Computational Systems Biology In Medicine And Biotechnology

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Computational Systems Biology in Medicine and Biotechnology

Sonia Cortassa,Miguel A. Aon
Computational Systems Biology in Medicine and Biotechnology Book PDF

Author : Sonia Cortassa,Miguel A. Aon
Publisher : Springer Nature
Page : 494 pages
File Size : 46,8 Mb
Release : 2022-05-23
Category : Science
ISBN : 9781071618318

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Computational Systems Biology in Medicine and Biotechnology by Sonia Cortassa,Miguel A. Aon Pdf

This volume addresses the latest state-of-the-art systems biology-oriented approaches that--driven by big data and bioinformatics--are utilized by Computational Systems Biology, an interdisciplinary field that bridges experimental tools with computational tools to tackle complex questions at the frontiers of knowledge in medicine and biotechnology. The chapters in this book are organized into six parts: systems biology of the genome, epigenome, and redox proteome; metabolic networks; aging and longevity; systems biology of diseases; spatiotemporal patterns of rhythms, morphogenesis, and complex dynamics; and genome scale metabolic modeling in biotechnology. In every chapter, readers will find varied methodological approaches applied at different levels, from molecular, cellular, organ to organisms, genome to phenome, and health and disease. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics; criteria utilized for applying specific methodologies; lists of the necessary materials, reagents, software, databases, algorithms, mathematical models, and dedicated analytical procedures; step-by-step, readily reproducible laboratory, bioinformatics, and computational protocols all delivered in didactic and clear style and abundantly illustrated with express case studies and tutorials; and tips on troubleshooting and advice for achieving reproducibility while avoiding mistakes and misinterpretations. The overarching goal driving this volume is to excite the expert and stimulate the newcomer to the field of Computational Systems Biology. Cutting-edge and authoritative, Computational Systems Biology in Medicine and Biotechnology: Methods and Protocols is a valuable resource for pre- and post-graduate students in medicine and biotechnology, and in diverse areas ranging from microbiology to cellular and organismal biology, as well as computational and experimental biologists, and researchers interested in utilizing comprehensive systems biology oriented methods.

Systems Biology and Bioinformatics

Kayvan Najarian,Siamak Najarian,Shahriar Gharibzadeh,Christopher N. Eichelberger
Systems Biology and Bioinformatics Book PDF

Author : Kayvan Najarian,Siamak Najarian,Shahriar Gharibzadeh,Christopher N. Eichelberger
Publisher : CRC Press
Page : 190 pages
File Size : 41,5 Mb
Release : 2009-04-13
Category : Medical
ISBN : 9781439882948

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Systems Biology and Bioinformatics by Kayvan Najarian,Siamak Najarian,Shahriar Gharibzadeh,Christopher N. Eichelberger Pdf

The availability of molecular imaging and measurement systems enables today's biologists to swiftly monitor thousands of genes involved in a host of diseases, a critical factor in specialized drug development. Systems Biology and Bioinformatics: A Computational Approach provides students with a comprehensive collection of the computational methods

Systems Biology in Biotech & Pharma

Aleš Prokop,Seth Michelson
Systems Biology in Biotech Pharma Book PDF

Author : Aleš Prokop,Seth Michelson
Publisher : Springer Science & Business Media
Page : 137 pages
File Size : 40,9 Mb
Release : 2012-01-05
Category : Medical
ISBN : 9789400728493

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Systems Biology in Biotech & Pharma by Aleš Prokop,Seth Michelson Pdf

The US is currently well ahead of the rest of the world in the development and application of SB and its principles especially as they pertain to basic medical research and development. This lead is largely due to its earlier start in the academic arena. However, there is evidence of rapid development in both the UK/EU and Japan, and the gap is narrowing, particularly in the UK. From an industrial point of view, the Pharmaceutical Industry based in the US and UK can capitalize on these opportunities and gain the benefits of this technology. Many educational institutions (particularly their medical divisions) at present are heavily business-oriented, realize that in this particular industrial environment, that every dollar counts.

