Developmental Genetics Of The Pharyngeal Arch System

Author : Jeffry M. Cesario,André Landin Malt,Juhee Jeong
Publisher : Biota Publishing
Page : 120 pages
File Size : 40,5 Mb
Release : 2015-05-01
Category : Science
ISBN : 9781615046812

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Developmental Genetics of the Pharyngeal Arch System by Jeffry M. Cesario,André Landin Malt,Juhee Jeong Pdf

The pharyngeal arches are embryonic structures that develop into the face, neck, a part of the heart, and several endocrine glands in animals. They are thought to have played a key role in vertebrate evolution as their derivatives impact the mode of feeding and breathing. Moreover, perturbation in pharyngeal arch development is associated with several major groups of birth defects in humans. During early embryonic development, cells from all three germ layers come together to assemble the pharyngeal arches. Subsequently, the pharyngeal arches undergo growth, morphogenesis, and cell type differentiation to give rise to musculoskeletal, cardiovascular, neural, and glandular components. These processes are guided by interactions amongst different tissues, via signaling molecules. A large number of genes, with a complex network of regulatory relationships, govern each aspect of pharyngeal arch development. With the advance of molecular genetics tools in model organisms such as mice, we are beginning to understand the molecular and cellular mechanisms underlying development of the pharyngeal arches and related birth defects. This eBook will provide an introduction into development of the pharyngeal arch system, with a detailed discussion on the genetic regulation of this process.

Author : Sherri M. Jones,Timothy A. Jones
Publisher : Plural Publishing
Page : 289 pages
File Size : 55,9 Mb
Release : 2011-08-01
Category : Medical
ISBN : 9781597566278

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Genetics, Embryology, and Development of Auditory and Vestibular Systems by Sherri M. Jones,Timothy A. Jones Pdf

Author : Peter Thorogood,Cheryll Tickle
Publisher : Unknown
Page : 274 pages
File Size : 46,5 Mb
Release : 1988
Category : Bones
ISBN : UOM:39015013802106

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Craniofacial Development by Peter Thorogood,Cheryll Tickle Pdf

Author : John Barton Furness,Marcello Costa
Publisher : Unknown
Page : 312 pages
File Size : 52,5 Mb
Release : 1987
Category : Medical
ISBN : UOM:39015012463215

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The Enteric Nervous System by John Barton Furness,Marcello Costa Pdf

Author : Peter D Turnpenny,Sian Ellard
Publisher : Elsevier Health Sciences
Page : 465 pages
File Size : 41,5 Mb
Release : 2011-03-04
Category : Medical
ISBN : 9780702045059

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Emery's Elements of Medical Genetics E-Book by Peter D Turnpenny,Sian Ellard Pdf

Master the genetics you need to know with the updated 14th Edition of Emery’s Elements of Medical Genetics by Drs. Peter Turnpenny and Sian Ellard. Review the field’s latest and most important topics with user-friendly coverage designed to help you better understand and apply the basic principles of genetics to clinical situations. Learning is easy with the aid of clear, full-color illustrative diagrams, a wealth of clinical photographs of genetic diseases, multiple-choice and case-based review questions, and end-of-chapter summaries. With this highly visual, award-winning classic in your hands, you have all the genetics knowledge you need for exams or practice. This title includes additional digital media when purchased in print format. For this digital book edition, media content is not included. Get a broad view of medical genetics with a unique three-part structure that looks at the Principles of Human Genetics, Genetics in Medicine, and Clinical Genetics. Visualize the appearance of genetic disorders with a fantastic art program that presents many clinical photos of genetic diseases, and work through complicated ideas with an array of full-color illustrative diagrams. Master the material you need to know with a title preferred by faculty and students alike over the last three decades and awarded the British Medical Association Medial Student Textbook of the Year in 2008. Access to www.studentconsult.com, including 150 USMLE-style multiple choice questions to aid study and self-testing. Apply the latest research with chapters on developmental genetics, cancer genetics, prenatal testing and reproduction genetics, ‘clonal’ sequencing, and more. Understand complex concepts with the help of an increased number of diagrams. Be fully aware of social, ethical, and counseling issues by reviewing an improved section on these topics.

