Development Of Therapeutic Cancer Vaccines

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Vaccines for Cancer Immunotherapy

Nima Rezaei,Mahsa Keshavarz-Fathi
Vaccines for Cancer Immunotherapy Book PDF

Author : Nima Rezaei,Mahsa Keshavarz-Fathi
Publisher : Academic Press
Page : 198 pages
File Size : 55,7 Mb
Release : 2018-10-17
Category : Medical
ISBN : 9780128140406

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Vaccines for Cancer Immunotherapy by Nima Rezaei,Mahsa Keshavarz-Fathi Pdf

Therapeutic cancer vaccines represent a type of active cancer immunotherapy. Clinicians, scientists, and researchers working on cancer treatment require evidence-based and up-to-date resources relating to therapeutic cancer vaccines. Vaccines for Cancer Immunotherapy provides a reference for cancer treatment for clinicians and presents a well-organized resource for determining high-potential research areas. The book considers that this promising modality can be made more feasible as a treatment for cancer. Chapters cover cancer immunology, general approaches to cancer immunotherapy, vaccines, tumor antigens, the strategy of allogeneic and autologous cancer vaccines, personalized vaccines, whole-tumor antigen vaccines, protein and peptide vaccines, dendritic cell vaccines, genetic vaccines, candidate cancers for vaccination, obstacles to developing therapeutic cancer vaccines, combination therapy, future perspectives and concluding remarks on therapeutic cancer vaccines. Introduces the feasible immunotherapeutic vaccines for patients with different types of cancer Presents the status of past and current vaccines for cancer treatment Considers advantages and disadvantages of different therapeutic cancer vaccines Looks at the combination of vaccines and other modalities, including immunotherapeutic and conventional methods Analyzes obstacles to development of therapeutic cancer vaccines Gives a view on future perspectives in the application of therapeutic cancer vaccines

Cancer Vaccines as Immunotherapy of Cancer

Luigi Buonaguro,Sjoerd Van Der Burg
Cancer Vaccines as Immunotherapy of Cancer Book PDF

Author : Luigi Buonaguro,Sjoerd Van Der Burg
Publisher : Academic Press
Page : 273 pages
File Size : 50,7 Mb
Release : 2022-03-04
Category : Science
ISBN : 9780128239025

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Cancer Vaccines as Immunotherapy of Cancer by Luigi Buonaguro,Sjoerd Van Der Burg Pdf

Cancer Vaccines as Immunotherapy of Cancer provides extensive and state-of-the-art information about the meaning, relevance and limitation of therapeutic cancer vaccines. It covers all the aspects involved in the vaccine research and development (identification of optimal target antigens, formulations, delivery strategies, adjuvants among others) as well as their use in combination with other immunomodulatory approaches. The book discusses topics such as identification of tumor associated and specific antigens, proteogenomic for identification of novel target tumor antigens, antigen-specific T cells, and Peptide and RNA based vaccines. Additionally, it covers oncolytic viruses for antigen delivery, cancer vaccine targeting viral antigens and combinatorial immunotherapy strategies. Written by leading experts worldwide, this is a valuable resource for cancer researchers, oncologists and members of biomedical field who wants to understand in depth the recent findings in the field of cancer vaccines. Describes the state-of-the-art of the research and development of therapeutic cancer vaccines Presents detailed diagrams to help the reader understand the functionality of each type of vaccine discussed Encompasses recent findings in the field through chapters written by leading experts worldwide

Development of Therapeutic Cancer Vaccines

Fred Brown,John C. Petricianni
Development of Therapeutic Cancer Vaccines Book PDF

Author : Fred Brown,John C. Petricianni
Publisher : S. Karger AG (Switzerland)
Page : 264 pages
File Size : 43,6 Mb
Release : 2004
Category : Medical
ISBN : UOM:39015060584177

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Development of Therapeutic Cancer Vaccines by Fred Brown,John C. Petricianni Pdf

