Complement And Kidney Disease

Author : Peter F Zipfel
Publisher : Springer Science & Business Media
Page : 242 pages
File Size : 46,8 Mb
Release : 2006-03-09
Category : Medical
ISBN : 9783764374280

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Complement and Kidney Disease by Peter F Zipfel Pdf

The understanding how complement relates to glomerular diseases has evolved considerably during the last years. Substantial evidence has accumulated that explain how a defective or deregulated complement system results in kidney diseases. The combination and close interaction of basic research with clinical medicine has demonstrated an important role of complement effector and regulatory proteins in pathological settings of the kidney. A large panel of distinct human kidney diseases such as hemolytic uremic syndrome (HUS), membrano proliferative glomerulonephritis (MPGN), systemic lupus erythematosus (SLE) and in ischemic reperfusions injury and transplantation are caused by defective complement control. Genetic analyses have identified mutations in complement regulators that are associated with these diseases. Mutations have been identified in the fluid phase alternative pathway regulator Factor H and the membrane regulator Membrane Cofactor Protein MCP (CD46). The functional characterization of the mutant proteins allows to define the pathophysiological events on a molecular level. These new concepts and data on disease mechanisms already allowed to establish new diagnostic and novel promising therapeutic approaches for several human kidney diseases.

Author : Mihály Józsi,Roberta Bulla
Publisher : Frontiers Media SA
Page : 172 pages
File Size : 47,7 Mb
Release : 2023-05-03
Category : Medical
ISBN : 9782832522271

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Updates on the Complement System in Kidney Diseases by Mihály Józsi,Roberta Bulla Pdf

Author : Bi-Cheng Liu,Hui-Yao Lan,Lin-Li Lv
Publisher : Springer
Page : 709 pages
File Size : 40,8 Mb
Release : 2019-08-09
Category : Science
ISBN : 9789811388712

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Renal Fibrosis: Mechanisms and Therapies by Bi-Cheng Liu,Hui-Yao Lan,Lin-Li Lv Pdf

This book systemically presents the latest research on renal fibrosis, covering all the major topics in the field, including the possible mechanisms, biomarkers, and strategies for prevention and treatment of chronic kidney disease (CKD). Due to its high prevalence, CKD represents a huge global economic and social burden. Irrespective of the initial causes, CKD progresses to end stage kidney disease (ESKD) due to renal fibrosis, which is characterized by glomerulosclerosis, tubule atrophy and atresia, and the excessive accumulation of extracellular matrix (ECM) in the kidney. Unfortunately, an estimated 1%-2% of the adult population living with CKD will need renal replacement therapy at some point as a result of ESKD. As such, strategies for preventing or slowing CKD progression to ESKD are of utmost importance, and studies aiming to understand the mechanisms of renal fibrosis have been the focus of intensive research. Recently, novel insights into the pathophysiological processes have furthered our understanding of the pathogenesis of renal fibrosis, and more importantly, promoted studies on the early diagnosis and treatment of CKD. This book draws lessons from the extensive, state-of-the-art research in this field, elaborating the new theories and new techniques to offer readers a detailed and comprehensive understanding of renal fibrosis and as well as inspiration for future research directions.

Author : Scott F. Gilbert,Daniel E. Weiner,National Kidney Foundation
Publisher : Elsevier Health Sciences
Page : 752 pages
File Size : 40,6 Mb
Release : 2022-01-25
Category : Medical
ISBN : 9780323791236

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National Kidney Foundation Primer on Kidney Diseases, E-Book by Scott F. Gilbert,Daniel E. Weiner,National Kidney Foundation Pdf

Well organized and highly readable, the National Kidney Foundation Primer on Kidney Diseases has offered clear, comprehensive coverage of adult and pediatric kidney diseases for more than 25 years. The thoroughly revised 8th Edition of this authoritative, practical reference covers every relevant topic in the field, making it an excellent resource for residency, fellowship, clinical practice, and board review. It brings you completely up to date with key topics in this fast-changing field, including ongoing clinical research and changing treatment protocols. This powerful learning tool and clinical reference is a joint publication of Elsevier and the National Kidney Foundation. Covers every relevant topic in nephrology—from anatomy, physiology, and pathophysiology to diagnosis and management of kidney disease, to fluid and electrolyte disorders, hypertension, dialysis, and renal transplantation. Presents complex material in a clear, easy-to-understand manner that is both accessible for residents and fellows and comprehensive enough for practicing nephrologists. Offers new guidance for management of COVID-19 in the Viral Nephropathies chapter. Contains two new chapters on Global Kidney Disease, and Conservative Kidney Management (CKM), a palliative care option for treating kidney failure without dialysis.