Author : Billie Wilson
Publisher : Scientific e-Resources
Page : 304 pages
File Size : 46,6 Mb
Release : 2018-04-14
Category : Electronic
ISBN : 9781839472664

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Developmental Genetics by Billie Wilson Pdf

Developmental Genetics studies how the genes regulate developmental changes in behavior and influence scientific approaches in several fields. Genetics is the study of heredity. Heredity is a biological process where a parent passes certain genes onto their children or offspring. Every child inherits genes from both of their biological parents and these genes in turn express specific traits. Some of these traits may be physical for example hair and eye color and skin color etc. On the other hand some genes may also carry the risk of certain diseases and disorders that may pass on from parents to their offspring. Development is behind what one looks like. It is directed by genes, the units of heredity, which are made up of deoxyribonucleic acid (DNA) in all animals (including man), plants, microorganisms and most of the viruses except in some viruses where Ribonucleic Acid (RNA) is the genetic material. Developmental Genetics integrates the two disciplines of development and genetics into one. Differential gene expression from genetically identical nuclei creates different cell types. Differential gene expression can occur at the levels of gene transcription, nuclear RNA processing, mRNA translation, and protein modification. Genes are usually repressed. Activation of a gene often means inhibiting its repressor. This leads to thinking in double and triple negatives: Activation is often the inhibition of the inhibitor; repression is the inhibition of the inhibitor of the inhibitor. Besides useful to the students and teachers of the subject the book will also serve as a reference tool to the researchers in genetics developmental biology regenerative medicine and cell biology.

Author : Yamin Liu
Publisher : BoD – Books on Demand
Page : 166 pages
File Size : 43,6 Mb
Release : 2018-10-17
Category : Medical
ISBN : 9781789842012

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Genetic Diversity and Disease Susceptibility by Yamin Liu Pdf

Polymorphism or variation in DNA sequence can affect individual phenotypes such as color of skin or eyes, susceptibility to diseases, and response to drugs, vaccines, chemicals, and pathogens. Especially, the interfaces between genetics, disease susceptibility, and pharmacogenomics have recently been the subject of intense research activity. This book is a self-contained collection of valuable scholarly papers related to genetic diversity and disease susceptibility, pharmacogenomics, ongoing advances in technology, and analytic methods in this field. The book contains nine chapters that cover the three main topics of genetic polymorphism, genetic diversity, and disease susceptibility and pharmacogenomics. Hence, this book is particularly useful to academics, scientists, physicians, pharmacists, practicing researchers, and postgraduate students whose work relates to genetic polymorphisms.

Author : Duan Ma,Desheng Liang,Weinian Shou,Richard Q. Lu,Qihua Fu
Publisher : Frontiers Media SA
Page : 332 pages
File Size : 50,7 Mb
Release : 2022-11-07
Category : Science
ISBN : 9782889767632

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Role of Genetics and Epigenetics in Major Structural Malformations by Duan Ma,Desheng Liang,Weinian Shou,Richard Q. Lu,Qihua Fu Pdf

Author : Sally A. Moody
Publisher : Academic Press
Page : 784 pages
File Size : 45,6 Mb
Release : 2014-09-02
Category : Science
ISBN : 9780124059238

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Principles of Developmental Genetics by Sally A. Moody Pdf

Providing expert coverage of all major events in early embryogenesis and the organogenesis of specific systems, and supplemented with representative clinical syndromes, Principles of Developmental Genetics, Second Edition discusses the processes of normal development in embryonic and prenatal animals, including humans. The new edition of this classic work supports clinical researchers developing future therapies with its all-new coverage of systems biology, stem cell biology, new technologies, and clinical disorders. A crystal-clear layout, exceptional full-color design, and bulleted summaries of major takeaways and clinical pathways assist comprehension and readability of the highly complex content. All-new coverage of systems biology and stem cell biology in context of evolving technologies places the work squarely on the modern sciences Chapters are complemented with a bulleted summary for easy digestion of the major points, with a clinical summary for therapeutic application Clinical highlights provides a bridge between basic developmental biology and clinical sciences in embryonic and prenatal syndromes

