Drug Discovery From Natural Products

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Natural Products and Drug Discovery

Subhash C. Mandal,Vivekananda Mandal,Tetsuya Konishi
Natural Products and Drug Discovery Book PDF

Author : Subhash C. Mandal,Vivekananda Mandal,Tetsuya Konishi
Publisher : Elsevier
Page : 776 pages
File Size : 40,5 Mb
Release : 2018-02-16
Category : Science
ISBN : 9780081021040

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Natural Products and Drug Discovery by Subhash C. Mandal,Vivekananda Mandal,Tetsuya Konishi Pdf

Natural Products and Drug Discovery: An Integrated Approach provides an applied overview of the field, from traditional medicinal targets, to cutting-edge molecular techniques. Natural products have always been of key importance to drug discovery, but as modern techniques and technologies have allowed researchers to identify, isolate, extract and synthesize their active compounds in new ways, they are once again coming to the forefront of drug discovery. Combining the potential of traditional medicine with the refinement of modern chemical technology, the use of natural products as the basis for drugs can help in the development of more environmentally sound, economical, and effective drug discovery processes. Natural Products & Drug Discovery: An Integrated Approach reflects on the current changes in this field, giving context to the current shift and using supportive case studies to highlight the challenges and successes faced by researchers in integrating traditional medicinal sources with modern chemical technologies. It therefore acts as a useful reference to medicinal chemists, phytochemists, biochemists, pharma R&D professionals, and drug discovery students and researchers. Reviews the changing role of natural products in drug discovery, integrating traditional knowledge with modern molecular technologies Highlights the potential future role of natural products in preventative medicine Supported by real world case studies throughout

Natural Products

Lixin Zhang,Arnold L. Demain
Natural Products Book PDF

Author : Lixin Zhang,Arnold L. Demain
Publisher : Springer Science & Business Media
Page : 380 pages
File Size : 54,7 Mb
Release : 2007-11-17
Category : Medical
ISBN : 9781592599769

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Natural Products by Lixin Zhang,Arnold L. Demain Pdf

A fresh examination of the past successes of natural products as medicines and their new future from both conventional and new technologies. High-performance liquid chromatography profiling, combinatorial synthesis, genomics, proteomics, DNA shuffling, bioinformatics, and genetic manipulation all now make it possible to rapidly evaluate the activities of extracts as well as purified components derived from microbes, plants, and marine organisms. The authors apply these methods to new natural product drug discoveries, to microbial diversity, to specific groups of products (Chinese herbal drugs, antitumor drugs from microbes and plants, terpenoids, and arsenic compounds), and to specific sources (the sea, rainforest, and endophytes). These new opportunities show how research and development trends in the pharmaceutical industry can advance to include both synthetic compounds and natural products, and how this paradigm shift can be more productive and efficacious.

Drug Discovery from Natural Products

Olga Genilloud,Francisca Vicente
Drug Discovery from Natural Products Book PDF

Author : Olga Genilloud,Francisca Vicente
Publisher : Royal Society of Chemistry
Page : 435 pages
File Size : 54,7 Mb
Release : 2012
Category : Medical
ISBN : 9781849733618

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Drug Discovery from Natural Products by Olga Genilloud,Francisca Vicente Pdf

An integrated review of the most recent trends in natural products, drug discovery, and key lead candidates that are outstanding for their chemistry and biology in novel drug development.

Natural Products and Drug Discovery

Pinarosa Avato
Natural Products and Drug Discovery Book PDF

Author : Pinarosa Avato
Publisher : MDPI
Page : 392 pages
File Size : 51,5 Mb
Release : 2020-04-22
Category : Medical
ISBN : 9783039287468

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Natural Products and Drug Discovery by Pinarosa Avato Pdf

Natural products hold a prominent position in the current discovery and development of drugs and have diverse indications for both human and animal health. Plants, in particular, play a leading role as a source of specialized metabolites with medical effects. Other organisms, such as marine and terrestrial animals and microorganisms, produce very important drug candidate molecules. Specialized metabolites from these varied natural sources can be used directly as bioactive compounds or drug precursors. In addition, due to their broad chemical diversity, they can act as drug prototypes and/or be used as pharmacological tools for different targets. Some examples of natural metabolites that have been developed into useful medical drug are cardiotonic digoxin from Digitalis sp., antimalarial artemisinin from Artemisia annua, anti-cancer taxol from Taxus sp., or podophyllotoxin from Podophyllum peltatum, which served as a synthetic model for the anti-cancer etoposide. The study of natural products is still attracting great scientific attention and their current importance, as a valuable lead for drug discovery, is undebatable. I cordially invite authors to contribute original articles, as well as survey articles, that give the readers of Molecules **MOLECULES NEEDS TO BE ITALICIZED** updated and new perspectives on natural products in drug discovery, including but not limited to natural sources, identification and separation of bioactive phytochemicals, standardization, new biological targets, pre-clinical and clinical trials, pharmacological effects/side effects, and bioassays.

