Developmental Toxicology 3e

Author : Ramesh C. Gupta
Publisher : Academic Press
Page : 1460 pages
File Size : 41,8 Mb
Release : 2017-03-24
Category : Medical
ISBN : 9780128042403

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Reproductive and Developmental Toxicology by Ramesh C. Gupta Pdf

Reproductive and Developmental Toxicology, Second Edition, is a comprehensive and authoritative resource that provides the latest literature on this complex subject with a primary focus on three core components—parent, placenta, and fetus—and the continuous changes that occur in each. Enriched with relevant references describing every aspect of reproductive toxicology, this revised and updated resource addresses the totality of the subject, discussing a broad range of topics, including nanoparticles and radiation, gases and solvents, smoking, alcohol and drug abuse, and metals, amongst others. With a special focus on placental toxicity, this book is the only available reference to connect the three key risk stages, also including discussions on reproductive and developmental toxicity in domestic animals, fish, and wildlife. Completely revised and updated to include the most recent developments in the field, the book is an essential resource for advanced students and researchers in toxicology, as well as biologists, pharmacologists, and teratologists from academia, industry, and regulatory agencies. Provides a complete, up-to-date, integrated source of information on the key risk stages during reproduction and development Includes new chapters covering significant developments, such as dose-response assessment for developmental toxicity, juvenile toxicity, and neural tube defects, as well as emerging science, such as stem cell application, toxicoproteomics, metabolomics, endocrine disruption, surveillance and regulatory considerations, and risk assessment Offers diverse and unique in vitro and in vivo toxicity models for reproductive and developmental toxicity testing in a user-friendly format that assists in comparative analysis

Author : Ronald D. Hood,Ronald D Hood
Publisher : CRC Press
Page : 1164 pages
File Size : 55,6 Mb
Release : 2005-08-30
Category : Medical
ISBN : 9781420040548

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Developmental and Reproductive Toxicology by Ronald D. Hood,Ronald D Hood Pdf

Completely revised and updated, Developmental and Reproductive Toxicology: A Practical Approach, Second Edition draws together valuable information typically scattered throughout the literature, plus some not previously published, into one complete resource. In addition to the traditional aspects of developmental toxicity testing, the book covers e

Author : James L. Schardein,Orest T. Macina
Publisher : CRC Press
Page : 427 pages
File Size : 54,7 Mb
Release : 2006-08-15
Category : Medical
ISBN : 9781420006759

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Human Developmental Toxicants by James L. Schardein,Orest T. Macina Pdf

Presenting the first database of its kind, this unique reference illustrates the relationships between the chemistry and developmental toxicity of a number of important pharmaceuticals and industrial toxicants. Human Developmental Toxicants contains up-to-date and concise information on the chemical structures, properties, and biological activities

Author : Keith Snell
Publisher : Springer Science & Business Media
Page : 375 pages
File Size : 52,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461597902

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Developmental Toxicology by Keith Snell Pdf

Since the 1930s and the work of Hale and Warkany on birth defects produced by variations in dietary vitamin A, it has been recognised that the developing fetus is particularly vulnerable to adverse influences in the environment. . Studies of malformations at birth remained largely in the hands of paediatricians who, for instance, quickly established the con nection between rubella infection in early pregnancy and the birth of severely affected infants. However, it was through the tragic events of 1962, when dramatic increases in the incidence of phocomelia in newborn infants in Germany, the United Kingdom, Japan, and other countries were traced to the use of the apparently non-toxic sedative thalidomide by pregnant women, that toxicologists were brought face to face with the devastating possibility of chemically-induced developmental abnormalities. It had been shown earlier that chemotherapeutic agents could cause damage to the developing organism, but the absence of any known examples of drug-induced birth defects had produced an air of complacency which was reinforced by the lack of any specific regulatory requirements for safety evaluation in this area. The magnitude of the thalidomide tragedy, affecting some 10000 malformed children, was sufficient to cause an immediate, and some would say hasty, reaction by government drug regulatory agencies throughout the world to construct a test protocol which would detect potential teratogenic substances that might give rise to anatomical malformations.

Author : Ronald D. Hood
Publisher : CRC Press
Page : 794 pages
File Size : 52,5 Mb
Release : 1996-10-23
Category : Medical
ISBN : 0849301351

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Handbook of Developmental Toxicology by Ronald D. Hood Pdf

Developmental toxicology, an increasingly important area, encompasses the study of toxicant effects on development, from conception through puberty. The Handbook of Developmental Toxicology provides useful insights gained from hands-on experience, as well as a theoretical foundation. In this convenient reference you will find information not previously gathered in one source-including comparative developmental milestones, historical data, and a glossary of terms used in developmental toxicity evaluation. This handbook is a practical guide for individuals who are responsible for testing chemical agents and for regulatory scientists who must evaluate studies, interpret data, and perform risk assessments. Packed with features, the Handbook of Developmental Toxicology is ideal for training students and technicians in developmental toxicology.

