Natural Product Chemistry For Drug Discovery

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Natural Products and Drug Discovery

Subhash C. Mandal,Vivekananda Mandal,Tetsuya Konishi
Natural Products and Drug Discovery Book PDF

Author : Subhash C. Mandal,Vivekananda Mandal,Tetsuya Konishi
Publisher : Elsevier
Page : 776 pages
File Size : 43,7 Mb
Release : 2018-02-16
Category : Science
ISBN : 9780081021040

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Natural Products and Drug Discovery by Subhash C. Mandal,Vivekananda Mandal,Tetsuya Konishi Pdf

Natural Products and Drug Discovery: An Integrated Approach provides an applied overview of the field, from traditional medicinal targets, to cutting-edge molecular techniques. Natural products have always been of key importance to drug discovery, but as modern techniques and technologies have allowed researchers to identify, isolate, extract and synthesize their active compounds in new ways, they are once again coming to the forefront of drug discovery. Combining the potential of traditional medicine with the refinement of modern chemical technology, the use of natural products as the basis for drugs can help in the development of more environmentally sound, economical, and effective drug discovery processes. Natural Products & Drug Discovery: An Integrated Approach reflects on the current changes in this field, giving context to the current shift and using supportive case studies to highlight the challenges and successes faced by researchers in integrating traditional medicinal sources with modern chemical technologies. It therefore acts as a useful reference to medicinal chemists, phytochemists, biochemists, pharma R&D professionals, and drug discovery students and researchers. Reviews the changing role of natural products in drug discovery, integrating traditional knowledge with modern molecular technologies Highlights the potential future role of natural products in preventative medicine Supported by real world case studies throughout

Natural Product Chemistry for Drug Discovery

Antony D. Buss,Mark S. Butler
Natural Product Chemistry for Drug Discovery Book PDF

Author : Antony D. Buss,Mark S. Butler
Publisher : Royal Society of Chemistry
Page : 459 pages
File Size : 47,7 Mb
Release : 2010
Category : Medical
ISBN : 9780854041930

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Natural Product Chemistry for Drug Discovery by Antony D. Buss,Mark S. Butler Pdf

This text provides a comprehensive summary of where natural product chemistry is today in drug discovery. It covers emerging technologies and case studies and is a source of up-to-date information on the topical subject of natural products.

Natural Products in Clinical Trials

Atta-ur- Rahman,Shazia Anjum,Hesham El-Seedi
Natural Products in Clinical Trials Book PDF

Author : Atta-ur- Rahman,Shazia Anjum,Hesham El-Seedi
Publisher : Bentham Science Publishers
Page : 253 pages
File Size : 45,7 Mb
Release : 2018-03-03
Category : Medical
ISBN : 9781681082134

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Natural Products in Clinical Trials by Atta-ur- Rahman,Shazia Anjum,Hesham El-Seedi Pdf

Natural products continue to play a key role in drug development. A recent analysis of the drug market in the developed world revealed that 40% of total clinically approved drugs were either unmodified natural products or their semi-synthetic derivatives. This book series focuses on reviews of exciting new bioactive natural products that have huge potential as drugs. It highlights the everlasting importance of natural products in our lives. Each volume brings reviews contributed by eminent scientists in the field. The first volume covers the following topics: - bioactive compounds from marine invertebrates - natural product derived drugs for immunological and inflammatory diseases - clinical trials of curcumin, camptothecin, astaxanthin, and biochanin - antibacterial and antifungal drugs from natural sources - natural products as anti-HIV medicines.

Studies in Natural Products Chemistry

Atta-ur- Rahman
Studies in Natural Products Chemistry Book PDF

Author : Atta-ur- Rahman
Publisher : Elsevier
Page : 438 pages
File Size : 54,7 Mb
Release : 2012-12-06
Category : Science
ISBN : 9780444595157

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Studies in Natural Products Chemistry by Atta-ur- Rahman Pdf

Natural products play an integral and ongoing role in promoting numerous aspects of scientific advancement, and many aspects of basic research programs are intimately related to natural products. With articles written by leading authorities in their respective fields of research, Studies in Natural Products Chemistry, Volume 37 presents current frontiers and future guidelines for research based on important discoveries made in the field of bioactive natural products. It is a valuable source for researchers and engineers working in natural products and medicinal chemistry. Describes the chemistry of bioactive natural products Contains contributions by leading authorities in the field A valuable source for researchers and engineers working in natural product and medicinal chemistry