Author : Rajesh V. Thakker,Michael P. Whyte,John Eisman,Takashi Igarashi
Publisher : Academic Press
Page : 878 pages
File Size : 40,6 Mb
Release : 2017-10-31
Category : Medical
ISBN : 9780128041987

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Genetics of Bone Biology and Skeletal Disease by Rajesh V. Thakker,Michael P. Whyte,John Eisman,Takashi Igarashi Pdf

Genetics of Bone Biology and Skeletal Disease, Second Edition, is aimed at students of bone biology and genetics and includes general introductory chapters on bone biology and genetics. More specific disease orientated chapters comprehensively summarize the clinical, genetic, molecular, animal model, molecular pathology, diagnostic, counseling, and treatment aspects of each disorder. The book is organized into five sections that each emphasize a particular theme, general background to bone biology, general background to genetics and epigenetics, disorders of bone and joint, parathyroid and related disorders, and vitamin D and renal disorders. The first section is specifically devoted to providing an overview of bone biology and structure, joint and cartilage biology, principles of endocrine regulation of bone, and the role of neuronal regulation and energy homeostasis. The second section reviews the principles and progress of medical genetics and epigenetics related to bone disease, including genome-wide association studies (GWAS), genomic profiling, copy number variation, prospects of gene therapy, pharmacogenomics, genetic testing and counseling, as well as the generation and utilizing of mouse models. The third section details advances in the genetics and molecular biology of bone and joint diseases, both monogenic and polygenic, as well as skeletal dysplasias, and rarer bone disorders. The fourth section highlights the central role of the parathyroids in calcium and skeletal homeostasis by reviewing the molecular genetics of: hyperparathyroidism, hypoparathyrodism, endocrine neoplasias, and disorders of the PTH and calcium-sensing receptors. The fifth section details molecular and cellular advances across associated renal disorders such as vitamin D and rickets. Identifies and analyzes the genetic basis of bone disorders in humans and demonstrates the utility of mouse models in furthering the knowledge of mechanisms and evaluation of treatments Demonstrates how the interactions between bone and joint biology, physiology, and genetics have greatly enhanced the understanding of normal bone function as well as the molecular pathogenesis of metabolic bone disorders Summarizes the clinical, genetic, molecular, animal model, molecular pathology, diagnostic, counseling, and treatment aspects of each disorder

Author : Geoffrey H. Sperber,Steven M. Sperber,Geoffrey D. Guttmann
Publisher : PMPH-USA
Page : 264 pages
File Size : 48,7 Mb
Release : 2010
Category : Developmental genetics
ISBN : 1607950324

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Craniofacial Embryogenetics and Development by Geoffrey H. Sperber,Steven M. Sperber,Geoffrey D. Guttmann Pdf

Provides clinicians with a basic background for treating craniofacial anomalies. Includes a CD-ROM with entire text and illustrations of the book in fully searchable PDF files Accompanying CD also contains three-dimensional movies that show reconstructions of embryos

Author : Brian Nelms,Patricia Labosky
Publisher : Biota Publishing
Page : 246 pages
File Size : 52,6 Mb
Release : 2010-02-01
Category : Science
ISBN : 9781615040490

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Transcriptional Control of Neural Crest Development by Brian Nelms,Patricia Labosky Pdf

The neural crest is a remarkable embryonic population of cells found only in vertebrates and has the potential to give rise to many different cell types contributing throughout the body. These derivatives range from the mesenchymal bone and cartilage comprising the facial skeleton, to neuronal derivatives of the peripheral sensory and autonomic nervous systems, to melanocytes throughout the body, and to smooth muscle of the great arteries of the heart. For these cells to correctly progress from an unspecifi ed, nonmigratory population to a wide array of dynamic, differentiated cell types—some of which retain stem cell characteristics presumably to replenish these derivatives—requires a complex network of molecular switches to control the gene programs giving these cells their defi ning structural, enzymatic, migratory, and signaling capacities. This review will bring together current knowledge of neural crest-specifi c transcription factors governing these progressions throughout the course of development. A more thorough understanding of the mechanisms of transcriptional control in differentiation will aid in strategies designed to push undifferentiated cells toward a particular lineage, and unraveling these processes will help toward reprogramming cells from a differentiated to a more naive state. Table of Contents: Introduction / AP Genes / bHLH Genes / ETS Genes / Fox Genes / Homeobox Genes / Hox Genes / Lim Genes / Pax Genes / POU Domain Genes / RAR/RXR Genes / Smad Genes / Sox Genes / Zinc Finger Genes / Other Miscellaneous Genes / References / Author Biographies