Computational Systems Biology

Andres Kriete,Roland Eils
Computational Systems Biology Book PDF

Author : Andres Kriete,Roland Eils
Publisher : Academic Press
Page : 548 pages
File Size : 53,6 Mb
Release : 2013-11-26
Category : Computers
ISBN : 9780124059382

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Computational Systems Biology by Andres Kriete,Roland Eils Pdf

This comprehensively revised second edition of Computational Systems Biology discusses the experimental and theoretical foundations of the function of biological systems at the molecular, cellular or organismal level over temporal and spatial scales, as systems biology advances to provide clinical solutions to complex medical problems. In particular the work focuses on the engineering of biological systems and network modeling. Logical information flow aids understanding of basic building blocks of life through disease phenotypes Evolved principles gives insight into underlying organizational principles of biological organizations, and systems processes, governing functions such as adaptation or response patterns Coverage of technical tools and systems helps researchers to understand and resolve specific systems biology problems using advanced computation Multi-scale modeling on disparate scales aids researchers understanding of dependencies and constraints of spatio-temporal relationships fundamental to biological organization and function.

An Introduction to Computational Systems Biology

Karthik Raman
An Introduction to Computational Systems Biology Book PDF

Author : Karthik Raman
Publisher : CRC Press
Page : 359 pages
File Size : 43,7 Mb
Release : 2021-05-30
Category : Computers
ISBN : 9780429944529

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An Introduction to Computational Systems Biology by Karthik Raman Pdf

Emphasises a hands-on approach to modelling Strong emphasis on coding and software tools for systems biology Covers the entire spectrum of modelling, from static networks, to dynamic models Thoughtful exercises to test and enable student understanding of concepts Current chapters on exciting new developments like whole-cell modelling and community modelling

Systemic Approaches in Bioinformatics and Computational Systems Biology: Recent Advances

Lecca, Paola
Systemic Approaches in Bioinformatics and Computational Systems Biology Recent Advances Book PDF

Author : Lecca, Paola
Publisher : IGI Global
Page : 471 pages
File Size : 48,8 Mb
Release : 2011-12-31
Category : Medical
ISBN : 9781613504369

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Systemic Approaches in Bioinformatics and Computational Systems Biology: Recent Advances by Lecca, Paola Pdf

The convergence of biology and computer science was initially motivated by the need to organize and process a growing number of biological observations resulting from rapid advances in experimental techniques. Today, however, close collaboration between biologists, biochemists, medical researchers, and computer scientists has also generated remarkable benefits for the field of computer science. Systemic Approaches in Bioinformatics and Computational Systems Biology: Recent Advances presents new techniques that have resulted from the application of computer science methods to the organization and interpretation of biological data. The book covers three subject areas: bioinformatics, computational biology, and computational systems biology. It focuses on recent, systemic approaches in computer science and mathematics that have been used to model, simulate, and more generally, experiment with biological phenomena at any scale.

Elements of Computational Systems Biology

Huma M. Lodhi,Stephen H. Muggleton
Elements of Computational Systems Biology Book PDF

Author : Huma M. Lodhi,Stephen H. Muggleton
Publisher : John Wiley & Sons
Page : 435 pages
File Size : 46,5 Mb
Release : 2010-03-25
Category : Computers
ISBN : 9780470556740

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Elements of Computational Systems Biology by Huma M. Lodhi,Stephen H. Muggleton Pdf

