Computer Assisted Method Development For High Performance Liquid Chromatography

Author : Joseph L. Glajch,Lloyd R. Snyder
Publisher : Elsevier Publishing Company
Page : 714 pages
File Size : 43,8 Mb
Release : 1990
Category : Science
ISBN : UOM:39015021866408

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Computer-assisted Method Development for High-performance Liquid Chromatography by Joseph L. Glajch,Lloyd R. Snyder Pdf

This book deals with the use of the computer as an aid in selecting adequate or optimum conditions for a given analytical separation. Originally published as Volume 485 of the Journal of Chromatography, it has now been reprinted in book form, since the information is so useful that many chromatographers want a copy readily available in the lab. An extensive Introduction is added to the book edition. This surveys the field and refers to the pages where particular items are discussed in the book. The addition of a Glossary of Terms, an Author Index and a Subject Index make this book an invaluable source of easily consulted information for the practising chromatographer. For the purpose of this book, computer-assisted method development will be limited to specific procedures which are intended to be used with a computer - rather than their manually applied precursors. In that sense, the subject can be considered to have begun around 1980. The ongoing, intense research activity into various forms of computer assisted HPLC method development provides the assurance that this approach can really assist the practical chromatographer working in an industrial laboratory.

Author : Szabolcs Fekete,Imre Molnar
Publisher : World Scientific
Page : 364 pages
File Size : 44,8 Mb
Release : 2018-08-01
Category : Science
ISBN : 9781786345479

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Software-assisted Method Development In High Performance Liquid Chromatography by Szabolcs Fekete,Imre Molnar Pdf

'The book is a useful contribution in the field of HPLC, and may represent a valuable tool for chromatography practitioners in different fields, as well as teachers and instructors. The 12 chapters provide comprehensive insights of current day retention and resolution modelling in HPLC, and its applications for small and large molecule analysis. It may be a useful reference for specialists in pharmaceuticals but not limited to … It may be a valuable resource to assist scientists involved in method development, aiming to achieve the best results with reduced costs, time, and efforts.'Analytical and Bioanalytical ChemistryThis handbook gives a general overview of the possibilities in recent developments in chromatographic retention modeling. As a result of the latest developments in modeling software, several new features are now accessible, opening a new level in HPLC method development.Many of these current possibilities in software assisted liquid chromatographic method modeling for analytical purposes are presented. Several modes of chromatography, including Reversed-Phase Liquid Chromatography (RPLC), Ion Exchange Chromatography (IEX), Hydrophobic Interaction Chromatography (HIC), and Hydrophilic Interaction Liquid Chromatography (HILIC) are explained in detail. For all these chromatographic modes, the most important variables for tuning retention and selectivity are exposed.Beside the industrial and practical benefits of retention modeling, the possibilities in teaching and education are also illustrated. Finally, numerous representative industrial examples are shown, to highlight the benefits, time and cost savings offered by state-of-the-art software assisted HPLC method development.

Author : Lloyd R. Snyder,Joseph J. Kirkland,Joseph L. Glajch
Publisher : John Wiley & Sons
Page : 665 pages
File Size : 41,9 Mb
Release : 2012-12-03
Category : Science
ISBN : 9781118591512

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Practical HPLC Method Development by Lloyd R. Snyder,Joseph J. Kirkland,Joseph L. Glajch Pdf

This revision brings the reader completely up to date on the evolving methods associated with increasingly more complex sample types analyzed using high-performance liquid chromatography, or HPLC. The book also incorporates updated discussions of many of the fundamental components of HPLC systems and practical issues associated with the use of this analytical method. This edition includes new or expanded treatments of sample preparation, computer assisted method development, as well as biochemical samples, and chiral separations.

Author : Tomasz Tuzimski,Joseph Sherma
Publisher : CRC Press
Page : 583 pages
File Size : 54,9 Mb
Release : 2015-05-20
Category : Science
ISBN : 9781466568822

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High Performance Liquid Chromatography in Pesticide Residue Analysis by Tomasz Tuzimski,Joseph Sherma Pdf

HPLC is the principal separation technique for identification of the pesticides in environmental samples and for quantitative analysis of analytes. At each stage of the HPLC procedure, the chromatographer should possess both the practical and theoretical skills required to perform HPLC experiments correctly and to obtain reliable, repeatable, and r

Author : Monika Waksmundzka-Hajnos,Joseph Sherma
Publisher : CRC Press
Page : 996 pages
File Size : 42,7 Mb
Release : 2010-11-08
Category : Health & Fitness
ISBN : 1420092618

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High Performance Liquid Chromatography in Phytochemical Analysis by Monika Waksmundzka-Hajnos,Joseph Sherma Pdf

The powerful, efficient technique of high performance liquid chromatography (HPLC) is essential to the standardization of plant-based drugs, identification of plant material, and creation of new herbal medicines. Filling the void in this critical area, High Performance Liquid Chromatography in Phytochemical Analysis is the first book to give a comp

