Drug Metabolism And Pharmacokinetics

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Drug Metabolism and Pharmacokinetics Quick Guide

Siamak Cyrus Khojasteh,Harvey Wong,Cornelis E.C.A. Hop
Drug Metabolism and Pharmacokinetics Quick Guide Book PDF

Author : Siamak Cyrus Khojasteh,Harvey Wong,Cornelis E.C.A. Hop
Publisher : Springer Science & Business Media
Page : 222 pages
File Size : 51,9 Mb
Release : 2011-04-07
Category : Medical
ISBN : 9781441956293

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Drug Metabolism and Pharmacokinetics Quick Guide by Siamak Cyrus Khojasteh,Harvey Wong,Cornelis E.C.A. Hop Pdf

Drug Metabolism and Pharmacokinetics Quick Guide covers a number of aspects of drug assessment at drug discovery and development stages, topics such as pharmacokinetics, absorption, metabolism, enzyme kinetics, drug transporters, drug interactions, drug-like properties, assays and in silico calculations. It covers key concepts, with useful tables on physiological parameters (eg. blood flow to organs in x-species, expression and localization of enzymes and transporters), chemical structure, nomenclature, and moieties leading to bioactivation (with examples). Overall it includes a number of key topics useful at the drug discovery stage, which would serve as a quick reference with several examples from the literature to illustrate the concept.

Pharmacokinetics and Metabolism in Drug Design

Dennis A. Smith,Han van de Waterbeemd,Don K. Walker
Pharmacokinetics and Metabolism in Drug Design Book PDF

Author : Dennis A. Smith,Han van de Waterbeemd,Don K. Walker
Publisher : John Wiley & Sons
Page : 207 pages
File Size : 43,5 Mb
Release : 2006-08-21
Category : Medical
ISBN : 9783527608287

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Pharmacokinetics and Metabolism in Drug Design by Dennis A. Smith,Han van de Waterbeemd,Don K. Walker Pdf

In this new edition of a bestseller, all the contents have been updated and new material has been added, especially in the areas of toxicity testing and high throughput analysis. The authors, all of them employed at Pfizer in the discovery and development of new active substances, discuss the significant parameters and processes important for the absorption, distribution and retention of drug compounds in the body, plus the potential problems created by their transformation into toxic byproducts. They cover everything from the fundamental principles right up to the impact of pharmacokinetic parameters on the discovery of new drugs. While aimed at all those dealing professionally with the development and application of pharmaceutical substances, the readily comprehensible style makes this book equally suitable for students of pharmacy and related subjects.

Drug Metabolism, Pharmacokinetics and Bioanalysis

Hye Suk Lee,Kwang-Hyeon Liu
Drug Metabolism Pharmacokinetics and Bioanalysis Book PDF

Author : Hye Suk Lee,Kwang-Hyeon Liu
Publisher : MDPI
Page : 230 pages
File Size : 42,6 Mb
Release : 2019-06-12
Category : Medical
ISBN : 9783038979166

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Drug Metabolism, Pharmacokinetics and Bioanalysis by Hye Suk Lee,Kwang-Hyeon Liu Pdf

Drug metabolism/pharmacokinetics and drug interaction studies have been extensively carried out in order to secure the druggability and safety of new chemical entities throughout the development of new drugs. Recently, drug metabolism and transport by phase II drug metabolizing enzymes and drug transporters, respectively, as well as phase I drug metabolizing enzymes, have been studied. A combination of biochemical advances in the function and regulation of drug metabolizing enzymes and automated analytical technologies are revolutionizing drug metabolism research. There are also potential drug–drug interactions with co-administered drugs due to inhibition and/or induction of drug metabolic enzymes and drug transporters. In addition, drug interaction studies have been actively performed to develop substrate cocktails that do not interfere with each other and a simultaneous analytical method of substrate drugs and their metabolites using a tandem mass spectrometer. This Special Issue has the aim of highlighting current progress in drug metabolism/pharmacokinetics, drug interactions, and bioanalysis.

