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Computational Neuroscience in Epilepsy by Ivan Soltesz,Kevin Staley Pdf
Epilepsy is a neurological disorder that affects millions of patients worldwide and arises from the concurrent action of multiple pathophysiological processes. The power of mathematical analysis and computational modeling is increasingly utilized in basic and clinical epilepsy research to better understand the relative importance of the multi-faceted, seizure-related changes taking place in the brain during an epileptic seizure. This groundbreaking book is designed to synthesize the current ideas and future directions of the emerging discipline of computational epilepsy research. Chapters address relevant basic questions (e.g., neuronal gain control) as well as long-standing, critically important clinical challenges (e.g., seizure prediction). Computational Neuroscience in Epilepsy should be of high interest to a wide range of readers, including undergraduate and graduate students, postdoctoral fellows and faculty working in the fields of basic or clinical neuroscience, epilepsy research, computational modeling and bioengineering. Covers a wide range of topics from molecular to seizure predictions and brain implants to control seizures Contributors are top experts at the forefront of computational epilepsy research Chapter contents are highly relevant to both basic and clinical epilepsy researchers
The Changing Face of Epilepsy Surgery: Contributions of Computational Neuroscience and Robotics to the Field by Jorge Alvaro Gonzalez-Martinez,Stéphan Chabardès,Patrick Chauvel Pdf
Topic Editor Prof. Jorge Alvaro Gonzalez-Martinez has received a consulting grant from Zimmer Biomet. Prof. Stéphan Chabardès has also worked as a consultant for Zimmer Biomet. Prof. Chauvel has declared no competing interests with regards to the Research Topic subject.
Computational Neuroscience by Wanpracha Chaovalitwongse,Panos M. Pardalos,Petros Xanthopoulos Pdf
This volume includes contributions from diverse disciplines including electrical engineering, biomedical engineering, industrial engineering, and medicine, bridging a vital gap between the mathematical sciences and neuroscience research. Covering a wide range of research topics, this volume demonstrates how various methods from data mining, signal processing, optimization and cutting-edge medical techniques can be used to tackle the most challenging problems in modern neuroscience.
Computational Neurology and Psychiatry by Péter Érdi,Basabdatta Sen Bhattacharya,Amy L. Cochran Pdf
This book presents the latest research in computational methods for modeling and simulating brain disorders. In particular, it shows how mathematical models can be used to study the relationship between a given disorder and the specific brain structure associated with that disorder. It also describes the emerging field of computational psychiatry, including the study of pathological behavior due to impaired functional connectivity, pathophysiological activity, and/or aberrant decision-making. Further, it discusses the data analysis techniques that will be required to analyze the increasing amount of data being generated about the brain. Lastly, the book offers some tips on the application of computational models in the field of quantitative systems pharmacology. Mainly written for computational scientists eager to discover new application fields for their model, this book also benefits neurologists and psychiatrists wanting to learn about new methods.
Seizure Prediction in Epilepsy by Björn Schelter,Jens Timmer,Andreas Schulze-Bonhage Pdf
Comprising some 30 contributions, experts from around the world present and discuss recent advances related to seizure prediction in epilepsy. The book covers an extraordinarily broad spectrum, starting from modeling epilepsy in single cells or networks of a few cells to precisely-tailored seizure prediction techniques as applied to human data. This unique overview of our current level of knowledge and future perspectives provides theoreticians as well as practitioners, newcomers and experts with an up-to-date survey of developments in this important field of research.
Invasive Studies of the Human Epileptic Brain by Samden D. Lhatoo,Philippe Kahane,Hans O. Luders Pdf
No other neurological condition allows the same opportunities for an intracranial electrophysiological study of the human brain as epilepsy does. Epileptic surgery is designed to remove the epileptic focus from the human brain, thereby effecting either cure or substantial reduction of seizures in an individual with an otherwise intractable condition. Its use as a treatment modality dates from the late 19th century, and it has become a widely used treatment option throughout the world in the last 20-30 years. The complexity of epilepsy cases in surgical centres, and the need for invasive electrode studies for pre-surgical evaluation, are both greatly increasing. Invasive Studies of the Human Epileptic Brain is the definitive reference text on the use of invasive electroencephalographic (EEG) diagnostic studies in human epilepsy. Written by some of the most renowned epilepsy experts of the 20th and 21st centuries, the authors provide their expertise and insights into the identification and mapping of intracranial epileptiform and non-epileptiform activity, mapping of the human brain function, and approaches in the use of invasive electroencephalography in a variety of clinical situations. The book is organized into an easily readable series of chapters and is brilliantly illustrated with case studies; each providing an intuitively comprehensive approach to invasive brain studies.