Natural Products

Lixin Zhang,Arnold L. Demain
Natural Products Book PDF

Author : Lixin Zhang,Arnold L. Demain
Publisher : Springer Science & Business Media
Page : 380 pages
File Size : 44,5 Mb
Release : 2007-11-17
Category : Medical
ISBN : 9781592599769

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Natural Products by Lixin Zhang,Arnold L. Demain Pdf

A fresh examination of the past successes of natural products as medicines and their new future from both conventional and new technologies. High-performance liquid chromatography profiling, combinatorial synthesis, genomics, proteomics, DNA shuffling, bioinformatics, and genetic manipulation all now make it possible to rapidly evaluate the activities of extracts as well as purified components derived from microbes, plants, and marine organisms. The authors apply these methods to new natural product drug discoveries, to microbial diversity, to specific groups of products (Chinese herbal drugs, antitumor drugs from microbes and plants, terpenoids, and arsenic compounds), and to specific sources (the sea, rainforest, and endophytes). These new opportunities show how research and development trends in the pharmaceutical industry can advance to include both synthetic compounds and natural products, and how this paradigm shift can be more productive and efficacious.

Bioactive Natural Products

Goutam Brahmachari
Bioactive Natural Products Book PDF

Author : Goutam Brahmachari
Publisher : World Scientific
Page : 695 pages
File Size : 55,9 Mb
Release : 2012
Category : Science
ISBN : 9789814335379

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Bioactive Natural Products by Goutam Brahmachari Pdf

Bioactive natural products are a rich source of novel therapeutics. Thus, the search for bioactive molecules from nature continues to play an important role in fashioning new medicinal agents. This volume, which comprises sixteen chapters written by active researchers and leading experts in natural products chemistry, brings together an overview of current discoveries in this remarkable field. It also provides information on the industrial application of natural products for medicinal purposes. This book will serve as a valuable resource for researchers to predict promising leads for developing pharmaceuticals to treat various ailments and disease manifestations.

Natural Products Analysis

Vladimir Havlicek,Jaroslav Spizek
Natural Products Analysis Book PDF

Author : Vladimir Havlicek,Jaroslav Spizek
Publisher : John Wiley & Sons
Page : 634 pages
File Size : 49,5 Mb
Release : 2014-10-13
Category : Science
ISBN : 9781118466612

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Natural Products Analysis by Vladimir Havlicek,Jaroslav Spizek Pdf

This book highlights analytical chemistry instrumentation and practices applied to the analysis of natural products and their complex mixtures, describing techniques for isolating and characterizing natural products. • Applies analytical techniques to natural products research – an area of critical importance to drug discovery • Offers a one-stop shop for most analytical methods: x-ray diffraction, NMR analysis, mass spectrometry, and chemical genetics • Includes coverage of natural products basics and highlights antibacterial research, particularly important as efforts to combat drug resistance gain prominence • Covers instrumental techniques with enough detail for both current practitioners and beginning researchers

Introduction to Natural Products Chemistry

Rensheng Xu,Yang Ye,Weimin Zhao
Introduction to Natural Products Chemistry Book PDF

Author : Rensheng Xu,Yang Ye,Weimin Zhao
Publisher : CRC Press
Page : 381 pages
File Size : 47,5 Mb
Release : 2011-07-20
Category : Medical
ISBN : 9781439860779

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Introduction to Natural Products Chemistry by Rensheng Xu,Yang Ye,Weimin Zhao Pdf

Natural products chemistry-the chemistry of metabolite products of plants, animals and microorganisms-is involved in the investigation of biological phenomena ranging from drug mechanisms to gametophytes and receptors and drug metabolism in the human body to protein and enzyme chemistry. Introduction to Natural Products Chemistry has collected the

The Role of Natural Products in Drug Discovery

J. Mulzer,R. Bohlmann
The Role of Natural Products in Drug Discovery Book PDF

Author : J. Mulzer,R. Bohlmann
Publisher : Springer Science & Business Media
Page : 363 pages
File Size : 48,5 Mb
Release : 2013-04-17
Category : Medical
ISBN : 9783662040423

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The Role of Natural Products in Drug Discovery by J. Mulzer,R. Bohlmann Pdf

Natural Products have been important sources of useful drugs from prehistoric times to the present. This book gives an overview about this field and provides important recent contributions to the discovery of new drugs generated by research on natural products. Total synthesis of natural products with interesting biological activities is paving the way for the preparation of new and improved analogs. The methods of combinatorial chemistry permit the selection of the best drug from a large number of candidates. Beyond synthesis and evaluation of organic molecules a number of new bioorganic methods are coming to the fore and will be discucced in this isue of the ERnst schering Research Foundation workshop proceedings.