This monograph contains the proceedings of a conference devoted to progress and emerging issues in therapeutic cancer vaccine development since the 1998 FDA/NCI workshop. The emphasis is on progress in the clinical trials of cancer vaccines in late-stage development, but the volume also includes presentations and discussions on exciting earlier-stage products as well as updates on regulatory positions in the USA, Canada, Europe, and Australia. Session I concentrates on regulatory considerations in cancer vaccine development, including a round table of regulatory agency representatives from North America, Europe, and Australia. Session II continues with a consideration of several different types of cancer vaccines, including whole cells, cell lysates, multivalent recombinants and peptides. Session III highlights dendritic cell vaccines and dendritic cells fused to tumour cell vaccines. Session IV focuses on preventive cancer vaccines for cervical carcinoma and liver cancer and various aspects of the immune response to cancer vaccines.

Cancer Vaccines and Tumor Immunity

Rimas Orentas,James W. Hodge,Bryon D. Johnson
Cancer Vaccines and Tumor Immunity Book PDF

Author : Rimas Orentas,James W. Hodge,Bryon D. Johnson
Publisher : John Wiley & Sons
Page : 352 pages
File Size : 43,8 Mb
Release : 2007-10-26
Category : Medical
ISBN : 9780470170106

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Cancer Vaccines and Tumor Immunity by Rimas Orentas,James W. Hodge,Bryon D. Johnson Pdf

Cancer Vaccines and Tumor Immunity offers a review of the basic scientific discoveries that have moved forward into clinical trials. Presented in the context of real-world human research and experimentation, these major scientific advances demonstrate how our understanding of immune activation, T-regulatory cells, and autoimmunity will impact cancer vaccine design. The authors also explain how vaccination in the context of bone marrow transplantation will open new avenues for clinical study in the future.

Cancer Vaccines and Immunotherapy

Peter L. Stern,Peter C. L. Beverley,Miles Carroll
Cancer Vaccines and Immunotherapy Book PDF

Author : Peter L. Stern,Peter C. L. Beverley,Miles Carroll
Publisher : Cambridge University Press
Page : 304 pages
File Size : 52,8 Mb
Release : 2000-08-17
Category : Medical
ISBN : 0521622638

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Cancer Vaccines and Immunotherapy by Peter L. Stern,Peter C. L. Beverley,Miles Carroll Pdf

Rapid progress in the definition of tumor antigens, and improved immunization methods, bring effective cancer vaccines within reach. In this wide-ranging survey, leading clinicians and scientists review therapeutic cancer vaccine strategies against a variety of diseases and molecular targets. Intended for an interdisciplinary readership, their contributions cover the rationale, development, and implementation of vaccines in human cancer treatment, with specific reference to cancer of the cervix, breast, colon, bladder, and prostate, and to melanoma and lymphoma. They review target identification, delivery vectors and clinical trial design. The book begins and ends with lucid overviews from the editors, that discuss the most recent developments.

Approaches to Advance Cancer Vaccines to Clinical Utility

An M. T. Van Nuffel,Caroline Boudousquié,Sandra Tuyaerts
Approaches to Advance Cancer Vaccines to Clinical Utility Book PDF

Author : An M. T. Van Nuffel,Caroline Boudousquié,Sandra Tuyaerts
Publisher : Frontiers Media SA
Page : 196 pages
File Size : 48,9 Mb
Release : 2019-12-27
Category : Electronic
ISBN : 9782889631605

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Approaches to Advance Cancer Vaccines to Clinical Utility by An M. T. Van Nuffel,Caroline Boudousquié,Sandra Tuyaerts Pdf

Although cancer vaccines have yielded promising results both in vitro and in animal models, their translation into clinical application has not been very successful so far. Through the success of immune checkpoint inhibitors, the tumor immunotherapy field revived and led to important new insights. A better understanding of the functional capacity of different dendritic cell (DC) subsets and the immunogenicity of tumor antigens, more particularly of neoantigens, have important implications for the improvement of cancer vaccines. These insights can guide the development of novel strategies, to enhance the clinical utility of cancer vaccines. The aim of this Research Topic is therefore to provide a comprehensive overview of current issues regarding cancer vaccine development with an emphasis on novel approaches toward enhancing their efficacy.

