Molecular And Cellular Methods In Developmental Toxicology

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Molecular and Cellular Methods in Developmental Toxicology

George P. Daston
Molecular and Cellular Methods in Developmental Toxicology Book PDF

Author : George P. Daston
Publisher : CRC Press
Page : 336 pages
File Size : 52,7 Mb
Release : 2019-04-30
Category : Medical
ISBN : 9781439810668

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Molecular and Cellular Methods in Developmental Toxicology by George P. Daston Pdf

This new manual provides a convenient source of experimental procedures, including the most modern and frequently used molecular and cellular techniques. Experimental protocols have been carefully selected by developmental toxicologists for developmental toxicologists. The most important new trends, such as evaluation of the safety of therapeutic antisense oligonucleotides, studies of the role of cell death in abnormal development, and the identification of sparingly expressed developmental control genes are featured. This is the perfect manual for scientists trained in classical developmental toxicology who want to add molecular and cellular methods to their research.

Developmental Toxicology

Craig Harris,Jason M. Hansen
Developmental Toxicology Book PDF

Author : Craig Harris,Jason M. Hansen
Publisher : Humana Press
Page : 484 pages
File Size : 50,6 Mb
Release : 2016-05-01
Category : Medical
ISBN : 1493962078

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Developmental Toxicology by Craig Harris,Jason M. Hansen Pdf

This book details methods used to study developmental toxicology. It highlights the evolution of methods from classical teratology approaches to dynamic, state-of-the-art molecular methods, systems biology, and next generation models and procedures.

Computational Methods for Reproductive and Developmental Toxicology

Donald R. Mattison
Computational Methods for Reproductive and Developmental Toxicology Book PDF

Author : Donald R. Mattison
Publisher : CRC Press
Page : 330 pages
File Size : 54,7 Mb
Release : 2015-12-02
Category : Medical
ISBN : 9781439861080

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Computational Methods for Reproductive and Developmental Toxicology by Donald R. Mattison Pdf

Building from the perspective of reproductive and developmental biology, Computational Methods for Reproductive and Developmental Toxicology provides a timely and comprehensive overview of approaches in reproductive and developmental toxicology. The book, which is part of the QSAR in Environmental and Health Sciences series, is divided into three broad sections. The first provides a review of methods and approaches to meet the need for safety assessments in product development and regulatory approaches for environmental chemicals. The next one reviews the biological processes and endpoints involved in reproduction and development. The final and largest section summarizes protocols for evaluating biological processes and endpoints within reproduction and development. It also discusses informatics resources and computational methods. The book takes a cross-disciplinary approach bringing together developmental, reproductive and systems biology, chemistry, toxicology, pharmacology, biostatistics, information sciences, bioinformatics, and computational approaches. This valuable resource provides those in the field with the necessary knowledge to evaluate both classic and recent approaches to characterize toxicity.

Methods in Developmental Toxicology & Biology

Stephen Klug,R. Thiel
Methods in Developmental Toxicology Biology Book PDF

Author : Stephen Klug,R. Thiel
Publisher : Wiley-Blackwell
Page : 240 pages
File Size : 47,8 Mb
Release : 1997-03-21
Category : Science
ISBN : 0632041870

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Methods in Developmental Toxicology & Biology by Stephen Klug,R. Thiel Pdf

Experimental work in animal systems involves investigations of organisms at the molecular and the cellular level. This book provides information on the latest research from the areas of both developmental toxicology and developmental biology. It covers a wide spectrum of the most powerful techniques currently available for studying the basic parameters of in vitro and in vivo development. The detailed theoretical background allows critical assessment and application of these techniques. The authors--all accomplished and world renowned experts in their topic areas--supply their accounts of the current research status in developmental toxicology and biology. This book is intended to catalyze exchange and collaboration between scientists in these disciplines and to provide newcomers with an entry to this research field.

