Developmental Toxicology

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Reproductive and Developmental Toxicology

Ramesh C. Gupta
Reproductive and Developmental Toxicology Book PDF

Author : Ramesh C. Gupta
Publisher : Academic Press
Page : 1220 pages
File Size : 55,9 Mb
Release : 2011-04-04
Category : Medical
ISBN : 0123820332

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Reproductive and Developmental Toxicology by Ramesh C. Gupta Pdf

Reproductive toxicology is a complex subject dealing with three components—parent, placenta, and fetus—and the continuous changes that occur in each. Reproductive and Developmental Toxicology is a comprehensive and authoritative resource providing the latest literature enriched with relevant references describing every aspect of this area of science. It addresses a broad range of topics including nanoparticles and radiation, gases and solvents, smoking, alcohol and drugs of abuse, food additives, nutraceuticals and pharmaceuticals, and metals, among others. With a special focus on placental toxicity, this book is the only available reference to connect the three key risk stages, and is the only resource to include reproductive and developmental toxicity in domestic animals, fish, and wildlife. Provides a complete, integrated source of information on the key risk stages during reproduction and development Includes coverage of emerging science such as stem cell application, toxicoproteomics, metabolomics, phthalates, infertility, teratogenicity, endocrine disruption, surveillance and regulatory considerations, and risk assessment Offers diverse and unique in vitro and in vivo toxicity models for reproductive and developmental toxicity testing in a user-friendly format that assists in comparative analysis

Scientific Frontiers in Developmental Toxicology and Risk Assessment

National Research Council,Commission on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Developmental Toxicology
Scientific Frontiers in Developmental Toxicology and Risk Assessment Book PDF

Author : National Research Council,Commission on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Developmental Toxicology
Publisher : National Academies Press
Page : 348 pages
File Size : 50,8 Mb
Release : 2000-12-21
Category : Nature
ISBN : 9780309070867

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Scientific Frontiers in Developmental Toxicology and Risk Assessment by National Research Council,Commission on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Developmental Toxicology Pdf

Scientific Frontiers in Developmental Toxicology and Risk Assessment reviews advances made during the last 10-15 years in fields such as developmental biology, molecular biology, and genetics. It describes a novel approach for how these advances might be used in combination with existing methodologies to further the understanding of mechanisms of developmental toxicity, to improve the assessment of chemicals for their ability to cause developmental toxicity, and to improve risk assessment for developmental defects. For example, based on the recent advances, even the smallest, simplest laboratory animals such as the fruit fly, roundworm, and zebrafish might be able to serve as developmental toxicological models for human biological systems. Use of such organisms might allow for rapid and inexpensive testing of large numbers of chemicals for their potential to cause developmental toxicity; presently, there are little or no developmental toxicity data available for the majority of natural and manufactured chemicals in use. This new approach to developmental toxicology and risk assessment will require simultaneous research on several fronts by experts from multiple scientific disciplines, including developmental toxicologists, developmental biologists, geneticists, epidemiologists, and biostatisticians.

Developmental and Reproductive Toxicology

Ronald D. Hood,Ronald D Hood
Developmental and Reproductive Toxicology Book PDF

Author : Ronald D. Hood,Ronald D Hood
Publisher : CRC Press
Page : 1168 pages
File Size : 45,7 Mb
Release : 2005-08-30
Category : Medical
ISBN : 9781420040548

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Developmental and Reproductive Toxicology by Ronald D. Hood,Ronald D Hood Pdf

Completely revised and updated, Developmental and Reproductive Toxicology: A Practical Approach, Second Edition draws together valuable information typically scattered throughout the literature, plus some not previously published, into one complete resource. In addition to the traditional aspects of developmental toxicity testing, the book covers evaluating and interpreting data. Originally titled Handbook of Developmental Toxicology, the second edition's new name reflects significant changes in its content and scope. New coverage in the Second Edition: Genomics and proteomics Tests for endocrine disruptors Testing for male and female reproductive toxicity Extensive treatment of the significance, reliability, and interpretation of developmental and reproductive toxicity data Toxicity testing in neonatal and juvenile animals Postnatal developmental milestones FDA perspective on risk assessment Extensive glossaries of developmental defect terminology Previous books on this subject have largely been academically oriented and not intended to guide the practicing developmental or reproductive toxicologist. Useful and informative, this book blends the theoretical foundation with insights gained from hands-on experience. It includes tables of comparative developmental milestones - both pre- and postnatal, glossaries of descriptive terms used in developmental toxicity evaluation, and both US and international regulatory guidelines. Bridging the gap between theory and application, this is a handy single-source of essential information to use in planning, conducting, and interpreting studies.