Epilepsy, one of the most prevalent neurological disorders, affects approximately 1% (greater than 60 million) of the world's population. In an estimated 20 million of these patients, seizures are not controlled even by multiple anti-seizure drugs, and are extremely difficult to predict. Epilepsy: The Intersection of Neurosciences, Biology, Mathematics, Engineering, and Physics seamlessly brings together the neurosciences, mathematics, computational sciences, engineering, physics, and clinical epileptology to present to readers a highly didactic, integrated, clear and practically useful knowledge base and research directions. Laying out the foundations of signal analysis, data conditioning, linear and non-linear analysis, introduction to dynamical systems and fundamental anatomical and neurophysiological concepts, this book: Introduces non-physicians to language and concepts necessary to establish a meaningful dialog with epileptologists Introduces physicians to dynamical theory and signal processing without which interdisciplinary collaborations would not be productive Mines knowledge from fields devoted to the investigation of aperiodic paroxysmal relaxation phenomena, such as earthquakes, which bear dynamical similarities with epilepsy, so as to lay the proper scientific foundations for epileptology and foster much needed therapeutic advances efficiently Reviews spatiotemporal behavior of seizures, mechanisms of epileptogenesis and ictogenesis as well as of seizure control and ancillary technology Calls attention to nocturnal frontal lobe epilepsy as a potentially fruitful paradigm for advancing seizure prediction. Of all neurological disorders, epilepsy demands of investigators the broadest and deepest knowledge of dynamical, control, and system theories, knowledge that cannot be amassed without possessing a certain level of sophistication in relevant areas of neurosciences, physics, mathematics, and engineering. Narrowing the inescapable cultural chasm that commonly fragments multidisciplinary efforts, this book captures and enriches the burgeoning interdisciplinary synergism in the nascent field of dynamical epileptology.
Bundle for Epilepsy Researchers by Ruben Kuzniecky,Asla Pitkänen,Ivan Soltesz,Professor of Anatomy and Neurobiology Ivan Soltesz Pdf
Combining three essential Academic Press books, this bundle provides reference information for epilepsy researchers at a great price. Magnetic Resonance in Epilepsy is an in-depth look at the advances in imaging techology as applied to epilepsy research. Models of Seizures and Epilepsy speaks to the needs of both basic neuroscientists and clinical neurologists, in understanding the pathophysiology of seizures and the epilepsies and predicting the clinical effectiveness of antiepileptic treatments. Computational Neuroscience in Epilepsy is the first-ever book solely dedicated to the emerging discipline of computational epilepsy research.
Epilepsy by Ivan Osorio,Hitten P. Zaveri,Mark G. Frei,Susan Arthurs Pdf
Epilepsy, one of the most prevalent neurological disorders, affects approximately 1% (greater than 60 million) of the world's population. In an estimated 20 million of these patients, seizures are not controlled even by multiple anti-seizure drugs, and are extremely difficult to predict. Epilepsy: The Intersection of Neurosciences, Biology, Mathematics, Engineering, and Physics seamlessly brings together the neurosciences, mathematics, computational sciences, engineering, physics, and clinical epileptology to present to readers a highly didactic, integrated, clear and practically useful knowledge base and research directions. Laying out the foundations of signal analysis, data conditioning, linear and non-linear analysis, introduction to dynamical systems and fundamental anatomical and neurophysiological concepts, this book: Introduces non-physicians to language and concepts necessary to establish a meaningful dialog with epileptologists Introduces physicians to dynamical theory and signal processing without which interdisciplinary collaborations would not be productive Mines knowledge from fields devoted to the investigation of aperiodic paroxysmal relaxation phenomena, such as earthquakes, which bear dynamical similarities with epilepsy, so as to lay the proper scientific foundations for epileptology and foster much needed therapeutic advances efficiently Reviews spatiotemporal behavior of seizures, mechanisms of epileptogenesis and ictogenesis as well as of seizure control and ancillary technology Calls attention to nocturnal frontal lobe epilepsy as a potentially fruitful paradigm for advancing seizure prediction. Of all neurological disorders, epilepsy demands of investigators the broadest and deepest knowledge of dynamical, control, and system theories, knowledge that cannot be amassed without possessing a certain level of sophistication in relevant areas of neurosciences, physics, mathematics, and engineering. Narrowing the inescapable cultural chasm that commonly fragments multidisciplinary efforts, this book captures and enriches the burgeoning interdisciplinary synergism in the nascent field of dynamical epileptology.
Cognitive and Computational Neuroscience by Seyyed Abed Hosseini Pdf
The book "Cognitive and Computational Neuroscience - Principles, Algorithms and Applications" will answer the following question and statements: System-level neural modeling: what and why? We know a lot about the brain! Need to integrate data: molecular/cellular/system levels. Complexity: need to abstract away higher-order principles. Models are tools to develop explicit theories, constrained by multiple levels (neural and behavioral). Key: models (should) make novel testable predictions on both neural and behavioral levels. Models are useful tools for guiding experiments. The hope is that the information provided in this book will trigger new researches that will help to connect basic neuroscience to clinical medicine.
