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Distinct Roles For E12 And E47 In Lymphocyte Development Book in PDF, ePub and Kindle version is available to download in english. Read online anytime anywhere directly from your device. Click on the download button below to get a free pdf file of Distinct Roles For E12 And E47 In Lymphocyte Development book. This book definitely worth reading, it is an incredibly well-written.
Author : Gretchen Wendy Bain
Publisher : Unknown
Page : 334 pages
File Size : 54,7 Mb
Release : 1996
Category : Electronic
ISBN : UCSD:31822018585406
Author : Anonim
Publisher : CSHL Press
Page : 621 pages
File Size : 42,5 Mb
Release : 1999
Category : Medical
ISBN : 9780879695699
Provides a dialogue on the nature of the membrane signals and intracytoplasmic events that provoke immunity. The debate ranges over biochemistry, physiology, molecular genetics, as well as classical cellular immunology. Input came from over 70 of the world's leading investigators.
Author : John G. Monroe,Ellen Rothenberg
Publisher : Springer Science & Business Media
Page : 582 pages
File Size : 55,7 Mb
Release : 2013-03-14
Category : Science
ISBN : 9781475727784
Despite the tremendous diversity of the cells of the hematopoietic system, they are all derived from common precursor cells that are generated in the fetus and persist into adult life. In this regard, Band T lymphocytes, which comprise the two arms of the antigen-specific and inducible immune system, though functionally very different, are descendants of the same stem cell precursor. In the past several years, we have witnessed an explosion of information regarding the process by which differentiation of B-and T-cells from stem cells occurs. This information, like the answers to most important biological questions, has come from multiple and diverse directions. Because all hematopoietic cells arise from common precursors, complex regulatory processes must be involved in determining commitment to various lineages. Understanding commitment to the B- or T-cell lineage remains incomplete; however, identification of transcription factors necessary for progression along specific B-and T-cell pathways suggests that we are on the verge of understanding the molecules involved in the initial fate-determining steps. Studies of this type previously could be accomplished only in nonmammalian systems that are more amenable to genetic approaches. However, new technologies allow increasingly elegant and informative studies in mammalian systems, particularly for cells of the hematopoietic system.
Author : Ananda L Roy
Publisher : Frontiers Media SA
Page : 145 pages
File Size : 45,7 Mb
Release : 2015-04-14
Category : Chromatin
ISBN : 9782889195107
Signaling through the cell surface antigen receptor is a hallmark of various stages of lymphocyte development and adaptive immunity. Besides the adaptive immune system, the innate immunity is equally important for protection. However, the mechanistic connection between signaling, chromatin changes and downstream transcriptional pathways in both innate and adaptive immune system remains incompletely understood in hematopoiesis. A related issue is how the enhancers communicate to the promoters in a stage specific fashion and in the context of chromatin. Because the factors that regulate chromatin are generally present and active in most cell types, how could cell type and/or stage specific chromatin architecture is achieved in response to a particular immune signal? The genetic loci that encode lymphocyte cell surface receptors are in an ‘unrearranged” or “germline” configuration during the early stages of development. Thus, in addition to expressing lineage and/or stage specific transcription factors during each developmental stage, lymphocytes also need to rearrange their cognate receptor loci in a strictly ordered fashion. Hence, there must be a tightly coordinated communication between the recombination machinery and the transcriptional machinery (including chromatin regulators) at every developmental step. Mature B cells also undergo classswitch recombination and somatic hypermutation. Importantly, along the way, these cells must avoid autoimmune responses and only those cells capable of recognizing foreignantigens are preserved to reach peripheral organs where they must function. The exquisite regulation that govern chromatin accessibility, recombination and transcription regulation in response to the environmental signals in the immune system is discussed here is a series of articles.
