Dna Sensors And Inflammasomes

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DNA Sensors and Inflammasomes

Anonim
DNA Sensors and Inflammasomes Book PDF

Author : Anonim
Publisher : Academic Press
Page : 368 pages
File Size : 50,7 Mb
Release : 2019-08-25
Category : Science
ISBN : 9780128183601

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DNA Sensors and Inflammasomes by Anonim Pdf

DNA Sensors and Inflammasomes, Volume 625, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. New sections in this release include Phosphorylation and dimerization of STING and IRF3, cGAS enzymology, Synthesis and identification of immuno-stimulatory CDNs, Tracking cGAS activity/ cGAMP formation using SPR/NMR, Using an enzyme coupled assay to track cGAS activity under steady states, Tracking the polymerization of DNA sensors, inflammasome receptors, and downstream signaling partners using FRET, NLRC4 structure, Tracking TREX1 activity, DNA association and dissociation kinetics of PARP1, and more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Methods in Enzymology series Includes the latest information on DNA sensors and inflammasomes

The Inflammasomes

Isabelle Couillin,Virginie Pétrilli,Fabio Martinon
The Inflammasomes Book PDF

Author : Isabelle Couillin,Virginie Pétrilli,Fabio Martinon
Publisher : Springer Science & Business Media
Page : 226 pages
File Size : 44,9 Mb
Release : 2011-07-02
Category : Medical
ISBN : 9783034801485

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The Inflammasomes by Isabelle Couillin,Virginie Pétrilli,Fabio Martinon Pdf

The inflammasome was first described in 2002 as a molecular complex activating proinflammatory caspases and therefore regulating the maturation and biological activities of cytokines such as IL-1 and IL-18. This finding was substantiated by the identification of several mutations in the cias1 gene, encoding the human NLRP3 protein, responsible for several autoinflammatory disorders such as the Muckle Wells syndrome. Since, the interest for this complex has constantly increased and several inflammasome complexes with different specificities have been described. These inflammasomes sense a wide variety of pathogens and danger signals and are key players in the inflammatory response. With the contributions of leading international experts in the field, this book provides an extensive overview of the current knowledge of inflammasome biology and their role in health and disease.

Biological DNA Sensor

Ken Ishii,Choon Kit Tang
Biological DNA Sensor Book PDF

Author : Ken Ishii,Choon Kit Tang
Publisher : Academic Press
Page : 368 pages
File Size : 48,9 Mb
Release : 2013-10-30
Category : Science
ISBN : 9780124051683

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Biological DNA Sensor by Ken Ishii,Choon Kit Tang Pdf

Biological DNA Sensor defines the meaning of DNA sensing pathways and demonstrates the importance of the innate immune responses induced by double stranded DNA (dsDNA) through its influencing functions in disease pathology and immune activity of adjuvants for vaccines. Though discussed in specific subsections of existing books, dsDNA and its immunogenic properties has never received the complete treatment given in this book. Biological DNA Sensor approaches the impact of dsDNA's immunogenicity on disease and vaccinology holistically. It paints a complete and concise picture on the topic so you can understand this area of study and make more informed choices for your respective research needs. Chapters are authored by researchers who are renowned for their research focus, ensuring that this book provides the most complete views on the topics. Multi-authored by a distinguished panel of world-class experts Ideal source of information for those wanting to learn about DNA sensing Provides in-depth explanations of DNA sensing pathways and the innate immune system, bridging the gap between them

Biological DNA Sensor

Jan Naujoks,Bastian Opitz
Biological DNA Sensor Book PDF

Author : Jan Naujoks,Bastian Opitz
Publisher : Elsevier Inc. Chapters
Page : 368 pages
File Size : 48,6 Mb
Release : 2013-10-30
Category : Medical
ISBN : 9780128068809

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Biological DNA Sensor by Jan Naujoks,Bastian Opitz Pdf

The detection of bacterial pathogens by the innate immune system is mediated by various pattern recognition receptors that sense microbial molecules such as cell wall components, virulence factors or nucleic acids. Bacterial DNA is recognized by Toll-like receptor 9 (TLR9) at endosomal compartments and by cyclic GMP-AMP synthase, polymerase III/RIG-I, AIM2-like receptors (ALRs), DNA helicases as well as other incompletely characterized proteins in the host cell cytosol. Depending on the receptor and specific engagement of the adapter molecules MyD88, STING, MAVS or ASC, sensing of bacterial DNA triggers expression of NF-κB-dependent proinflammatory genes, type I IFN responses, and/or inflammasome activation. Whereas inflammatory gene expression and inflammasome activation are required for an effective host defense to most bacterial infections, type I IFNs appear to play a regulatory role and can be beneficial or detrimental for the host. This chapter summarizes the current knowledge about the mechanisms of DNA sensing and its function in bacterial infections.

