Composition And Function Of The Extracellular Matrix In The Human Body

Author : Francesco Travascio
Publisher : BoD – Books on Demand
Page : 376 pages
File Size : 53,9 Mb
Release : 2016-06-15
Category : Science
ISBN : 9789535124153

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Composition and Function of the Extracellular Matrix in the Human Body by Francesco Travascio Pdf

The extracellular matrix (ECM) is an ensemble of non-cellular components present within all tissues and organs of the human body. The ECM provides structural support for scaffolding cellular constituents and biochemical and biomechanical support for those events leading to tissue morphogenesis, differentiation and homeostasis. Essential components of all ECMs are water, proteins and polysaccharides. However, their composition, architecture and bioactivity greatly vary from tissue to tissue in relation to the specific role the ECM is required to assume. This book overviews the role of the ECM in different tissues and organs of the human body.

Author : Bela Suki
Publisher : Academic Press
Page : 284 pages
File Size : 47,8 Mb
Release : 2021-11-27
Category : Technology & Engineering
ISBN : 9780128226056

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Structure and Function of the Extracellular Matrix by Bela Suki Pdf

Structure and Function of the Extracellular Matrix: A Multiscale Quantitative Approach introduces biomechanics and biophysics with applications to understand the biological function of the extracellular matrix in health and disease. A general multiscale approach is followed by investigating behavior from the scale of single molecules, through fibrils and fibers, to tissues of various organ systems. Through mathematical models and structural information, quantitative description of the extracellular matrix function is derived with tissue specific details. The book introduces the properties and organization of extracellular matrix components and quantitative models of the matrix, and guides the reader through predicting functional properties. This book integrates evolutionary biology with multiscale structure to quantitatively understand the function of the extracellular matrix. This approach allows a fresh look into normal functioning as well as the pathological alterations of the extracellular matrix. Professor Suki’s book is written to be useful to undergraduates, graduate students, and researchers interested in the quantitative aspects of the extracellular matrix. Researchers working in mechanotransduction, respiratory and cardiovascular mechanics, and multiscale biomechanics of tendon, cartilage, skin, and bone may also be interested in this book. Examines the evolutionary origins and consequences of the extracellular matrix Delivers the first book to quantitatively treat the extracellular matrix as a multiscale system Presents problems and a set of computational laboratory projects in various chapters to aid teaching and learning Provides an introduction to the properties and organization of the extracellular matrix components

Author : Douglas W. DeSimone,Robert Mecham
Publisher : Springer Science & Business Media
Page : 260 pages
File Size : 50,9 Mb
Release : 2013-03-15
Category : Science
ISBN : 9783642359354

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Extracellular Matrix in Development by Douglas W. DeSimone,Robert Mecham Pdf

Cells in the developing embryo depend on signals from the extracellular environment to help guide their differentiation. An important mediator in this process is the extracellular matrix – secreted macromolecules that interact to form large protein networks outside the cell. During development, the extracellular matrix serves to separate adjacent cell groups, participates in establishing morphogenic gradients, and, through its ability to interact directly will cell-surface receptors, provides developmental clocks and positional information. This volume discusses how the extracellular matrix influences fundamental developmental processes and how model systems can be used to elucidate ECM function. The topics addressed range from how ECM influences early development as well as repair processes in the adult that recapitulate developmental pathways.

Author : Robert Mecham
Publisher : Springer Science & Business Media
Page : 426 pages
File Size : 55,8 Mb
Release : 2011-02-16
Category : Science
ISBN : 9783642165559

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The Extracellular Matrix: an Overview by Robert Mecham Pdf

Knowledge of the extracellular matrix (ECM) is essential to understand cellular differentiation, tissue development, and tissue remodeling. This volume of the series “Biology of Extracellular Matrix” provides a timely overview of the structure, regulation, and function of the major macromolecules that make up the extracellular matrix. It covers topics such as collagen types and assembly of collagen-containing suprastructures, basement membrane, fibronectin and other cell-adhesive glycoproteins, proteoglycans, microfibrils, elastin, fibulins and matricellular proteins, such as thrombospondin. It also explores the concept that ECM components together with their cell surface receptors can be viewed as intricate nano-devices that allow cells to physically organize their 3-D-environment. Further, the role of the ECM in human disease and pathogenesis is discussed as well as the use of model organisms in elucidating ECM function.