Groundbreaking, long-ranging research in this emergent field that enables solutions to complex biological problems Computational systems biology is an emerging discipline that is evolving quickly due to recent advances in biology such as genome sequencing, high-throughput technologies, and the recent development of sophisticated computational methodologies. Elements of Computational Systems Biology is a comprehensive reference covering the computational frameworks and techniques needed to help research scientists and professionals in computer science, biology, chemistry, pharmaceutical science, and physics solve complex biological problems. Written by leading experts in the field, this practical resource gives detailed descriptions of core subjects, including biological network modeling, analysis, and inference; presents a measured introduction to foundational topics like genomics; and describes state-of-the-art software tools for systems biology. Offers a coordinated integrated systems view of defining and applying computational and mathematical tools and methods to solving problems in systems biology Chapters provide a multidisciplinary approach and range from analysis, modeling, prediction, reasoning, inference, and exploration of biological systems to the implications of computational systems biology on drug design and medicine Helps reduce the gap between mathematics and biology by presenting chapters on mathematical models of biological systems Establishes solutions in computer science, biology, chemistry, and physics by presenting an in-depth description of computational methodologies for systems biology Elements of Computational Systems Biology is intended for academic/industry researchers and scientists in computer science, biology, mathematics, chemistry, physics, biotechnology, and pharmaceutical science. It is also accessible to undergraduate and graduate students in machine learning, data mining, bioinformatics, computational biology, and systems biology courses.

Computational Systems Bioinformatics

Xiaobo Zhou,Stephen T. C. Wong
Computational Systems Bioinformatics Book PDF

Author : Xiaobo Zhou,Stephen T. C. Wong
Publisher : World Scientific
Page : 398 pages
File Size : 52,7 Mb
Release : 2008
Category : Science
ISBN : 9789812707048

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Computational Systems Bioinformatics by Xiaobo Zhou,Stephen T. C. Wong Pdf

Computational systems biology is a new and rapidly developing field of research, concerned with understanding the structure and processes of biological systems at the molecular, cellular, tissue, and organ levels through computational modeling as well as novel information theoretic data and image analysis methods. By focusing on either information processing of biological data or on modeling physical and chemical processes of biosystems, and in combination with the recent breakthrough in deciphering the human genome, computational systems biology is guaranteed to play a central role in disease prediction and preventive medicine, gene technology and pharmaceuticals, and other biotechnology fields. This book begins by introducing the basic mathematical, statistical, and data mining principles of computational systems biology, and then presents bioinformatics technology in microarray and sequence analysis step-by-step. Offering an insightful look into the effectiveness of the systems approach in computational biology, it focuses on recurrent themes in bioinformatics, biomedical applications, and future directions for research.

Computational Systems Biology of Cancer

Emmanuel Barillot,Laurence Calzone,Philippe Hupe,Jean-Philippe Vert,Andrei Zinovyev
Computational Systems Biology of Cancer Book PDF

Author : Emmanuel Barillot,Laurence Calzone,Philippe Hupe,Jean-Philippe Vert,Andrei Zinovyev
Publisher : CRC Press
Page : 461 pages
File Size : 48,7 Mb
Release : 2012-08-25
Category : Computers
ISBN : 9781439831458

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Computational Systems Biology of Cancer by Emmanuel Barillot,Laurence Calzone,Philippe Hupe,Jean-Philippe Vert,Andrei Zinovyev Pdf

The future of cancer research and the development of new therapeutic strategies rely on our ability to convert biological and clinical questions into mathematical models-integrating our knowledge of tumour progression mechanisms with the tsunami of information brought by high-throughput technologies such as microarrays and next-generation sequencin

Computational Systems Bioinformatics - Methods And Biomedical Applications

Wong Stephen Tin Chi,Zhou Xiaobo
Computational Systems Bioinformatics Methods And Biomedical Applications Book PDF

Author : Wong Stephen Tin Chi,Zhou Xiaobo
Publisher : World Scientific Publishing Company
Page : 400 pages
File Size : 43,9 Mb
Release : 2008-01-02
Category : Science
ISBN : 9789813106994

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Computational Systems Bioinformatics - Methods And Biomedical Applications by Wong Stephen Tin Chi,Zhou Xiaobo Pdf

