary patterns such as Mediterranean diet.

Age Later

Nir Barzilai, M.D.
Age Later Book PDF

Author : Nir Barzilai, M.D.
Publisher : St. Martin's Press
Page : 320 pages
File Size : 52,8 Mb
Release : 2020-06-16
Category : Health & Fitness
ISBN : 9781250230867

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Age Later by Nir Barzilai, M.D. Pdf

How do some people avoid the slowing down, deteriorating, and weakening that plagues many of their peers decades earlier? Are they just lucky? Or do they know something the rest of us don’t? Is it possible to grow older without getting sicker? What if you could look and feel fifty through your eighties and nineties? Founder of the Institute for Aging Research at the Albert Einstein College of Medicine and one of the leading pioneers of longevity research, Dr. Nir Barzilai’s life’s work is tackling the challenges of aging to delay and prevent the onset of all age-related diseases including “the big four”: diabetes, cancer, heart disease, and Alzheimer’s. One of Dr. Barzilai’s most fascinating studies features volunteers that include 750 SuperAgers—individuals who maintain active lives well into their nineties and even beyond—and, more importantly, who reached that ripe old age never having experienced cardiovascular disease, cancer, diabetes, or cognitive decline. In Age Later, Dr. Barzilai reveals the secrets his team has unlocked about SuperAgers and the scientific discoveries that show we can mimic some of their natural resistance to the aging process. This eye-opening and inspirational book will help you think of aging not as a certainty, but as a phenomenon—like many other diseases and misfortunes—that can be targeted, improved, and even cured.

Origin and Evolution of Telomeres

Jozef Nosek
Origin and Evolution of Telomeres Book PDF

Author : Jozef Nosek
Publisher : CRC Press
Page : 194 pages
File Size : 52,7 Mb
Release : 2008-05-26
Category : Science
ISBN : 9781498713498

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Origin and Evolution of Telomeres by Jozef Nosek Pdf

Linear chromosomes represent an evolutionary innovation associated with the origin of eukaryotic cells. This book describes how linear chromosomes and primordial pathways for maintaining their terminal structures, telomeres, emerged in early eukaryotes.Telomeres, derived from the Greek meaning terminal part, were first described by Hermann Muller i

Telomeres and Telomerase

Derek J. Chadwick,Gail Cardew
Telomeres and Telomerase Book PDF

Author : Derek J. Chadwick,Gail Cardew
Publisher : John Wiley & Sons
Page : 250 pages
File Size : 54,5 Mb
Release : 2008-04-30
Category : Science
ISBN : 9780470515440

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Telomeres and Telomerase by Derek J. Chadwick,Gail Cardew Pdf

Telomeres and Telomerase Chairman: Sydney Brenner, 1997 Telomeres are the protective genetic elements located at the ends of chromosomes and are essential for correct chromosomal structure and function. They are not fully replicated by the conventional DNA polymerase system because DNA synthesis occurs only in the 5' to 3' direction and requires an RNA primer for initiation. Consequently, cells require a special enzyme to maintain the telomeric ends of chromosomes during each round of replication. This enzyme, telomerase, is a ribonucleoprotein that extends chromosome ends by adding short stretches of nucleotide repeats using a portion of its integral RNA component as the template. Recently, much excitement has been generated by the suggestion that telomerase, or rather the absence of telomerase and the resultant loss of terminal DNA, is a cause of human ageing. The evidence for this is twofold: the telomeres of certain cells in culture shorten during their lifespan; and immortalization of cells is associated, at least in some cases, with the maintenance of telomeres and telomerase activity. The latter observation prompted the analysis of clinical samples from patients with cancer and the demonstration that, in contrast to normal somatic cells, malignant cells possess telomerase activity. This is a unique book. Not only does it contain the latest experimental results from an international group of experts, but it also includes critical examinations of the current evidence, and discussions that attempt to identify the central and underlying concepts of this rapidly expanding field.