Natural Products Chemistry

Raymond Cooper,George Nicola
Natural Products Chemistry Book PDF

Author : Raymond Cooper,George Nicola
Publisher : CRC Press
Page : 210 pages
File Size : 53,6 Mb
Release : 2014-07-29
Category : Medical
ISBN : 9781466567610

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Natural Products Chemistry by Raymond Cooper,George Nicola Pdf

Notoriously cumbersome to isolate and challenging to synthesize, the path of natural products to viable drugs is an arduous journey. Yet compounds isolated from nature may possess fascinating structures, biological profiles and pharmaceutical potential far greater than anything made by man. Natural Products Chemistry: Sources, Separations and Structures presents a practical guide to sourcing, isolating, and discovering new compounds from nature many of which become pharmaceutical drugs. This book emphasizes the challenges and advantages of products acquired from nature, compared to those obtained from combinatorial chemistry. A basic introduction, the book describes the whole cycle from farm to final compound, backed up by case studies drawn from industry and research applications. It broadens the scope of applications and draws upon examples from various sources. Natural products chemistry, as taught today, draws its examples mainly from marine chemistry or plant chemistry; however, there is also a fascinating and rich world of fermented (microbial and algal) products leading to complex structures. Thus, the book draws upon examples from the microbial world and from insects too. Therefore, this is a source of bioactive metabolites, not traditionally available in academic settings, more the mainstay of the pharmaceutical industry. Providing a roadmap of the process of collecting a compound from nature, isolating the active ingredient, and determining the chemical structure, this book provides a unique approach to the world of natural products.

Drug Discovery and Development

Ramarao Poduri
Drug Discovery and Development Book PDF

Author : Ramarao Poduri
Publisher : Springer Nature
Page : 522 pages
File Size : 47,7 Mb
Release : 2021-02-15
Category : Medical
ISBN : 9789811555343

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Drug Discovery and Development by Ramarao Poduri Pdf

This book describes the processes that are involved in the development of new drugs. The authors discuss the history, role of natural products and concept of receptor interactions with regard to the initial stages of drug discovery. In a single, highly readable volume, it outlines the basics of pharmacological screening, drug target identification, and genetics involved in early drug discovery. The final chapters introduce readers to stem therapeutics, pharmacokinetics, pharmacovigilance, and toxicological testing. Given its scope, the book will enable research scholars, professionals and young scientists to understand the key fundamentals of drug discovery, including stereochemistry, pharmacokinetics, clinical trials, statistics and toxicology.

Natural Products in Medicinal Chemistry

Stephen Hanessian
Natural Products in Medicinal Chemistry Book PDF

Author : Stephen Hanessian
Publisher : John Wiley & Sons
Page : 800 pages
File Size : 46,7 Mb
Release : 2013-12-18
Category : Medical
ISBN : 9783527676569

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Natural Products in Medicinal Chemistry by Stephen Hanessian Pdf

The inspiration provided by biologically active natural products to conceive of hybrids, congeners, analogs and unnatural variants is discussed by experts in the field in 16 highly informative chapters. Using well-documented studies over the past decade, this timely monograph demonstrates the current importance and future potential of natural products as starting points for the development of new drugs with improved properties over their progenitors. The examples are chosen so as to represent a wide range of natural products with therapeutic relevance among others, as anticancer agents, antimicrobials, antifungals, antisense nucleosides, antidiabetics, and analgesics. From the content: * Part I: Natural Products as Sources of Potential Drugs and Systematic Compound Collections * Part II: From Marketed Drugs to Designed Analogs and Clinical Candidates * Part III: Natural Products as an Incentive for Enabling Technologies * Part IV: Natural Products as Pharmacological Tools * Part V: Nature: The Provider, the Enticer, and the Healer

Discovery and Development of Antidiabetic Agents from Natural Products

Goutam Brahmachari
Discovery and Development of Antidiabetic Agents from Natural Products Book PDF

