Natural Products In Clinical Trials

Author : Atta-ur- Rahman,Shazia Anjum,Hesham El-Seedi
Publisher : Bentham Science Publishers
Page : 253 pages
File Size : 46,8 Mb
Release : 2018-03-03
Category : Medical
ISBN : 9781681082134

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Natural Products in Clinical Trials by Atta-ur- Rahman,Shazia Anjum,Hesham El-Seedi Pdf

Natural products continue to play a key role in drug development. A recent analysis of the drug market in the developed world revealed that 40% of total clinically approved drugs were either unmodified natural products or their semi-synthetic derivatives. This book series focuses on reviews of exciting new bioactive natural products that have huge potential as drugs. It highlights the everlasting importance of natural products in our lives. Each volume brings reviews contributed by eminent scientists in the field. The first volume covers the following topics: - bioactive compounds from marine invertebrates - natural product derived drugs for immunological and inflammatory diseases - clinical trials of curcumin, camptothecin, astaxanthin, and biochanin - antibacterial and antifungal drugs from natural sources - natural products as anti-HIV medicines.

Author : Atta-ur-Rahman,Shazia Anjum,Hesham R. El-Seedi
Publisher : Bentham Science Publishers
Page : 280 pages
File Size : 49,6 Mb
Release : 2020-08-20
Category : Medical
ISBN : 9789811425752

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Natural Products in Clinical Trials: Volume 2 by Atta-ur-Rahman,Shazia Anjum,Hesham R. El-Seedi Pdf

Natural compounds continue to play a key role in drug development. Many clinically approved drugs are either unmodified natural products or their semi-synthetic derivatives. This book series presents reviews of exciting new bioactive natural products that have huge potential as drugs. Each volume presents comprehensive chapters contributed by eminent scientists. The volumes focus on drug candidates which are in the later stages of drug development and are being evaluated in clinical trials. The series, therefore, highlights the importance of natural products in our lives. The second volume covers the following topics: - A review of recent patents and natural products in clinical trials to treat schistosomiasis - Natural products: the new intervention regimen for metabolic disorders - Fluorine-containing drugs and drug candidates derived from natural products - Natural products for the management of cardiovascular diseases - Implication of natural compounds for the prevention of ocular diseases.

Author : Pinarosa Avato
Publisher : MDPI
Page : 392 pages
File Size : 50,7 Mb
Release : 2020-04-22
Category : Medical
ISBN : 9783039287468

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Natural Products and Drug Discovery by Pinarosa Avato Pdf

Natural products hold a prominent position in the current discovery and development of drugs and have diverse indications for both human and animal health. Plants, in particular, play a leading role as a source of specialized metabolites with medical effects. Other organisms, such as marine and terrestrial animals and microorganisms, produce very important drug candidate molecules. Specialized metabolites from these varied natural sources can be used directly as bioactive compounds or drug precursors. In addition, due to their broad chemical diversity, they can act as drug prototypes and/or be used as pharmacological tools for different targets. Some examples of natural metabolites that have been developed into useful medical drug are cardiotonic digoxin from Digitalis sp., antimalarial artemisinin from Artemisia annua, anti-cancer taxol from Taxus sp., or podophyllotoxin from Podophyllum peltatum, which served as a synthetic model for the anti-cancer etoposide. The study of natural products is still attracting great scientific attention and their current importance, as a valuable lead for drug discovery, is undebatable. I cordially invite authors to contribute original articles, as well as survey articles, that give the readers of Molecules **MOLECULES NEEDS TO BE ITALICIZED** updated and new perspectives on natural products in drug discovery, including but not limited to natural sources, identification and separation of bioactive phytochemicals, standardization, new biological targets, pre-clinical and clinical trials, pharmacological effects/side effects, and bioassays.

Author : Valdir Cechinel Filho
Publisher : Springer
Page : 531 pages
File Size : 55,6 Mb
Release : 2018-12-07
Category : Science
ISBN : 9783030005450

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Natural Products as Source of Molecules with Therapeutic Potential by Valdir Cechinel Filho Pdf

This book addresses the highly relevant and complex subject of research on drugs from natural products, discussing the current hot topics in the field. It also provides a detailed overview of the strategies used to research and develop these drugs. Respected experts explore issues involved in the production chain and when looking for new medicinal agents, including aspects such as therapeutic potential, functional foods, ethnopharmacology, metabolomics, virtual screening and regulatory scenarios. Further, the book describes strategic methods of isolation and characterization of active principles, biological assays, biotechnology of plants, synthesis, clinical trials and the use of tools to identity active principles.

