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Author : Julia Thom Oxford
Publisher : MDPI
Page : 357 pages
File Size : 51,7 Mb
Release : 2019-02-21
Category : Electronic
ISBN : 9783038975700
This book is a printed edition of the Special Issue "Extracellular Matrix in Development and Disease" that was published in IJMS
Author : Douglas W. DeSimone,Robert Mecham
Publisher : Springer Science & Business Media
Page : 260 pages
File Size : 50,8 Mb
Release : 2013-03-15
Category : Science
ISBN : 9783642359354
Cells in the developing embryo depend on signals from the extracellular environment to help guide their differentiation. An important mediator in this process is the extracellular matrix – secreted macromolecules that interact to form large protein networks outside the cell. During development, the extracellular matrix serves to separate adjacent cell groups, participates in establishing morphogenic gradients, and, through its ability to interact directly will cell-surface receptors, provides developmental clocks and positional information. This volume discusses how the extracellular matrix influences fundamental developmental processes and how model systems can be used to elucidate ECM function. The topics addressed range from how ECM influences early development as well as repair processes in the adult that recapitulate developmental pathways.
Author : Julia Oxford
Publisher : Unknown
Page : 1 pages
File Size : 45,6 Mb
Release : 2019
Category : Electronic books
ISBN : 3038975710
The extracellular matrix in development and disease deals with the molecular and cellular aspects of development and disease. Cells exist in three-dimensional scaffolding called the extracellular matrix. The matrix holds together the millions of cells that make up our blood vessels, organs, skin, and all tissues of the body. The matrix serves as a reservoir of signaling molecules as well. In bacterial cultures, biofilms form as an extracellular matrix and play essential roles in disease and drug resistance. Topics such as matrix structure and function, cell attachment and cell surface proteins mediating cell-matrix interactions, synthesis, regulation, composition, structure, assembly, remodeling, and function of the matrix are included. A common thread uniting the topics is the essential nature that the matrix plays in normal development and pathophysiology. Providing new knowledge will lead us to improved diagnostics, the preventions of disease progression, and therapeutic strategies for the repair and regeneration of tissues. Topics such as the extracellular matrix in hereditary diseases, reproduction, cancer, muscle, and tissue engineering applications, and diverse roles for integrins, are included in this collection.
Author : Jeffrey H. Miner
Publisher : Elsevier
Page : 268 pages
File Size : 44,6 Mb
Release : 2005-11-18
Category : Science
ISBN : 0444518460
Extracellular matrix proteins are serious, common human diseases that are caused by mutations in genes that encode these proteins. This has spurred a great number of researchers to study the extracellular matrix, sometimes by choice and sometimes by necessity. Much progress has been made in the last decade towards understanding what matrix proteins do and how cells interact with and respond to them. Volume 15 is a compilation of reviews by experts in their respective fields. The chapters in this book address the biology of a broad spectrum of extracellular matrix molecules and their functions in development and disease. This book has been designed to focus on a diverse subset of matrix proteins that have been shown to be important for development, function, and disease. The book therefore both presents a broad view of the field and provides crucial details about some of the best-studied matrix molecules. * Written by leaders in the field * Discusses the potential of matrix components to be used as therapeutic tools for the treatment and prevention of cancer * Offers a section on integrin signaling and the development of the central nervous system, detailing the migration of neurons and the glia * Covers a diverse array of molecules such as laminins, collagens, heparan sulfate proteoglycans, integrins, and more
Author : Robert Mecham
Publisher : Springer Science & Business Media
Page : 429 pages
File Size : 53,5 Mb
Release : 2011-02-16
Category : Science
ISBN : 9783642165559
Knowledge of the extracellular matrix (ECM) is essential to understand cellular differentiation, tissue development, and tissue remodeling. This volume of the series “Biology of Extracellular Matrix” provides a timely overview of the structure, regulation, and function of the major macromolecules that make up the extracellular matrix. It covers topics such as collagen types and assembly of collagen-containing suprastructures, basement membrane, fibronectin and other cell-adhesive glycoproteins, proteoglycans, microfibrils, elastin, fibulins and matricellular proteins, such as thrombospondin. It also explores the concept that ECM components together with their cell surface receptors can be viewed as intricate nano-devices that allow cells to physically organize their 3-D-environment. Further, the role of the ECM in human disease and pathogenesis is discussed as well as the use of model organisms in elucidating ECM function.