Author : Goutam Brahmachari
Publisher : Elsevier
Page : 332 pages
File Size : 47,5 Mb
Release : 2016-10-11
Category : Science
ISBN : 9780128096925

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Discovery and Development of Antidiabetic Agents from Natural Products by Goutam Brahmachari Pdf

Discovery and Development of Antidiabetic Agents from Natural Products brings together global research on the medicinal chemistry of active agents from natural sources for the prevention and treatment of diabetes and associated disorders. From the identification of promising leads, to the extraction and synthesis of bioactive molecules, this book explores a range of important topics to support chemists in the discovery and development of safer, more economical therapeutics that are desperately needed in response to this emerging global epidemic. Beginning with an overview of bioactive chemical compounds from plants with anti-diabetic properties, the book goes on to outline the identification and extraction of anti-diabetic agents and antioxidants from natural sources. It then explores anti-diabetic plants from specific regions before looking more closely at the background, isolation, and synthesis of key therapeutic compounds and their derivatives, including Mangiferin, Resveratrol, natural saponins, and alpha-glucosidase enzyme inhibitors. The book concludes with a consideration of current and potential future applications. Combining the expertise of specialists from around the world, this volume aims to support and encourage medicinal chemists investigating natural sources as starting points for the development of standardized, safe, and effective antidiabetic therapeutics. Contains chapters written by active researchers and leading global experts who are deeply engaged in the research field of natural product chemistry for drug discovery Provides comprehensive coverage of cutting-edge research advances in the design of medicinal natural products with potential as preventives and therapeutics for diabetes and related metabolic issues Presents a practical review of the identification, isolation, and extraction techniques that help support medicinal chemists in the lab

Chemistry of Biologically Potent Natural Products and Synthetic Compounds

Shahid Ul-Islam,Javid Ahmad Banday
Chemistry of Biologically Potent Natural Products and Synthetic Compounds Book PDF

Author : Shahid Ul-Islam,Javid Ahmad Banday
Publisher : John Wiley & Sons
Page : 434 pages
File Size : 44,8 Mb
Release : 2021-06-29
Category : Science
ISBN : 9781119640349

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Chemistry of Biologically Potent Natural Products and Synthetic Compounds by Shahid Ul-Islam,Javid Ahmad Banday Pdf

In view of their promising biological and pharmaceutical activities, natural product inspired and heterocyclic compounds have recently gained a reputation in the field of medicinal chemistry. Over the past decades, intensive research efforts have been ongoing to understand the synthesis, biochemistry and engineering involved in their preparation and action mechanisms. Several novel natural product derivatives, heterocyclic and other synthetic compounds, have been reported to have shown interesting biological activities including anticancer, antimicrobial, anti-inflammatory, anti-glycemic, anti-allergy and antiviral etc. Chemistry of Biologically Potent Natural Products and Synthetic Compounds provides up-to-date information on new developments and most recent medicinal applications of the natural products and derivatives, as well as the chemistry and synthesis of heterocyclic and other related compounds.

Drug Discovery from Natural Products

Olga Genilloud,Francisca Vicente
Drug Discovery from Natural Products Book PDF

Author : Olga Genilloud,Francisca Vicente
Publisher : Royal Society of Chemistry
Page : 432 pages
File Size : 53,5 Mb
Release : 2012-08-21
Category : Science
ISBN : 9781849734950

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Drug Discovery from Natural Products by Olga Genilloud,Francisca Vicente Pdf

This book offers an integrated review of the most recent trends in natural products drug discovery and key lead candidates that are outstanding for their chemistry and biology as a starting point in novel drug development. The authors focus on different trends that are and will continue to be impacting multiples stages of modern drug discovery from NPs that have not been included in other works. This is complemented with a series of case studies from leading experts from industry and academia on key molecules and derivatives that have been chosen for their novelty in chemistry, biology and clinical applications. The book intends to reflect the current confluence of different disciplines in chemical biology and synthetic chemistry supported by a more profound knowledge of systems biology that ensures the concurrency and synergisms of expertise from different research fields that impact in the discovery of novel molecules. In the first section the chapters reflect recent approaches to exploit the biosynthetic potential of microbial resources (including genome mining, metagenomic and epigenetic approaches), as well as biosynthetic chemistry tools to respond to product supply and novel screening alternatives that have lead to the discovery of novel chemistry. The second part reviews, in the form of case studies, some examples of bioactive molecules in the important therapeutic areas of antiinfectives, oncology and antiparasitics.