Recent Advances in Predicting and Preventing Epileptic Seizures by Ronald Tetzlaff,Christian E Elger,Klaus Lehnertz Pdf
This book is to improve our understanding of mechanisms leading to seizures in humans and in developing new therapeutic options. The book covers topics such as recent approaches to seizure control, recent developments in signal processing of interest for seizure prediction, ictogenesis in complex epileptic brain networks, active probing of the pre-seizure state, non-EEG based approaches to the transition to seizures, microseizures and their role in the generation of clinical seizures, the impact of sleep and long-biological cycles on seizure prediction, as well as animal and computational models of seizures and epilepsy. Furthermore the book covers recent developments of international databases and of parallel computing structures based on Cellular Nonlinear Networks that can play an important role in the realization of a portable seizure warning device. Contents:Epileptic Networks and Their Role for Seizure Prediction and Seizure Control:Transition Into and Out of a Focal Seizure (M de Curtis)Neuronal and Network Dynamics Preceding Experimental Seizures (P Jiruska, F Mormann and J G R Jefferys)Interictal EEG and Its Relevance for Seizure Prediction (A Schulze-Bonhage)Invasive Brain Stimulation in the Treatment of Epilepsy (M Sprengers, R Raedt, A Meurs, E Carrette, D van Roost, P Boon and K Vonck)Computational Models of Seizures and Epilepsy:Patient-Specific Neural Mass Modeling — Stochastic and Deterministic Methods (D R Freestone, L Kuhlmann, M S Chong, D Nesic and D B Grayden)Computational Modelling of Microseizures and Focal Seizure Onset (Y Wang, M Goodfellow, P N Taylor, D J Garry and G Baier)Predictability of Seizure-Like Events in a Complex Network Model of Integrate-and-Fire Neurons (A Rothkegel and K Lehnertz)Bursting and Synchrony in Networks of Model Neurons (C Geier, A Rothkegel and K Lehnertz)Advances in Analysis and Measurement Techniques:Signal Processing of the EEG: Approaches Tailored to Epilepsy (B Schelter, M Thiel, M Mader and W Mader)From Time Series to Complex Networks: An Overview (S Bialonski and K Lehnertz)Visualizing and Quantifying EEG Complexity on the Base of Ordinal Pattern Distributions (K Keller)Dynamics of Linear and Nonlinear Interrelation Networks in Peri-Ictal Intracranial EEG: Seizure Onset and Termination (C Rummel, M Müller, M Hauf, R Wiest and K Schindler)On the Centrality of the Focus in Human Epileptic Brain Networks (C Geier, M-T Kuhnert, C E Elger and K Lehnertz)Pre-Seizure States in Epileptic Brain Nnetworks: A Surrogate-Assisted, Weighted Network Analysis (G Ansmann, M-T Kuhnert, C E Elger and K Lehnertz)Network Analysis of Generalized Epileptic Discharges (P Ossenblok, P van Houdt, A Lüttjohann and G van Luijtelaar)Signal Processing Platform Based on Cellular Nonlinear Networks (J Müller, J Müller, R Becker and R Tetzlaff)Seizure Prediction by Cellular Nonlinear Networks? (V Senger and R Tetzlaff)Measuring Directed Interactions Using Cellular Neural Networks with Complex Connection Topologies (H Dickten, C E Elger and K Lehnertz)Seizure Prediction Using Optical Measurements of Blood Flow and Oxygenation (M Zhao, H Ma and T H Schwartz)Observing the Sleep-Wake Regulatory System to Improve Prediction of Seizures (M Sedigh-Sarvestani and B J Gluckman)The World's Largest Epilepsy Database: Content and Structure (M Ihle, B Schelter, J Timmer and A Schulze-Bonhage) Readership: Graduate students and professionals in the field of epileptology, neurosurgery and neuroscience. Keywords:Epileptic Networks;Seizure Prediction;Seizure Control;Computational Models;EpilepsyKey Features:Provides latest findings in the field of epilepsy research
Oxford Textbook of Epilepsy and Epileptic Seizures by Samden Lhatoo Pdf
Part of the Oxford Textbooks in Clinical Neurology (OTCN) series, this volume covers the scientific basis, clinical diagnosis, and treatment of epilepsy and epileptic seizures, and is complemented by an online edition.
Seizure Forecasting and Detection: Computational Models, Machine Learning, and Translation into Devices by Sharon Chiang,Vikram Rao,Gregory Worrell,Maxime O. Baud Pdf
This second edition of 'Seizures and Epilepsy' is completely revised, due to tremendous advances in the understanding of the fundamental neuronal mechanisms underlying epileptic phenomena, as well as current diagnosis and treatment, which have been heavily influenced over the past several decades by seminal neuroscientific developments, particularly the introduction of molecular neurobiology, genetics, and modern neuroimaging. This resource covers a broad range of both basic and clinical epileptology.
Author : Joseph I. Tracy,Benjamin M. Hampstead,K. Sathian Publisher : Oxford University Press, USA Page : 433 pages File Size : 49,7 Mb Release : 2014-12-02 Category : Medical ISBN : 9780199965243
Cognitive Plasticity in Neurologic Disorders by Joseph I. Tracy,Benjamin M. Hampstead,K. Sathian Pdf
This volume makes clear that the cognitive and behavioural symptoms of neurologic disorders and syndromes are dynamic and changing. Each chapter describes the neuroplastic processes at work in a particular condition, giving rise to these ongoing cognitive changes.