Nucleic Acid Sensing and Immunity, Part A

Anonim
Nucleic Acid Sensing and Immunity Part A Book PDF

Author : Anonim
Publisher : Academic Press
Page : 269 pages
File Size : 52,9 Mb
Release : 2019-02-22
Category : Science
ISBN : 9780128159804

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Nucleic Acid Sensing and Immunity, Part A by Anonim Pdf

Nucleic Acid Sensing and Immunity - PART A, Volume 344, provides a comprehensive overview of the nucleic acid machinery, from plants to mammalians, as well as their regulation. Specific chapters in this updated release include Molecular bases of discrimination between self from non-self nucleic acids, Intracellular RNA sensing in mammalian cells, Nuclear DNA damage and nucleic acid sensing, Negative regulation of nucleic acid sensing, Dendritic cell responses to exogenous nucleic acids, Activating the nucleic acid-sensing machinery for anticancer immunity, and Nucleic acid sensing and inflammasomes, amongst other topics. Provides an accurate, state-of-the-art resource on RNA sensing Includes the work of a well-known tumor immunologist Links intestinal host defense and viral nucleic acid sensing Presents a chapter on the negative regulation of DNA sensing, a timely topic

Non-Canonical Autophagy

Giulia Petroni,Lorenzo Galluzzi
Non Canonical Autophagy Book PDF

Author : Giulia Petroni,Lorenzo Galluzzi
Publisher : Academic Press
Page : 184 pages
File Size : 52,6 Mb
Release : 2021-04-21
Category : Science
ISBN : 9780128209110

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Non-Canonical Autophagy by Giulia Petroni,Lorenzo Galluzzi Pdf

Non-canonical Autophagy: Mechanisms and Pathophysiological Implications outlines the differences between ‘canonical’ and ‘non-canonical’ forms of autophagy, highlighting the discoveries concerning the molecular mechanisms underlying these unconventional forms of autophagy and the advancements in pathophysiological features of ‘non-canonical’ autophagy. The book discusses all forms of ‘non-canonical’ autophagy and the complexity of autophagy-dependent cell death. Readers will gain a better understanding of mechanisms underlying ‘non-canonical’ autophagy so that they can interpret the biological effects of autophagy correctly and identify reliable, novel and effective treatment strategies. Presents the most advanced information surrounding the molecular mechanisms underlying non-canonical autophagy Outlines the increasing evidence regarding the involvement of non-canonical autophagy in multiple physiological and pathological processes Discusses the therapeutic potential of autophagy modulators and the obstacles that have limited their development

Dynamics of Immune Activation in Viral Diseases

Pallaval Veera Bramhachari
Dynamics of Immune Activation in Viral Diseases Book PDF

Author : Pallaval Veera Bramhachari
Publisher : Springer Nature
Page : 283 pages
File Size : 52,5 Mb
Release : 2020-02-24
Category : Medical
ISBN : 9789811510458

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Dynamics of Immune Activation in Viral Diseases by Pallaval Veera Bramhachari Pdf

This book discusses various components of the innate and adaptive immune response in combating viral infections, presenting the recent advances in our understanding of innate immunity recognition of viruses and highlighting the important role of inflammation, cytokines such as interferon, toll-like receptors and leukocytes in the initial detection of invading viruses and subsequent activation of adaptive immunity. It also summarizes the role of the adaptive immunity against viral infections through clearance of virus and establishment of memory response that protects against the recurrent infections. In addition, the book examines the role of DNA and RNA sensors in viral recognition and in controlling viral infection. Lastly, it reviews the latest developments in the development of the rational viral vaccines. As such it is a useful resource book for postgraduate and early researchers wanting to gain insights into the immune response to viral infections.

