Drug Discovery In Africa

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Drug Discovery in Africa

Kelly Chibale,Mike Davies-Coleman,Collen Masimirembwa
Drug Discovery in Africa Book PDF

Author : Kelly Chibale,Mike Davies-Coleman,Collen Masimirembwa
Publisher : Springer Science & Business Media
Page : 453 pages
File Size : 41,9 Mb
Release : 2012-08-09
Category : Science
ISBN : 9783642281754

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Drug Discovery in Africa by Kelly Chibale,Mike Davies-Coleman,Collen Masimirembwa Pdf

Drug discovery originating in Africa has the potential to provide significantly improved treatment of endemic diseases such as malaria, tuberculosis and HIV/AIDS. This book critically reviews the current status of drug discovery research and development in Africa, for diseases that are a major threat to the health of people living in Africa. Compiled by leading African and international experts, this book presents the science and strategies of modern drug discovery. It explores how the use of natural products and traditional medicines can benefit from conventional drug discovery approaches, and proposes solutions to current technological, infrastructural, human resources, and economic challenges, which are presented when attempting to engage in full-scale drug discovery. Topics addressed are varied; from African medicinal plants to marine bioprospecting, pharmacogenetics and the use of nanotechnology. This book brings together for the first time a collection of strategies and techniques that need to be considered when developing drugs in an African setting. It is an unprecedented and truly international effort, highlighting the remarkable effort made so far in the area of drug discovery research by African scientists, and scientists from other parts of the world working on African health problems.

Synthesizing Hope

Anne Pollock
Synthesizing Hope Book PDF

Author : Anne Pollock
Publisher : University of Chicago Press
Page : 198 pages
File Size : 44,7 Mb
Release : 2019-05-08
Category : Medical
ISBN : 9780226629186

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Synthesizing Hope by Anne Pollock Pdf

Synthesizing Hope opens up the material and social world of pharmaceuticals by focusing on an unexpected place: iThemba Pharmaceuticals. Founded in 2009 with a name taken from the Zulu word for hope, the small South African startup with an elite international scientific board was tasked with drug discovery for tuberculosis, HIV, and malaria. Anne Pollock uses this company as an entry point for exploring how the location of scientific knowledge production matters, not only for the raw materials, manufacture, licensing, and distribution of pharmaceuticals but also for the making of basic scientific knowledge. Consideration of this case exposes the limitations of global health frameworks that implicitly posit rich countries as the only sites of knowledge production. Analysis of iThemba identifies the problems inherent in global north/south divides at the same time as it highlights what is at stake in who makes knowledge and where. It also provides a concrete example for consideration of the contexts and practices of postcolonial science, its constraints, and its promise. Synthesizing Hope explores the many legacies that create conditions of possibility for South African drug discovery, especially the specific form of settler colonialism characterized by apartheid and resource extraction. Paying attention to the infrastructures and laboratory processes of drug discovery underscores the materiality of pharmaceuticals from the perspective of their makers, and tracing the intellectual and material infrastructures of South African drug discovery contributes new insights about larger social, political, and economic orders.

Synthesizing Hope

Anne Pollock
Synthesizing Hope Book PDF

Author : Anne Pollock
Publisher : University of Chicago Press
Page : 198 pages
File Size : 49,9 Mb
Release : 2019-05-08
Category : Medical
ISBN : 9780226629216

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Synthesizing Hope by Anne Pollock Pdf

Synthesizing Hope opens up the material and social world of pharmaceuticals by focusing on an unexpected place: iThemba Pharmaceuticals. Founded in 2009 with a name taken from the Zulu word for hope, the small South African startup with an elite international scientific board was tasked with drug discovery for tuberculosis, HIV, and malaria. Anne Pollock uses this company as an entry point for exploring how the location of scientific knowledge production matters, not only for the raw materials, manufacture, licensing, and distribution of pharmaceuticals but also for the making of basic scientific knowledge. Consideration of this case exposes the limitations of global health frameworks that implicitly posit rich countries as the only sites of knowledge production. Analysis of iThemba identifies the problems inherent in global north/south divides at the same time as it highlights what is at stake in who makes knowledge and where. It also provides a concrete example for consideration of the contexts and practices of postcolonial science, its constraints, and its promise. Synthesizing Hope explores the many legacies that create conditions of possibility for South African drug discovery, especially the specific form of settler colonialism characterized by apartheid and resource extraction. Paying attention to the infrastructures and laboratory processes of drug discovery underscores the materiality of pharmaceuticals from the perspective of their makers, and tracing the intellectual and material infrastructures of South African drug discovery contributes new insights about larger social, political, and economic orders.