In Vitro Methods in Developmental Toxicology

Gary L. Kimmel,Devendra M. Kochhar
In Vitro Methods in Developmental Toxicology Book PDF

Author : Gary L. Kimmel,Devendra M. Kochhar
Publisher : CRC Press
Page : 190 pages
File Size : 48,7 Mb
Release : 2019-06-04
Category : Medical
ISBN : 9781000006261

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In Vitro Methods in Developmental Toxicology by Gary L. Kimmel,Devendra M. Kochhar Pdf

First Published in 1990, this text brings together the work of several investigators who used in vitro techniques to probe the nature of embryonic cell response to a diverse group of chemical agents. It focuses on the approaches, limitations, usefulness and applicability of defining mechanisms underlying altered development. This work includes discussions on pharmacodynamic principles and placental transfer mechanisms. It also examines the potential for in vitro systems to serve as an adjunct to the risk assessment process. Ideal for both the layman and the expert in this area, this volume provides a general understanding of the types of approaches that can be used and specific approaches in investigating altered development.

Molecular and Cellular Methods in Developmental Toxicology

George P. Daston
Molecular and Cellular Methods in Developmental Toxicology Book PDF

Author : George P. Daston
Publisher : CRC Press
Page : 256 pages
File Size : 54,6 Mb
Release : 2019-04-30
Category : Medical
ISBN : 9780429526176

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Molecular and Cellular Methods in Developmental Toxicology by George P. Daston Pdf

This new manual provides a convenient source of experimental procedures, including the most modern and frequently used molecular and cellular techniques. Experimental protocols have been carefully selected by developmental toxicologists for developmental toxicologists. The most important new trends, such as evaluation of the safety of therapeutic antisense oligonucleotides, studies of the role of cell death in abnormal development, and the identification of sparingly expressed developmental control genes are featured. This is the perfect manual for scientists trained in classical developmental toxicology who want to add molecular and cellular methods to their research.

Molecular and Biochemical Toxicology

Robert C. Smart,Ernest Hodgson
Molecular and Biochemical Toxicology Book PDF

Author : Robert C. Smart,Ernest Hodgson
Publisher : John Wiley & Sons
Page : 1060 pages
File Size : 50,7 Mb
Release : 2018-01-04
Category : Science
ISBN : 9781119042419

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Molecular and Biochemical Toxicology by Robert C. Smart,Ernest Hodgson Pdf

Written as an advanced text for toxicology students, this book is much more than an introduction and provides in-depth information describing the underlying mechanisms through which toxicants produce their adverse responses. • Links traditional toxicology to modern molecular techniques, important for teaching to graduate courses and professional studies • Uses a didactic approach with basic biological or theoretical background for the methodology presented • Brings together and comprehensively covers a range of dynamic aspects in biochemical and molecular toxicology • Guides student and professional toxicologists in comprehending a broad range of issues, compiled and authored by a diverse group of experts • “A good introductory textbook covering the biochemical toxicology of organic substances and the relevant methodology in some detail.... It offers good value for money and can be recommended as a textbook for appropriate courses” – BTS Newsletter review of the 4th edition

Scientific Frontiers in Developmental Toxicology and Risk Assessment

National Research Council,Commission on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Developmental Toxicology
Scientific Frontiers in Developmental Toxicology and Risk Assessment Book PDF

Author : National Research Council,Commission on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Developmental Toxicology
Publisher : National Academies Press
Page : 348 pages
File Size : 43,9 Mb
Release : 2000-12-21
Category : Nature
ISBN : 9780309070867

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Scientific Frontiers in Developmental Toxicology and Risk Assessment by National Research Council,Commission on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Developmental Toxicology Pdf

Scientific Frontiers in Developmental Toxicology and Risk Assessment reviews advances made during the last 10-15 years in fields such as developmental biology, molecular biology, and genetics. It describes a novel approach for how these advances might be used in combination with existing methodologies to further the understanding of mechanisms of developmental toxicity, to improve the assessment of chemicals for their ability to cause developmental toxicity, and to improve risk assessment for developmental defects. For example, based on the recent advances, even the smallest, simplest laboratory animals such as the fruit fly, roundworm, and zebrafish might be able to serve as developmental toxicological models for human biological systems. Use of such organisms might allow for rapid and inexpensive testing of large numbers of chemicals for their potential to cause developmental toxicity; presently, there are little or no developmental toxicity data available for the majority of natural and manufactured chemicals in use. This new approach to developmental toxicology and risk assessment will require simultaneous research on several fronts by experts from multiple scientific disciplines, including developmental toxicologists, developmental biologists, geneticists, epidemiologists, and biostatisticians.