Handbook of Cancer Vaccines

Michael A. Morse,Timothy M. Clay,H. Kim Lyerly
Handbook of Cancer Vaccines Book PDF

Author : Michael A. Morse,Timothy M. Clay,H. Kim Lyerly
Publisher : Springer Science & Business Media
Page : 585 pages
File Size : 54,8 Mb
Release : 2004-01-28
Category : Medical
ISBN : 9781592596805

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Handbook of Cancer Vaccines by Michael A. Morse,Timothy M. Clay,H. Kim Lyerly Pdf

An authoritative survey of the scientific background for therapeutic cancer vaccines, the challenges to their development, and their current uses in treating cancer. The authors examine the basic issues that effect all vaccines (such as immune adjuvants and prime-boost strategies), describe the methods for antigen discovery, and review the preclinical development phases for each major vaccine strategy. They also spell out the clinical results for cancer vaccines now beginning to be used in the treatment of many common cancers.

Cancer Immunotherapy

Jeffrey Schlom,James W. Hodge,Claudia Palena,John W. Greiner,Kwong-Yok Tsang,Benedetto Farsaci,Ravi A. Madan,James L. Gulley
Cancer Immunotherapy Book PDF

Author : Jeffrey Schlom,James W. Hodge,Claudia Palena,John W. Greiner,Kwong-Yok Tsang,Benedetto Farsaci,Ravi A. Madan,James L. Gulley
Publisher : Elsevier Inc. Chapters
Page : 684 pages
File Size : 47,6 Mb
Release : 2013-06-04
Category : Medical
ISBN : 9780128059166

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Cancer Immunotherapy by Jeffrey Schlom,James W. Hodge,Claudia Palena,John W. Greiner,Kwong-Yok Tsang,Benedetto Farsaci,Ravi A. Madan,James L. Gulley Pdf

This article reviews progress made in the design and development of recombinant poxviral-based vaccines that express transgenes for tumor-associated antigens (TAAs) and human T-cell co-stimulatory molecules (designated TRICOM). The TRICOM vaccine platform consists of priming with a recombinant vaccinia (rV-) vector and multiple boosts with a replication defective fowlpox (rF-) vector. The rV, rF-PSA-TRICOM (PROSTVAC) has demonstrated survival benefit in randomized trials. rV, rF-CEA-MUC1-TRICOM (PANVAC) has demonstrated evidence of benefit in patients with colorectal, breast and ovarian cancers. Preclinical studies with TRICOM-based vaccines have demonstrated their ability to be used in combination with anti-CTLA4 monoclonal antibody, radiation, chemotherapeutics, and small molecule targeted therapies to enhance vaccine-mediated immune responses and antitumor activity. Randomized clinical studies have been completed, are ongoing, and are planned employing several of these TRICOM vaccine combination therapies. The importance of trial design in terms of patient population and clinical trial endpoint has been demonstrated in these studies.

Nanotherapeutics in Cancer Vaccination and Challenges

Mahfoozur Rahman,Sarwar Beg,Waleed H Almalki,Nabil A. Alhakamy,Hani Choudhry
Nanotherapeutics in Cancer Vaccination and Challenges Book PDF

Author : Mahfoozur Rahman,Sarwar Beg,Waleed H Almalki,Nabil A. Alhakamy,Hani Choudhry
Publisher : Academic Press
Page : 496 pages
File Size : 54,7 Mb
Release : 2022-03-03
Category : Business & Economics
ISBN : 9780128236871

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Nanotherapeutics in Cancer Vaccination and Challenges by Mahfoozur Rahman,Sarwar Beg,Waleed H Almalki,Nabil A. Alhakamy,Hani Choudhry Pdf