Author : Ramarao Poduri
Publisher : Springer Nature
Page : 522 pages
File Size : 53,9 Mb
Release : 2021-02-15
Category : Medical
ISBN : 9789811555343

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Drug Discovery and Development by Ramarao Poduri Pdf

This book describes the processes that are involved in the development of new drugs. The authors discuss the history, role of natural products and concept of receptor interactions with regard to the initial stages of drug discovery. In a single, highly readable volume, it outlines the basics of pharmacological screening, drug target identification, and genetics involved in early drug discovery. The final chapters introduce readers to stem therapeutics, pharmacokinetics, pharmacovigilance, and toxicological testing. Given its scope, the book will enable research scholars, professionals and young scientists to understand the key fundamentals of drug discovery, including stereochemistry, pharmacokinetics, clinical trials, statistics and toxicology.

Author : Canada. Natural Health Products Directorate
Publisher : Unknown
Page : 112 pages
File Size : 46,7 Mb
Release : 2005
Category : Clinical trials
ISBN : UIUC:30112080037622

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Clinical Trials for Natural Health Products by Canada. Natural Health Products Directorate Pdf

Author : Atta-ur Rahman,Shazia Anjum,Hesham El-Seedi
Publisher : Unknown
Page : 128 pages
File Size : 40,5 Mb
Release : 2018-03-02
Category : Electronic
ISBN : 1681082144

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Natural Products in Clinical Trials Volume by Atta-ur Rahman,Shazia Anjum,Hesham El-Seedi Pdf

Natural products continue to play a key role in drug development. A recent analysis of the drug market in the developed world revealed that 40% of total clinically approved drugs were either unmodified natural products or their semi-synthetic derivatives. This book series focuses on reviews of exciting new bioactive natural products that have huge potential as drugs. It highlights the everlasting importance of natural products in our lives. Each volume presents comprehensive reviews in cutting edge fields contributed by eminent scientists. The first volume covers the following topics: bioactive compounds from marine invertebrates natural product derived drugs for immunological and inflammatory diseases clinical trials of curcumin, camptothecin, astaxanthin, and biochanin antibacterial and antifungal drugs from natural sources natural products as anti-HIV medicines

Author : Dilip Ghosh,Pulok K. Mukherjee
Publisher : CRC Press
Page : 632 pages
File Size : 49,6 Mb
Release : 2019-07-18
Category : Medical
ISBN : 9781351741354

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Natural Medicines by Dilip Ghosh,Pulok K. Mukherjee Pdf

Globally, natural medicine has been considered as an important alternative to modern allopathic medicine. Although natural medicines are popular in society, only limited medicinal herbs have been scientifically evaluated for their potential in medical treatment. This book connects various aspects of the complex journey from traditional medicine to modern medicine. It provides information on topics including global regulations and regulatory hurdles, diverse nutritional challenges and potential health benefits, novel food innovations especially seed-to-clinic approaches, and future trends. FEATURES • Provides information on sustainable use of natural products in the development of new drugs and clinically validated herbal remedies • Discusses issues on evaluation and clinical aspects of herbal medicine, promotion and development, safety evaluation, metabolite profiling, biomarker analysis, formulation, and stability testing • Describes traditional uses of natural medicine through identification, isolation and structural characterization of their active components • Elucidates mechanisms of biological action, adverse effects and identification of their molecular targets of natural medicine • Multidisciplinary appeal including chemistry, pharmacology, pharmacognosy and cell and molecular biology, as well as integration with clinical medicine This book serves as an essential guide for individuals researching natural medicines, and industry employees in areas including drug development, pharmacology, natural products chemistry, clinical efficacy, ethnopharmacology, pharmacognosy, phytotherapy, phyto-technology and herbal science.

Author : J. Mulzer,R. Bohlmann
Publisher : Springer Science & Business Media
Page : 363 pages
File Size : 48,5 Mb
Release : 2013-04-17
Category : Medical
ISBN : 9783662040423

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The Role of Natural Products in Drug Discovery by J. Mulzer,R. Bohlmann Pdf

Natural Products have been important sources of useful drugs from prehistoric times to the present. This book gives an overview about this field and provides important recent contributions to the discovery of new drugs generated by research on natural products. Total synthesis of natural products with interesting biological activities is paving the way for the preparation of new and improved analogs. The methods of combinatorial chemistry permit the selection of the best drug from a large number of candidates. Beyond synthesis and evaluation of organic molecules a number of new bioorganic methods are coming to the fore and will be discucced in this isue of the ERnst schering Research Foundation workshop proceedings.