Inflammasomes: Clinical and Therapeutic Implications

Mario D. Cordero,Elísabet Alcocer-Gómez
Inflammasomes Clinical and Therapeutic Implications Book PDF

Author : Mario D. Cordero,Elísabet Alcocer-Gómez
Publisher : Springer
Page : 400 pages
File Size : 51,5 Mb
Release : 2018-09-04
Category : Science
ISBN : 9783319893907

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Inflammasomes: Clinical and Therapeutic Implications by Mario D. Cordero,Elísabet Alcocer-Gómez Pdf

The inflammasome is a protein complex composed of an intracellular sensor—typically a Nod-like receptor (NLR), the precursor procaspase-1, and the adaptor ASC. Inflammasome activation leads to the maturation of caspase-1 and the processing of its substrates, IL-1β and IL-18. The inflammasome has been implicated numerous diseases, and blockade of inflammasome-derived IL-1β has beneficial effects on several of these diseases. Different books have been edited about the biology of inflammasomes and about methods to study, however, the implication of this complex in the different diseases and pathological conditions show the need of a book about the clinical implications and therapeutic options. This project will show the context where inflammasomes are being studied and the molecular implications in the medical and clinical contexts. Other important topic of the inflammasomes will be the development of pharmacological inhibitors in order to improve new clinical applications. In this sense, we can find new drugs with inhibitory effects or old drugs with an inhibitory potential effect. There is a need for re-establishing the real benefits of the inflammasome inhibitions in pathological situations and the management of the differents diseases where inflammasomes are implicated.

Textbook of Autoinflammation

Philip J. Hashkes,Ronald M. Laxer,Anna Simon
Textbook of Autoinflammation Book PDF

Author : Philip J. Hashkes,Ronald M. Laxer,Anna Simon
Publisher : Springer
Page : 820 pages
File Size : 54,9 Mb
Release : 2019-02-13
Category : Medical
ISBN : 9783319986050

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Textbook of Autoinflammation by Philip J. Hashkes,Ronald M. Laxer,Anna Simon Pdf

This book, the first complete textbook on this novel field in Medicine, comprehensively covers the clinical presentation, pathogenesis, genetics, and latest management strategies for autoinflammatory disorders as well as the basic science of autoinflammation. Relevant concepts such as how translational science of genetics and immunology relates to the innate immune system and autoinflammation are covered. Descriptions of the monogenic and polygenic/complex diseases that fall under the umbrella of autoinflammatory diseases are provided. Further topics covered include the latest clinical and genetic diagnostic approaches, concepts on the relationship between autoinflammation and autoimmunity/immunodeficiency, the role of autoinflammation in cancer, treatments and management strategies for these diseases, and potential areas of future development. The Textbook of Autoinflammation systematically describes and reviews diagnostic and treatment options for autoinflammatory disorders as well as all aspects of the concept of autoinflammation, and represents a valuable resource for professionals in a variety of disciplines who encounter these patients or who study autoinflammation.

Innate Immunity and Inflammation

Ruslan Medzhitov
Innate Immunity and Inflammation Book PDF

Author : Ruslan Medzhitov
Publisher : Cold Spring Harbor Perspective
Page : 0 pages
File Size : 45,9 Mb
Release : 2015
Category : Medical
ISBN : 1621820297

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Innate Immunity and Inflammation by Ruslan Medzhitov Pdf

"A subject collection from Cold Spring Harbor perspectives in biology."

The Inflammasome

Christine M. De Nardo,Eicke Latz
The Inflammasome Book PDF

Author : Christine M. De Nardo,Eicke Latz
Publisher : Humana
Page : 0 pages
File Size : 43,8 Mb
Release : 2013-07-13
Category : Medical
ISBN : 1627035222

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The Inflammasome by Christine M. De Nardo,Eicke Latz Pdf

This Methods in Molecular Biology book offers methods for studying inflammasome function, including generation of inflammasome stimuli, monitoring of caspase-1 activity and processing, activation of IL-1β cytokines, plus lab protocols, material lists and tips.

Principles of Nutrigenetics and Nutrigenomics

Raffaele De Caterina,J. Alfredo Martinez,Martin Kohlmeier
Principles of Nutrigenetics and Nutrigenomics Book PDF

Author : Raffaele De Caterina,J. Alfredo Martinez,Martin Kohlmeier
Publisher : Academic Press
Page : 586 pages
File Size : 44,6 Mb
Release : 2019-09-22
Category : Medical
ISBN : 9780128045879

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Principles of Nutrigenetics and Nutrigenomics by Raffaele De Caterina,J. Alfredo Martinez,Martin Kohlmeier Pdf