Author : Eli Grushka,Nelu Grinberg
Publisher : CRC Press
Page : 270 pages
File Size : 49,8 Mb
Release : 2016-11-03
Category : Science
ISBN : 9781315353319

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Advances in Chromatography, Volume 53 by Eli Grushka,Nelu Grinberg Pdf

For more than four decades, scientists and researchers have relied on the Advances in Chromatography series for the most up-to-date information on a wide range of developments in chromatographic methods and applications. For Volume 53, the series editors have invited established, well-known chemists to offer cutting-edge reviews of chromatographic methods with applications in the life sciences. The clear presentation of topics and vivid illustrations for which this series has become known makes the material accessible and engaging to analytical, biochemical, organic, polymer, and pharmaceutical chemists at all levels of technical skill.

Author : Stephen Vance Medlin
Publisher : Unknown
Page : 366 pages
File Size : 43,9 Mb
Release : 1993
Category : High performance liquid chromatography
ISBN : MSU:31293010192338

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Development of an Intelligent Automated High Performance Liquid Chromatography System by Stephen Vance Medlin Pdf

Author : Vikas Anand Saharan
Publisher : Springer Nature
Page : 767 pages
File Size : 47,5 Mb
Release : 2022-05-30
Category : Medical
ISBN : 9789811651809

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Computer Aided Pharmaceutics and Drug Delivery by Vikas Anand Saharan Pdf

This book examines the role of computer-assisted techniques for discovering, designing, optimizing and manufacturing new, effective, and safe pharmaceutical formulations and drug delivery systems. The book discusses computational approaches, statistical modeling and molecular modeling for the development and safe delivery of drugs in humans. The application of concepts of QbD (Quality by Design), DoE (Design of Experiments), artificial intelligence and in silico pharmacokinetic assessment/simulation have been made a lot easier with the help of commercial software and expert systems. This title provides in-depth knowledge of such useful software with illustrations from the latest researches. The book also fills in the gap between pharmaceutics and molecular modeling at micro, meso and maro scale by covering topics such as advancements in computer-aided Drug Design (CADD), drug-polymer interactions in drug delivery systems, molecular modeling of nanoparticles and pharmaceutics/bioinformatics. This book provides abundant applications of computers in formulation designing and characterization are provided as examples, case studies and illustrations. Short reviews of software, databases and expert systems have also been added to culminate the interest of readers for novel applications in formulation development and drug delivery. Computer-aided pharmaceutics and drug delivery is an authoritative reference source for all the latest scholarly update on emerging developments in computed assisted techniques for drug designing and development. The book is ideally designed for pharmacists, medical practitioners, students and researchers.

Author : James M. Miller
Publisher : John Wiley & Sons
Page : 518 pages
File Size : 44,6 Mb
Release : 2005-12-16
Category : Science
ISBN : 9780471980599

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Chromatography by James M. Miller Pdf

The first edition of Chromatography: Concepts and Contrasts, published in 1988, was one of the first books to discuss all the different types of chromatography under one cover. The second edition continues with these principles but has been updated to include new chapters on sampling and sample preparation, capillary electrophoresis and capillary electrochromatography (CEC), chromatography with mass spec detection, and industrial and governmental practices in regulated industries. Covers extraction, solid phase extraction (SPE), and solid phase microextraction (SPME), and introduces mass spectrometry Updated with the latest techniques in chromatography Discusses both liquid chromatography (LC)and gas chromatography(GC)

Author : R.M. Smith
Publisher : Elsevier
Page : 456 pages
File Size : 44,9 Mb
Release : 1995-01-13
Category : Science
ISBN : 0080858651

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Retention and Selectivity in Liquid Chromatography by R.M. Smith Pdf

This book brings together a number of studies which examine the ways in which the retention and selectivity of separations in high-performance liquid chromatography are dependent on the chemical structure of the analytes and the properties of the stationary and mobile phases. Although previous authors have described the optimisation of separations by alteration of the mobile phase, little emphasis has previously been reported of the influence of the structure and properties of the analyte. The initial chapters describe methods based on retention index group increments and log P increments for the prediction of the retention of analytes and the ways in which these factors are influenced by mobile phases and intramolecular interactions. The values of a wide range of group increments in different eluents are tabulated. Different scales of retention indices in liquid chromatography are described for the comparison of separations, the identification of analytes and the comparison of stationary phases. Applications of these methods in the pharmaceutical, toxicology, forensic, metabolism, environmental, food and other fields are reviewed. The effects of different mobile phases on the selectivity of the retention indices are reported. A compilation of sources of reported retention index values are given. Methods for the comparison of stationary phases based on the interactions of different analytes are covered, including lipophilic and polar indices, shape selectivity comparisons, their application to novel stationary phases, and chemometric methods for column comparisons.