Holland-Frei Cancer Medicine

Robert C. Bast, Jr.,Carlo M. Croce,William N. Hait,Waun Ki Hong,Donald W. Kufe,Martine Piccart-Gebhart,Raphael E. Pollock,Ralph R. Weichselbaum,Hongyang Wang,James F. Holland
Holland Frei Cancer Medicine Book PDF

Author : Robert C. Bast, Jr.,Carlo M. Croce,William N. Hait,Waun Ki Hong,Donald W. Kufe,Martine Piccart-Gebhart,Raphael E. Pollock,Ralph R. Weichselbaum,Hongyang Wang,James F. Holland
Publisher : John Wiley & Sons
Page : 2008 pages
File Size : 53,5 Mb
Release : 2017-03-10
Category : Medical
ISBN : 9781119000846

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Holland-Frei Cancer Medicine by Robert C. Bast, Jr.,Carlo M. Croce,William N. Hait,Waun Ki Hong,Donald W. Kufe,Martine Piccart-Gebhart,Raphael E. Pollock,Ralph R. Weichselbaum,Hongyang Wang,James F. Holland Pdf

Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates

Pharmacokinetics and Metabolism in Drug Design

Dennis A. Smith,Charlotte Allerton,Amit S. Kalgutkar,Han van de Waterbeemd,Don K. Walker
Pharmacokinetics and Metabolism in Drug Design Book PDF

Author : Dennis A. Smith,Charlotte Allerton,Amit S. Kalgutkar,Han van de Waterbeemd,Don K. Walker
Publisher : John Wiley & Sons
Page : 269 pages
File Size : 41,5 Mb
Release : 2012-05-14
Category : Medical
ISBN : 9783527329540

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Pharmacokinetics and Metabolism in Drug Design by Dennis A. Smith,Charlotte Allerton,Amit S. Kalgutkar,Han van de Waterbeemd,Don K. Walker Pdf

In this new edition of a bestseller, all the contents have been brought upto-date by addressing current standards and best practices in the assessment and prediction of ADMET properties. Although the previous chapter layout has been retained, substantial revisions have been made, with new topics such as pro-drugs, active metabolites and transporters covered in detail in a manner useful to the Drug Discovery scientist. The authors discuss the parameters and processes important for the absorption, distribution and retention of drug compounds in the body, plus the potential problems created by their transformation into toxic byproducts. While aimed at all those dealing professionally with the development and application of pharmaceutical substances, the readily comprehensible style makes this book equally suitable for students of pharmacy and related subjects. Uniquely comprehensive, the book relates physicochemistry and chemical structure to pharmacokinetic properties and ultimately drug efficacy and safety.

Handbook of Essential Pharmacokinetics, Pharmacodynamics and Drug Metabolism for Industrial Scientists

Younggil Kwon
Handbook of Essential Pharmacokinetics Pharmacodynamics and Drug Metabolism for Industrial Scientists Book PDF

Author : Younggil Kwon
Publisher : Springer Science & Business Media
Page : 291 pages
File Size : 51,8 Mb
Release : 2007-05-08
Category : Medical
ISBN : 9780306468209

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Handbook of Essential Pharmacokinetics, Pharmacodynamics and Drug Metabolism for Industrial Scientists by Younggil Kwon Pdf

In the pharmaceutical industry, the incorporation of the disciplines of pharma- kinetics, pharmacodynamics, and drug metabolism (PK/PD/DM) into various drug development processes has been recognized to be extremely important for approp- ate compound selection and optimization. During discovery phases, the identifi- tion of the critical PK/PD/DM issues of new compounds plays an essential role in understanding their pharmacological profiles and structure-activity relationships. Owing to recent progress in analytical chemistry, a large number of compounds can be screened for their PK/PD/DM properties within a relatively short period of time. During development phases as well, the toxicology and clinical study designs and trials of a compound should be based on a thorough understanding of its PK/PD/DM properties. During my time as an industrial scientist, I realized that a reference work designed for practical industrial applications of PK/PD/DM could be a very valuable tool for researchers not only in the pharmacokinetics and drug metabolism departments, but also for other discovery and development groups in pharmaceutical companies. This book is designed specifically for industrial scientists, laboratory assistants, and managers who are involved in PK/PD/DM-related areas. It consists of thirteen chapters, each of which deals with a particular PK/PD/DM issue and its industrial applications. Chapters 3 and 12 in particular address recent topics on higher throughput in vivo exposure screening and the prediction of pharmacokinetics in humans, respectively. Chapter 8 covers essential information on drug metabolism for industrial scientists.

Pharmacokinetics in Drug Development

Peter L. Bonate
Pharmacokinetics in Drug Development Book PDF

Author : Peter L. Bonate
Publisher : Springer Science & Business Media
Page : 648 pages
File Size : 52,5 Mb
Release : 2005-12-05
Category : Medical
ISBN : 0971176744

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Pharmacokinetics in Drug Development by Peter L. Bonate Pdf

These volumes are designed to be the most complete guide to pharmacokinetics (PK) and its role in drug development. They fill a gap between the academic science and the practical application of that knowledge in drug development. Volume 1 discusses the role that PK plays in selected clinical study designs. Volume 2 details the key regulatory and development paradigms in which PK supplements decision-making during drug development.