Author : E.D. Hay
Publisher : Springer Science & Business Media
Page : 478 pages
File Size : 49,6 Mb
Release : 2013-11-11
Category : Science
ISBN : 9781461537700

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Cell Biology of Extracellular Matrix by E.D. Hay Pdf

In the ten-year interval since the first edition of this volume went to press, our knowledge of extracellular matrix (ECM) function and structure has enor mously increased. Extracellular matrix and cell-matrix interaction are now routine topics in the meetings and annual reviews sponsored by cell biology societies. Research in molecular biology has so advanced the number of known matrix molecules and the topic of gene structure and regulation that we won dered how best to incorporate the new material. For example, we deliberated over the inclusion of chapters on molecular genetics. We decided that with judicious editing we could present the recent findings in molecular biology within the same cell biology framework that was used for the first edition, using three broad headings: what is extracellular matrix, how is it made, and what does it do for cells? Maintaining control over the review of literature on the subject of ECM was not always an easy task, but we felt it was essential to production of a highly readable volume, one compact enough to serve the the student as an introduction and the investigator as a quick update on graduate the important recent discoveries. The first edition of this volume enjoyed con hope the reader finds this edition equally useful. siderable success; we D. Hay Elizabeth vii Contents Introductory Remarks 1 Elizabeth D. Hay PART I. WHAT IS EXTRACELLULAR MATRIX? Chapter 1 Collagen T. F. Linsenmayer 1. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 2. The Collagen Molecule . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 2. 1. Triple-Helical Domain(s) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 43,5 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181

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Molecular Biology of The Cell by Bruce Alberts Pdf

Author : Francesco Travascio
Publisher : BoD – Books on Demand
Page : 202 pages
File Size : 45,8 Mb
Release : 2017-12-20
Category : Medical
ISBN : 9789535137177

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The Role of Matrix Metalloproteinase in Human Body Pathologies by Francesco Travascio Pdf

Matrix metalloproteinases (MMPs) are a family of proteolytic zinc-containing enzymes involved in physiological as well as in pathological processes in the human organism. MMPs play a key role in the remodeling of the extracellular matrix. Such a process may occur because of tissue homeostasis, morphogenesis, and tissue repair. However, remodeling could also be a part of many pathological states such as arthritis, cardiovascular diseases, neurodegenerative diseases, or impaired development in congenital anomalies. This book overviews the role of MMPs in different pathologies affecting the human body.

Author : Julia Thom Oxford
Publisher : MDPI
Page : 357 pages
File Size : 50,8 Mb
Release : 2019-02-21
Category : Electronic
ISBN : 9783038975700

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Extracellular Matrix in Development and Disease by Julia Thom Oxford Pdf

This book is a printed edition of the Special Issue "Extracellular Matrix in Development and Disease" that was published in IJMS

Author : Thomas W. Myers
Publisher : Elsevier Health Sciences
Page : 308 pages
File Size : 40,6 Mb
Release : 2009-01-01
Category : Medical
ISBN : 9780443102837

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Anatomy Trains by Thomas W. Myers Pdf

An accessible comprehensive approach to the anatomy and function of the fascial system in the body combined with a holistic.

Author : J. Gordon Betts,Peter DeSaix,Jody E. Johnson,Oksana Korol,Dean H. Kruse,Brandon Poe,James A. Wise,Mark Womble,Kelly A. Young
Publisher : Unknown
Page : 0 pages
File Size : 41,9 Mb
Release : 2013-04-25
Category : Electronic
ISBN : 1947172808

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Anatomy and Physiology by J. Gordon Betts,Peter DeSaix,Jody E. Johnson,Oksana Korol,Dean H. Kruse,Brandon Poe,James A. Wise,Mark Womble,Kelly A. Young Pdf

Author : Hussein Abdelhay Essayed Kaoud
Publisher : BoD – Books on Demand
Page : 207 pages
File Size : 51,5 Mb
Release : 2018-06-06
Category : Technology & Engineering
ISBN : 9781789232608

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Tissue Regeneration by Hussein Abdelhay Essayed Kaoud Pdf

Tissue regeneration is a vast subject, with many different important aspects to consider. Regenerative medicine is a new branch of medicine that tries to change the course of chronic diseases and, in many cases, regenerates the organ systems that fail due to age, disease, damage, or genetic defects. The main purpose of this book is to point out the interest of some important topics of tissue regeneration and the progress in this field as well as the variety of different surgical fields and operations. This book includes 7 sections and 11 chapters that provide an overview of the essentials in tissue regeneration science and their potential applications in surgery. The authors of each chapter have given consolidated information on ground realities and attempted to provide a comprehensive knowledge of tissue engineering and regeneration. This book will be useful to researchers and students of biological and biomedical sciences (medical and veterinarian researchers).

