Coupling And Decoupling Of Diverse Molecular Units In Glycosciences

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Coupling and Decoupling of Diverse Molecular Units in Glycosciences

Zbigniew J. Witczak,Roman Bielski
Coupling and Decoupling of Diverse Molecular Units in Glycosciences Book PDF

Author : Zbigniew J. Witczak,Roman Bielski
Publisher : Springer
Page : 335 pages
File Size : 40,8 Mb
Release : 2017-11-20
Category : Science
ISBN : 9783319655871

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Coupling and Decoupling of Diverse Molecular Units in Glycosciences by Zbigniew J. Witczak,Roman Bielski Pdf

This unique book covers the latest developments in coupling and decoupling of biomolecules containing functionalized carbohydrate components, being one of the first collections in this important area of applied medicinal chemistry. Connecting molecules, often referred as bio-conjugation, has become one of the most often performed procedures in modern medicinal chemistry. Sometimes, when the connected molecules are not useful anymore, they must be disconnected. The molecules that must be connected (coupled) may belong to both small and large molecules and include such constructs as glycoproteins, glycopeptides and glycans. In this work, more than 15 experts address a comprehensive range of potential and current uses of in vitro and in vivo bio-conjugation methodologies, leading to a variety of glycoconjugates. The analytical aspects of bio-conjugation are also here discussed. Medicinal and organic chemists from graduate level onwards will understand the appeal of this important book.

Beyond LC MS: The Next Frontier in Clinical Mass Spectrometry, An Issue of the Clinics in Laboratory Medicine,E-Book

Sankha (Bobby) Basu
Beyond LC MS The Next Frontier in Clinical Mass Spectrometry An Issue of the Clinics in Laboratory Medicine E Book Book PDF

Author : Sankha (Bobby) Basu
Publisher : Elsevier Health Sciences
Page : 169 pages
File Size : 49,5 Mb
Release : 2021-05-31
Category : Medical
ISBN : 9780323813303

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Beyond LC MS: The Next Frontier in Clinical Mass Spectrometry, An Issue of the Clinics in Laboratory Medicine,E-Book by Sankha (Bobby) Basu Pdf

Beyond LC MS: The Next Frontier in Clinical Mass Spectrometry, An Issue of the Clinics in Laboratory Medicine,E-Book

Click Chemistry in Glycoscience

Zbigniew J. Witczak,Roman Bielski
Click Chemistry in Glycoscience Book PDF

Author : Zbigniew J. Witczak,Roman Bielski
Publisher : John Wiley & Sons
Page : 402 pages
File Size : 54,5 Mb
Release : 2013-02-04
Category : Science
ISBN : 9781118526897

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Click Chemistry in Glycoscience by Zbigniew J. Witczak,Roman Bielski Pdf

Lays the foundation for new methods and applications of carbohydrate click chemistry Introduced by K. Barry Sharpless of The Scripps Research Institute in 2001, click chemistry mimics nature, giving researchers the tools needed to generate new substances quickly and reliably by joining small units together. With contributions from more than thirty pioneering researchers in the field, this text explores the many promising applications of click chemistry in glycoscience. Readers will learn both the basic concepts of carbohydrate click chemistry as well as its many biomedical applications, including synthetic antigens, analogs of cell-surface receptors, immobilized enzymes, targeted drug delivery systems, and multivalent cancer vaccines. Click Chemistry in Glycoscience examines a broad range of methodologies and strategies that have emerged from this rapidly evolving field. Each chapter describes new approaches, ideas, consequences, and applications resulting from the introduction of click processes. Divided into four sections, the book covers: Click chemistry strategies and decoupling Thio-click chemistry of carbohydrates Carbohydrate click chemistry for novel synthetic targets Carbohydrate click chemistry in biomedical sciences Thoroughly researched, the book reflects the most recent findings published in the literature. Diagrams and figures throughout the book enable readers to more easily grasp complex concepts and reaction processes. At the end of each chapter, references lead to the primary literature for further investigation of individual topics. The application of click chemistry to carbohydrates has tremendous implications for research. With this book as their guide, researchers have a solid foundation from which they can develop new methods and applications of carbohydrate click chemistry, including new carbohydrate-based therapeutics.