Ethnomedicine and Drug Discovery

M.M. Iwu,J. Wootton
Ethnomedicine and Drug Discovery Book PDF

Author : M.M. Iwu,J. Wootton
Publisher : Elsevier
Page : 344 pages
File Size : 46,7 Mb
Release : 2002-03-01
Category : Medical
ISBN : 0080531253

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Ethnomedicine and Drug Discovery by M.M. Iwu,J. Wootton Pdf

The emergence of new infectious, chronic and drug resistant diseases have prompted scientists to look towards medicinal plants as agents for treatment and prevention. This book provides an interphase between ethnomedical and ethnobotanical approaches to new drug discovery and advances in biotechnology and molecular science that has made it increasingly feasible to transform traditional medicines into modern drugs. These novel approaches also raise new issues and the volume explores economic, ethical and policy considerations of drug development based on indigenous knowledge or traditional medicine. This work also features standardization and development of phytomedicines for major therapeutic indications, including emerging infectious diseases affecting developing and developed countries. The publication provides state-of-the-art information on the most innovative science, the research, the industry, the market, and the future of ethnomedicine and drug discovery.

The Emerging Threat of Drug-Resistant Tuberculosis in Southern Africa

Academy of Science of South Africa,Institute of Medicine,Board on Health Sciences Policy,Forum on Drug Discovery, Development, and Translation
The Emerging Threat of Drug Resistant Tuberculosis in Southern Africa Book PDF

Author : Academy of Science of South Africa,Institute of Medicine,Board on Health Sciences Policy,Forum on Drug Discovery, Development, and Translation
Publisher : National Academies Press
Page : 146 pages
File Size : 50,8 Mb
Release : 2011-03-22
Category : Medical
ISBN : 9780309211604

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The Emerging Threat of Drug-Resistant Tuberculosis in Southern Africa by Academy of Science of South Africa,Institute of Medicine,Board on Health Sciences Policy,Forum on Drug Discovery, Development, and Translation Pdf

Tuberculosis (TB) kills approximately 4,500 people worldwide every day. While most cases of TB can be treated with antibiotics, some strains have developed drug resistance that makes their treatment more expensive, more toxic and less effective for the patient. The IOM Forum on Drug Discovery, Development, and Translation and the Academy of Science of South Africa held a workshop to discuss ways to fight the growing threat of drug-resistant TB.

Drug Discovery from African Medicinal Plants

Fidele Ntie-Kang
Drug Discovery from African Medicinal Plants Book PDF

Author : Fidele Ntie-Kang
Publisher : Unknown
Page : 0 pages
File Size : 44,7 Mb
Release : 2021*
Category : Electronic
ISBN : OCLC:1241683743

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Drug Discovery from African Medicinal Plants by Fidele Ntie-Kang Pdf

African flora, compound libraries, docking, in silico, lead compounds, natural product database, pharmacophore, QSAR, virtual screening.

Neglected Tropical Diseases and Phytochemicals in Drug Discovery

Chukwuebuka Egbuna,Muhammad Akram,Jonathan Chinenye Ifemeje
Neglected Tropical Diseases and Phytochemicals in Drug Discovery Book PDF

Author : Chukwuebuka Egbuna,Muhammad Akram,Jonathan Chinenye Ifemeje
Publisher : John Wiley & Sons
Page : 628 pages
File Size : 52,6 Mb
Release : 2021-11-09
Category : Science
ISBN : 9781119616603

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Neglected Tropical Diseases and Phytochemicals in Drug Discovery by Chukwuebuka Egbuna,Muhammad Akram,Jonathan Chinenye Ifemeje Pdf