Author : Richard O. Hynes,Kenneth M. Yamada
Publisher : Unknown
Page : 0 pages
File Size : 41,5 Mb
Release : 2012
Category : Cell interaction
ISBN : 1936113384
In most tissues, cells are surrounded by an extracellular matrix (ECM) containing proteins such as collagen, laminin, and fibronectin. The ECM plays an important role in regulating cell function. ECM proteins bind to integrins and other cell surface receptors, activating signaling pathways that regulate cellular morphology, adhesion, cell migration, cell proliferation, and apoptosis. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology covers all aspects of ECM composition and function, as well as alterations in the ECM that occur during development, tumorigenesis, and other disease states. The contributors examine the various ECM proteins and proteoglycans, ECM receptors such as integrins, and the signaling pathways that mediate the effects of the ECM on cells. They also describe ECM functions in specific biological contexts, including angiogenesis, hemostasis, and thrombosis. Covering not only the biochemistry and cell biology of the ECM but also its roles in development, physiology, and pathology, this volume is an indispensable reference for cell biologists and all those interested in exploring the myriad functions of the ECM.
Author : William C. Parks,Robert Mecham
Publisher : Springer Science & Business Media
Page : 262 pages
File Size : 43,7 Mb
Release : 2011-04-07
Category : Science
ISBN : 9783642168611
Regulated turnover of extracellular matrix (ECM) is an important component of tissue homeostasis. In recent years, the enzymes that participate in, and control ECM turnover have been the focus of research that touches on development, tissue remodeling, inflammation and disease. This volume in the Biology of Extracellular Matrix series provides a review of the known classes of proteases that degrade ECM both outside and inside the cell. The specific EMC proteases that are discussed include cathepsins, bacterial collagenases, matrix metalloproteinases, meprins, serine proteases, and elastases. The volume also discusses the domains responsible for specific biochemical characteristics of the proteases and the physical interactions that occur when the protease interacts with substrate. The topics covered in this volume provide an important context for understanding the role that matrix-degrading proteases play in normal tissue remodeling and in diseases such as cancer and lung disease.
Author : Toshio Nakanishi,Roger R. Markwald,H.Scott Baldwin,Bradley B. Keller,Deepak Srivastava,Hiroyuki Yamagishi
Publisher : Springer
Page : 0 pages
File Size : 55,6 Mb
Release : 2018-06-07
Category : Medical
ISBN : 4431566333
This volume focuses on the etiology and morphogenesis of congenital heart diseases. It reviews in detail the early development and differentiation of the heart, and later morphologic events of the cardiovascular system, covering a wide range of topics such as gene functions, growth factors, transcription factors and cellular interactions that are implicated in cardiac morphogenesis and congenital heart disease. This book also presents recent advances in stem cell and cell sheet tissue engineering technologies which have the potential to provide novel in vitro disease models and to generate regenerative paradigms for cardiac repair and regeneration. This is the ideal resource for physician scientists and investigators looking for updates on recent investigations on the origins of congenital heart disease and potential future therapies.
Author : Robert L. Trelstad,Society for Developmental Biology. Symposium
Publisher : New York : A.R. Liss
Page : 674 pages
File Size : 44,9 Mb
Release : 1984
Category : Science
ISBN : UCAL:B4299879
Author : Elena Aikawa
Publisher : BoD – Books on Demand
Page : 544 pages
File Size : 51,9 Mb
Release : 2013-06-12
Category : Medical
ISBN : 9789535111504
Due to population aging, calcific aortic valve disease (CAVD) has become the most common heart valve disease in Western countries. No therapies exist to slow this disease progression, and surgical valve replacement is the only effective treatment. Calcific Aortic Valve Disease covers the contemporary understanding of basic valve biology and the mechanisms of CAVD, provides novel insights into the genetics, proteomics, and metabolomics of CAVD, depicts new strategies in heart valve tissue engineering and regenerative medicine, and explores current treatment approaches. As we are on the verge of understanding the mechanisms of CAVD, we hope that this book will enable readers to comprehend our current knowledge and focus on the possibility of preventing disease progression in the future.