Principles of Nutrigenetics and Nutrigenomics: Fundamentals for Individualized Nutrition is the most comprehensive foundational text on the complex topics of nutrigenetics and nutrigenomics. Edited by three leaders in the field with contributions from the most well-cited researchers conducting groundbreaking research in the field, the book covers how the genetic makeup influences the response to foods and nutrients and how nutrients affect gene expression. Principles of Nutrigenetics and Nutrigenomics: Fundamentals for Individualized Nutrition is broken into four parts providing a valuable overview of genetics, nutrigenetics, and nutrigenomics, and a conclusion that helps to translate research into practice. With an overview of the background, evidence, challenges, and opportunities in the field, readers will come away with a strong understanding of how this new science is the frontier of medical nutrition. Principles of Nutrigenetics and Nutrigenomics: Fundamentals for Individualized Nutrition is a valuable reference for students and researchers studying nutrition, genetics, medicine, and related fields. Uniquely foundational, comprehensive, and systematic approach with full evidence-based coverage of established and emerging topics in nutrigenetics and nutrigenomics Includes a valuable guide to ethics for genetic testing for nutritional advice Chapters include definitions, methods, summaries, figures, and tables to help students, researchers, and faculty grasp key concepts Companion website includes slide decks, images, questions, and other teaching and learning aids designed to facilitate communication and comprehension of the content presented in the book

Bioactive Food Components Activity in Mechanistic Approach

Cinthia Bau Betim Cazarin,Juliano Lemos Bicas,Glaucia Maria Pastore,Mario Roberto Marostica Junior
Bioactive Food Components Activity in Mechanistic Approach Book PDF

Author : Cinthia Bau Betim Cazarin,Juliano Lemos Bicas,Glaucia Maria Pastore,Mario Roberto Marostica Junior
Publisher : Academic Press
Page : 257 pages
File Size : 48,9 Mb
Release : 2021-11-22
Category : Technology & Engineering
ISBN : 9780128225905

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Bioactive Food Components Activity in Mechanistic Approach by Cinthia Bau Betim Cazarin,Juliano Lemos Bicas,Glaucia Maria Pastore,Mario Roberto Marostica Junior Pdf

Bioactive Food Components Activity in Mechanistic Approach presents the role of functional foods and bioactive compounds in inflammation. This book focuses on bioactive compounds, including phenolics, prebiotics, carotenoids, tocopherols, bioactive peptides, probiotics, polyunsaturated and monounsaturated fatty acids, and describes their actions in several diseases, mainly obesity and co-morbidities, inflammatory bowel disease, cognitive decline and cancer, and aging. Intended for food, nutrition, and nutraceutical researchers, as well as those studying related fields, the book offers a mechanistic approach that is currently lacking in the market. Explores the mechanistic approach of functional foods in health and disease Contains definitions, case studies, applications, literature reviews, recent developments and text boxes Provides coverage of phenolic compounds, prebiotics and probiotics, carotenoids, tocopherols, bioactive peptides, polyunsaturated and monounsaturated fatty acids, and sulfur compounds

Cancer Gene Therapy

David T. Curiel,Joanne T. Douglas
Cancer Gene Therapy Book PDF

Author : David T. Curiel,Joanne T. Douglas
Publisher : Springer Science & Business Media
Page : 490 pages
File Size : 44,8 Mb
Release : 2007-11-03
Category : Medical
ISBN : 9781592597857

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Cancer Gene Therapy by David T. Curiel,Joanne T. Douglas Pdf

A complete introduction and guide to the latest developments in cancer gene therapy-from bench to bedside. The authors comprehensively review the anticancer genes and gene delivery methods currently available for cancer gene therapy, including the transfer of genetic material into the cancer cells, stimulation of the immune system to recognize and eliminate cancer cells, and the targeting of the nonmalignant stromal cells that support their growth. They also thoroughly examine the advantages and limitations of the different therapies and detail strategies to overcome obstacles to their clinical implementation. Topics of special interest include vector-targeting techniques, the lessons learned to date from clinical trials of cancer gene therapy, and the regulatory guidelines for future trials. Noninvasive techniques to monitor the extent of gene transfer and disease regression during the course of treatment are also discussed.

Handbook on Immunosenescence

Tamas Fulop,Claudio Franceschi,Katsuiki Hirokawa,Graham Pawelec
Handbook on Immunosenescence Book PDF

Author : Tamas Fulop,Claudio Franceschi,Katsuiki Hirokawa,Graham Pawelec
Publisher : Springer Science & Business Media
Page : 1693 pages
File Size : 46,8 Mb
Release : 2009-02-27
Category : Medical
ISBN : 9781402090639

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Handbook on Immunosenescence by Tamas Fulop,Claudio Franceschi,Katsuiki Hirokawa,Graham Pawelec Pdf

This authoritative handbook covers all aspects of immunosenescence, with contributions from experts in the research and clinical areas. It examines methods and models for studying immunosenescence; genetics; mechanisms including receptors and signal transduction; clinical relevance in disease states including infections, autoimmunity, cancer, metabolic syndrome, neurodegenerative diseases, frailty and osteoporosis; and much more.