NEGLECTED TROPICAL DISEASES AND PHYTOCHEMICALS IN DRUG DISCOVERY Explore novel drug discovery updates from medicinal plants to help fight the devastating effects of neglected tropical diseases Neglected Tropical Diseases and Phytochemicals in Drug Discovery delivers a comprehensive exploration of the drug discovery process as it pertains to neglected tropical diseases. The book covers recent advancements in drug discovery, as well as druggable targets and new challenges facing the industry. It offers readers expansive discussions of specific diseases, including protozoan, helminth, bacterial, viral, fungal, and ectoparasitic infections. This book provides readers with insightful perspectives from leading industry voices on fifty years of trends and progress in the search for new, safe, and affordable therapeutic drugs in the fight against neglected tropical diseases. It includes information beneficial to researchers in a variety of fields of biology, chemistry, medicine, and pharmaceuticals. The distinguished authors cover topics including the effects of phytochemicals on the causative agent of leprosy and the potential applicability of phytochemicals in the management of Dengue fever. Readers will also enjoy the inclusion of: Thorough introductions to neglected tropical diseases, phytochemicals, protein targets, and mechanisms in drug discovery, as well as the epidemiology of neglected tropical diseases An exploration of novel bioactive lead compounds for drug discovery against neglected tropical diseases, leishmaniasis, lymphatic filariasis, trypanosomiasis, and schistosomiasis Discussions of protozoan infections, including herbal, nutritional, and traditional remedies for giardiasis and the anti-leishmanial potentials of phytochemicals Examinations of helminth infections, including the prospects of phytochemicals in the treatment of helminthiasis Perfect for medicinal chemists, drug developers, and research and development scientists, Neglected Tropical Diseases and Phytochemicals in Drug Discovery will also earn a place in the libraries of toxicologists and researchers in biology, chemistry, medicinal chemistry, ethnobotany, and bioinformatics seeking a one-stop resource for drug discovery for neglected tropical diseases.

Social and Technological Innovation in Africa

Solomon Nwaka
Social and Technological Innovation in Africa Book PDF

Author : Solomon Nwaka
Publisher : Springer Nature
Page : 207 pages
File Size : 46,9 Mb
Release : 2021-07-16
Category : Social Science
ISBN : 9789811601552

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Social and Technological Innovation in Africa by Solomon Nwaka Pdf

This book examines the landscape of sustained investment in research and innovation in Africa, which are critical for development. This cutting-edge analysis is based on empirical evidence and the author’s experience in managing health and related innovations on the continent and globally. It concludes, for the first time, that African innovation is largely driven by the principles of Social, rather than Technological innovation. The significance of this finding and the need to optimize, scale and sustain this dominant innovation is addressed in various chapters that analyze the status, challenges and opportunities. Particularly, the financing, collaboration and coordination patterns for these activities on the continent show a fragmented ecosystem that is largely dependent on external donors and aid. The importance of supportive policies, leadership and venture mechanisms that incentivizes public and private entities to innovate is further exemplified by the lessons of the COVID-19 pandemic. The book proposes mechanism to address identified challenges.

Toxicological Survey of African Medicinal Plants

Victor Kuete
Toxicological Survey of African Medicinal Plants Book PDF

Author : Victor Kuete
Publisher : Elsevier
Page : 744 pages
File Size : 51,6 Mb
Release : 2014-05-30
Category : Medical
ISBN : 9780128004753

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Toxicological Survey of African Medicinal Plants by Victor Kuete Pdf

Toxicological Survey of African Medicinal Plants provides a detailed overview of toxicological studies relating to traditionally used medicinal plants in Africa, with special emphasis on the methodologies and tools used for data collection and interpretation. The book considers the physical parameters of these plants and their effect upon various areas of the body and human health, including chapters dedicated to genotoxicity, hepatotoxicity, nephrotoxicity, cardiotoxicity, neurotoxicity, and specific organs and systems. Following this discussion of the effects of medicinal plants is a critical review of the guidelines and methods in use for toxicological research as well as the state of toxicology studies in Africa. With up-to-date research provided by a team of experts, Toxicological Survey of African Medicinal Plants is an invaluable resource for researchers and students involved in pharmacology, toxicology, phytochemistry, medicine, pharmacognosy, and pharmaceutical biology. Offers a critical review of the methods used in toxicological survey of medicinal plants Provides up-to-date toxicological data on African medicinal plants and families Serves as a resource tool for students and scientists in the various areas of toxicology