The Role of Natural Products in Drug Discovery

J. Mulzer,R. Bohlmann
The Role of Natural Products in Drug Discovery Book PDF

Author : J. Mulzer,R. Bohlmann
Publisher : Springer Science & Business Media
Page : 363 pages
File Size : 50,8 Mb
Release : 2013-04-17
Category : Medical
ISBN : 9783662040423

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The Role of Natural Products in Drug Discovery by J. Mulzer,R. Bohlmann Pdf

Natural Products have been important sources of useful drugs from prehistoric times to the present. This book gives an overview about this field and provides important recent contributions to the discovery of new drugs generated by research on natural products. Total synthesis of natural products with interesting biological activities is paving the way for the preparation of new and improved analogs. The methods of combinatorial chemistry permit the selection of the best drug from a large number of candidates. Beyond synthesis and evaluation of organic molecules a number of new bioorganic methods are coming to the fore and will be discucced in this isue of the ERnst schering Research Foundation workshop proceedings.

Discovery and Development of Antidiabetic Agents from Natural Products

Goutam Brahmachari
Discovery and Development of Antidiabetic Agents from Natural Products Book PDF

Author : Goutam Brahmachari
Publisher : Elsevier
Page : 332 pages
File Size : 46,5 Mb
Release : 2016-10-11
Category : Science
ISBN : 9780128096925

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Discovery and Development of Antidiabetic Agents from Natural Products by Goutam Brahmachari Pdf

Discovery and Development of Antidiabetic Agents from Natural Products brings together global research on the medicinal chemistry of active agents from natural sources for the prevention and treatment of diabetes and associated disorders. From the identification of promising leads, to the extraction and synthesis of bioactive molecules, this book explores a range of important topics to support chemists in the discovery and development of safer, more economical therapeutics that are desperately needed in response to this emerging global epidemic. Beginning with an overview of bioactive chemical compounds from plants with anti-diabetic properties, the book goes on to outline the identification and extraction of anti-diabetic agents and antioxidants from natural sources. It then explores anti-diabetic plants from specific regions before looking more closely at the background, isolation, and synthesis of key therapeutic compounds and their derivatives, including Mangiferin, Resveratrol, natural saponins, and alpha-glucosidase enzyme inhibitors. The book concludes with a consideration of current and potential future applications. Combining the expertise of specialists from around the world, this volume aims to support and encourage medicinal chemists investigating natural sources as starting points for the development of standardized, safe, and effective antidiabetic therapeutics. Contains chapters written by active researchers and leading global experts who are deeply engaged in the research field of natural product chemistry for drug discovery Provides comprehensive coverage of cutting-edge research advances in the design of medicinal natural products with potential as preventives and therapeutics for diabetes and related metabolic issues Presents a practical review of the identification, isolation, and extraction techniques that help support medicinal chemists in the lab

Drug Discovery and Development

Ramarao Poduri
Drug Discovery and Development Book PDF

Author : Ramarao Poduri
Publisher : Springer Nature
Page : 522 pages
File Size : 41,6 Mb
Release : 2021-02-15
Category : Medical
ISBN : 9789811555343

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Drug Discovery and Development by Ramarao Poduri Pdf

This book describes the processes that are involved in the development of new drugs. The authors discuss the history, role of natural products and concept of receptor interactions with regard to the initial stages of drug discovery. In a single, highly readable volume, it outlines the basics of pharmacological screening, drug target identification, and genetics involved in early drug discovery. The final chapters introduce readers to stem therapeutics, pharmacokinetics, pharmacovigilance, and toxicological testing. Given its scope, the book will enable research scholars, professionals and young scientists to understand the key fundamentals of drug discovery, including stereochemistry, pharmacokinetics, clinical trials, statistics and toxicology.