Developmental Toxicology

CaroleAKimmel
Developmental Toxicology Book PDF

Author : CaroleAKimmel
Publisher : CRC Press
Page : 502 pages
File Size : 49,8 Mb
Release : 1994-06-30
Category : Medical
ISBN : 0781701376

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Developmental Toxicology by CaroleAKimmel Pdf

The Second Edition of this highly regarded work provides a state-of-the-art review of developmental toxicology from basic science, clinical, epidemiological, and regulatory perspectives. This new edition highlights the latest approaches to understanding the mechanisms of developmental toxicity, testing pharmaceutical and environmental agents, and interpreting developmental toxicity data.; The contributors demonstrate how new information on molecular embryology and cell biology is being applied to problems in developmental toxicology. Chapters describe the effects of toxic exposure on the functional development of various organs, examine the relationship between maternal and developmental toxicity, and discuss current techniques for studying chemical disposition, metabolism, and placental transfer. Close attention is given to the use of mathematical and statistical techniques in data interpretation, as well as to the regulatory aspects of testing and risk assessment. Other chapters focus on pre- and post conceptional clinical care and on genetic factors in clinical developmental toxicology.

Developmental Toxicology, Third Edition

Deborah K. Hansen,Barbara D. Abbott
Developmental Toxicology Third Edition Book PDF

Author : Deborah K. Hansen,Barbara D. Abbott
Publisher : CRC Press
Page : 0 pages
File Size : 41,8 Mb
Release : 2008-10-22
Category : Medical
ISBN : 1420054376

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Developmental Toxicology, Third Edition by Deborah K. Hansen,Barbara D. Abbott Pdf

Highlighting latest advances in genetics and biochemistry, the completely revised Third Edition reviews the field from basic science, clinical, epidemiological, and regulatory perspectives. Contributions from top opinion leaders in the field bring together developments in molecular embryology and cell biology as they apply to problems in developmental toxicology. It covers testing of pharmaceutical and environmental agents and interpretation of developmental toxicology data, highlighting mathematical and statistical techniques, as well as the effects of toxic exposure on the functional development of various organs. The relationship between maternal and developmental toxicology is examined, in addition to current techniques for studying chemical disposition, metabolism, and placental transfer. Close attention is given to the regulatory aspects of testing and risk assessment. Pre- and postconceptional clinical care and genetic factors in clinical developmental toxicology are also discussed. Key topics include: the roles of apoptosis and signal transduction pathways in normal and abnormal development the role of epigenetic changes in development the role of nutrition and individual susceptibility the utility of bioinformatics global and targeted gene expression changes

Reproductive Toxicology

Jesús del Mazo
Reproductive Toxicology Book PDF

Author : Jesús del Mazo
Publisher : Springer Science & Business Media
Page : 221 pages
File Size : 55,9 Mb
Release : 2013-06-29
Category : Medical
ISBN : 9781489900890

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Reproductive Toxicology by Jesús del Mazo Pdf

Numerous reports demonstrate that the reproductive system could be affected by multiple potential toxicological agents. The volume includes different aspects of the development of new approaches to in vitro testing using sperm cells and systems involved on reproduction in mammals. Comparative analysis of in vivo and in vitro methods has been included to take steps towards the further development of and applications of new systems for germline toxicology.