Author : Robert L. Trelstad
Publisher : Wiley-Liss
Page : 643 pages
File Size : 50,8 Mb
Release : 1984-07-12
Category : Science
ISBN : 0471834270
Author : Robert Mecham
Publisher : Springer
Page : 426 pages
File Size : 48,5 Mb
Release : 2011-03-25
Category : Science
ISBN : 3642165567
Knowledge of the extracellular matrix (ECM) is essential to understand cellular differentiation, tissue development, and tissue remodeling. This volume of the series “Biology of Extracellular Matrix” provides a timely overview of the structure, regulation, and function of the major macromolecules that make up the extracellular matrix. It covers topics such as collagen types and assembly of collagen-containing suprastructures, basement membrane, fibronectin and other cell-adhesive glycoproteins, proteoglycans, microfibrils, elastin, fibulins and matricellular proteins, such as thrombospondin. It also explores the concept that ECM components together with their cell surface receptors can be viewed as intricate nano-devices that allow cells to physically organize their 3-D-environment. Further, the role of the ECM in human disease and pathogenesis is discussed as well as the use of model organisms in elucidating ECM function.
Author : Francesco Travascio
Publisher : BoD – Books on Demand
Page : 376 pages
File Size : 50,8 Mb
Release : 2016-06-15
Category : Science
ISBN : 9789535124153
The extracellular matrix (ECM) is an ensemble of non-cellular components present within all tissues and organs of the human body. The ECM provides structural support for scaffolding cellular constituents and biochemical and biomechanical support for those events leading to tissue morphogenesis, differentiation and homeostasis. Essential components of all ECMs are water, proteins and polysaccharides. However, their composition, architecture and bioactivity greatly vary from tissue to tissue in relation to the specific role the ECM is required to assume. This book overviews the role of the ECM in different tissues and organs of the human body.
Author : Martin Götte,Karin Forsberg-Nilsson
Publisher : Springer Nature
Page : 314 pages
File Size : 49,5 Mb
Release : 2021-06-07
Category : Science
ISBN : 9783030734534
This book provides a state-of-the-art compendium on the role of proteoglycans and glycosaminoglycans during development and in cancer. It also suggests directions for novel therapeutic and biotechnological applications in stem cell biology. Proteoglycans and glycosaminoglycans, as part of the extracellular matrix, are multifunctional modulators of growth factor, cytokine, integrin and morphogen signaling, which determine both self-renewal, senescence and/or differentiation of stem cells during development. Since proteoglycans modulate cell adhesion and migration they are important organizers of the extracellular matrix within the proper stem cell niche. A malfunctioning of proteoglycans and glycosaminoglycans contributes to the cancer stem cell phenotype, which is linked to therapeutic resistance and recurrence in malignant disease. This book is essential reading for anyone interested in the extracellular matrix and its role in development. The series Biology of Extracellular Matrix is published in collaboration with the American Society for Matrix Biology.
Author : Alfred Pischinger
Publisher : North Atlantic Books
Page : 233 pages
File Size : 53,8 Mb
Release : 2007-07-17
Category : Science
ISBN : 9781556436888
The workings of the suitable environment for cells—called the extracellular matrix (ECM) and ground regulation—has occupied the European medical tradition since the early part of the 20th century. As it has become more clear that the origin of disease and its first signals register in the connective tissue, or myofascia, cellular pathologists and biochemists have sought to circumscribe networks of cell communication and microcirculation in the ECM. Alfred Pischinger (1899-1982) continued this line of work by further studying, in work published from 1926 through the late seventies, the connections of the ECM to the hormonal and autonomic systems. In the last twenty years Professor and Doctor of Natural Sciences Hartmut Heine and his colleagues have carried on Pischinger’s work, here summarized in one volume. Part One encompasses theoretical underpinnings; Parts Two and Three address applications and directions for further research. This updated English-language translation not only is an account of the work of Pischinger’s successors—Heine, Otto Bergsmann, and Felix Perger, (the three editors of this volume) and their many colleagues—but notes the positive development of complementary therapies based on this understanding of histology. Acupuncture is referenced directly. Both in Europe and the States the work of manual therapists, including Rolfers, cranio- sacral therapists, and other somatic disciplines have been informed for many years by Pischinger’s outsider model of how changes in the EMC register in the central nervous system and the brain, and are conveyed back to the periphery and connected organs. Heine’s exciting recent work shows that the regulation and construction of the ECM have relationships to cybernetic non-linear systems and phase transitions.