Pharmacokinetics and Drug Metabolism in Canada: The Current Landscape

Neal M. Davies,Kishor M. Wasan
Pharmacokinetics and Drug Metabolism in Canada The Current Landscape Book PDF

Author : Neal M. Davies,Kishor M. Wasan
Publisher : MDPI
Page : 311 pages
File Size : 44,8 Mb
Release : 2018-03-23
Category : Electronic book
ISBN : 9783038427971

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Pharmacokinetics and Drug Metabolism in Canada: The Current Landscape by Neal M. Davies,Kishor M. Wasan Pdf

This book is a printed edition of the Special Issue "Pharmacokinetics and Drug Metabolism in Canada: The Current Landscape" that was published in Pharmaceutics

Metabolism, Pharmacokinetics, and Toxicity of Functional Groups

Dennis A. Smith
Metabolism Pharmacokinetics and Toxicity of Functional Groups Book PDF

Author : Dennis A. Smith
Publisher : Royal Society of Chemistry
Page : 545 pages
File Size : 52,9 Mb
Release : 2010
Category : Medical
ISBN : 9781849730167

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Metabolism, Pharmacokinetics, and Toxicity of Functional Groups by Dennis A. Smith Pdf

Written by medicinal chemists and ADMET scientists with a combined experience of over 300 years this aid to discovering drugs provides detailed coverage on absorption, distribution, metabolism, excretion and toxicology issues associated with new drugs.

Interindividual Variability in Human Drug Metabolism

Gian Maria Pacifici,Olavi Pelkonen
Interindividual Variability in Human Drug Metabolism Book PDF

Author : Gian Maria Pacifici,Olavi Pelkonen
Publisher : CRC Press
Page : 560 pages
File Size : 50,6 Mb
Release : 2001-05-24
Category : Medical
ISBN : 0748408649

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Interindividual Variability in Human Drug Metabolism by Gian Maria Pacifici,Olavi Pelkonen Pdf

The book provides an exhaustive, authoritative and updated review on the interindividual variability in drug metabolism in humans. Four chapters address the general background: genetic factors causing variability, interethnic variability, environmental factors and developing and ageing as sources of variability. Six chapters address variability of drug metabolism in vivo: variability of psychotropic drugs, antiepileptic drugs, the dopamine precursor levodopa, cardiovascular active drugs and anti HIV drugs. Seven chapters address the interindividual variability of the main drug metabolizing enzymes: CYP-450s, acetyltransferases, glucuronosyl transferase, methyl transferases, sulfotransferases and glutathione transferases in human liver and extrahepatic tissues. A separate chapter discusses the prediction of drug interaction. Comprehensive in coverage, and with contributions from the leading international experts, this book is essential reading for researchers from both academia and the pharmaceutical industry. Advanced undergraduates and postgraduates in pharmacology, clinical pharmacology, toxicology, biochemistry and epidemiology who are interested in drug metabolism will also find this an indispensable resource.

Pharmacokinetics and Drug Metabolism in Canada: The Current Landscape

Neal Davies,Kishor Wasan
Pharmacokinetics and Drug Metabolism in Canada The Current Landscape Book PDF

Author : Neal Davies,Kishor Wasan
Publisher : Unknown
Page : 128 pages
File Size : 51,5 Mb
Release : 2018
Category : Electronic
ISBN : 3038427985

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Pharmacokinetics and Drug Metabolism in Canada: The Current Landscape by Neal Davies,Kishor Wasan Pdf

Pharmacokinetics and Drug Metabolism in Canada: The Current Landscape.

Drug Metabolism and Pharmacokinetics

Anonim
Drug Metabolism and Pharmacokinetics Book PDF

Author : Anonim
Publisher : BoD – Books on Demand
Page : 136 pages
File Size : 44,9 Mb
Release : 2024-02-14
Category : Medical
ISBN : 9780850141474

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Drug Metabolism and Pharmacokinetics by Anonim Pdf