Author : Kenneth S . Korach
Publisher : CRC Press
Page : 748 pages
File Size : 53,5 Mb
Release : 1998-03-27
Category : Medical
ISBN : 1420002899

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Reproductive and Developmental Toxicology by Kenneth S . Korach Pdf

This timely resource offers extensive discussions on the pharmacological, environmental,endocrinological, and natural factors that alter reproductive or developmental processes-elucidating the effects of toxicants on mechanisms of reproduction. Describing biological actions common to both genders as well as gender-specific processes, Reproducti

Author : Ronald D. Hood
Publisher : Van Nostrand Reinhold Company
Page : 296 pages
File Size : 49,8 Mb
Release : 1990
Category : Abnormalities
ISBN : UCAL:B5021886

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Developmental Toxicology by Ronald D. Hood Pdf

TECHNICAL

Author : Ali S. Faqi
Publisher : Humana
Page : 314 pages
File Size : 44,5 Mb
Release : 2018-06-15
Category : Medical
ISBN : 1493984160

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Developmental and Reproductive Toxicology by Ali S. Faqi Pdf

This meticulous volume covers metabolism and drug-drug interactions during pregnancy, critical periods of developmental toxicology, in vivo and alternative methods to assess potential developmental toxicity for drugs and chemicals, and effects of chemicals on testes and mammary glands. Evaluation of developmental and reproductive toxicology endpoints is an integral part of the safety assessment process for compounds with potential use in women of childbearing age or females that might be exposed during pregnancy as well as men of reproductive potential. The in vivo assessments included here are guideline-driven and are required for submissions for product approval. Written for the Methods in Pharmacology and Toxicology series, this collection includes the kind of detailed implementation advice necessary for success in the lab. Authoritative and practical, Developmental and Reproductive Toxicology is an ideal resource for researchers working in this vital field of study./div

Author : National Research Council,Commission on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Developmental Toxicology
Publisher : National Academies Press
Page : 348 pages
File Size : 51,5 Mb
Release : 2000-12-21
Category : Nature
ISBN : 9780309070867

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Scientific Frontiers in Developmental Toxicology and Risk Assessment by National Research Council,Commission on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Developmental Toxicology Pdf

Scientific Frontiers in Developmental Toxicology and Risk Assessment reviews advances made during the last 10-15 years in fields such as developmental biology, molecular biology, and genetics. It describes a novel approach for how these advances might be used in combination with existing methodologies to further the understanding of mechanisms of developmental toxicity, to improve the assessment of chemicals for their ability to cause developmental toxicity, and to improve risk assessment for developmental defects. For example, based on the recent advances, even the smallest, simplest laboratory animals such as the fruit fly, roundworm, and zebrafish might be able to serve as developmental toxicological models for human biological systems. Use of such organisms might allow for rapid and inexpensive testing of large numbers of chemicals for their potential to cause developmental toxicity; presently, there are little or no developmental toxicity data available for the majority of natural and manufactured chemicals in use. This new approach to developmental toxicology and risk assessment will require simultaneous research on several fronts by experts from multiple scientific disciplines, including developmental toxicologists, developmental biologists, geneticists, epidemiologists, and biostatisticians.

Author : Ronald D. Hood
Publisher : Wiley
Page : 279 pages
File Size : 46,6 Mb
Release : 1990-08-15
Category : Medical
ISBN : 0471290793

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Developmental Toxicology by Ronald D. Hood Pdf

Author : Charlene A. McQueen
Publisher : Unknown
Page : 367 pages
File Size : 55,7 Mb
Release : 2010
Category : Toxicology
ISBN : 0080468802

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Comprehensive Toxicology: Developmental toxicology by Charlene A. McQueen Pdf

Author : George P. Daston
Publisher : CRC Press
Page : 256 pages
File Size : 50,9 Mb
Release : 2019-04-30
Category : Medical
ISBN : 9780429526176

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Molecular and Cellular Methods in Developmental Toxicology by George P. Daston Pdf

This new manual provides a convenient source of experimental procedures, including the most modern and frequently used molecular and cellular techniques. Experimental protocols have been carefully selected by developmental toxicologists for developmental toxicologists. The most important new trends, such as evaluation of the safety of therapeutic antisense oligonucleotides, studies of the role of cell death in abnormal development, and the identification of sparingly expressed developmental control genes are featured. This is the perfect manual for scientists trained in classical developmental toxicology who want to add molecular and cellular methods to their research.

Author : Gary L. Kimmel,Devendra M. Kochhar
Publisher : CRC Press
Page : 190 pages
File Size : 44,8 Mb
Release : 2019-06-04
Category : Medical
ISBN : 9781000006261

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In Vitro Methods in Developmental Toxicology by Gary L. Kimmel,Devendra M. Kochhar Pdf

First Published in 1990, this text brings together the work of several investigators who used in vitro techniques to probe the nature of embryonic cell response to a diverse group of chemical agents. It focuses on the approaches, limitations, usefulness and applicability of defining mechanisms underlying altered development. This work includes discussions on pharmacodynamic principles and placental transfer mechanisms. It also examines the potential for in vitro systems to serve as an adjunct to the risk assessment process. Ideal for both the layman and the expert in this area, this volume provides a general understanding of the types of approaches that can be used and specific approaches in investigating altered development.

Author : Craig Harris,Jason M. Hansen
Publisher : Humana Press
Page : 484 pages
File Size : 42,6 Mb
Release : 2016-05-01
Category : Medical
ISBN : 1493962078

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Developmental Toxicology by Craig Harris,Jason M. Hansen Pdf

This book details methods used to study developmental toxicology. It highlights the evolution of methods from classical teratology approaches to dynamic, state-of-the-art molecular methods, systems biology, and next generation models and procedures.

Author : Robert W. Kapp,Rochelle W. Tyl
Publisher : CRC Press
Page : 422 pages
File Size : 51,7 Mb
Release : 2016-04-19
Category : Medical
ISBN : 9781420073447

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Reproductive Toxicology by Robert W. Kapp,Rochelle W. Tyl Pdf

Thoroughly examining the popular and expanding field of reproductive toxicology, this newly revised and expanded third edition provides the latest, cutting-edge scientific developments in this constantly evolving discipline. Reproductive Toxicology's contributors are experienced regulatory agency and Clinical Research Organization representatives w