Drug Determination In Therapeutic And Forensic Contexts

Author : Eric Reid,Ian D. Wilson
Publisher : Springer Science & Business Media
Page : 407 pages
File Size : 41,7 Mb
Release : 2013-03-12
Category : Science
ISBN : 9781461323976

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Drug Determination in Therapeutic and Forensic Contexts by Eric Reid,Ian D. Wilson Pdf

Acknowledgements. - Valuable support for the Forum came from the Cancer Research Campaign, from Johnson Matthey & Co., and from U. K. pharmaceutical companies - Beechams, Glaxo, ICI and Smith, Kline & French. Moreover, some speakers came without full financial coverage. The choice of presentations was guided by Honorary Advisers including Drs. S.H. Curry (Chairman), J.A.F. de Silva, L.E. Martin, J. Chamberlain and G.G. Skellern. Drs. Jim Leppard and Joan Reid are thanked for Index drafting. As mentioned in the text, some Figs. have already appeared in journals, whose publishers (e.g. Elsevier, Dekker, Preston) are thanked: sources include Journal of Chroma- tography, Journal of Liquid Chromatography and Journal of Chromatographic Science, also (art. #E-S) a Wiley book edited by M. Trimble. Abbreviations.- In connection with HPLC ('LC' is a pet aver- sion) this Editor has often deplored the upstart use of 'ECD'-a term hallowed by its GC usage as in art. #F -2 later in the book. To connote 'electrochemical' the term 'EC' is now used, but 'ECD' is reserved for the electron-capture detector.Other abbreviations which, although well known, are generally defined in each article concerned include NP, normal-phase HPLC); RP, reverse(d)-phase; i.s., internal standard; MS, mass spectrometry (EI, electron-impact; CI, chemic, al-ionization); RIA, radioimmunoassay; UV, ultraviolet (usually absorbance)

Author : Joseph Chamberlain
Publisher : CRC Press
Page : 419 pages
File Size : 51,6 Mb
Release : 2018-02-06
Category : Medical
ISBN : 9781351411431

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The Analysis of Drugs in Biological Fluids by Joseph Chamberlain Pdf

This new edition focuses on a variety of techniques available for the analysis of drugs in biological fluids. Over 150 figures and tables help to describe the latest advances and give examples of their applications. Current chiral analysis methods as well as discussions on the impact of chirality are described. Practical aspects of bioanalytical work, including many examples of laboratory problems not often reported in the scientific literature, are examined in depth.

Author : Seth Kwabena Amponsah,Yashwant V. Pathak
Publisher : Springer Nature
Page : 384 pages
File Size : 46,7 Mb
Release : 2022-10-25
Category : Medical
ISBN : 9783031123986

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Recent Advances in Therapeutic Drug Monitoring and Clinical Toxicology by Seth Kwabena Amponsah,Yashwant V. Pathak Pdf

This book gives an overview of therapeutic drug monitoring (TDM) and its clinical application. It also highlights recent advances in toxicological studies, as they relate to therapeutic drug monitoring. This is one of the few books available on the market that covers TDM. Therapeutic drug monitoring (TDM) is a clinical decision-making tool that enables dosage regimen adjustments based on clinical and laboratory measurements. TDM not only involves the measuring of drug concentrations but also interpretation of the results. There is a strong correlation between drug concentrations in body fluids and outcome than between dose and outcome. The chapters include coverage of analytical techniques, pharmacokinetics, therapeutic indices, artificial intelligence and recent advances in toxicological studies. The book fills a gap in published literature and provides reliable information on; Analytical techniques in TDM and clinical toxicology TDM and pharmacokinetic studies TDM of drugs with narrow therapeutic indices Artificial intelligence in TDM and clinical toxicology Future directions and challenges

Author : Robert J Flanagan,David Perrett,Robin Whelpton
Publisher : Royal Society of Chemistry
Page : 244 pages
File Size : 42,8 Mb
Release : 2007-10-31
Category : Science
ISBN : 9781847550729

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Electrochemical Detection in HPLC by Robert J Flanagan,David Perrett,Robin Whelpton Pdf

Electrochemical Detection in HPLC: Analysis of Drugs and Poisons is the first monograph devoted to the application of this mode of analysis to the assay of exogenous compounds such as drugs in biological fluids and associated areas. The introductory chapters provide information on basic electrochemistry and HPLC-ED, and on trouble-shooting. The specialized area of thiol analysis is also discussed in detail. Salient practical details of published applications of the technique in analytical toxicology and related areas are provided in a standard format. Alternative techniques are suggested throughout. The emphasis is on the analysis of exogenous compounds, although catecholamines and other endogenous species are discussed in so far as they may be used as drugs. The practical nature of this book will make it useful to professionals working in the field. It will also be of benefit to analysts wishing to use HPLC-ED in the analysis of biological samples for analytes not specifically covered in the volume.