Author : Takao Saito,John H. Stone,Hitoshi Nakashima,Takako Saeki,Mitsuhiro Kawano
Publisher : Springer
Page : 298 pages
File Size : 47,8 Mb
Release : 2016-11-09
Category : Medical
ISBN : 9784431556879

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IgG4-Related Kidney Disease by Takao Saito,John H. Stone,Hitoshi Nakashima,Takako Saeki,Mitsuhiro Kawano Pdf

This book offers a detailed review of the pathological and imaging features, diagnosis and treatment of IgG4-Related Kidney Disease (IgG4-RKD). IgG4-related disease (IgG4-RD), which is characterized by an elevated serum IgG4 level and infiltration of systemic organs by IgG4 positive plasma cells, is a newly recognized systemic disease. Diverse renal manifestations including specific tubulointerstitial nephritis, membranous nephropathy, and tumor-like urological diseases extending to the pelvis and urinary tract in IgG4-RD have been reported and are recently attracting attention as IgG4-RKD. In this book, leading researchers in the field present the latest insights into the broad spectrum of IgG4-RKD characteristics. In addition, they provide a detailed explanation of the pathology of IgG4-RKD including comparisons between the kidney and other affected organs, such as the lacrimal, salivary glands and pancreas in the histopathological section. IgG4-Related Kidney Disease will have a major impact on future immunological and nephrological studies and offers a useful resource not only for nephrologists but also general physicians and investigators in related fields.

Author : Denis F. Geary,Franz Schaefer
Publisher : Springer
Page : 2005 pages
File Size : 45,7 Mb
Release : 2017-02-16
Category : Medical
ISBN : 9783662529720

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Pediatric Kidney Disease by Denis F. Geary,Franz Schaefer Pdf

The new edition of this valuable clinical resource offers a state of the art, comprehensive review on every clinical condition encountered in pediatric nephrology. International experts present the latest knowledge on epidemiology, diagnosis, management, and prognosis in one concise, clinically focused text, in which care has been taken to couple just the right amount of "need-to-know" basic science with practical clinical guidance that will enable the reader to make efficient, informed decisions. The topics covered include: disorders of renal development, glomerular disorders, the kidney and systemic disease, renal tubular disorders, tubulointerstitial disease, urinary tract disorders, acute kidney injury, hypertension, chronic and end-stage renal disease, and renal replacement therapy. The full-color, highly visual, meticulously crafted format will ensure that the practitioner is able to source and apply information with remarkable ease.

Author : Harvest F. Gu,Martin H. De Borst
Publisher : Frontiers Media SA
Page : 119 pages
File Size : 51,6 Mb
Release : 2020-05-22
Category : Electronic
ISBN : 9782889637379

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Genetics of Kidney Diseases by Harvest F. Gu,Martin H. De Borst Pdf

Author : Neil N. Turner,Norbert Lameire,David J. Goldsmith,Christopher G. Winearls,Jonathan Himmelfarb,Giuseppe Remuzzi
Publisher : Oxford University Press
Page : 3045 pages
File Size : 51,5 Mb
Release : 2015-10-29
Category : Medical
ISBN : 9780191017650

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Oxford Textbook of Clinical Nephrology by Neil N. Turner,Norbert Lameire,David J. Goldsmith,Christopher G. Winearls,Jonathan Himmelfarb,Giuseppe Remuzzi Pdf

