Current Perspectives In Micrornas Mirna

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Current Perspectives in microRNAs (miRNA)

Shao-Yao Ying
Current Perspectives in microRNAs miRNA Book PDF

Author : Shao-Yao Ying
Publisher : Springer Science & Business Media
Page : 461 pages
File Size : 55,9 Mb
Release : 2008-09-12
Category : Medical
ISBN : 9781402085338

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Current Perspectives in microRNAs (miRNA) by Shao-Yao Ying Pdf

Nearly 97% of the human genome is the non-coding DNA, which varies from one species to another, and changes in these sequences are frequently noticed to manifest clinical and circumstantial malfunction. Numerous non-protein-coding genes are recently found to encode microRNAs, which are responsible for RNA-mediated gene silencing through RNA interference (RNAi)-like pathways. MicroRNAs (miRNAs), small single-stranded 17–25 nucleotide RNAs capable of interfering with intracellular messenger RNAs (mRNAs) that contain either complete or partial complementarity, are useful for the design of new therapies against cancer polymorphism and viral mutation. Currently over 1000 native miRNA species found in vertebrates and many more new miRNA homologs continue to be identified; however, most of their functions remain to be determined. In this book, many new perspectives of the miRNA research are reviewed and discussed, including their roles in stem cell maintenance, embryonic development, tissue differentiation, adult physiology, disease pathology, cancer research, viral infection, genetic engineering in plants, and utility in cosmetic applications. These new findings may not only provide significant insight into the various mechanisms of miRNAs but also offer a great opportunity in developing new therapeutic interventions.

MicroRNAs in Cancer

César López-Camarillo,Laurence A. Marchat
MicroRNAs in Cancer Book PDF

Author : César López-Camarillo,Laurence A. Marchat
Publisher : CRC Press
Page : 428 pages
File Size : 46,5 Mb
Release : 2013-02-22
Category : Science
ISBN : 9781466576766

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MicroRNAs in Cancer by César López-Camarillo,Laurence A. Marchat Pdf

MicroRNA (miRNA) biology is a cutting-edge topic in basic as well as biomedical research. This is a specialized book focusing on the current understanding of the role of miRNAs in the development, progression, invasion, and metastasis of diverse types of cancer. It also reviews their potential for applications in cancer diagnosis, prognosis, and therapeutic targets as well as the potential use in translational medicine. Chapters present comprehensive and expert perspectives on the roles of miRNAs in most common cancers from bench to bedside applications and are written by an international team of renowned experts in the field.

MicroRNAs in Cancer Translational Research

William C.S. Cho
MicroRNAs in Cancer Translational Research Book PDF

Author : William C.S. Cho
Publisher : Springer Science & Business Media
Page : 553 pages
File Size : 45,7 Mb
Release : 2011-01-25
Category : Medical
ISBN : 9789400702981

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MicroRNAs in Cancer Translational Research by William C.S. Cho Pdf

MicroRNA (miRNA) is a cutting-edge topic in the scientific and medical fields. This is a timely and specialized book focusing on the current understanding of miRNAs and the potential for their application in cancer diagnosis, prognosis, and therapeutic targets. It also provides discussion of the lessons learned from translational miRNA studies and exploration of the next steps required to advance this field. The unique book comprises 22 in-depth chapters by gathering unparalleled topics of interest in miRNAs by international team of world-renowned experts in the field. The first fifteen chapters provide comprehensive and expert perspectives on the most common cancers from bench to bedside applications, there is no current book structured in this cancer-oriented way. The next seven chapters providing thorough overviews of miRNAs and cancer stem cells; miRNAs in cancer invasion and metastasis; miRNAs in predicting radiotherapy and chemotherapy response; as well as expounding the role of miRNA in anti-cancer drug resistance and as blood-based cancer biomarkers. Furthermore, this book explicates the interplay of miRNAs in cancer metabolism and an update on the pioneering RNAi-based treatment approaches is also presented. This specialized book will contribute great to the scientific and medical community by providing the up-to-date discoveries of miRNAs and their important roles in cancer translational research.