Author : Anonim
Publisher : Academic Press
Page : 454 pages
File Size : 49,6 Mb
Release : 2015-11-16
Category : Medical
ISBN : 9780128033302
Molecular Mechanisms That Orchestrate the Assembly of Antigen Receptor Loci, the latest volume in the Advances in Immunology series focuses on the generation of an effective immune response to invading pathogens As B and T lymphocytes are characterized by the expression of antigen receptors that specifically recognize determinants expressed on pathogens, this volume discusses how antigen receptors are synthesized in B and T lymphocytes. Focuses on the generation of an effective immune response to invading pathogens Contains contributions from leading authorities Informs and updates on all the latest developments in the field of immunology
Author : Wilfried Ellmeier,Ichiro Taniuchi
Publisher : Springer
Page : 334 pages
File Size : 55,9 Mb
Release : 2014-09-02
Category : Medical
ISBN : 9783319073958
Insights into the regulation of immune cell lineage differentiation and specification as well as into the control of lineage integrity, stability and plasticity are of fundamental importance to understanding innate and adaptive immune responses. In this volume, leading experts provide an up-to-date and comprehensive overview of recent advances in the transcriptional control mechanisms and transcription factor networks that regulate these processes in a variety of different immune cell lineages. The chapters cover the regulation of T versus B cell lineage choice, discuss early B cell development and pre-B cell leukemia prevention, address transcriptional control mechanisms during the differentiation, in regulatory T cells and iNKT cells, detail genomic switches in helper cell fate choice and plasticity and highlight the role of the BTB-zinc finger family of transcription factors in T cells. Moreover, the chapters discuss transcriptional networks in DCs, NK cells and in innate lymphoid cells. Together, the reviews illustrate key transcriptional control mechanisms that regulate the development and function of immune cells and demonstrate the impressive advances made over the last decade.
Author : John C. Cambier
Publisher : Unknown
Page : 308 pages
File Size : 51,7 Mb
Release : 2005
Category : Aging
ISBN : NWU:35557000121796
Author : Katya Ravid,Jonathan D. Licht
Publisher : John Wiley & Sons
Page : 640 pages
File Size : 49,5 Mb
Release : 2003-11-04
Category : Science
ISBN : 9780471461067
Transcription Factors Normal and Malignant Development of Blood Cells Katya Ravid and Jonathan Licht The role of transcription factors in activating specific genes in blood cells is an important facet of hematopoiesis. Equally important, however, is the pursuit of genes rearranged and aberrantly activated in leukemias (blood malignancies). Transcription Factors: Normal and Malignant Development of Blood Cells focuses on those major transcription factors involved in activation of lineage-specific gene expression during normal versus malignant development of specific blood lineages, as revealed from gene promoter studies, knockout of transcription factors in mice models, and the identification and characterization of chromosomal rearrangement in human blood leukemias. This complete digest of current transcription factor data offers comprehensive coverage of the myriad of transcription factors in blood cell development, composed by established experts in the field. In addition to updating the reader on the connection between chromosomal translocations involving transcription factors and cellular transformation leading to leukemia, Transcription Factors also reviews such subjects as: * Transcription factors and the megakaryocytic, myeloid, and erythroid lineages * Leukemias due to chromosomal translocations involving gene encoding transcription factors * Oncogenesis and hematopoiesis * In vivo studies of transcription factors implicated in hematopoiesis * And much more Appealing to both the researcher and the clinician in the field of hematology, Transcription Factors is a timely presentation of cell lineage development and sheds light on the processes involved in the development of specific leukemias. Providing insight into the study of transcription factors, readers will gain an understanding of mechanisms that lead to normal lineage commitment and terminal differentiation.