Author : Nicholas T. Lappas,Courtney M. Lappas
Publisher : Academic Press
Page : 545 pages
File Size : 42,9 Mb
Release : 2021-10-22
Category : Medical
ISBN : 9780128192870

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Forensic Toxicology by Nicholas T. Lappas,Courtney M. Lappas Pdf

The second edition of Forensic Toxicology: Principles and Concepts takes the reader back to the origins of forensic toxicology providing an overview of the largely unchanging principles of the discipline. The text focuses on the major tenets in forensic toxicology, including an introduction to the discipline, principles of forensic toxicology including pharmacokinetics, pharmacodynamics, drug interactions and toxicogenomics, fundamentals of forensic toxicology analysis, types of interpretations based on analytical forensic toxicology results, and reporting from the laboratory to the courtroom. Also included in the second edition is a Unit focused on the forensic toxicology of individual drugs of abuse. Includes significant emphasis on the fundamental principles and concepts of forensic toxicology Provides students with an introduction to the core tenets of the discipline, focusing on the concepts, strategies, and methodologies utilized by professionals in the field Coauthored by a forensic toxicologist with over 40 years of experience as a professor who has taught graduate courses in forensic and analytical toxicology and who has served as a consultant and expert witness in civil and criminal cases

Author : Eric Reid,Ian D. Wilson,J.D. Robinson
Publisher : Springer Science & Business Media
Page : 389 pages
File Size : 45,6 Mb
Release : 2013-11-21
Category : Science
ISBN : 9781475794243

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Bioanalysis of Drugs and Metabolites, Especially Anti-Inflammatory and Cardiovascular by Eric Reid,Ian D. Wilson,J.D. Robinson Pdf

vi as did non-appreciation that % values for bought-in solutions (notably ammonia) may be on a weight basis, not made evident by the manufacturer. Notwithstanding the shortcomings or lateness of some texts, authors are thanked for compiling them amidst other pressures. Elsevier and the American Chemical Society are also thanked, for Figures now reproduced with source acknowledgement. This Editor has generally respected authors' phrasing, whilst shuddering when the term 'incubate' is encountered in a 0° context. He remains a 'diehard' in certain respects, notably in favouring 'M' rather than 'mol/I', and a wt./ml basis for drug concentrations in test samples; he regards 'mmol/l' as a fatuous fashion. Concerning infelicitous abbreviations, a distinction is made between electron capture (detector context; 'ECD') and electrochemical ('EC', never 'ECD'); the hallowed GC term 'FID' means free induction decay to NMR practi tione:ts, who may pardon the term 'Fid' as introduced editorially. The convention for ,0C' throughout the book is '0'. Undefined but well-known abbreviations include GC, HPLC and TLC. MS (mass spectrometry), NPD (nitrogen-phosphorus detector), tr (retention time) and RIA (radioimmunoassay) are usually defined in the article concerned, as are the HPLC modes NP (normal-/straight phase) and RP (reversed-phase; C-lS and ODS are synonymous), and i.s.

Author : E. Reid,Bryan Scales,I.D. Wilson
Publisher : Springer Science & Business Media
Page : 411 pages
File Size : 43,5 Mb
Release : 2013-11-21
Category : Technology & Engineering
ISBN : 9781475718928

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BIOACTIVE ANALYTES, Including CNS Drugs, Peptides, and Enantiomers by E. Reid,Bryan Scales,I.D. Wilson Pdf

Author : J. Descotes
Publisher : Elsevier
Page : 839 pages
File Size : 50,6 Mb
Release : 1996-09-02
Category : Medical
ISBN : 0080534228

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Human Toxicology by J. Descotes Pdf

This excellent volume was designed and edited with two major ideas in mind: firstly, the field of clinical toxicology is changing and an acknowledgement of these changes is warranted; secondly, no comprehensive compilation of recently published case reports of, and clinical studies on, human poisonings is available, which is in sharp contrast to the closely related field of drug-induced side-effects. The book focusses on issues of recent concern, or issues poorly documented in the past. It is important that clinical toxicologists gain a better knowledge of all the available techniques of toxicological analysis. A better understanding of the way a sound interpretation of results should be conducted for the benefit of the patient's management, and a comprehensive set of data on the kinetics of the most common pharmaceutical drugs and many chemicals is required. Human Toxicology is a timely reference work which will be welcomed by a broad audience of toxicology professionals.