Domino and Intramolecular Rearrangement Reactions as Advanced Synthetic Methods in Glycoscience

Zbigniew J. Witczak,Roman Bielski
Domino and Intramolecular Rearrangement Reactions as Advanced Synthetic Methods in Glycoscience Book PDF

Author : Zbigniew J. Witczak,Roman Bielski
Publisher : John Wiley & Sons
Page : 372 pages
File Size : 55,7 Mb
Release : 2016-02-23
Category : Science
ISBN : 9781119044208

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Domino and Intramolecular Rearrangement Reactions as Advanced Synthetic Methods in Glycoscience by Zbigniew J. Witczak,Roman Bielski Pdf

The book consists of a brief introduction, a foreward provided by professor Danishefsky of Columbia University, and about 14 - 16 chapters, each written by one or two eminent scholars/authors describing their recent research in the area of either domino reactions or intramolecular rearrangements in carbohydrate chemistry. Three or four chapters will be reviews. The domino (cascade, tandem) reactions are always intramolecular. They are usually very fast, clean and offer highly complex structures in a one pot process. Intramolecular rearrangements offer very similar advantages and often lead to highly complex products as well. Although many recently isolated carbohydrates fulfill various sophisticated functions, their structures are often very complex. The editors cover the broadest scope of novel methodologies possible. All the synthetic and application aspects of domino/cascade reactions are explored in this book. A second theme that will be covered is intramolecular rearrangement, which is also fast, stereoselective, and often constitutes one or more steps of domino / cascade process. Selected examples of intramolecular rearrangements are presented. Together, both processes offer an elegant and convenient approach to the synthesis of many complex molecules, which are normally difficult to synthesize via alternative routes. It appears that domino and intramolecular rearrangements are ideally suited to synthesize certain specific modified monosaccharides. What is particularly important is that both processes are intermolecular and almost always yield products with very well-defined stereochemistry. This high definition is absolutely crucial when synthesizing advanced, modified mono and oligosaccharides. The choice of contributors reflects an emphasis on both therapeutic and pharmacological aspects of carbohydrate chemistry.

The Perfect Slime

Hans-Curt Flemming,Dr Thomas R. Neu,Dr Jost Wingender
The Perfect Slime Book PDF

Author : Hans-Curt Flemming,Dr Thomas R. Neu,Dr Jost Wingender
Publisher : IWA Publishing
Page : 336 pages
File Size : 46,6 Mb
Release : 2016-09-15
Category : Science
ISBN : 9781780407418

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The Perfect Slime by Hans-Curt Flemming,Dr Thomas R. Neu,Dr Jost Wingender Pdf

The Perfect Slime presents the latest state of knowledge and all aspects of the Extracellular Polymeric Substances, (EPS) matrix – from the ecological and health to the antifouling perspectives. The book brings together all the current material in order to expand our understanding of the functions, properties and characteristics of the matrix as well as the possibilities to strengthen or weaken it. The EPS matrix represents the immediate environment in which biofilm organisms live. From their point of view, this matrix has paramount advantages. It allows them to stay together for extended periods and form synergistic microconsortia, it retains extracellular enzymes and turns the matrix into an external digestion system and it is a universal recycling yard, it protects them against desiccation, it allows for intense communication and represents a huge genetic archive. They can remodel their matrix, break free and eventually, they can use it as a nutrient source. The EPS matrix can be considered as one of the emergent properties of biofilms and are a major reason for the success of this form of life. Nevertheless, they have been termed the “black matter of biofilms” for good reasons. First of all: the isolation methods define the results. In most cases, only water soluble EPS components are investigated; insoluble ones such as cellulose or amyloids are much less included. In particular in environmental biofilms with many species, it is difficult to impossible isolate, separate the various EPS molecules they are encased in and to define which species produced which EPS. The regulation and the factors which trigger or inhibit EPS production are still very poorly understood. Furthermore: bacteria are not the only microorganisms to produce EPS. Archaea, Fungi and algae can also form EPS. This book investigates the questions, What is their composition, function, dynamics and regulation? What do they all have in common?