Computational systems biology is a new and rapidly developing field of research, concerned with understanding the structure and processes of biological systems at the molecular, cellular, tissue, and organ levels through computational modeling as well as novel information theoretic data and image analysis methods. By focusing on either information processing of biological data or on modeling physical and chemical processes of biosystems, and in combination with the recent breakthrough in deciphering the human genome, computational systems biology is guaranteed to play a central role in disease prediction and preventive medicine, gene technology and pharmaceuticals, and other biotechnology fields.This book begins by introducing the basic mathematical, statistical, and data mining principles of computational systems biology, and then presents bioinformatics technology in microarray and sequence analysis step-by-step. Offering an insightful look into the effectiveness of the systems approach in computational biology, it focuses on recurrent themes in bioinformatics, biomedical applications, and future directions for research.

Systems Biology

Nikolaus Rajewsky,Stefan Jurga,Jan Barciszewski
Systems Biology Book PDF

Author : Nikolaus Rajewsky,Stefan Jurga,Jan Barciszewski
Publisher : Springer
Page : 401 pages
File Size : 42,6 Mb
Release : 2018-08-29
Category : Science
ISBN : 9783319929675

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Systems Biology by Nikolaus Rajewsky,Stefan Jurga,Jan Barciszewski Pdf

Many breakthroughs in experimental devices, advanced software, as well as analytical methods for systems biology development have helped shape the way we study DNA, RNA and proteins, on the genomic, transcriptional, translational and posttranslational level. This book highlights the comprehensive topics that encompass systems biology with enormous progress in the development of genome sequencing, proteomic and metabolomic methods in designing and understanding biological systems. Topics covered in this book include fundamentals of modelling networks, circuits and pathways, spatial and multi cellular systems, image-driven systems biology, evolution, noise and decision-making in single cells, systems biology of disease and immunology, and personalized medicine. Special attention is paid to epigenomics, in particular environmental conditions that impact genetic background. The breadth of exciting new data towards discovering fundamental principles and direct application of epigenetics in agriculture is also described. The chapter “Deciphering the Universe of RNA Structures and Trans RNA-RNA Interactions of Transcriptomes in vivo - from Experimental Protocols to Computational Analyses” is available open access under a CC BY 4.0 license via link.springer.com.

Computational Systems Biology

Paola Lecca,Angela Re,Adaoha Elizabeth Ihekwaba,Ivan Mura,Thanh-Phuong Nguyen
Computational Systems Biology Book PDF

Author : Paola Lecca,Angela Re,Adaoha Elizabeth Ihekwaba,Ivan Mura,Thanh-Phuong Nguyen
Publisher : Woodhead Publishing
Page : 180 pages
File Size : 55,7 Mb
Release : 2016-07-29
Category : Science
ISBN : 9780081001158

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Computational Systems Biology by Paola Lecca,Angela Re,Adaoha Elizabeth Ihekwaba,Ivan Mura,Thanh-Phuong Nguyen Pdf

Computational Systems Biology: Inference and Modelling provides an introduction to, and overview of, network analysis inference approaches which form the backbone of the model of the complex behavior of biological systems. This book addresses the challenge to integrate highly diverse quantitative approaches into a unified framework by highlighting the relationships existing among network analysis, inference, and modeling. The chapters are light in jargon and technical detail so as to make them accessible to the non-specialist reader. The book is addressed at the heterogeneous public of modelers, biologists, and computer scientists. Provides a unified presentation of network inference, analysis, and modeling Explores the connection between math and systems biology, providing a framework to learn to analyze, infer, simulate, and modulate the behavior of complex biological systems Includes chapters in modular format for learning the basics quickly and in the context of questions posed by systems biology Offers a direct style and flexible formalism all through the exposition of mathematical concepts and biological applications

Systems Biology in Biotech & Pharma

Ales Prokop,Seth Michelson
Systems Biology in Biotech Pharma Book PDF

Author : Ales Prokop,Seth Michelson
Publisher : Springer
Page : 127 pages
File Size : 52,9 Mb
Release : 2012-01-26
Category : Medical
ISBN : 9400728506