MicroRNA Interference Technologies

Zhiguo Wang
MicroRNA Interference Technologies Book PDF

Author : Zhiguo Wang
Publisher : Springer Science & Business Media
Page : 198 pages
File Size : 47,7 Mb
Release : 2009-06-11
Category : Science
ISBN : 9783642004896

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MicroRNA Interference Technologies by Zhiguo Wang Pdf

MicroRNAs (miRNAs), endogenous noncoding regulatory mRNAs of around 22-nucleotides long, have rapidly emerged as one of the key governors of the gene expression regulatory program in cells of varying species, with ever-increasing implications in the control of the fundamental biological processes and in the pathogenesis of adult humans. The exciting findings in this field have inspired us with a premise and a promise that miRNAs will ultimately be taken to the heart for therapy of human disease. While miRNAs have been considered potential therapeutic targets for disease treatment, it remains obscured what strategies we can use to achieve the goal. In the past years, we have witnessed a rapid evolving of many creative, innovative, inventive strategies and methodologies pertinent to miRNA research and applications. These technologies have convincingly demonstrated their efficacy and reliability in producing gain-of-function or loss-of-function of miRNAs through targeting miRNA expression/biogenesis/function, providing new tools for elucidating miRNA functions and opening up a new avenue for the development of new agents targeting miRNAs for therapeutic aims. The present book provides comprehensive descriptions of these technologies and their applications to miRNA research and to new drug design for miRNA-related diseases. It starts with an overview of up-to-date knowledge of miRNA biology and the potential of miRNAs as therapeutic targets for human disease, followed by an introduction of the new concept of miRNA interference (miRNAi) and the perspectives of miRNAi technologies in general terms. In the following, each chapter introduces one of the miRNAi technologies with detailed descriptions of state-of-the-art design, procedures, principles and applications to basic research, R and D and clinical therapy.

MicroRNA

Jaishree Paul,Rohini Muthuswami
MicroRNA Book PDF

Author : Jaishree Paul,Rohini Muthuswami
Publisher : CRC Press
Page : 231 pages
File Size : 43,6 Mb
Release : 2018-02-19
Category : Medical
ISBN : 9781351679879

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MicroRNA by Jaishree Paul,Rohini Muthuswami Pdf

This book explores the role of miRNA as therapeutic agents, the progress made in this direction and the problems that need to be addressed for miRNA based therapies to become successful. It also discusses the basic biology of miRNA sythesis, regulation, and their role in disease biology.

MicroRNAs in Development

Eran Hornstein
MicroRNAs in Development Book PDF

Author : Eran Hornstein
Publisher : Academic Press
Page : 327 pages
File Size : 49,9 Mb
Release : 2012-03-02
Category : Medical
ISBN : 9780123870384

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MicroRNAs in Development by Eran Hornstein Pdf

This new volume in the Current topics in Developmental Biology series concentrates on MicroRNAs in Development. It includes chapters on such topics as miRNA networks in neuronal development, let-7 in development, and Hox networks and miRNA. With an international team of authors, this volume is a must-have addition for researchers and students alike. Concentrates on microRNAs in development Includes chapters on such topics as miRNA networks in neuronal development, let-7 in development, and Hox networks and miRNA With an international team of authors, this volume is a must-have addition for researchers and students alike

MicroRNAs in Cancer Translational Research

William C.S. Cho
MicroRNAs in Cancer Translational Research Book PDF

Author : William C.S. Cho
Publisher : Springer
Page : 557 pages
File Size : 48,6 Mb
Release : 2011-04-08
Category : Medical
ISBN : 940070299X

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MicroRNAs in Cancer Translational Research by William C.S. Cho Pdf

MicroRNA (miRNA) is a cutting-edge topic in the scientific and medical fields. This is a timely and specialized book focusing on the current understanding of miRNAs and the potential for their application in cancer diagnosis, prognosis, and therapeutic targets. It also provides discussion of the lessons learned from translational miRNA studies and exploration of the next steps required to advance this field. The unique book comprises 22 in-depth chapters by gathering unparalleled topics of interest in miRNAs by international team of world-renowned experts in the field. The first fifteen chapters provide comprehensive and expert perspectives on the most common cancers from bench to bedside applications, there is no current book structured in this cancer-oriented way. The next seven chapters providing thorough overviews of miRNAs and cancer stem cells; miRNAs in cancer invasion and metastasis; miRNAs in predicting radiotherapy and chemotherapy response; as well as expounding the role of miRNA in anti-cancer drug resistance and as blood-based cancer biomarkers. Furthermore, this book explicates the interplay of miRNAs in cancer metabolism and an update on the pioneering RNAi-based treatment approaches is also presented. This specialized book will contribute great to the scientific and medical community by providing the up-to-date discoveries of miRNAs and their important roles in cancer translational research.