Carbohydrate Chemistry

Laura Cipolla
Carbohydrate Chemistry Book PDF

Author : Laura Cipolla
Publisher : Unknown
Page : 506 pages
File Size : 54,6 Mb
Release : 2015
Category : Medical
ISBN : 1783267194

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Carbohydrate Chemistry by Laura Cipolla Pdf

The structural complexity and the synthetic challenges facing glycans have historically hampered efforts to study their multifaceted roles and the application of carbohydrates in drug development. However, in very recent years, new synthetic techniques flanked by the growing knowledge about carbohydrate involvement in physiological and pathological states has spurred renewed interest in the chemistry, biology and therapeutic potentialities of carbohydrates. This book offers an overview of key aspects of carbohydrate biology and chemistry that are fundamental for the design of novel therapeutics. The four-part structure of this book introduces these essential components to life, starting from their structure and biological roles and covering analytical methods and synthesis which pave the way for the development of a wide range of therapeutic applications. Leading experts from around the world are brought together to offer their recent research with the ultimate aim of enlightening the reader on the complex yet exciting field of carbohydrate chemistry. Academic and industrial researchers in structural biology, drug discovery and carbohydrate chemistry will find this book an essential guide to the latest research and future potential of medicinal chemistry.

Carbohydrate-Based Vaccines

A. Krishna Prasad
Carbohydrate Based Vaccines Book PDF

Author : A. Krishna Prasad
Publisher : ACS Symposium
Page : 0 pages
File Size : 51,9 Mb
Release : 2019-09-23
Category : Medical
ISBN : 0841233373

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Carbohydrate-Based Vaccines by A. Krishna Prasad Pdf

The past three decades have witnessed the development and regulatory approval of glycoconjugate vaccines against several medically important bacterial pathogens, including Haemophilus influenzae type b, Streptococcus pneumoniae, Neisseria meningitides, and Salmonella typhi. Immunologic protection against these and many other bacterial diseases is mediated through opsonophagocytic antibodies directed against the surface carbohydrates that define the bacterial serogroup or serotype and serve as virulence factors. These vaccines are composed of bacterial capsular polysaccharides chemically conjugated to immunogenic carrier proteins. Given that the diseases caused by these bacterial pathogens are most pronounced in infants and young children, the development of the glycoconjugate vaccine technology has had a considerable impact on public health. Many of the chapters in this volume were assembled as a follow-up from a symposium entitled "Carbohydrate-Based Vaccines and Adjuvants" which took place at the 254th American Chemical Society National Meeting held in Washington, DC (August 2017). The symposium was sponsored by Pfizer and the Carbohydrate (CARB) and Biotechnology (BIOT) divisions. This book, therefore, reflects the importance of this field toward design, development, manufacture and licensure of the complex carbohydrate-based (glycoconjugate) vaccines. The book has been organized into thirteen chapters, which cover a comprehensive landscape including the clinical history, design, development, chemistry, manufacturing and control (CMC) aspects, pre-clinical assays, adjuvants and the various approaches used to develop carbohydrate-based vaccines.

Biocatalysis in Polymer Science

American Chemical Society. Meeting
Biocatalysis in Polymer Science Book PDF

Author : American Chemical Society. Meeting
Publisher : Unknown
Page : 360 pages
File Size : 54,5 Mb
Release : 2003
Category : Language Arts & Disciplines
ISBN : UOM:39015056277745

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Biocatalysis in Polymer Science by American Chemical Society. Meeting Pdf

Biocatalysis in Polymer Science provides current information on biocatalysis, which is the use of enzymes or living organisms to carry out chemical reactions. All of the authors, including the editors, are experts and practitioners of polymer biocatalysis. Topics covered in this book include synthetic polymers, natural polymers, oligomers, and monomers. These topics amply demonstrate the versatility of this technology. Organic chemists, polymer chemists, biochemists, and graduate students will find this book a useful experience.