Telomere Miracle

Ed Park, MD
Telomere Miracle Book PDF

Author : Ed Park, MD
Publisher : Hay House, Inc
Page : 280 pages
File Size : 46,6 Mb
Release : 2018-01-23
Category : Health & Fitness
ISBN : 9781401952587

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Telomere Miracle by Ed Park, MD Pdf

What if everything you think you know about getting older and staying healthy is wrong? Ed Park, M.D., offers the revolutionary idea that disease and aging in humans all arises from a single source: genetic errors caused by shortening of telomeres, or the sequences of DNA at the ends of our chromosomes. Telomeres naturally wear down over time, and thus when cells replicate (as they do all the time in our bodies), they’re creating progressively poorer-quality duplicates of themselves, like making a Xerox of a Xerox of a Xerox. Ultimately, the body deteriorates, resulting in a range of ailments, many of which we associate with aging—from diabetes to hypertension to macular degeneration to cancer. Happily, Ed tells us, it’s possible to slow or even reverse this process and effectively turn back the clock. In The Telomere Miracle, he explains cutting-edge science in a lively style, using illustrations and metaphors ranging from auto parts to superheroes. Then he shows readers how they can intervene in the aging process by boosting the activity of the enzyme telomerase naturally by understanding and optimizing six key areas of breathing, mindset, sleep, exercise, diet, and supplements.

Telomere

Marcelo Larramendy
Telomere Book PDF

Author : Marcelo Larramendy
Publisher : BoD – Books on Demand
Page : 228 pages
File Size : 55,6 Mb
Release : 2016-11-23
Category : Medical
ISBN : 9789535127529

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Telomere by Marcelo Larramendy Pdf

This book, Telomere - A Complex End of a Chromosome, is organized into nine chapters containing the latest aspects of the current knowledge about the structure of telomeres and the crucial role that telomerase plays not only in maintaining chromosomal stability but also in relation to cell immortality, cell instability, and cancer biology. We now appreciate that these unusual complexes of DNA and proteins we all know as "telomeres" are dynamic and key structures that depend on telomerase and other cellular factors for continuance. Regulation of telomere activity is a dynamic area of current research, and new insights into telomeres and their role in aging and cancer, among other biological functions and pathologies, appear regularly in the scientific world. However, one fact is more than understandable in this difficult biological conundrum: the end of the telomere story is far from being totally unraveled.

Elizabeth Blackburn and the Story of Telomeres

Catherine Brady
Elizabeth Blackburn and the Story of Telomeres Book PDF

Author : Catherine Brady
Publisher : MIT Press
Page : 405 pages
File Size : 42,7 Mb
Release : 2009-02-13
Category : Biography & Autobiography
ISBN : 9780262261968

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Elizabeth Blackburn and the Story of Telomeres by Catherine Brady Pdf

The story of molecular biologist Elizabeth Blackburn and her groundbreaking research on telomeres and what it reveals about the resourceful opportunism that characterizes the best scientific thinking. Molecular biologist Elizabeth Blackburn—one of Time magazine's 100 “Most Influential People in the World” in 2007—made headlines in 2004 when she was dismissed from the President's Council on Bioethics after objecting to the council's call for a moratorium on stem cell research and protesting the suppression of relevant scientific evidence in its final report. But it is Blackburn's groundbreaking work on telomeric DNA, which launched the field of telomere research, that will have the more profound and long-lasting effect on science and society. In this compelling biography, Catherine Brady tells the story of Elizabeth Blackburn's life and work and the emergence of a new field of scientific research on the specialized ends of chromosomes and the enzyme, telomerase, that extends them. In the early stages of telomere research, telomerase, heralded as a potential cure for cancer and diseases related to aging, attracted the voracious interest of biotech companies. The surrounding hype succeeded in confusing the role of telemorase in extending the life of a cell with a mechanism that might extend the lifespan of an entire organism. In Brady's hands, Blackburn's story reveals much about the tension between pure and applied science, the politicking that makes research science such a competitive field, and the resourceful opportunism that characterizes the best scientific thinking. Brady describes the science accessibly and compellingly. She explores Blackburn's struggle to break down barriers in an elite, male-dominated profession, her role as a mentor to other women scientists (many of whom have made their mark in telomere research), and the collaborative nature of scientific work. This book gives us a vivid portrait of an exceptional woman and a new understanding of the combination of curiosity, imaginative speculation, and aesthetic delight that powers scientific discovery.