Author : Nelu Grinberg,Peter W. Carr
Publisher : CRC Press
Page : 195 pages
File Size : 49,7 Mb
Release : 2019-02-07
Category : Medical
ISBN : 9780429651960

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Advances in Chromatography by Nelu Grinberg,Peter W. Carr Pdf

For more than five decades, scientists and researchers have relied on the Advances in Chromatography series for the most up-todate information on a wide range of developments in chromatographic methods and applications. The clear presentation of topics and vivid illustrations for which this series has become known makes the material accessible and engaging to analytical, biochemical, organic, polymer, and pharmaceutical chemists at all levels of technical skill. Key Features: Includes a chapter dedicated to Izaak Maurits Kolthoff, offering a unique look at his non-professional life as well as his impact and legacy in Analytical Chemistry. Discusses recent advances in two-dimensional liquid chromatography for the characterization of monoclonal antibodies and other therapeutic proteins. Reviews solvation processes, methodologies of their measurement, and parameters influenced solvation Explores recent advances in TLC analysis of natural colorings, determination of synthetic dyes, and determination of EU-permitted natural colors, in foods. Offers comprehensive and critical insights on the key aspects of CE-MS analysis of intact proteins

Author : Anonim
Publisher : Unknown
Page : 128 pages
File Size : 48,6 Mb
Release : 1999
Category : High performance liquid chromatography
ISBN : OCLC:943263831

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High Performance Liquid Chromatography by Anonim Pdf

Author : Danilo Corradini,Elena Eksteen (Katz),Roy Eksteen,Peter Schoenmakers,Neil Miller
Publisher : CRC Press
Page : 1018 pages
File Size : 44,8 Mb
Release : 2011-01-03
Category : Science
ISBN : 0203909755

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Handbook of HPLC by Danilo Corradini,Elena Eksteen (Katz),Roy Eksteen,Peter Schoenmakers,Neil Miller Pdf

Delineating its usage in separation, purification and detection processes across a variety of disciplines, from industry to applied research, this work discusses the principles, techniques and instrumentation involving HPLC within a detailed framework. Over 100 tables present previously scattered experimental data.

Author : L.M.C. Buydens,P.J. Schoenmakers
Publisher : Elsevier
Page : 346 pages
File Size : 45,8 Mb
Release : 1993-09-03
Category : Computers
ISBN : 0080868401

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Intelligent Software for Chemical Analysis by L.M.C. Buydens,P.J. Schoenmakers Pdf

Various emerging techniques for automating intelligent functions in the laboratory are described in this book. Explanations on how systems work are given and possible application areas are suggested. The main part of the book is devoted to providing data which will enable the reader to develop and test his own systems. The emphasis is on expert systems; however, promising developments such as self-adaptive systems, neural networks and genetic algorithms are also described. The book has been written by chemists with a great deal of practical experience in developing and testing intelligent software, and therefore offers first-hand knowledge. Laboratory staff and managers confronted with commercial intelligent software will find information on the functioning, possibilities and limitations thereof, enabling them to select and use modern software in an optimum fashion. Finally, computer scientists and information scientists will find a wealth of data on the application of contemporary artificial intelligence techniques.

Author : Lloyd R. Snyder,Joseph J. Kirkland,John W. Dolan
Publisher : John Wiley & Sons
Page : 831 pages
File Size : 55,5 Mb
Release : 2011-09-20
Category : Science
ISBN : 9781118210390

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Introduction to Modern Liquid Chromatography by Lloyd R. Snyder,Joseph J. Kirkland,John W. Dolan Pdf

The latest edition of the authoritative reference to HPLC High-performance liquid chromatography (HPLC) is today the leading technique for chemical analysis and related applications, with an ability to separate, analyze, and/or purify virtually any sample. Snyder and Kirkland's Introduction to Modern Liquid Chromatography has long represented the premier reference to HPLC. This Third Edition, with John Dolan as added coauthor, addresses important improvements in columns and equipment, as well as major advances in our understanding of HPLC separation, our ability to solve problems that were troublesome in the past, and the application of HPLC for new kinds of samples. This carefully considered Third Edition maintains the strengths of the previous edition while significantly modifying its organization in light of recent research and experience. The text begins by introducing the reader to HPLC, its use in relation to other modern separation techniques, and its history, then leads into such specific topics as: The basis of HPLC separation and the general effects of different experimental conditions Equipment and detection The column—the "heart" of the HPLC system Reversed-phase separation, normal-phase chromatography, gradient elution, two-dimensional separation, and other techniques Computer simulation, qualitative and quantitative analysis, and method validation and quality control The separation of large molecules, including both biological and synthetic polymers Chiral separations, preparative separations, and sample preparation Systematic development of HPLC separations—new to this edition Troubleshooting tricks, techniques, and case studies for both equipment and chromatograms Designed to fulfill the needs of the full range of HPLC users, from novices to experts, Introduction to Modern Liquid Chromatography, Third Edition offers the most up-to-date, comprehensive, and accessible survey of HPLC methods and applications available.