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Systems Biology in Biotech & Pharma by Ales Prokop,Seth Michelson Pdf

The US is currently well ahead of the rest of the world in the development and application of SB and its principles especially as they pertain to basic medical research and development. This lead is largely due to its earlier start in the academic arena. However, there is evidence of rapid development in both the UK/EU and Japan, and the gap is narrowing, particularly in the UK. From an industrial point of view, the Pharmaceutical Industry based in the US and UK can capitalize on these opportunities and gain the benefits of this technology. Many educational institutions (particularly their medical divisions) at present are heavily business-oriented, realize that in this particular industrial environment, that every dollar counts.

Software Tools and Algorithms for Biological Systems

Hamid Arabnia,Quoc-Nam Tran
Software Tools and Algorithms for Biological Systems Book PDF

Author : Hamid Arabnia,Quoc-Nam Tran
Publisher : Springer Science & Business Media
Page : 776 pages
File Size : 50,6 Mb
Release : 2011-03-23
Category : Science
ISBN : 9781441970466

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Software Tools and Algorithms for Biological Systems by Hamid Arabnia,Quoc-Nam Tran Pdf

“Software Tools and Algorithms for Biological Systems" is composed of a collection of papers received in response to an announcement that was widely distributed to academicians and practitioners in the broad area of computational biology and software tools. Also, selected authors of accepted papers of BIOCOMP’09 proceedings (International Conference on Bioinformatics and Computational Biology: July 13-16, 2009; Las Vegas, Nevada, USA) were invited to submit the extended versions of their papers for evaluation.

Computational Systems Bioinformatics

Peter Markstein,Ying Xu,Life Sciences Society
Computational Systems Bioinformatics Book PDF

Author : Peter Markstein,Ying Xu,Life Sciences Society
Publisher : World Scientific
Page : 472 pages
File Size : 52,6 Mb
Release : 2007
Category : Computers
ISBN : 9781860948732

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Computational Systems Bioinformatics by Peter Markstein,Ying Xu,Life Sciences Society Pdf

This volume contains about 40 papers covering many of the latest developments in the fast-growing field of bioinformatics. The contributions span a wide range of topics, including computational genomics and genetics, protein function and computational proteomics, the transcriptome, structural bioinformatics, microarray data analysis, motif identification, biological pathways and systems, and biomedical applications. Abstracts from the keynote addresses and invited talks are also included. The papers not only cover theoretical aspects of bioinformatics but also delve into the application of new methods, with input from computation, engineering and biology disciplines. This multidisciplinary approach to bioinformatics gives these proceedings a unique viewpoint of the field. Sample Chapter(s). Chapter 1: Whole-Genome Analysis of Dorsal Gradient Thresholds in the Drosophila Embryo (102 KB). Contents: Learning Predictive Models of Gene Regulation (C Leslie); Algorithms for Selecting Breakpoint Locations to Optimize Diversity in Protein Engineering by Site-Directed Protein Recombination (W Zheng et al.); Cancer Molecular Pattern Discovery by Subspace Consensus Kernel Classification (X Han); Transcriptional Profiling of Definitive Endoderm Derived from Human Embryonic Stem Cells (H Liu et al.); A Markov Model Based Analysis of Stochastic Biochemical Systems (P Ghosh et al.); Clustering of Main Orthologs for Multiple Genomes (Z Fu & T Jiang); Extraction, Quantification and Visualization of Protein Pockets (X Zhang & C Bajaj); Consensus Contact Prediction by Linear Programming (X Gao et al.); An Active Visual Search Interface for Medline (W Xuan et al.); Exact and Heuristic Algorithms for Weighted Cluster Editing (S Rahmann et al.); Reconcilation with Non-binary Species Trees (B Vernot et al.); and other papers. Readership: Research and application community in bioinformatics, systems biology, medicine, pharmacology and biotechnology. Graduate researchers in bioinformatics and computational biology.