Author : Graham Melvin Scarr
Publisher : Jessica Kingsley Publishers
Page : 209 pages
File Size : 46,8 Mb
Release : 2019-03-25
Category : Medical
ISBN : 9781909141858

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Biotensegrity by Graham Melvin Scarr Pdf

The emerging science of biotensegrity provides a fresh context for rethinking our understanding of human movement, but its complexities can be formidable. Biotensegrity: The Structural Basis of Life, Second edition - now with full color illustrations throughout - explores and explains the concept of biotensegrity and provides an understanding and appreciation of anatomy and physiology in the light of the latest research findings. The reader learns that biotensegrity is an evolving science which gives researchers, teachers, and practitioners across a wide range of specialisms, including bodyworkers and movement teachers, a deeper understanding of the structure and function of the human body. They are then able to develop clinical practice and skills in light of this understanding, leading to more effective therapeutic approaches, with the aim of improved client outcomes. The second edition provides expanded coverage of the developmental and therapeutic aspects of biotensegrity. Coverage now includes: A more thorough look at life's internal processes Closed kinematic chains as the new biomechanics Embryological development as an evolutionary process The human body as a constantly evolving system based on a set of unchanging principles Emergence, heterarchies, soft-matter and small-world networks A deeper look at what constitutes the therapeutic process

Author : Jaroslava Halper
Publisher : Springer Science & Business Media
Page : 245 pages
File Size : 44,8 Mb
Release : 2014-01-18
Category : Medical
ISBN : 9789400778931

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Progress in Heritable Soft Connective Tissue Diseases by Jaroslava Halper Pdf

This volume is a reference handbook focusing on diseases like Marfan syndrome, Ehlers-Danlos syndrome, Loeys-Dietz syndrome and other heritable soft connective tissue diseases. The book presents detailed information for both basic scientists and for clinicians seeing patients. It is also a stepping stone for new investigations and studies that goes beyond the facts about the composition and biochemistry of the connective tissue and extracellular matrix, as the authors connect individual components to specific aspects of various soft tissue disorders and to the actual or potential treatment of them. Progress in Heritable Soft Connective Tissue Diseases features very prominent physicians and scientists as contributors who bring their most recent discoveries to the benefit of readers. Their expertise will help clinicians with proper diagnosis of sometimes elusive and uncommon heritable diseases of soft connective tissues. This book also offers an update on the pathophysiology of these diseases, including an emphasis on unifying aspects such as connections between embryonic development of the different types of connective tissues and systems, and the role of TGF-beta in development and physiology of soft tissues. This new set of data explains, at least in part, why many of these disorders are interconnected, though the primary pathophysiological events, such as gene mutations, may be different for each disorder.

Author : Lindsay Biga,Devon Quick,Sierra Dawson,Amy Harwell,Robin Hopkins,Joel Kaufmann,Mike LeMaster,Philip Matern,Katie Morrison-Graham,Jon Runyeon
Publisher : Unknown
Page : 128 pages
File Size : 47,5 Mb
Release : 2019-09-26
Category : Electronic
ISBN : 1955101159

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Anatomy & Physiology by Lindsay Biga,Devon Quick,Sierra Dawson,Amy Harwell,Robin Hopkins,Joel Kaufmann,Mike LeMaster,Philip Matern,Katie Morrison-Graham,Jon Runyeon Pdf

A version of the OpenStax text

Author : Paul A. Banaszkiewicz,Deiary F. Kader
Publisher : Cambridge University Press
Page : 301 pages
File Size : 51,8 Mb
Release : 2012-08-16
Category : Medical
ISBN : 9781107627369

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Postgraduate Orthopaedics by Paul A. Banaszkiewicz,Deiary F. Kader Pdf

The must-have book for candidates preparing for the oral component of the FRCS (Tr and Orth).