This fourth edition of the Oxford Textbook of Clinical Nephrology builds on the success and international reputation of the publication as an important resource for the practising clinician in the field. It provides practical, scholarly, and evidence-based coverage of the full spectrum of clinical nephrology, written by a global faculty of experts. The most relevant and important reference to clinical nephrology, this is an authoritative and comprehensive textbook combining the clinical aspects of renal disease essential to daily clinical practice with extensive information about the underlying basic science and current evidence available. Each section of the textbook has been critically and comprehensively edited under the auspices of a leading expert in the field. This new edition has been significantly expanded and reapportioned to reflect developments and new approaches to topics, and includes treatment algorithms to aid and enhance patient care where possible. The fourth edition offers increased focus on the medical aspects of transplantation, HIV-associated renal disease, and infection and renal disease, alongside entirely new sections on genetic topics and clinical and physiological aspects of fluid/electrolyte and tubular disorders. The emphasis throughout is on marrying advances in scientific research with clinical management. Richly illustrated throughout in full colour, this is a truly modern and attractive edition which reinforces the Oxford Textbook of Clinical Nephrology's position as an indispensable reference work of consistent quality and reliability. Enriched and refined by careful revision, this new edition continues the tradition of excellence. This print edition of The Oxford Textbook of Clinical Nephrology comes with a year's access to the online version on Oxford Medicine Online. By activating your unique access code, you can read and annotate the full text online, follow links from the references to primary research materials, and view, enlarge and download all the figures and tables. Oxford Medicine Online is mobile optimized for access when and where you need it.

Author : Xin J. Zhou,Zoltan G. Laszik,Tibor Nadasdy,Vivette D. D'Agati
Publisher : Cambridge University Press
Page : 691 pages
File Size : 43,9 Mb
Release : 2017-03-02
Category : Medical
ISBN : 9781316613986

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Silva's Diagnostic Renal Pathology by Xin J. Zhou,Zoltan G. Laszik,Tibor Nadasdy,Vivette D. D'Agati Pdf

An algorithmic approach to interpreting renal pathology, updated in light of recent advances in understanding and new classification schemes.

Author : National Collaborating Centre for Chronic Conditions (Great Britain)
Publisher : Royal College of Physicians
Page : 238 pages
File Size : 40,9 Mb
Release : 2008
Category : Medical
ISBN : 9781860163401

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Chronic Kidney Disease by National Collaborating Centre for Chronic Conditions (Great Britain) Pdf

This guideline presents clear criteria for testing of chronic kidney disease, for suspecting progressive CKD and referring people for specialist assessment.

Author : Z.-H. Liui,J.C. He
Publisher : Karger Medical and Scientific Publishers
Page : 274 pages
File Size : 55,5 Mb
Release : 2014-05-16
Category : Science
ISBN : 9783318026511

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Podocytopathy by Z.-H. Liui,J.C. He Pdf

The podocyte is a key cell that forms the last barrier of the kidney filtration unit. One of the most exciting developments in the field of nephrology in the last decade has been the elucidation of its biology and its role in the pathophysiology of inherited and acquired glomerular disease, termed podocytopathy. In this publication, world-renowned experts summarize the most recent findings and advances in the field: they describe the unique biological features and injury mechanisms of the podocyte, novel techniques used in their study, and diagnosis and potential therapeutic approaches to glomerular diseases. Due to its broad scope, this publication is of great value not only for clinical nephrologists and researchers, but also for students, residents, fellows, and postdocs.

Author : Robert B. Colvin,Anthony Chang,Lynn D. Cornell
Publisher : Elsevier Health Sciences
Page : 1267 pages
File Size : 44,5 Mb
Release : 2023-08-16
Category : Medical
ISBN : 9780443109232

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Diagnostic Pathology: Kidney Diseases E-Book by Robert B. Colvin,Anthony Chang,Lynn D. Cornell Pdf

This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Covering the full range of common and rare nonneoplastic renal diseases, it incorporates the most recent scientific and technical knowledge in the field to provide a comprehensive overview of all key issues relevant to today’s practice. Richly illustrated and easy to use, Diagnostic Pathology: Kidney Diseases, fourth edition, is a visually stunning, one-stop resource for every practicing pathologist, nephrologist, resident, student, or fellow as an ideal day-to-day reference or as a reliable training resource. Provides a comprehensive source for key pathologies and clinical features of more than 265 kidney diseases Features two dozen new chapters on a variety of timely topics, including COVID-19 nephropathies, xenografts, artificial intelligence (AI), digital pathology analysis, harmonized nephropathology terminology, newly identified types of amyloidosis, common artifacts and pitfalls on kidney biopsy, vaccination-associated renal disease, crystal nephropathies, and much more Includes updates from the International Kidney and Monoclonal Gammopathy (IKMG) research group, the American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) classification criteria for IgG4-related disease, Banff Foundation for Allograft Pathology, and others Details updated genetic causes of nephrotic syndromes and antinephrin antibodies in podocytopathies—by the investigator who discovered it Discusses the newly identified variant IgG nephropathy and novel membranous autoantigens Contains chapters on techniques, including immunofluorescence on paraffin sections, C4d staining, and polyomavirus detection in tissue Contains more than 4,300 print and online images, including high-resolution photographs and histologic images, full-color medical illustrations, radiologic images, and more Employs consistently templated chapters, bulleted content, key facts, a variety of tables, annotated images, pertinent references, and an extensive index for quick, expert reference at the point of care Shares the expertise of internationally recognized authors who provide fresh perspectives on multiple topics, with a particular emphasis on practical information that directly assists in making and supporting a diagnosis