This book, Drug Metabolism and Pharmacokinetics, delivers the latest information on biotransformation and other pharmacokinetic parameters required to assess drug safety in drug discovery and development. Drug metabolism and pharmacokinetics (DMPK) is considered a rational strategy for the design, optimization, and selection of successful drug candidates in the pre-clinical stages of drug discovery. The evaluation of various pharmacokinetic parameters such as aqueous solubility, lipophilicity, cell permeability, bioavailability, protein binding, and metabolism and elimination half-life, drug–drug interactions (DDIs), and toxicokinetics is essential for a candidate drug to become a successful therapeutic agent. This book discusses recent advances in in-silico tools and in vitro/in vivo experimental techniques applied in pharmacokinetic, metabolomic, and bioanalytical studies. Key Features: • Presents pharmacokinetic and biotransformation parameters used for pre-clinical safety evaluations • Depicts experimental and biophysical techniques used in bioanalytical and metabolomic studies • Summarizes in silico, in vitro, and in vivo methods used in drug–enzyme interactions, drug– drug interactions, and toxicokinetics Written by a global team of experts, this book is a valuable resource for drug discovery scientists, drug developers, medicinal chemists, pharmacologists, biochemists, clinicians, biomedical scientists, healthcare professionals, researchers, teaching faculty, and students.

Handbook of Drug Metabolism, Third Edition

Paul G. Pearson,Larry C. Wienkers
Handbook of Drug Metabolism Third Edition Book PDF

Author : Paul G. Pearson,Larry C. Wienkers
Publisher : CRC Press
Page : 755 pages
File Size : 55,6 Mb
Release : 2019-05-20
Category : Medical
ISBN : 9781482262049

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Handbook of Drug Metabolism, Third Edition by Paul G. Pearson,Larry C. Wienkers Pdf

This book continues to be the definitive reference on drug metabolism with an emphasis on new scientific and regulatory developments. It has been updated based on developments that have occurred in the last 5 years, with new chapters on large molecules disposition, stereo-selectivity in drug metabolism, drug transporters and metabolic activation of drugs. Some chapters have been prepared by new authors who have emerged as subject area experts in the decade that has passed since publication of the first edition.

Pharmacology and Pharmacokinetics

T. Teorell
Pharmacology and Pharmacokinetics Book PDF

Author : T. Teorell
Publisher : Springer Science & Business Media
Page : 386 pages
File Size : 48,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781468420555

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Pharmacology and Pharmacokinetics by T. Teorell Pdf

This collection of papers by leading pharmacokineticists and pharmacolo gists is the proceedings of a conference held at the John E. · Fogarty International Center for Advanced Study in the Health Sciences, National Institutes of Health, October 30 to November 1, 1972. As part of its advanced study program, the Center conducts workshops, seminars, and conferences on topics related to the biomedical interests of the Scholars-in Residence. Professor Torsten Teorell came to the Center in 1970 as one of the first Scholars. In 1971 and 1972, he spent several months at the Center devoting his attention to contemporary problems in the application of pharmacoki netics to experimental and clinical pharmacology. As one of the founders of pharmacokinetics, Professor Teorell has made many contributions to the field since he first presented a formal multicompartment model for the analysis of drug action and drug metabolism in 1937 (Teorell, 1937). Since the appearance of his original paper, pharmacodynamics, or pharmacoki netics, has become increasingly important as a tool for the study of drug action in patients. The translation of experimental pharmacological findings into therapeutic regimens is today increasingly dependent on ade qua te models of drug action. The purpose of the conference, of which this book is the proceedings, was to discuss contemporary findings in this important biomedical research field. The conference program was designed by Professor Teorell with the help of a small committee which included Drs. Edward R.

Drug Disposition and Pharmacokinetics

Stephen H. Curry,Robin Whelpton
Drug Disposition and Pharmacokinetics Book PDF

Author : Stephen H. Curry,Robin Whelpton
Publisher : Wiley
Page : 388 pages
File Size : 43,7 Mb
Release : 2010-12-01
Category : Science
ISBN : 0470684461

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Drug Disposition and Pharmacokinetics by Stephen H. Curry,Robin Whelpton Pdf

This is an authoritative, comprehensive book on the fate of drug molecules in the body, including implications for pharmacological and clinical effects. The text provides a unique, balanced approach, examining the specific physical and biological factors affecting the absorption, distribution, metabolism and excretion of drugs, together with mathematical assessment of the concentrations in plasma and body fluids. Understanding the equations requires little more than a basic knowledge of algebra, laws of indices and logarithms, and very simple calculus. A companion web site contains additional illustrations, further equations and numerous worked examples. Whilst this book has its roots in the highly acclaimed book of the same name, written by Stephen Curry nearly thirty years ago, it is essentially a new book having been restructured and largely rewritten. This readable and informative book is an invaluable resource for professionals and students needing to develop a rational approach to the investigation and application of drugs.