Nanotherapeutics in Cancer Vaccination and Challenges consolidates the current research on cancer nanomedicine and therapeutic cancer vaccination to explore the most effective and promising avenues. The book covers cancer vaccines before exploring nanotherapeutics, DNA and mRNA vaccines in cancer treatment. Finally, it considers regulatory and industrial perspectives on cancer vaccination and nanotherapeutics. This resource will be useful for pharmaceutical scientists and researchers focused on biomedical engineering, chemical engineering, vaccine development, and cancer immunotherapy, along with advanced students in these subjects. Cancer is arguably the most complex and challenging disease known to mankind. Over the last two-decades, significant advancements have been made in new and novel concepts of cancer nanomedicines. Therapeutic cancer vaccines may be utilized to inhibit further growth of advanced cancers and/or relapsed tumors that are refractory to conventional therapies, such as surgery, radiation therapy and chemotherapy. Presents the progress made in cancer medicines from conventional to targeted therapy Covers the present state-of-the-art of cancer nanomedicines and upcoming therapeutic cancer vaccination Contains a focus on advanced nanomaterials that are utilized for encapsulation of nucleic acid, mRNA, DNA, siRNA

Trends in cancer treatment and prevention

Praveen Kumar Vemuri
Trends in cancer treatment and prevention Book PDF

Author : Praveen Kumar Vemuri
Publisher : GRIN Verlag
Page : 40 pages
File Size : 55,6 Mb
Release : 2020-02-04
Category : Science
ISBN : 9783346107619

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Trends in cancer treatment and prevention by Praveen Kumar Vemuri Pdf

Project Report from the year 2019 in the subject Biology - Diseases, Health, Nutrition, grade: 10, , language: English, abstract: In this work the developments in cancer therapy, especially by emphasizing vaccine development against cancer, are discussed. Moreover, the development of immunocytokines for cancer and a discussion of preclinical and clinical data on specific immunocytokines are investigated as a potential cancer therapy. This work explores the many facets of cancer research from basic genetic and cellular mechanisms to the influence of lifestyle and various strategies for predictive, preventive and personalized medicine in cancer. Cancer became a big question for scientific community as no existing treatments could solve the problems related to this disease. Research is in progress but it failed to give a right solution to fight against it. However, the developments in science and technology facilitated scientists to develop new methods of treatments. One such mile stone treatments against cancer are cancer vaccines. The aim of cancer vaccines is to stimulate the immune system to be able to recognize cancer cells as abnormal and destroy them. Majorly, cancer vaccine research is in progress to develop universal as well as specific cancer vaccines.

Novel Technologies for Vaccine Development

Igor S Lukashevich,Haval Shirwan
Novel Technologies for Vaccine Development Book PDF

Author : Igor S Lukashevich,Haval Shirwan
Publisher : Springer
Page : 393 pages
File Size : 42,6 Mb
Release : 2014-11-13
Category : Medical
ISBN : 9783709118184

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Novel Technologies for Vaccine Development by Igor S Lukashevich,Haval Shirwan Pdf

This book presents a detailed overview of the development of new viral vector-based vaccines before discussing two major applications: preventive vaccines for infectious diseases and therapeutic cancer vaccines. Viral vector-based vaccines hold a great potential for development into successful pharmaceutical products and several examples at the advanced pre-clinical or clinical stage are presented. Nevertheless, the most efforts were focused on novel and very innovative technologies for new generation of vector-based vaccines. Furthermore, specific topics such as delivery and adjuvant and protection strategies for cell-mediated-based vaccines are presented. Given its scope, the book is a “must read” for all those involved in vaccine development, both in academia and industrial vaccine development.