Africa and the War on Drugs

Neil Carrier,Gernot Klantschnig
Africa and the War on Drugs Book PDF

Author : Neil Carrier,Gernot Klantschnig
Publisher : Zed Books Ltd.
Page : 117 pages
File Size : 40,9 Mb
Release : 2012-10-11
Category : Social Science
ISBN : 9781848139695

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Africa and the War on Drugs by Neil Carrier,Gernot Klantschnig Pdf

Nigerian drug lords in UK prisons, khat-chewing Somali pirates hijacking Western ships, crystal meth-smoking gangs controlling South Africa's streets, and narco-traffickers corrupting the state in Guinea-Bissau: these are some of the vivid images surrounding drugs in Africa which have alarmed policymakers, academics and the general public in recent years. In this revealing and original book, the authors weave these aspects into a provocative argument about Africa's role in the global trade and control of drugs. In doing so, they show how foreign-inspired policies have failed to help African drug users but have strengthened the role of corrupt and brutal law enforcement officers, who are tasked with halting the export of heroin and cocaine to European and American consumer markets. A vital book on an overlooked front of the so-called war on drugs.

Making Medicines in Africa

Maureen Mackintosh,Geoffrey Banda,Watu Wamae,Paula Tibandebage
Making Medicines in Africa Book PDF

Author : Maureen Mackintosh,Geoffrey Banda,Watu Wamae,Paula Tibandebage
Publisher : Springer
Page : 334 pages
File Size : 44,6 Mb
Release : 2016-02-03
Category : Political Science
ISBN : 9781137546470

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Making Medicines in Africa by Maureen Mackintosh,Geoffrey Banda,Watu Wamae,Paula Tibandebage Pdf

This book is open access under a CC-BY license. The importance of the pharmaceutical industry in Sub-Saharan Africa, its claim to policy priority, is rooted in the vast unmet health needs of the sub-continent. Making Medicines in Africa is a collective endeavour, by a group of contributors with a strong African and more broadly Southern presence, to find ways to link technological development, investment and industrial growth in pharmaceuticals to improve access to essential good quality medicines, as part of moving towards universal access to competent health care in Africa. The authors aim to shift the emphasis in international debate and initiatives towards sustained Africa-based and African-led initiatives to tackle this huge challenge. Without the technological, industrial, intellectual, organisational and research-related capabilities associated with competent pharmaceutical production, and without policies that pull the industrial sectors towards serving local health needs, the African sub-continent cannot generate the resources to tackle its populations' needs and demands. Research for this book has been selected as one of the 20 best examples of the impact of UK research on development. See http://www.ukcds.org.uk/the-global-impact-of-uk-research for further details.

Poisonous Plants and Phytochemicals in Drug Discovery

Andrew G. Mtewa,Chukwuebuka Egbuna,G. M. Narasimha Rao
Poisonous Plants and Phytochemicals in Drug Discovery Book PDF

Author : Andrew G. Mtewa,Chukwuebuka Egbuna,G. M. Narasimha Rao
Publisher : John Wiley & Sons
Page : 444 pages
File Size : 45,8 Mb
Release : 2020-12-22
Category : Science
ISBN : 9781119650232

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Poisonous Plants and Phytochemicals in Drug Discovery by Andrew G. Mtewa,Chukwuebuka Egbuna,G. M. Narasimha Rao Pdf

Focusing on phytochemicals and their potential for drug discovery, this book offers a comprehensive resource on poisonous plants and their applications in chemistry and in pharmacology. Provides a comprehensive resource on phytotoxins, covering historical perspectives, modern applications, and their potential in drug discovery Covers the mechanisms, benefits, risks and management protocols of phytotoxins in a scientific laboratory and the usefulness in drug discovery Presents chapters in a carefully designed, clear order, making it an ideal resource for the academic researcher or the industry professional at any stage in their career