Reproductive and Developmental Toxicology

Ramesh C. Gupta
Reproductive and Developmental Toxicology Book PDF

Author : Ramesh C. Gupta
Publisher : Academic Press
Page : 1460 pages
File Size : 41,5 Mb
Release : 2017-03-24
Category : Medical
ISBN : 9780128042403

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Reproductive and Developmental Toxicology by Ramesh C. Gupta Pdf

Reproductive and Developmental Toxicology, Second Edition, is a comprehensive and authoritative resource that provides the latest literature on this complex subject with a primary focus on three core components—parent, placenta, and fetus—and the continuous changes that occur in each. Enriched with relevant references describing every aspect of reproductive toxicology, this revised and updated resource addresses the totality of the subject, discussing a broad range of topics, including nanoparticles and radiation, gases and solvents, smoking, alcohol and drug abuse, and metals, amongst others. With a special focus on placental toxicity, this book is the only available reference to connect the three key risk stages, also including discussions on reproductive and developmental toxicity in domestic animals, fish, and wildlife. Completely revised and updated to include the most recent developments in the field, the book is an essential resource for advanced students and researchers in toxicology, as well as biologists, pharmacologists, and teratologists from academia, industry, and regulatory agencies. Provides a complete, up-to-date, integrated source of information on the key risk stages during reproduction and development Includes new chapters covering significant developments, such as dose-response assessment for developmental toxicity, juvenile toxicity, and neural tube defects, as well as emerging science, such as stem cell application, toxicoproteomics, metabolomics, endocrine disruption, surveillance and regulatory considerations, and risk assessment Offers diverse and unique in vitro and in vivo toxicity models for reproductive and developmental toxicity testing in a user-friendly format that assists in comparative analysis

Human Developmental Toxicants

James L. Schardein,Orest T. Macina
Human Developmental Toxicants Book PDF

Author : James L. Schardein,Orest T. Macina
Publisher : CRC Press
Page : 427 pages
File Size : 52,9 Mb
Release : 2006-08-15
Category : Medical
ISBN : 9781420006759

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Human Developmental Toxicants by James L. Schardein,Orest T. Macina Pdf

Presenting the first database of its kind, this unique reference illustrates the relationships between the chemistry and developmental toxicity of a number of important pharmaceuticals and industrial toxicants. Human Developmental Toxicants contains up-to-date and concise information on the chemical structures, properties, and biological activities

Developmental Toxicology

Ronald D. Hood
Developmental Toxicology Book PDF

Author : Ronald D. Hood
Publisher : Van Nostrand Reinhold Company
Page : 296 pages
File Size : 41,6 Mb
Release : 1990
Category : Abnormalities
ISBN : UCAL:B5021886

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Developmental Toxicology by Ronald D. Hood Pdf

TECHNICAL

Handbook of Developmental Toxicology

Ronald D. Hood
Handbook of Developmental Toxicology Book PDF

Author : Ronald D. Hood
Publisher : CRC Press
Page : 794 pages
File Size : 42,5 Mb
Release : 1996-10-23
Category : Medical
ISBN : 0849301351

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Handbook of Developmental Toxicology by Ronald D. Hood Pdf

Developmental toxicology, an increasingly important area, encompasses the study of toxicant effects on development, from conception through puberty. The Handbook of Developmental Toxicology provides useful insights gained from hands-on experience, as well as a theoretical foundation. In this convenient reference you will find information not previously gathered in one source-including comparative developmental milestones, historical data, and a glossary of terms used in developmental toxicity evaluation. This handbook is a practical guide for individuals who are responsible for testing chemical agents and for regulatory scientists who must evaluate studies, interpret data, and perform risk assessments. Packed with features, the Handbook of Developmental Toxicology is ideal for training students and technicians in developmental toxicology.