Telomeres

Carole Saintome
Telomeres Book PDF

Author : Carole Saintome
Publisher : John Wiley & Sons
Page : 326 pages
File Size : 50,5 Mb
Release : 2024-06-12
Category : Science
ISBN : 9781394300792

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Telomeres by Carole Saintome Pdf

Telomeres are specialized DNA–protein structures that protect the ends of chromosomes to maintain their integrity. They are chromosome sentinels. This book, written by multiple authors, presents current knowledge and the most recent discoveries relating to telomeres. The first chapters describe telomere structures (DNA and proteins), organization, dynamics and replication in a range of organisms including ciliates, yeast and mammals. The following chapters cover mechanisms that maintain telomere length involving telomerase and Alternative Lengthening Telomeres (ALT) mechanisms. Interestingly, telomeres are transcribed into repetitive RNA called TERRA (Telomeric repeat-containing RNA), the state of the art regarding mammalian telomere transcripts is presented here. Two chapters are dedicated to the description of how telomere biology impacts the development of cancer and how their disfunctions induce telomeropathies (telomere biology disorders). Finally, the book ends with a chapter presenting telomere and telomerase targeting agents as potential anticancer agents, a promising therapeutic approach.

Telomeres and Telomerase

Zhou Songyang
Telomeres and Telomerase Book PDF

Author : Zhou Songyang
Publisher : Humana Press
Page : 191 pages
File Size : 53,8 Mb
Release : 2011-04-07
Category : Science
ISBN : 1617790915

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Telomeres and Telomerase by Zhou Songyang Pdf

New and rapid advances in technology have equipped us with a variety of tools and platforms to ask fundamental questions of telomere regulation and have allowed investigators to carry out experiments using diverse model systems. For example, proteomic, genomic, and molecular approaches have afforded us unprecedented insight into the complex protein interaction networks at work on the telomere chromatin and the detailed information regarding telomere dynamics in response to stress or stimuli. Telomeres and Telomerase: Methods and Protocols, Second Edition builds upon the telomerase assays featured in the popular first edition to encompass many different assays that allow investigators to query the function of telomere proteins and the responses of the telomere DNA, including detailed examinations of biochemical, molecular, and proteomic approaches. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and expert tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Telomeres and Telomerase: Methods and Protocols, Second Edition serves as an ideal, up-to-date guide for investigators further pursing this vital field of study.

The Evolving Telomeres

Arthur J. Lustig,Kurt Runge
The Evolving Telomeres Book PDF

Author : Arthur J. Lustig,Kurt Runge
Publisher : Frontiers Media SA
Page : 76 pages
File Size : 55,9 Mb
Release : 2016-07-19
Category : Genetics
ISBN : 9782889198818

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The Evolving Telomeres by Arthur J. Lustig,Kurt Runge Pdf

What controls the different rates of evolution to give rise to conserved and divergent proteins and RNAs? How many trials until evolution can adapt to physiological changes? Every organism has arisen through multiple molecular changes, and the mechanisms that are employed (mutagenesis, recombination, transposition) have been an issue left to the elegant discipline of evolutionary biology. But behind the theory are realities that we have yet to ascertain: How does an evolving cell accommodate its requirements for both conserving its essential functions, while also providing a selective advantage? In this volume, we focus on the evolution of the eukaryotic telomere, the ribo-nuclear protein complex at the end of a linear chromosome. The telomere is an example of a single chromosomal element that must function to maintain genomic stability. The telomeres of all species must provide a means to avoid the attrition from semi-conservative DNA replication and a means of telomere elongation (the telomere replication problem). For example, telomerase is the most well-studied mechanism to circumvent telomere attrition by adding the short repeats that constitutes most telomeres. The telomere must also guard against the multiple activities that can act on an unprotected double strand break requiring a window (or checkpoint) to compensate for telomere sequence loss as well as protection against non-specific processes (the telomere protection problem). This volume describes a range of methodologies including mechanistic studies, phylogenetic comparisons and data-based theoretical approaches to study telomere evolution over a broad spectrum of organisms that includes plants, animals and fungi. In telomeres that are elongated by telomerases, different components have widely different rates of evolution. Telomerases evolved from roots in archaebacteria including splicing factors and LTR-transposition. At the conserved level, the telomere is a rebel among double strand breaks (DSBs) and has altered the function of the highly conserved proteins of the ATM pathway into an elegant means of protecting the chromosome end and maintaining telomere size homeostasis through a competition of positive and negative factors. This homeostasis, coupled with highly conserved capping proteins, is sufficient for protection. However, far more proteins are present at the telomere to provide additional species-specific functions. Do these proteins provide insight into how the cell allows for rapid change without self-destruction?