Africa and the Sustainable Development Goals

Maano Ramutsindela,David Mickler
Africa and the Sustainable Development Goals Book PDF

Author : Maano Ramutsindela,David Mickler
Publisher : Springer
Page : 295 pages
File Size : 41,9 Mb
Release : 2019-06-13
Category : Science
ISBN : 9783030148577

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Africa and the Sustainable Development Goals by Maano Ramutsindela,David Mickler Pdf

The book draws upon the expertise and international research collaborations forged by the Worldwide Universities Network Global Africa Group to critically engage with the intersection, in theory and practice, of the Sustainable Development Goals (SDGs) and Africa’s development agendas and needs. Further, it argues that – and demonstrates how – the SDGs should be understood as an aspirational blueprint for development with multiple meanings that are situated in dynamic and contested terrains. As the SDGs have substantial implications for development policy and resourcing at both the macro and micro levels, their relevance is not only context-specific but should also be assessed in terms of the aspirations and needs of ordinary citizens across the continent. Drawing on analyses and evidence from both the natural and social sciences, the book demonstrates that progress towards the SDGs must meet demands for improving human well-being under diverse and challenging socio-economic, political and environmental conditions. Examples include those from the mining industry, public health, employment and the media. In closing, it highlights how international collaboration in the form of research networks can enhance the production of critical knowledge on and engagement with the SDGs in Africa.

The African and Arabian Moringa Species

Solomon Habtemariam
The African and Arabian Moringa Species Book PDF

Author : Solomon Habtemariam
Publisher : Elsevier
Page : 230 pages
File Size : 49,9 Mb
Release : 2017-06-09
Category : Science
ISBN : 9780081022948

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The African and Arabian Moringa Species by Solomon Habtemariam Pdf

The African and Arabian Moringa Species: Chemistry, Bioactivity and Therapeutic Applications reviews the botany, socioeconomic significance and underlying chemistry of these interesting plants. The book begins by addressing the botanical and socioeconomic aspect of M. stenopetala, one of the most widely cultivated species within the genus. Next, it reviews the chemistry of the plant, with a systematic presentation covering the seed oil, various secondary metabolites, and issues relating to quality control. Final sections address the chemistry behind the reported use of the plant for the management of various diseases, highlighting potential antioxidant, antimicrobial, antidiabetic, anticancer properties and more. Other African and Arabian Moringa species, from their botany, to their chemical and pharmacological profiles are also included. Drawing on the author’s latest research and the most current literature in the field, this book is an invaluable guide for researchers in medicinal chemistry, herbal medicine, drug discovery/development, and plant derived natural products within both industry and academic environments. Outlines the botanical description, traditional uses and socioeconomic significance of the African and Arabian Moringa plants Exhaustively discusses the chemistry of these plants to highlight secondary metabolites and methodologies for their isolation, identification and quality control Discusses the future potential of the plants and their chemical components for various disease conditions

Making Medicines in Africa

Maureen Mackintosh,Geoffrey Banda,Paula Tibandebage,Watu Wamae
Making Medicines in Africa Book PDF

Author : Maureen Mackintosh,Geoffrey Banda,Paula Tibandebage,Watu Wamae
Publisher : Unknown
Page : 334 pages
File Size : 51,6 Mb
Release : 2016
Category : Economics
ISBN : 134956544X

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Making Medicines in Africa by Maureen Mackintosh,Geoffrey Banda,Paula Tibandebage,Watu Wamae Pdf

This book is open access under a CC-BY license. This book is about medicines production in sub-Saharan Africa, an enquiry driven by the vast unmet health needs of the sub-continent. It is a collective endeavour by a group of editors and authors with a strong African and more broadly Southern presence to find ways forward that link technological development, investment and industrial growth in pharmaceuticals to improve access to essential good quality medicines, as part of moving towards universal access to competent health care. We aim to shift the emphasis in international debate to give much more attention to the scope for sustained Africa-based and African-led initiatives to tackle this huge challenge. Without the technological, industrial, intellectual, organisational and research-related capabilities associated with competent pharmaceutical production, and without policies that pull the industrial sectors towards serving local health needs, the African sub-continent cannot generate the resources to tackle the needs and demands of its population.