RNAi and microRNA-Mediated Gene Regulation in Stem Cells

Baohong Zhang,Edmund J. Stellwag
RNAi and microRNA Mediated Gene Regulation in Stem Cells Book PDF

Author : Baohong Zhang,Edmund J. Stellwag
Publisher : Humana Press
Page : 240 pages
File Size : 50,6 Mb
Release : 2011-08-24
Category : Science
ISBN : 1607617706

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RNAi and microRNA-Mediated Gene Regulation in Stem Cells by Baohong Zhang,Edmund J. Stellwag Pdf

Recent stem cell research has revealed that miRNA and RNAi-mediated gene regulation is one of the vital determinates controlling the state of cell differentiation, with the small RNAs serving as key elements involved in regulatory network control of pluripotent cell fate determination. In RNAi and microRNA-Mediated Gene Regulation in Stem Cells: Methods, Protocols, and Applications, expert authors from laboratories across the globe contribute an accessible compendium of up-to-date, proven methods focused on the study of the titular topic. Divided into three sections, the book first gives a brief introduction to RNAi and miRNAs in stem cells, with a focus on the current status of research and future perspectives, then it continues with detailed methods and protocols for RNAi screening, transfection, and the knockdown of specific genes and pathways in several animal species, including humans and mice, concluding with a section on recently developed methods for identification of miRNAs, including a general protocol for preparation and analysis of miRNA libraries for deep sequencing, knock down of a specific gene using miRNA-based shRNA, and miRNA expression analysis using qRT-PCR. Written in the highly successful Methods in Molecular BiologyTM series format, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes highlighting tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, RNAi and microRNA-Mediated Gene Regulation in Stem Cells: Methods, Protocols, and Applications serves as a valuable resource for scientists and aspiring graduate students interested in the intersection of RNAi, miRNA, and stem cell molecular biology and the exciting areas of medicine, including regenerative medicine, aging, cancer, and neurological disorders, that can be advanced through this expanding area of research.

MicroRNA Cancer Regulation

Ulf Schmitz,Olaf Wolkenhauer,Julio Vera
MicroRNA Cancer Regulation Book PDF

Author : Ulf Schmitz,Olaf Wolkenhauer,Julio Vera
Publisher : Springer Science & Business Media
Page : 352 pages
File Size : 46,8 Mb
Release : 2013-02-03
Category : Medical
ISBN : 9789400755901

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MicroRNA Cancer Regulation by Ulf Schmitz,Olaf Wolkenhauer,Julio Vera Pdf

This edited reflects the current state of knowledge about the role of microRNAs in the formation and progression of solid tumours. The main focus lies on computational methods and applications, together with cutting edge experimental techniques that are used to approach all aspects of microRNA regulation in cancer. We are sure that the emergence of high-throughput quantitative techniques will make this integrative approach absolutely necessary in the near future. This book will be a resource for researchers starting out with cancer microRNA research, but is also intended for the experienced researcher who wants to incorporate concepts and tools from systems biology and bioinformatics into his work. Bioinformaticians and modellers are provided with a general perspective on microRNA biology in cancer, and the state-of-the-art in computational microRNA biology.

MicroRNA and Cancer

Wei Wu
MicroRNA and Cancer Book PDF

Author : Wei Wu
Publisher : Humana Press
Page : 0 pages
File Size : 48,9 Mb
Release : 2010-10-21
Category : Medical
ISBN : 1607618621

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MicroRNA and Cancer by Wei Wu Pdf

The tiny microRNAs (miRNAs) can have huge impacts on the regulation of a variety of genes and play crucial roles in the fundamental cellular processes. Recent miRNA studies change the landscape of cancer genetics by scrutinizing the alterations of genome-wide miRNA expressions in most common cancers and their regulatory functions during the development of cancer. The connections between miRNAs and cancer are widespread enough to warrant more comprehensive investigations in the systems biology perspective. In MicroRNA and Cancer: Methods and Protocols, internationally renowned experts provide the latest miRNA knowledge, the various techniques and methodologies currently available for cancer research application. Ranging from the fundamental concepts to practical applications, this book presents: • Overview of microRNA biogenesis, computational prediction of new miRNAs in the cancer genome, and miRNA-based therapeutic approaches for cancer treatment • Detailed experimental protocols in miRNA detection with novel and high-throughput technology, miRNA library cloning, miRNA epigenetic regulation, and miRNA pathway study • Stepwise computational and bioinformatic procedures for miRNA complex networks in cancer genomes with a variety of softwares and programs • Cross-cited notes on troubleshooting and avoiding known pitfalls Authoritative and cutting-edge, MicroRNA and Cancer: Methods and Protocols serves researchers with the basic principles of experimental and computational methods for microRNA study in cancer research and provides a firm grounding for those who wish to further develop their own applications and tailor them to their own specific research needs.