Author : Michele Kay Anderson,Juan Carlos Zuniga-Pflucker,Mikael Sigvardsson,Barbara L. Kee
Publisher : Frontiers Media SA
Page : 162 pages
File Size : 50,5 Mb
Release : 2022-12-01
Category : Medical
ISBN : 9782832508138
Author : Anne O'Garra,Michel Nussenzweig,Stephen T. Smale,David Johnston Stewart,Bruce Stillman
Publisher : Unknown
Page : 312 pages
File Size : 55,8 Mb
Release : 2013
Category : Immune system
ISBN : 162182084X
The 78th Symposium volume covers many aspects of the immune system including the genetics, biochemistry, molecular and cell biology, and developmental biology of immune responses. New approaches intended to harness the immune system to treat disease, particularly cancer, are also discussed. The volume's broad synthesis of the current knowledge about immunity and tolerance includes molecular mechanisms of B and T lymphocyte development from the single cell to the entire organism and from single genes to genomes. There is a focus on the development and function of innate cells, including myeloid cells, natural killer cells, and a more recently defined innate lymphoid cell that resembles a T cell. Transcriptional regulation of key immune pathways in innate and adaptive cells of the immune system are covered. The effect of metabolic pathways on immune responses is discussed and, conversely, how immune cells may affect cell and tissue physiology outside of the immune response. Other topics include the protective effect of commensal bacteria, the diverse immune mechanisms underlying chronic infection or immune control in HIV and tuberculosis, and insights into autoimmune diseases that may lead to new clinical therapies. Specific coverage includes: - Stem cells and cell fate decisions - Regulation of immune cell development - Antigen receptor gene assembly and modification - Signal transduction - Regulation of lymphocyte function - Innate immune response and inflammation - Adaptive immunity - Mucosal immunity - Organ specific immunity - Immune regulation and tolerance - Autoimmunity and allergy - Immunity and cancer - Pathogen-immune system interactions - Vaccine development - Novel strategies to engineer/harness immunity
Author : Tasuku Honjo,Michael Reth,Andreas Radbruch,Frederick Alt
Publisher : Elsevier
Page : 600 pages
File Size : 41,5 Mb
Release : 2014-10-09
Category : Science
ISBN : 9780123984906
Molecular Biology of B Cells, Second Edition is a comprehensive reference to how B cells are generated, selected, activated and engaged in antibody production. All of these developmental and stimulatory processes are described in molecular, immunological, and genetic terms to give a clear understanding of complex phenotypes. Molecular Biology of B Cells, Second Edition offers an integrated view of all aspects of B cells to produce a normal immune response as a constant, and the molecular basis of numerous diseases due to B cell abnormality. The new edition continues its success with updated research on microRNAs in B cell development and immunity, new developments in understanding lymphoma biology, and therapeutic targeting of B cells for clinical application. With updated research and continued comprehensive coverage of all aspects of B cell biology, Molecular Biology of B Cells, Second Edition is the definitive resource, vital for researchers across molecular biology, immunology and genetics. Covers signaling mechanisms regulating B cell differentiation Provides information on the development of therapeutics using monoclonal antibodies and clinical application of Ab Contains studies on B cell tumors from various stages of B lymphocytes Offers an integrated view of all aspects of B cells to produce a normal immune response
Author : Sudhir Gupta,Frederick W. Alt,Max D. Cooper,Fritz Melchers,Klaus Rajewsky
Publisher : Springer Science & Business Media
Page : 197 pages
File Size : 46,6 Mb
Release : 2007-05-21
Category : Medical
ISBN : 9780387465302
In recent years, major developments have increased understanding of various genetic and epigenetic regulatory processes that are critical for the generation of B cell repertoires. These include the role of chromatin regulation and nuclear organization in understating the IgH gene regulation. These proceedings highlight recent developments in lymphocyte development, Ig gene rearrangements and somatic hypermutation, chromatin structure modification, B lymphocyte signaling and fate, receptor editing, and autoimmunity.
Author : Anonim
Publisher : Unknown
Page : 856 pages
File Size : 41,5 Mb
Release : 2000
Category : Dissertations, Academic
ISBN : STANFORD:36105110578775
Author : Anonim
Publisher : Unknown
Page : 896 pages
File Size : 44,6 Mb
Release : 1995
Category : Dissertation abstracts
ISBN : UOM:39015086908210
Author : David Latchman,David S. Latchman
Publisher : Academic Press
Page : 488 pages
File Size : 40,6 Mb
Release : 2010-07-28
Category : Science
ISBN : 0080561039
Transcription, or the process by which DNA produces RNA, is a central aspect of gene expression. Transcription factors regulate transcription during development and in disease states. As such, it is critical for researchers to gain a good understanding of the relationship between the structure of various families of transcription factors and their function, as well as roles in human disease. Since publication of the Fourth Edition, there have been major advances, notably in the areas of chromatin remodeling and genome-scale analyses. This complete update includes all new coverage of the latest developments, from enabling genomic technologies to studies on the importance of post-translational modifications beyond phosphorylation events. Potential of transcription factors as therapeutic targets in human disease Importance of histone modifications Use of genome-based sequence analysis and high-throughput methods Applications of the chromatin immunoprecipitation (ChIP) assay Transcriptional elongation Regulation by post-translational modifications Regulatory networks and bioinformatics