Bioactive Natural products in Drug Discovery

Joginder Singh,Vineet Meshram,Mahiti Gupta
Bioactive Natural products in Drug Discovery Book PDF

Author : Joginder Singh,Vineet Meshram,Mahiti Gupta
Publisher : Springer Nature
Page : 733 pages
File Size : 44,5 Mb
Release : 2020-04-30
Category : Medical
ISBN : 9789811513947

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Bioactive Natural products in Drug Discovery by Joginder Singh,Vineet Meshram,Mahiti Gupta Pdf

This book highlights different natural products that are derived from the plants and microbes that have shown potential as the lead compounds against infectious diseases and cancer. Natural products represent an untapped source of strikingly diverse chemotypes with novel mechanisms of action and the potential to serve as anticancer and anti-infective agents. The book discusses a range of biotechnologically valuable bioactive compounds and secondary metabolites that have been derived from plant and microorganisms from various ecological niches. It also reviews the latest developments in the field of genomics, bioinformatics and industrial fermentation for harnessing the microbial products for commercial applications. In turn, the book’s closing section reviews important biotechnological applications of various natural products. Combining the expertise of specialists in this field, the book’s goal is to promote the further investigation of natural sources for the development of standardized, safe and effective therapies.

Drug Discovery in Africa

Kelly Chibale,Mike Davies-Coleman,Collen Masimirembwa
Drug Discovery in Africa Book PDF

Author : Kelly Chibale,Mike Davies-Coleman,Collen Masimirembwa
Publisher : Springer Science & Business Media
Page : 453 pages
File Size : 48,8 Mb
Release : 2012-08-09
Category : Science
ISBN : 9783642281754

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Drug Discovery in Africa by Kelly Chibale,Mike Davies-Coleman,Collen Masimirembwa Pdf

Drug discovery originating in Africa has the potential to provide significantly improved treatment of endemic diseases such as malaria, tuberculosis and HIV/AIDS. This book critically reviews the current status of drug discovery research and development in Africa, for diseases that are a major threat to the health of people living in Africa. Compiled by leading African and international experts, this book presents the science and strategies of modern drug discovery. It explores how the use of natural products and traditional medicines can benefit from conventional drug discovery approaches, and proposes solutions to current technological, infrastructural, human resources, and economic challenges, which are presented when attempting to engage in full-scale drug discovery. Topics addressed are varied; from African medicinal plants to marine bioprospecting, pharmacogenetics and the use of nanotechnology. This book brings together for the first time a collection of strategies and techniques that need to be considered when developing drugs in an African setting. It is an unprecedented and truly international effort, highlighting the remarkable effort made so far in the area of drug discovery research by African scientists, and scientists from other parts of the world working on African health problems.

Lead Molecules from Natural Products

Anonim
Lead Molecules from Natural Products Book PDF

Author : Anonim
Publisher : Elsevier
Page : 448 pages
File Size : 46,7 Mb
Release : 2006-07-07
Category : Science
ISBN : 0080459331

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Lead Molecules from Natural Products by Anonim Pdf

Lead Molecules from Natural Products: Discovery and New Trends provides the reader with a thorough overview of current discoveries and trends in Natural Products research. This book consists of 22 chapters from well known scientists all over the world, with topics ranging from Natural Product Chemistry and Phytochemistry in their most basic form, to Molecular Biology and in silico drug design. Contributors describe their own laboratory experiences, revealing their findings, the legal issues encountered. The chapters, all of equally high quality, summarize years of extensive research in each area, and provide insight in the new themes of natural product research. The information will help to predict promising leads, useful for physicians in the treatment of different diseases and disease manifestations. * Explains the effects of plant extracts on gene expression profiling. * Details medicinal plant research from around the world * Explores a variety of medicinal uses of plants from traditional remedies, to anti-cancer agents and anti-salmonella agents.

Natural Products in Clinical Trials

Atta-ur- Rahman,Shazia Anjum,Hesham El-Seedi
Natural Products in Clinical Trials Book PDF

Author : Atta-ur- Rahman,Shazia Anjum,Hesham El-Seedi
Publisher : Bentham Science Publishers
Page : 253 pages
File Size : 52,9 Mb
Release : 2018-03-03
Category : Medical
ISBN : 9781681082134

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Natural Products in Clinical Trials by Atta-ur- Rahman,Shazia Anjum,Hesham El-Seedi Pdf

Natural products continue to play a key role in drug development. A recent analysis of the drug market in the developed world revealed that 40% of total clinically approved drugs were either unmodified natural products or their semi-synthetic derivatives. This book series focuses on reviews of exciting new bioactive natural products that have huge potential as drugs. It highlights the everlasting importance of natural products in our lives. Each volume brings reviews contributed by eminent scientists in the field. The first volume covers the following topics: - bioactive compounds from marine invertebrates - natural product derived drugs for immunological and inflammatory diseases - clinical trials of curcumin, camptothecin, astaxanthin, and biochanin - antibacterial and antifungal drugs from natural sources - natural products as anti-HIV medicines.