Human Developmental Toxicants

James L. Schardein,Orest T. Macina
Human Developmental Toxicants Book PDF

Author : James L. Schardein,Orest T. Macina
Publisher : CRC Press
Page : 631 pages
File Size : 47,9 Mb
Release : 2006-08-15
Category : Medical
ISBN : 9781000654165

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Human Developmental Toxicants by James L. Schardein,Orest T. Macina Pdf

Presenting the first database of its kind, this unique reference illustrates the relationships between the chemistry and developmental toxicity of a number of important pharmaceuticals and industrial toxicants. Human Developmental Toxicants contains up-to-date and concise information on the chemical structures, properties, and biological activities

In Vitro Methods in Developmental Toxicology

Gary L. Kimmel,Devendra M. Kochhar
In Vitro Methods in Developmental Toxicology Book PDF

Author : Gary L. Kimmel,Devendra M. Kochhar
Publisher : CRC Press
Page : 190 pages
File Size : 45,9 Mb
Release : 2019-06-04
Category : Medical
ISBN : 9781000006261

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In Vitro Methods in Developmental Toxicology by Gary L. Kimmel,Devendra M. Kochhar Pdf

First Published in 1990, this text brings together the work of several investigators who used in vitro techniques to probe the nature of embryonic cell response to a diverse group of chemical agents. It focuses on the approaches, limitations, usefulness and applicability of defining mechanisms underlying altered development. This work includes discussions on pharmacodynamic principles and placental transfer mechanisms. It also examines the potential for in vitro systems to serve as an adjunct to the risk assessment process. Ideal for both the layman and the expert in this area, this volume provides a general understanding of the types of approaches that can be used and specific approaches in investigating altered development.

Computational Methods for Reproductive and Developmental Toxicology

Donald R. Mattison
Computational Methods for Reproductive and Developmental Toxicology Book PDF

Author : Donald R. Mattison
Publisher : CRC Press
Page : 330 pages
File Size : 42,7 Mb
Release : 2015-12-02
Category : Medical
ISBN : 9781439861080

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Computational Methods for Reproductive and Developmental Toxicology by Donald R. Mattison Pdf

Building from the perspective of reproductive and developmental biology, Computational Methods for Reproductive and Developmental Toxicology provides a timely and comprehensive overview of approaches in reproductive and developmental toxicology. The book, which is part of the QSAR in Environmental and Health Sciences series, is divided into three broad sections. The first provides a review of methods and approaches to meet the need for safety assessments in product development and regulatory approaches for environmental chemicals. The next one reviews the biological processes and endpoints involved in reproduction and development. The final and largest section summarizes protocols for evaluating biological processes and endpoints within reproduction and development. It also discusses informatics resources and computational methods. The book takes a cross-disciplinary approach bringing together developmental, reproductive and systems biology, chemistry, toxicology, pharmacology, biostatistics, information sciences, bioinformatics, and computational approaches. This valuable resource provides those in the field with the necessary knowledge to evaluate both classic and recent approaches to characterize toxicity.

Reproductive and Developmental Toxicology

Kenneth S . Korach
Reproductive and Developmental Toxicology Book PDF

Author : Kenneth S . Korach
Publisher : CRC Press
Page : 748 pages
File Size : 48,6 Mb
Release : 1998-03-27
Category : Medical
ISBN : 1420002899

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Reproductive and Developmental Toxicology by Kenneth S . Korach Pdf

This timely resource offers extensive discussions on the pharmacological, environmental,endocrinological, and natural factors that alter reproductive or developmental processes-elucidating the effects of toxicants on mechanisms of reproduction. Describing biological actions common to both genders as well as gender-specific processes, Reproducti

Developmental Toxicology

Keith Snell
Developmental Toxicology Book PDF

Author : Keith Snell
Publisher : Springer Science & Business Media
Page : 350 pages
File Size : 51,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461597902