MicroRNA

Jaishree Paul,Rohini Muthuswami
MicroRNA Book PDF

Author : Jaishree Paul,Rohini Muthuswami
Publisher : CRC Press
Page : 202 pages
File Size : 46,7 Mb
Release : 2018
Category : MicroRNA
ISBN : 1138054836

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MicroRNA by Jaishree Paul,Rohini Muthuswami Pdf

"A CRC title, part of the Taylor & Francis imprint, a member of the Taylor & Francis Group, the academic division of T&F Informa plc."

Novel Perspectives in Micrornas

Daniel Fletcher
Novel Perspectives in Micrornas Book PDF

Author : Daniel Fletcher
Publisher : Murphy & Moore Publishing
Page : 0 pages
File Size : 47,5 Mb
Release : 2023-09-19
Category : Science
ISBN : 1639877223

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Novel Perspectives in Micrornas by Daniel Fletcher Pdf

MicroRNA (miRNA) refers to a small single-stranded non-coding RNA molecule. It can be found in animals, plants and some viruses. miRNAs function in post-transcriptional regulation of gene expression and RNA silencing. They work through base-pairing along with complementary sequences in mRNA molecules. Several mammalian cell types contain a high concentration of miRNAs as circulating in extracellular fluid, which are released into body fluids such as blood and cerebrospinal fluid, and could be used as biomarkers in a variety of disorders. MiRNAs play a role in gene regulation and can also produce histone modifications and DNA methylation at promoter sites, which can affect the target gene expression. MiRNAs are important in modulating complex enzymatic cascades, such as the hemostatic blood coagulation system. The topics included in this book on microRNAs are of utmost significance and bound to provide incredible insights to the readers. Researchers and students engaged in the study of this molecule will be assisted by it.

MicroRNA Profiling in Cancer

Yuriy Gusev
MicroRNA Profiling in Cancer Book PDF

Author : Yuriy Gusev
Publisher : CRC Press
Page : 273 pages
File Size : 51,9 Mb
Release : 2019-09-06
Category : Medical
ISBN : 9780429533723

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MicroRNA Profiling in Cancer by Yuriy Gusev Pdf

This book presents current advances in the emerging interdisciplinary field of microRNA research of human cancers from a unique perspective of quantitative sciences: bioinformatics, computational and systems biology, and mathematical modeling. This volume contains adaptations and critical reviews of recent state-of-the-art studies, ranging from technological advances in microRNA detection and profiling, clinically oriented microRNA profiling in several human cancers, to a systems biology analysis of global patterns of microRNA regulation of signaling and metabolic pathways. Interactions with transcription factor regulatory networks and mathematical modeling of microRNA regulation are also discussed.

Head & Neck Cancer: Current Perspectives, Advances, and Challenges

James A. Radosevich
Head Neck Cancer Current Perspectives Advances and Challenges Book PDF

Author : James A. Radosevich
Publisher : Springer Science & Business Media
Page : 1064 pages
File Size : 49,9 Mb
Release : 2013-05-24
Category : Medical
ISBN : 9789400758278

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Head & Neck Cancer: Current Perspectives, Advances, and Challenges by James A. Radosevich Pdf

This is a nearly complete collection of Chapters that provide an up to date overview of all aspects of Head and Neck cancer. It is written by professionals but is not only intended for other professionals, but students, patients, policy makers, etc. There are so many aspects to this group of diseases that even the most seasoned professional will learn something from having read this book.

miRNomics: MicroRNA Biology and Computational Analysis

Malik Yousef,Jens Allmer
miRNomics MicroRNA Biology and Computational Analysis Book PDF

Author : Malik Yousef,Jens Allmer
Publisher : Humana
Page : 0 pages
File Size : 40,5 Mb
Release : 2016-08-23
Category : Medical
ISBN : 1493962647

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miRNomics: MicroRNA Biology and Computational Analysis by Malik Yousef,Jens Allmer Pdf

In miRNomics: MicroRNA Biology and Computational Analysis, expert researchers in the field present an overview of the current state of the art and aim to put the respective areas of research into a larger perspective. These include methods and techniques ranging from miRNA biogenesis, their biological function, computational analyses to their medical implications and applications. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, miRNomics: MicroRNA Biology and Computational Analysis seeks to aid scientists in the further study into miRNA research and statistics.