Industrial Pharmaceutical Biotechnology

Heinrich Klefenz
Industrial Pharmaceutical Biotechnology Book PDF

Author : Heinrich Klefenz
Publisher : Wiley-VCH
Page : 328 pages
File Size : 53,8 Mb
Release : 2002-04-22
Category : Medical
ISBN : UOM:39015055598992

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Industrial Pharmaceutical Biotechnology by Heinrich Klefenz Pdf

This volume focuses on pharmaceutical biotechnology as a key area of life sciences. The complete range of concepts, processes and technologies of biotechnology is applied in modern industrial pharmaceutical research, development and production. The results of genome sequencing and studies of biological-genetic function are combined with chemical, micro-electronic and microsystem technology to produce medical devices and diagnostic biochips. A multitude of biologically active molecules is expanded by additional novel structures created with newly arranged gene clusters and bio-catalytic chemical processes. New organisational structures in the co-operation of institutes, companies and networks enable faster knowledge and product development and immediate application of the results of research and process development. This book is the ideal source of information for scientists and engineers in research and development, for decision-makers in biotech, pharma and chemical corporations, as well as for research institutes, but also for founders of biotech companies and people working for venture capital corporations.

Essentials of Glycobiology

Ajit Varki,Maarten J. Chrispeels
Essentials of Glycobiology Book PDF

Author : Ajit Varki,Maarten J. Chrispeels
Publisher : CSHL Press
Page : 694 pages
File Size : 42,9 Mb
Release : 1999
Category : Medical
ISBN : 0879696818

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Essentials of Glycobiology by Ajit Varki,Maarten J. Chrispeels Pdf

Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. "Essentials of Glycobiology" describes their biogenesis and function and offers a useful gateway to the understanding of glycans.

Novel Enzyme and Whole-Cell Biocatalysts

Anwar Sunna,Richard Daniellou
Novel Enzyme and Whole Cell Biocatalysts Book PDF

Author : Anwar Sunna,Richard Daniellou
Publisher : MDPI
Page : 332 pages
File Size : 54,7 Mb
Release : 2020-11-04
Category : Science
ISBN : 9783039434640

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Novel Enzyme and Whole-Cell Biocatalysts by Anwar Sunna,Richard Daniellou Pdf

The concept of a circular economy relies on waste reduction, valorization, and recycling. Global trends for “green” synthesis of chemicals have positioned the field of enzyme technology and biocatalysis (multi-enzymes and whole-cells) as an alternative for the synthesis of more social- and environmentally-responsible bio-based chemicals. Recent advances in synthetic biology, computational tools, and metabolic engineering have supported the discovery of new enzymes and the rational design of whole-cell biocatalysts. In this book, we highlight these current advances in the field of biocatalysis, with special emphasis on novel enzymes and whole-cell biocatalysts for applications in several industrial biotechnological applications.

Solid State NMR Spectroscopy

Melinda J. Duer
Solid State NMR Spectroscopy Book PDF

Author : Melinda J. Duer
Publisher : John Wiley & Sons
Page : 592 pages
File Size : 46,8 Mb
Release : 2008-04-15
Category : Science
ISBN : 9780470999387

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Solid State NMR Spectroscopy by Melinda J. Duer Pdf

This book is for those familiar with solution-state NMR who are encountering solid-state NMR for the first time. It presents the current understanding and applications of solid-state NMR with a rigorous but readable approach, making it easy for someone who merely wishes to gain an overall impression of the subject without details. This dual requirement is met through careful construction of the material within each chapter. The book is divided into two parts: "Fundamentals" and "Further Applications." The section on Fundamentals contains relatively long chapters that deal with the basic theory and practice of solid-state NMR. The essential differences and extra scope of solid-state NMR over solution-state is dealt with in an introductory chapter. The basic techniques that all chapters rely on are collected into a second chapter to avoid unnecessary repetition later. Remaining chapters in the "Fundamentals" part deal with the major areas of solid-state NMR which all solid-state NMR spectroscopists should know about. Each begins with an overview of the topic that puts the chapter in context. The basic principles upon which the techniques in the chapter rely are explained in a separate section. Each of these chapters exemplifies the principles and techniques with the applications most commonly found in current practice. The "Further Applications" section contains a series of shorter chapters which describe the NMR techniques used in other, more specific areas. The basic principles upon which these techniques rely will be expounded only if not already in the Fundamentals part.