Author : Anonim
Publisher : Springer Science & Business Media
Page : 130 pages
File Size : 45,8 Mb
Release : 2012-12-06
Category : Science
ISBN : 9783642730580

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Forensic Science Progress by Anonim Pdf

Competitive binding techniques such as radioimmunoassay (RIA) are widely used to measure an enormous variety of compounds in biological fluids. Current methods have 1 2 arisen from the pioneering work ofYalow and Berson in the U. S. A. and Ekins in the u. K. Much of the early development was concerned with the analysis of protein hormones, and nearly a decade passed before attention focussed also on small molecules such as steroids and drugs. The potential of immunoassay methods for drug monitoring in clinical and forensic laboratories and in addict treatment programmes resulted in the commercial production of immunoassays for various therapeutic and abused drugs, making the technique available to laboratories lacking the facilities to raise their own antisera and synthesise labelled compounds. However, commercial assays are not only expensive but are restricted in range, and so it is advantageous for a forensic laboratory to have the capability to devise "in-house" immunoassays suited to its particular requirements. This chapter describes the theory and practice of RIA in forensic drug analysis. Much of the theory and some of the practice are applicable to immunoassays in which non isotopic labels are used, but such assays are not described in detail since, to date, the versatility and sensitivity of RIA have made it the immunoassay technique of choice in forensic toxicology. The particular advantages of RIA are its sensitivity and the fact that samples such as haemolysed blood can be assayed with little or no prior preparation.

Author : Anonim
Publisher : Elsevier
Page : 442 pages
File Size : 49,7 Mb
Release : 2003-09-03
Category : Science
ISBN : 0080527868

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Bioanalytical Separations by Anonim Pdf

Bioanalytical Separations is volume 4 of the multi-volume series, Handbook of Analytical Separations, providing reviews of analytical separation methods and techniques used for the determination of analytes across a whole range of applications. The theme for this volume is bioanalysis, in this case specifically meaning the analysis of drugs and their metabolites in biological fluids. - Discusses new developments in instrumentation and methods of analyzing drugs and their metabolites in biological fluids - Provides guidance to the different methods, their relative value to the user, and the advantages and pitfalls of their use - Future trends are identified, in terms of the potential impact of new technologies

Author : E. Reid,G.M.W. Cooke,J.P. Luzio
Publisher : Springer Science & Business Media
Page : 484 pages
File Size : 48,7 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781468412833

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Cells, Membranes, and Disease, Including Renal by E. Reid,G.M.W. Cooke,J.P. Luzio Pdf

Author : Nicholas J. Kozel,Mario De la Rosa,Zili Sloboda,National Institute on Drug Abuse
Publisher : Unknown
Page : 328 pages
File Size : 47,6 Mb
Release : 1995
Category : Aerosol sniffing
ISBN : UOM:39015050822348

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Epidemiology of Inhalant Abuse by Nicholas J. Kozel,Mario De la Rosa,Zili Sloboda,National Institute on Drug Abuse Pdf

Author : Anonim
Publisher : Unknown
Page : 336 pages
File Size : 50,7 Mb
Release : 1976
Category : Drug abuse
ISBN : COLUMBIA:HR01752308

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NIDA Research Monograph by Anonim Pdf

Author : Anonim
Publisher : Unknown
Page : 332 pages
File Size : 45,6 Mb
Release : 1995
Category : Aerosol sniffing
ISBN : IND:30000130069143

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Epidemiology of Inhalant Abuse by Anonim Pdf

Author : Eric Reid,G.M.W. Cook,D.J. Morre
Publisher : Springer Science & Business Media
Page : 359 pages
File Size : 43,5 Mb
Release : 2013-03-09
Category : Science
ISBN : 9781468450064

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Investigation and Exploitation of Antibody Combining Sites by Eric Reid,G.M.W. Cook,D.J. Morre Pdf