Author : Renato Alberto Sinico,Loïc Guillevin
Publisher : Springer Nature
Page : 336 pages
File Size : 43,7 Mb
Release : 2019-09-13
Category : Medical
ISBN : 9783030022396

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Anti-Neutrophil Cytoplasmic Antibody (ANCA) Associated Vasculitis by Renato Alberto Sinico,Loïc Guillevin Pdf

This volume, written by well-known experts in the field, covers all aspects of Anti-Neutrophil Cytoplasmic Antibody (ANCA) Associated Vasculitis (AAV). The expression refers to a group of diseases, characterized by destruction and inflammation of small vessels. The clinical signs vary and affect several organs, such as the kidney, lung, skin, nervous system and others. The opening chapters give some historical hints, explain the genetic basis of the disease and provide insights into the pathogenesis derived from recent experimental studies and guides the reader through classification and nomenclature. A large part of the book is then devoted to a detailed description of the specific related diseases and their clinical presentations, the disease course, and potential complications. The advice regarding treatment is based on the best currently available evidence in this constantly evolving area. The book is part of Springer’s series Rare Diseases of the Immune System, which presents recently acquired knowledge on pathogenesis, diagnosis, and therapy with the aim of promoting a more holistic approach to these conditions. AAVs are systemic autoimmune diseases of unknown cause that affect small (to medium) sized blood vessels. They include granulomatosis with polyangiitis (formerly Wegener's granulomatosis), microscopic polyangiitis, and eosinophilic granulomatosis with polyangiitis (formerly Churg–Strauss syndrome). This volume will be an invaluable source of up-to-date information for all practitioners involved in the care of patients with these diseases.

Author : M. Meola,I. Petrucci,C. Ronco
Publisher : Karger Medical and Scientific Publishers
Page : 148 pages
File Size : 43,5 Mb
Release : 2016-05-13
Category : Medical
ISBN : 9783318058840

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Ultrasound Imaging in Acute and Chronic Kidney Disease by M. Meola,I. Petrucci,C. Ronco Pdf

Ultrasound imaging techniques are an indispensable complement to physical examination, which is often frustrating, if not useless, for diagnosing kidney problems. The application of ultrasound techniques in clinical routine helps clinicians to rule out, at first glance, some serious pathological conditions and to concentrate on the accurate diagnosis of the patient. Moreover, sonography can extend the spectrum of diagnostic criteria in acute kidney diseases. It makes it possible to determine morphological parameters without potentially toxic contrast media while exploring functional aspects with contrast enhanced or Doppler ultrasound techniques. This publication meets a growing demand for current information among physicians and nurses in the field. With a focus on the daily practice of diagnosing kidney disease, it is an important resource for both beginner and advanced users of ultrasound imaging techniques.

Author : Giuseppe Querques,Eric Souied
Publisher : Springer
Page : 120 pages
File Size : 52,8 Mb
Release : 2016-02-15
Category : Medical
ISBN : 9783319266213

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Macular Dystrophies by Giuseppe Querques,Eric Souied Pdf

​This book provides the ophthalmologist with the most recently available data on the macular dystrophies, a group of many different inherited or sporadic eye conditions linked by a problem with photoreceptors or other structures of the central retina. Internationally recognized experts in the field present the latest evidence and discuss their own personal experiences with regard to each of the principal dystrophies as well as some very rare entities. Topics covered include molecular biology, state-of-the-art diagnostic techniques, and the newest treatment options, including still experimental therapies. Attention is also devoted to a range of issues that continue to be debated. The editors have taken care to ensure that chapters are of a uniformly high standard while not sacrificing the originality of the individual authors. Macular Dystrophies will fully acquaint the reader with both the latest research findings and the current and emerging approaches to diagnosis and treatment.