Toxicogenomics-Based Cellular Models

Jos Kleinjans
Toxicogenomics Based Cellular Models Book PDF

Author : Jos Kleinjans
Publisher : Academic Press
Page : 362 pages
File Size : 43,8 Mb
Release : 2014-01-02
Category : Science
ISBN : 9780123978714

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Toxicogenomics-Based Cellular Models by Jos Kleinjans Pdf

Toxicogenomics-Based Cellular Models is a unique and valuable reference for all academic and professional researchers employing toxicogenomic methods with respect to animal testing for chemical safety. This resource offers cutting-edge information on the application of toxicogenomics to developing alternatives to current animal toxicity tests. By illustrating the development of toxicogenomics-based cellular models for critical endpoints of toxicity and providing real-world examples for validation and data analysis, this book provides an assessment of the current state of the field, as well as opportunities and challenges for the future. Written by renowned international toxicological experts, this book explores ‘omics technology for developing new assays for toxicity testing and safety assessment and provides the reader with a focused examination of alternative means to animal testing. Describes the state-of-the-art in developing toxicogenomics-based cellular models for chemical-induced carcinogenicity, immunotoxicity, developmental toxicity, neurotoxicity and reproduction toxicity Illustrates how to validate toxicogenomics-based alternative test models and provides an outlook to societal and economic implementation of these novel assays Includes an overview of current testing methods and risk assessment frameworks Provides a real-world assessment by articulating the current development and challenges in toxicogenomics while suggesting ways to move this field forward

Molecular and Cellular Toxicology

Lesley Stanley
Molecular and Cellular Toxicology Book PDF

Author : Lesley Stanley
Publisher : John Wiley & Sons
Page : 471 pages
File Size : 51,5 Mb
Release : 2014-04-02
Category : Medical
ISBN : 9781118526019

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Molecular and Cellular Toxicology by Lesley Stanley Pdf

Toxicology is the study of the adverse effects of chemical, physical, or biological agents on people, animals, and the environment. Toxicologists are trained to investigate, interpret, and communicate the nature of those effects. Over the last ten years the subject of toxicology has changed dramatically, moving from a discipline which was once firmly wedded to traditional methods to one which is keen to embrace the innovative techniques emerging from the developing fields of cell culture and molecular biology. There is an acute need for this to be reflected in a paradigm shift which takes advantage of the opportunities offered by modern developments in the life sciences, including new in vitro and in silico approaches, alternative whole organism (non-mammalian) models and the exploitation of ‘omics methods, high throughput screening (HTS) techniques and molecular imaging technologies. This concise, accessible introduction to the field includes the very latest concepts and methodologies. It provides MSc, PhD and final year undergraduate students in pharmacy, biomedical and life sciences, as well as individuals starting out in the cosmetics, consumer products, pharmaceutical and testing industries, with everything they need to know to get to grips with the fast moving field of toxicology and the current approaches used in the risk assessment of drugs and chemicals.

Molecular and Cellular Mechanisms of Toxicity

Lewis L. Smith,Francesco De Matteis
Molecular and Cellular Mechanisms of Toxicity Book PDF

Author : Lewis L. Smith,Francesco De Matteis
Publisher : CRC Press
Page : 235 pages
File Size : 45,8 Mb
Release : 2019-06-04
Category : Medical
ISBN : 9781000006001

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Molecular and Cellular Mechanisms of Toxicity by Lewis L. Smith,Francesco De Matteis Pdf

First Published in 1995: Written by specialists in their fields, this book contains short reviews intended to highlight points of growing interest in mechanistic toxicology. The first section considers selected aspects of molecular mechanisms, including selectivity of toxic agents and repair processes in the nervous system, toxicity of oxygen, fibers and aflatoxins. The second section discusses the interactions of carcinogens with DNA, and other targets, and their relevance to both molecular dosimetry of exposure and development of cancer. The final part is concerned with cellular and genetic aspects and includes coverage of some of the most recent and rapidly developing problems in toxicology.

Tobacco-Specific N-Nitrosamines Recent Advances

Roger O. McClellan
Tobacco Specific N Nitrosamines Recent Advances Book PDF

Author : Roger O. McClellan
Publisher : CRC Press
Page : 154 pages
File Size : 49,7 Mb
Release : 1996-05-10
Category : Medical
ISBN : 084931156X

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Tobacco-Specific N-Nitrosamines Recent Advances by Roger O. McClellan Pdf

This remarkable book provides updates on various aspects of tobacco - its chemical and biological nature, and its physiological effects.