Natural Product Chemistry for Drug Discovery

Antony D. Buss,Mark S. Butler
Natural Product Chemistry for Drug Discovery Book PDF

Author : Antony D. Buss,Mark S. Butler
Publisher : Royal Society of Chemistry
Page : 459 pages
File Size : 42,7 Mb
Release : 2010
Category : Medical
ISBN : 9780854041930

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Natural Product Chemistry for Drug Discovery by Antony D. Buss,Mark S. Butler Pdf

This text provides a comprehensive summary of where natural product chemistry is today in drug discovery. It covers emerging technologies and case studies and is a source of up-to-date information on the topical subject of natural products.

Pharmacognosy

Shagufta Perveen,Areej Al-Taweel
Pharmacognosy Book PDF

Author : Shagufta Perveen,Areej Al-Taweel
Publisher : BoD – Books on Demand
Page : 322 pages
File Size : 54,6 Mb
Release : 2019-06-19
Category : Medical
ISBN : 9781838806101

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Pharmacognosy by Shagufta Perveen,Areej Al-Taweel Pdf

Pharmacognosy is a term derived from the Greek words for drug (pharmakon) and knowledge (gnosis). It is a field of study within Chemistry focused on natural products isolated from different sources and their biological activities. Research on natural products began more than a hundred years ago and has continued up to now with a plethora of research groups discovering new ideas and novel active constituents. This book compiles the latest research in the field and will be of interest to scientists, researchers, and students.

Discovery and Development of Neuroprotective Agents from Natural Products

Goutam Brahmachari
Discovery and Development of Neuroprotective Agents from Natural Products Book PDF

Author : Goutam Brahmachari
Publisher : Elsevier
Page : 490 pages
File Size : 55,7 Mb
Release : 2017-05-18
Category : Science
ISBN : 9780128097694

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Discovery and Development of Neuroprotective Agents from Natural Products by Goutam Brahmachari Pdf

Discovery and Development of Neuroprotective Agents from Natural Products draws together global research on medicinal agents from natural sources as starting points for the design of neuroprotective drugs. From the prediction of promising leads and identification of active agents to the extraction of complex molecules, the book explores a range of important topics to support the development of safer, more economical therapeutics for these increasingly prevalent diseases. Beginning with an overview of current developments in the field, the book goes on to explore the identification, extraction and phytochemistry of such neuroprotective agents as antioxidants, biophenols and naturally occurring anti-inflammatory steroid analogues. Specific natural sources of bioactive agents are reviewed, and the development of these agents into therapeutics for a number of specific neurological disorders, including Alzheimer’s disease, Parkinson’s disease and ischemic brain stroke, are discussed. Combining the expertise of specialists from around the world, this in the Natural Products Drug Discovery series aims to support and encourage researchers in the investigation of natural sources as starting points for the development of standardized, safe and effective neuroprotective drugs. Features chapters written by active researchers and leading global experts deeply engaged in the research field of natural product chemistry for drug discovery Includes comprehensive coverage of cutting-edge research advances in the design of drugs from natural products targeted at different kinds of neurodegenerative diseases Offers a practical review of identification, isolation and extraction techniques to support medicinal chemists in the lab

Drug Discovery from Nature

S. Grabley,R. Thiericke
Drug Discovery from Nature Book PDF

Author : S. Grabley,R. Thiericke
Publisher : Springer Science & Business Media
Page : 380 pages
File Size : 49,8 Mb
Release : 1998-11-26
Category : Medical
ISBN : 3540648445

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Drug Discovery from Nature by S. Grabley,R. Thiericke Pdf

This book is unique in covering the present status and future potential of natural products in drug discovery. It provides readers with recent information regarding the impact on drug discovery, development and strategies, technical and automation aspects, and methods based on biochemistry as well as molecular biology, highlighting compounds from natural sources. Special emphasis is placed on the various strategies to gain access to natural compounds and combinatorial approaches by making use of both synthetic and biological methods.