Author : Olga Genilloud,Francisca Vicente
Publisher : Royal Society of Chemistry
Page : 435 pages
File Size : 42,8 Mb
Release : 2012
Category : Medical
ISBN : 9781849733618

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Drug Discovery from Natural Products by Olga Genilloud,Francisca Vicente Pdf

An integrated review of the most recent trends in natural products, drug discovery, and key lead candidates that are outstanding for their chemistry and biology in novel drug development.

Author : Antony D. Buss,Mark S. Butler
Publisher : Royal Society of Chemistry
Page : 459 pages
File Size : 45,5 Mb
Release : 2010
Category : Medical
ISBN : 9780854041930

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Natural Product Chemistry for Drug Discovery by Antony D. Buss,Mark S. Butler Pdf

This text provides a comprehensive summary of where natural product chemistry is today in drug discovery. It covers emerging technologies and case studies and is a source of up-to-date information on the topical subject of natural products.

Author : Sreeraj Gopi,Augustine Amalraj,Ajaikumar B. Kunnumakkara,Sabu Thomas
Publisher : Academic Press
Page : 420 pages
File Size : 50,5 Mb
Release : 2021-01-19
Category : Medical
ISBN : 9780128192191

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Inflammation and Natural Products by Sreeraj Gopi,Augustine Amalraj,Ajaikumar B. Kunnumakkara,Sabu Thomas Pdf

Approx.446 pages Approx.446 pages

Author : World Health Organization
Publisher : World Health Organization
Page : 228 pages
File Size : 52,6 Mb
Release : 2019-05-16
Category : Business & Economics
ISBN : 9789241515436

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WHO Global Report on Traditional and Complementary Medicine 2019 by World Health Organization Pdf

This report is structured in five parts: national framework for traditional and complementary medicine (T&CM); product regulation; practices and practitioners; the challenges faced by countries; and finally the country profiles. Apart from the section on practices and practitioners the report is consistent with the format of the report of the first global survey in order to provide a useful comparison. The section on practices and practitioners which covers providers education and health insurance is a new section incorporated to reflect the emerging trends in T&CM and to gather new information regarding these topics at a national level. All new information received has been incorporated into individual country profiles and data graphs. The report captures the three phases of progress made by Member States; that is before and after the first WHO Traditional Medicine Strategy (1999?2005) from the first global survey to the second global survey (2005?2012) and from the second survey to the most recent timeline (2012?2018).

Author : Karen Shapiro
Publisher : American Pharmacists Association (APhA)
Page : 264 pages
File Size : 50,7 Mb
Release : 2006
Category : Medical
ISBN : UOM:39015064117537

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Natural Products by Karen Shapiro Pdf

This text is intended for use in the classroom and as a reference for the practising professional. Selected natural products represent those commonly in use today and most likely to be encounted by health professionals.

Author : Charis M. Galanakis
Publisher : Academic Press
Page : 366 pages
File Size : 52,9 Mb
Release : 2019-08-04
Category : Technology & Engineering
ISBN : 9780128175163

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Nutraceuticals and Natural Product Pharmaceuticals by Charis M. Galanakis Pdf

Nutraceuticals and Natural Product Pharmaceuticals analyzes the nutraceutical and pharmaceutical research published over the last decade, paying particular attention to applications and recovery effects. The book emphasizes the great need for both nutritionists and pharmacologists to understand how these drugs can benefit human health. Topics explore innovative sources, bioavailability, pharmacokinetics, translating novel pathways and mechanisms of action into their clinical use, personalized nutrition and natural product medicine, the convergence between nutraceuticals and western medicine, interactions between drugs, nutrients, the microbiome and lifestyles, industrial applications and commercialization, metabolomics, nano-delivery systems and function, and more. Nutritionists and pharmacists working with natural products, food scientists, nutrition researchers and those interested in the development of innovative products, nutraceuticals, pharmaceuticals and functional foods are sure to benefit from this thorough resource. Connects research from the nutraceutical and pharmaceutical industries Promotes further communication and cooperation between pharmacologists and nutritionists by analyzing nutraceutical and pharmaceutical research in particular applications and recovery efforts Explores the health effects of target compounds and the development of applications in both sectors