Author : Peter D Turnpenny,Sian Ellard
Publisher : Elsevier Health Sciences
Page : 486 pages
File Size : 42,9 Mb
Release : 2016-11-30
Category : Medical
ISBN : 9780702066894

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Emery's Elements of Medical Genetics E-Book by Peter D Turnpenny,Sian Ellard Pdf

Everything a student needs to know about medical genetics is here in the 15th edition of this award-winning textbook. Thoroughly updated and revised throughout to map a fast-moving area, the 15th edition continues Emery’s enviable reputation for successfully balancing up-to-dateness in a rapidly developing field with a strong basis in practical clinical genetics for medical students. With MCQs and Case-Based Review Questions, end of chapter summaries, it is the essential tool for this complex but foundational topic for all medical undergraduates, as well as postgraduates seeking to improve their understanding and knowledge. Divided into three restructured sections to make the book easier to use for a variety of readers: Scientific Basis of Human Genetics; Genetics in Medicine and Genomic Medicine; Clinical Genetics, Counselling and Ethics •Interactive self-assessment questions •Case-based questions •Online hyperlinks to important genetics websites and clinical databases. •Update of clinical figures to include more full-colour images •An extensive glossary of terms •Full colour art to visualise the appearance of genetic disorders and assist with the understanding of complex genetic structures •Explore the social, ethical and counselling issues surrounding the study and treatment of genetic disorders. •Elements boxes at the end of each chapter summarizing the basics at a glance.

Author : Dhavendra Kumar,Perry Elliott
Publisher : Oxford University Press, USA
Page : 623 pages
File Size : 48,7 Mb
Release : 2010
Category : Language Arts & Disciplines
ISBN : 9780195368956

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Principles and Practice of Clinical Cardiovascular Genetics by Dhavendra Kumar,Perry Elliott Pdf

Consisting of contributions from experts in all specialties of cardiovascular genetics and applied clinical cardiology, Principles and Practice of Clinical Cardiovascular Genetics serves as the comprehensive volume for any clinician or resident in cardiology and genetics. Each chapter provides a detailed and comprehensive account on the molecular genetics and clinical practice related to specific disorders or groups of disorders, including Marfan syndrome, thoracic and abdominal aortic aneurysms, hypertrophic, dilated and restrictive cardiomyopathies and Arrhythmogenic right ventricular cardiomyopathy, as well as many others. All sections comprehensively address cardiovasuclar genetic disorders, beginning with an introduction and including separate sections on the disease's basic biological aspects, specific genetic mechanisms or issues, clinical aspects, genetic management (e.g., genetic diagnosis, risk assessment, genetic counseling, genetic testing), and clinical management issues. The final section exclusively addresses the management of cardiovascular genetic disorders, specifically considering stem cell therapy, genetic counseling, pharmacogenomics and the social and ethical issues surrounding disease treatment.

Author : Helga V. Toriello,Shelley D. Smith
Publisher : Oxford University Press
Page : 576 pages
File Size : 48,6 Mb
Release : 2013-06-20
Category : Medical
ISBN : 9780199313884

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Hereditary Hearing Loss and Its Syndromes by Helga V. Toriello,Shelley D. Smith Pdf

This is the third edition of the foremost medical reference on hereditary hearing loss. Chapters on epidemiology, embryology, non-syndromic hearing loss, and syndromic forms of hearing loss have all been updated with particular attention to the vast amount of new information on molecular mechanisms, and chapters on clinical and molecular diagnosis and on genetic susceptibility to ototoxic factors have been added. As in previous editions, the syndromes are grouped by system (visual, metabolic, cardiologic, neurologic, musculoskeletal, endocrine, etc.), with each chapter written by a recognized expert in the field. Written for practicing clinicians, this volume is an excellent reference for physicians, audiologists, and other professionals working with individuals with hearing loss and their families, and can also serve as a text for clinical training programs and for researchers in the hearing sciences.