Therapeutic Vaccination Strategies

P. Walden,W. Sterry,H. Hennekes
Therapeutic Vaccination Strategies Book PDF

Author : P. Walden,W. Sterry,H. Hennekes
Publisher : Springer Science & Business Media
Page : 195 pages
File Size : 51,6 Mb
Release : 2013-03-14
Category : Medical
ISBN : 9783662041833

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Therapeutic Vaccination Strategies by P. Walden,W. Sterry,H. Hennekes Pdf

The induction of immune responses against tumor cells by vaccination is rapidly evolving as a therapeutic modality with new potentials for the treatment of cancer. It is based on the fact that our immune system can identify tumor cells and, once activated, is capable of developing specific immunity against the neoplastic cells. Numerous observations and intense research clearly document the major contribution of the immune system to the prevention of cancer. And there are many re ports of patients suffering from malignant melanoma or other tumors who mount a spontaneous immune response against their tumor cells that results in tumor regression. Based on the recent advances in our understanding of the compo nents of our immune system, their interactions and the regulation of immune responses, we are now able to design vaccination strategies that induce or enhance cell-mediated immunity against tumors. A ma jor advancement came with the identification and characterization of relevant tumor antigens, which are suitable target structures for anti-tu mor immune response. First clinical trials using such vaccine strategies have yielded encouraging results in patients. However, in spite of many reported cases of successful therapy of cancer by vaccination many patients still do not experience relief after such treatments. These initial clinical trials and the accompanying investigations have revealed a number of important results that indicate the direction of future re search and development in the field.

Cancer Vaccines

Ralph M. Steinman,Kenichiro Hasumi,Olivera J. Finn,Jacques Banchereau
Cancer Vaccines Book PDF

Author : Ralph M. Steinman,Kenichiro Hasumi,Olivera J. Finn,Jacques Banchereau
Publisher : John Wiley & Sons
Page : 129 pages
File Size : 50,9 Mb
Release : 2009-10-12
Category : Medical
ISBN : 9781573317597

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Cancer Vaccines by Ralph M. Steinman,Kenichiro Hasumi,Olivera J. Finn,Jacques Banchereau Pdf

With ten million persons afflicted each year, no one is entirely immune to cancer and its devastating effects on individuals and families. But recent advances in the development of cancer vaccines—either as therapeutic agents or as preventative measures—are hopeful indicators of progress in this field. This volume comprises invited chapters from world-renowned researchers and clinicians that shed light on recent steps forward in immunotherapeutic and preventive approaches for future cancer vaccines. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member.

Immunotherapy of Cancer

Mary L. Disis
Immunotherapy of Cancer Book PDF

Author : Mary L. Disis
Publisher : Springer Science & Business Media
Page : 516 pages
File Size : 40,5 Mb
Release : 2007-10-28
Category : Medical
ISBN : 9781597450119

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Immunotherapy of Cancer by Mary L. Disis Pdf

Expert bench and clinical scientists join forces to concurrently review both the state-of-the-art in tumor immunology and its clinical translation into promising practical treatments. The authors explain in each chapter the scientific basis behind such therapeutic agents as monoclonal antibodies, cytokines, vaccines, and T-cells, and illustrate their clinical manipulation to combat cancer. Additional chapters address statistical analysis-both of clinical trials and assay evaluations-methods for the discovery of antigens, adoptive T cell therapy, and adaptive and innate immunity. The challenges in clinical trial design, the need for biomarkers of response-such as novel imaging techniques and immunologic monitoring-and the new advances and directions in cancer immunotherapy are also fully examined.

Advancements in Tumor Immunotherapy and Cancer Vaccines

Hilal Arnouk
Advancements in Tumor Immunotherapy and Cancer Vaccines Book PDF

Author : Hilal Arnouk
Publisher : BoD – Books on Demand
Page : 232 pages
File Size : 48,9 Mb
Release : 2012-02-03
Category : Medical
ISBN : 9789533079981

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Advancements in Tumor Immunotherapy and Cancer Vaccines by Hilal Arnouk Pdf

Harnessing the potential of the human body's own immune system to attack malignant tumor cells has been the goal of many scientific investigators in recent years, with advances in cancer biology and immunology enabling cancer immunotherapy to become a reality. World-class bench and clinical researchers have joined forces to collaborate and review current developments and trends in cancer immunology for the purposes of this book, and the result is a promising review of contemporary clinical treatments. In each chapter the authors present the scientific basis behind such therapeutic approaches, including cancer vaccines with special focus on prostate cancer, melanoma and novel approaches utilizing both innate and adaptive immune responses.