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Developmental Toxicology by Keith Snell Pdf

Since the 1930s and the work of Hale and Warkany on birth defects produced by variations in dietary vitamin A, it has been recognised that the developing fetus is particularly vulnerable to adverse influences in the environment. . Studies of malformations at birth remained largely in the hands of paediatricians who, for instance, quickly established the con nection between rubella infection in early pregnancy and the birth of severely affected infants. However, it was through the tragic events of 1962, when dramatic increases in the incidence of phocomelia in newborn infants in Germany, the United Kingdom, Japan, and other countries were traced to the use of the apparently non-toxic sedative thalidomide by pregnant women, that toxicologists were brought face to face with the devastating possibility of chemically-induced developmental abnormalities. It had been shown earlier that chemotherapeutic agents could cause damage to the developing organism, but the absence of any known examples of drug-induced birth defects had produced an air of complacency which was reinforced by the lack of any specific regulatory requirements for safety evaluation in this area. The magnitude of the thalidomide tragedy, affecting some 10000 malformed children, was sufficient to cause an immediate, and some would say hasty, reaction by government drug regulatory agencies throughout the world to construct a test protocol which would detect potential teratogenic substances that might give rise to anatomical malformations.

Test No. 422: Combined Repeated Dose Toxicity Study with the Reproduction/Developmental Toxicity Screening Test

OECD
Test No 422 Combined Repeated Dose Toxicity Study with the Reproduction Developmental Toxicity Screening Test Book PDF

Author : OECD
Publisher : OECD Publishing
Page : 14 pages
File Size : 54,8 Mb
Release : 1996-03-22
Category : Electronic
ISBN : 9789264070981

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Test No. 422: Combined Repeated Dose Toxicity Study with the Reproduction/Developmental Toxicity Screening Test by OECD Pdf

The test substance is administered in graduated doses to several groups of males and females. Males should be dosed for a minimum of four weeks; females should be dosed throughout the study (approximately 54 days). Normally, matings “one male to one ...

A Comprehensive Guide to Toxicology in Nonclinical Drug Development

Ali S. Faqi
A Comprehensive Guide to Toxicology in Nonclinical Drug Development Book PDF

Author : Ali S. Faqi
Publisher : Elsevier
Page : 1074 pages
File Size : 44,5 Mb
Release : 2024-02-11
Category : Medical
ISBN : 9780323984621

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A Comprehensive Guide to Toxicology in Nonclinical Drug Development by Ali S. Faqi Pdf

A Comprehensive Guide to Toxicology in Nonclinical Drug Development, Third Edition is a valuable reference providing a complete understanding of all aspects of nonclinical toxicology in pharmaceutical research. This updated edition has been expanded and re-developed covering a wide-range of toxicological issues in small molecules and biologics. Topics include ADME in drug discovery, pharmacokinetics, toxicokinetics, formulations, and genetic toxicology testing. The book has been thoroughly updated throughout to reflect the latest scientific advances and includes new information on antiviral drugs, anti-diabetic drugs, immunotherapy, and a discussion on post-pandemic drug development challenges and opportunities. This is an essential and practical resource for all toxicologists involved in nonclinical testing in industry, academic, and regulatory settings. Provides updated, unique content not covered in one comprehensive resource, including chapters on stem cells, antiviral drugs, anti-diabetic drugs, and immunotherapy Includes the latest international guidelines for nonclinical toxicology in both small and large molecules Incorporates practical examples in order to illustrate day-to-day activities and expectations associated with working in nonclinical toxicology

Developmental Toxicology

Craig Harris,Jason M. Hansen
Developmental Toxicology Book PDF

Author : Craig Harris,Jason M. Hansen
Publisher : Humana Press
Page : 484 pages
File Size : 42,6 Mb
Release : 2016-05-01
Category : Medical
ISBN : 1493962078

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Developmental Toxicology by Craig Harris,Jason M. Hansen Pdf

This book details methods used to study developmental toxicology. It highlights the evolution of methods from classical teratology approaches to dynamic, state-of-the-art molecular methods, systems biology, and next generation models and procedures.