Glycobiophysics

Yoshiki Yamaguchi,Koichi Kato
Glycobiophysics Book PDF

Author : Yoshiki Yamaguchi,Koichi Kato
Publisher : Springer
Page : 277 pages
File Size : 51,5 Mb
Release : 2018-11-27
Category : Science
ISBN : 9789811321580

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Glycobiophysics by Yoshiki Yamaguchi,Koichi Kato Pdf

This book presents state of the art biophysical approaches to issues in glycobiology that have cutting-edge applications. Despite the importance of glycosylation, the complexity, heterogeneity, and flexibility of the glycans have inhibited their study. Each chapter in this book explains very recent significant advances in biophysical approaches through the use of techniques such as NMR spectroscopy, mass spectrometry, single-molecule imaging, X-ray crystallography, high-speed atomic force microscopy, and computational simulation and their integrative application. Concrete examples are provided of the value of these techniques in addressing key problems in the field. In addition, significant functional glycobiological issues are considered. For example, glycolipids can form dynamic clusters on cell membranes and provide platforms for molecules involved in cell recognition and subsequent signal transduction. The detailed delineation of these molecular systems is discussed, revealing their structural complexity and ability to assemble transiently. This timely book will be of value for graduate students and postdocs interested in frontier topics in glycoscience and also for senior bio-researchers in academic and industrial fields.

Analysis of Protein Post-Translational Modifications by Mass Spectrometry

John R. Griffiths,Richard D. Unwin
Analysis of Protein Post Translational Modifications by Mass Spectrometry Book PDF

Author : John R. Griffiths,Richard D. Unwin
Publisher : John Wiley & Sons
Page : 414 pages
File Size : 48,7 Mb
Release : 2016-11-07
Category : Science
ISBN : 9781119045854

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Analysis of Protein Post-Translational Modifications by Mass Spectrometry by John R. Griffiths,Richard D. Unwin Pdf

Covers all major modifications, including phosphorylation, glycosylation, acetylation, ubiquitination, sulfonation and and glycation Discussion of the chemistry behind each modification, along with key methods and references Contributions from some of the leading researchers in the field A valuable reference source for all laboratories undertaking proteomics, mass spectrometry and post-translational modification research

The Art of Carbohydrate Analysis

Gerrit J. Gerwig
The Art of Carbohydrate Analysis Book PDF

Author : Gerrit J. Gerwig
Publisher : Springer Nature
Page : 362 pages
File Size : 43,9 Mb
Release : 2021-10-23
Category : Medical
ISBN : 9783030777913

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The Art of Carbohydrate Analysis by Gerrit J. Gerwig Pdf

The growing importance of glycobiology and carbohydrate chemistry in modern biotechnology and the pharmaceutical industry makes accurate carbohydrate analysis indispensable. This book provides the principles and protocols of various fundamental carbohydrate analysis methods. Choice of method is entirely dependent upon the type of material being investigated (biological samples, food products, etc.), and the level of structural detail required, i.e. sugar content, compositional analysis, linkages between the sugar components, or the total chemical structure of a given molecule. Full structural characterization of carbohydrate chains requires significant time, resources, and skill in several methods of analysis; no single technique can address all glycan analysis needs. This book summarizes several existing analytical techniques (both chemical and physical) in an introductory volume designed for the non-expert researcher or novice scientist. While background in carbohydrate chemistry is assumed, all information necessary to understanding the described techniques is addressed in the text.